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The map label for this gene is 222525954

Identifier: 222525954

GI number: 222525954

Start: 3344300

End: 3345559

Strand: Reverse

Name: 222525954

Synonym: Chy400_2710

Alternate gene names: NA

Gene position: 3345559-3344300 (Counterclockwise)

Preceding gene: 222525955

Following gene: 222525950

Centisome position: 63.5

GC content: 60.16

Gene sequence:

>1260_bases
ATGAACCCTATGCCACTCACCAGTTTTGTGCCAGTCGCGCCTGATAGCGACTTTCCACTGGAAAACTTACCCTACGGGGT
CTTTCGGCCCCGCGCCGGTGGCCCGGCCCGTATCGGTGTCGCCATTGGCGAGTATGTGCTCGATCTTGCTGTGATTGATG
AGGCCGGGCTACTATCGGCGACCCCGGTTGGCGGTCGTGGTATGTTTGCCCAAGACTCGTTGAATGCGTTTATGGCTGCC
GGCCCGACAGCCTGGCAGGCAGTACGGTCAGTGCTGCAACGCCTGCTCACCGCCGATGAACCAACGCTCCGCGACAATCA
GGTCCTGCGCGACGCCGCACTGCTGCCGCAACACACCATTGATCTGCTGCTACCGGCCCACATCGGCGATTACACCGACT
TCTATTCGTCGCTGTACCACGCCAGCAACGTCGGCAAGATGTTGCGTCCCGACAATCCACCTCTCTTTCCAAACTGGCGC
CACCTGCCGGTTGCCTACCATGGACGGGCGAGTACCGTTGTGGTGAGCGGAACACCAATCCATCGTCCATATGGTCAGAC
CAAACCGGCTGATAGCCCGGCACCAGTCTATGGCCCGACGCGAGCACTCGATTTTGAGCTAGAGCTGGGTATGTTCATTG
GGCCGGGCAACGATCTGGGCAGTCCAATTCCCATCGACCAGGCTGAAGACCATATCTTCGGCTTTGTGCTGGTCAATGAC
TGGAGTGCCCGCGATATTCAGGGGTGGGAATACCAGCCGCTCGGCCCATTCCTGGCCAAAAACTTCGCCACCTCAATCAG
CCCCTGGGTAGTGCCACTGGCAGCGCTGGAACCGTTCCGTTGTCAGGGCGAACCGCAAGACCCACCACCACTGCCGTATC
TGCAACCCGTGCGGCCCGGCCATTTTGCCATCACCCTGGAAGTCTGGCTGAACGACACCCGCATTTGTCAAAGCGACAGC
CGTTATCTCTACTGGAGCTGTGCGCAACAAATTGCCCACCACACTGTAAACGGCTGCCGCCTGCGACCGGGTGACCTGCT
GGCCTCCGGTACGATCAGCGGGCCGGACAAACACACTCGCGGTTGCCTGCTCGAACTCACCTGGCGTGGCAGCGAACCAT
TGACCCTGCGCGATGGCTCGCAACGGCGATGGCTCGAAGATGGTGATACCGTCACAATGCGCGGCTGGGCACAGGGTGAC
GGCTATCGCATCGGCTTTGGTGCGGTCAGCGGTACGATCCGCAGAGCCACGCTAGAATAA

Upstream 100 bases:

>100_bases
TCCCAGGGGATAGCGGTACGTGTCAACCACGATGGAGCGCTTCAGGGCGCAGCGTGAGCGTAAGATAGATATTGGGCCAA
GACGTTTAACCAGATTTGAT

Downstream 100 bases:

>100_bases
TTCGTCCAGCATGCGGTAATACGCGATTTTACCGGCATCAACCTGTTCAAGGCCGTAACACGCAAAAAAGTACTGCTCGT
ACTGGGGACCTAGATTATAA

Product: fumarylacetoacetase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetate Hydrolase Domain-Containing; Fumarylacetoacetate; Fumarylacetoacetase Hydrolase; 2-Hydroxyhepta-2 4-Diene-1 7-Dioate Isomerase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MNPMPLTSFVPVAPDSDFPLENLPYGVFRPRAGGPARIGVAIGEYVLDLAVIDEAGLLSATPVGGRGMFAQDSLNAFMAA
GPTAWQAVRSVLQRLLTADEPTLRDNQVLRDAALLPQHTIDLLLPAHIGDYTDFYSSLYHASNVGKMLRPDNPPLFPNWR
HLPVAYHGRASTVVVSGTPIHRPYGQTKPADSPAPVYGPTRALDFELELGMFIGPGNDLGSPIPIDQAEDHIFGFVLVND
WSARDIQGWEYQPLGPFLAKNFATSISPWVVPLAALEPFRCQGEPQDPPPLPYLQPVRPGHFAITLEVWLNDTRICQSDS
RYLYWSCAQQIAHHTVNGCRLRPGDLLASGTISGPDKHTRGCLLELTWRGSEPLTLRDGSQRRWLEDGDTVTMRGWAQGD
GYRIGFGAVSGTIRRATLE

Sequences:

>Translated_419_residues
MNPMPLTSFVPVAPDSDFPLENLPYGVFRPRAGGPARIGVAIGEYVLDLAVIDEAGLLSATPVGGRGMFAQDSLNAFMAA
GPTAWQAVRSVLQRLLTADEPTLRDNQVLRDAALLPQHTIDLLLPAHIGDYTDFYSSLYHASNVGKMLRPDNPPLFPNWR
HLPVAYHGRASTVVVSGTPIHRPYGQTKPADSPAPVYGPTRALDFELELGMFIGPGNDLGSPIPIDQAEDHIFGFVLVND
WSARDIQGWEYQPLGPFLAKNFATSISPWVVPLAALEPFRCQGEPQDPPPLPYLQPVRPGHFAITLEVWLNDTRICQSDS
RYLYWSCAQQIAHHTVNGCRLRPGDLLASGTISGPDKHTRGCLLELTWRGSEPLTLRDGSQRRWLEDGDTVTMRGWAQGD
GYRIGFGAVSGTIRRATLE
>Mature_419_residues
MNPMPLTSFVPVAPDSDFPLENLPYGVFRPRAGGPARIGVAIGEYVLDLAVIDEAGLLSATPVGGRGMFAQDSLNAFMAA
GPTAWQAVRSVLQRLLTADEPTLRDNQVLRDAALLPQHTIDLLLPAHIGDYTDFYSSLYHASNVGKMLRPDNPPLFPNWR
HLPVAYHGRASTVVVSGTPIHRPYGQTKPADSPAPVYGPTRALDFELELGMFIGPGNDLGSPIPIDQAEDHIFGFVLVND
WSARDIQGWEYQPLGPFLAKNFATSISPWVVPLAALEPFRCQGEPQDPPPLPYLQPVRPGHFAITLEVWLNDTRICQSDS
RYLYWSCAQQIAHHTVNGCRLRPGDLLASGTISGPDKHTRGCLLELTWRGSEPLTLRDGSQRRWLEDGDTVTMRGWAQGD
GYRIGFGAVSGTIRRATLE

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=419, Percent_Identity=55.6085918854415, Blast_Score=463, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17568863, Length=417, Percent_Identity=50.8393285371703, Blast_Score=417, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24657182, Length=413, Percent_Identity=54.2372881355932, Blast_Score=422, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 45960; Mature: 45960

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPMPLTSFVPVAPDSDFPLENLPYGVFRPRAGGPARIGVAIGEYVLDLAVIDEAGLLSA
CCCCCCCCEEECCCCCCCCHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHEEECCCCCEEC
TPVGGRGMFAQDSLNAFMAAGPTAWQAVRSVLQRLLTADEPTLRDNQVLRDAALLPQHTI
CCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHE
DLLLPAHIGDYTDFYSSLYHASNVGKMLRPDNPPLFPNWRHLPVAYHGRASTVVVSGTPI
EEEECCCCCCHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCC
HRPYGQTKPADSPAPVYGPTRALDFELELGMFIGPGNDLGSPIPIDQAEDHIFGFVLVND
CCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEC
WSARDIQGWEYQPLGPFLAKNFATSISPWVVPLAALEPFRCQGEPQDPPPLPYLQPVRPG
CCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCC
HFAITLEVWLNDTRICQSDSRYLYWSCAQQIAHHTVNGCRLRPGDLLASGTISGPDKHTR
CEEEEEEEEECCCEEECCCCCEEEHHHHHHHHHHCCCCCEECCCCEEECCCCCCCCCCCC
GCLLELTWRGSEPLTLRDGSQRRWLEDGDTVTMRGWAQGDGYRIGFGAVSGTIRRATLE
CEEEEEEECCCCCEEECCCCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCEEEEEECC
>Mature Secondary Structure
MNPMPLTSFVPVAPDSDFPLENLPYGVFRPRAGGPARIGVAIGEYVLDLAVIDEAGLLSA
CCCCCCCCEEECCCCCCCCHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHEEECCCCCEEC
TPVGGRGMFAQDSLNAFMAAGPTAWQAVRSVLQRLLTADEPTLRDNQVLRDAALLPQHTI
CCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHE
DLLLPAHIGDYTDFYSSLYHASNVGKMLRPDNPPLFPNWRHLPVAYHGRASTVVVSGTPI
EEEECCCCCCHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCC
HRPYGQTKPADSPAPVYGPTRALDFELELGMFIGPGNDLGSPIPIDQAEDHIFGFVLVND
CCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEC
WSARDIQGWEYQPLGPFLAKNFATSISPWVVPLAALEPFRCQGEPQDPPPLPYLQPVRPG
CCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCC
HFAITLEVWLNDTRICQSDSRYLYWSCAQQIAHHTVNGCRLRPGDLLASGTISGPDKHTR
CEEEEEEEEECCCEEECCCCCEEEHHHHHHHHHHCCCCCEECCCCEEECCCCCCCCCCCC
GCLLELTWRGSEPLTLRDGSQRRWLEDGDTVTMRGWAQGDGYRIGFGAVSGTIRRATLE
CEEEEEEECCCCCEEECCCCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA