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The map label for this gene is mfnA [H]

Identifier: 222525499

GI number: 222525499

Start: 2843796

End: 2845199

Strand: Direct

Name: mfnA [H]

Synonym: Chy400_2247

Alternate gene names: 222525499

Gene position: 2843796-2845199 (Clockwise)

Preceding gene: 222525498

Following gene: 222525500

Centisome position: 53.97

GC content: 57.91

Gene sequence:

>1404_bases
ATGGCTCCAGCCGAAATTCTGAGCGCACTACAGCGCTTTAAAATGGCCGATCTCGATTGGCAACACGGTCGGGTGTGGGC
GTATGTCTATCAACCAGATGCAGCGGCAACCGATCTCATGCAACAGGCGTATCTCCATTATCTGACCGAGAATTGCCTTG
ATCCCACCACCTTTCCCAGCACCGCTCACCTCGAACAGGAAGTGGTGCGGATGGTTGCCGATCTGCTCGGTGGTGATGAA
GAGACGTGCGGGAATGTGACATCAGGTGGGACTGAGAGTATTCTGCTCGCGGTCAAGACGGCTCGTGACTGGGCACGCCA
CCAGCGGCCAGGGATTGATCAACCCGAAATGGTGCTCTCGCGTACTGCCCATGCCGCTTTTCACAAAGCGGCGCACTATC
TGGGCGTCAAGCCGGTCGTGGTTGATTTTGACCCGCTAACCTTCGCGGCTGATGTGGCGGCGATGCGGGCCGCGATTAAC
GAGCGTACCATTATGCTGGTGGCGTCAGCGCCTTCGTATGCCCAGGGTGCGCTCGATCCGGTGGCCGACATCGCAGCACT
TGCCCAGGAATACGGCCTGCTTTGCCACGTTGATGCCTGTGTTGGTGGGATGTATCTGCCGTTTCTACGTCAGTTGGGTC
GTGAGATTCCGCCCTTCGATCTGAGTGTGCCGGGGGTGACATCGCTTTCGGTTGATTTGCACAAGTATGGCTACGCCGCC
AAAGGGGCATCGGTCATTCTCTACCGCCATCGTGCGTTGCGCCGCTATCAGTTGTTTGCTTCGACCGATACCACAGCCTA
TACGGTCATCAACCCAACGGTGCTCAGTTCTCGTTCGGCGGGGCCGCTGGCGGCGGCCTGGGCACTTTTGCGTTACCTCG
GTGCCGTCGGCTATCGTCAGATCGTGGCGGTTGTCCAGGACGCCACCGACCGTCTGATTGCCGGGATTGCGGCAATTCCC
GATCTTCAGGTGCTGGGTCAACCGGTGATGAGTATGGTGGCTGTGGCCTCACCAACCATCAACGTCTTTCAACTGGCCGA
TGCGATGCGTCGGCGTGGATGGTATGTTCAGCCGCAATTGTCAGCTCCACACTCGCCACGTAACATCCATTTCTCGGTTT
CGTATGGGGTAGCTGGCTACGTTGATGCACTGCTCGCCGATCTTGCAGCCTGCGTTGCCGAGGTGCGCCACTGGCCGCCG
GTTGACCGCAATCTGGTTGAGATGGCCGTTCGTTCGCTGACCGTTGATCATTCTCCGTCCGCTGTACAACAGCTCTGGCA
GGCCATCGGGTTGGCTGAAGGCCGGTTACCGACCGATATGGCTCTGATTAACGAAGTGCTCGATGCGCTGCCCGATGCGA
TTGCCAATGAACTAGTGATTGATGTCTTCAATGCGCTGTTTTAG

Upstream 100 bases:

>100_bases
TGATCATCGTCTTTTGTATGTGGAAGTATCCGTTGGAGCGAGCGCCGAAAGCGGCATTGGCGCCGGAAAGGGTTGTGTCG
TGAGTTTTCCTGCTACAGGA

Downstream 100 bases:

>100_bases
CGGTAGTTCCTGTCACCCGCTGCCTGGATGTTGGTTGCCACTGATGGTTTGCTGGCCTTGCTTGTGATGCGGCATAGCTG
CAGGAAGGGGTAGTATGACG

Product: Pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: TDC [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MAPAEILSALQRFKMADLDWQHGRVWAYVYQPDAAATDLMQQAYLHYLTENCLDPTTFPSTAHLEQEVVRMVADLLGGDE
ETCGNVTSGGTESILLAVKTARDWARHQRPGIDQPEMVLSRTAHAAFHKAAHYLGVKPVVVDFDPLTFAADVAAMRAAIN
ERTIMLVASAPSYAQGALDPVADIAALAQEYGLLCHVDACVGGMYLPFLRQLGREIPPFDLSVPGVTSLSVDLHKYGYAA
KGASVILYRHRALRRYQLFASTDTTAYTVINPTVLSSRSAGPLAAAWALLRYLGAVGYRQIVAVVQDATDRLIAGIAAIP
DLQVLGQPVMSMVAVASPTINVFQLADAMRRRGWYVQPQLSAPHSPRNIHFSVSYGVAGYVDALLADLAACVAEVRHWPP
VDRNLVEMAVRSLTVDHSPSAVQQLWQAIGLAEGRLPTDMALINEVLDALPDAIANELVIDVFNALF

Sequences:

>Translated_467_residues
MAPAEILSALQRFKMADLDWQHGRVWAYVYQPDAAATDLMQQAYLHYLTENCLDPTTFPSTAHLEQEVVRMVADLLGGDE
ETCGNVTSGGTESILLAVKTARDWARHQRPGIDQPEMVLSRTAHAAFHKAAHYLGVKPVVVDFDPLTFAADVAAMRAAIN
ERTIMLVASAPSYAQGALDPVADIAALAQEYGLLCHVDACVGGMYLPFLRQLGREIPPFDLSVPGVTSLSVDLHKYGYAA
KGASVILYRHRALRRYQLFASTDTTAYTVINPTVLSSRSAGPLAAAWALLRYLGAVGYRQIVAVVQDATDRLIAGIAAIP
DLQVLGQPVMSMVAVASPTINVFQLADAMRRRGWYVQPQLSAPHSPRNIHFSVSYGVAGYVDALLADLAACVAEVRHWPP
VDRNLVEMAVRSLTVDHSPSAVQQLWQAIGLAEGRLPTDMALINEVLDALPDAIANELVIDVFNALF
>Mature_466_residues
APAEILSALQRFKMADLDWQHGRVWAYVYQPDAAATDLMQQAYLHYLTENCLDPTTFPSTAHLEQEVVRMVADLLGGDEE
TCGNVTSGGTESILLAVKTARDWARHQRPGIDQPEMVLSRTAHAAFHKAAHYLGVKPVVVDFDPLTFAADVAAMRAAINE
RTIMLVASAPSYAQGALDPVADIAALAQEYGLLCHVDACVGGMYLPFLRQLGREIPPFDLSVPGVTSLSVDLHKYGYAAK
GASVILYRHRALRRYQLFASTDTTAYTVINPTVLSSRSAGPLAAAWALLRYLGAVGYRQIVAVVQDATDRLIAGIAAIPD
LQVLGQPVMSMVAVASPTINVFQLADAMRRRGWYVQPQLSAPHSPRNIHFSVSYGVAGYVDALLADLAACVAEVRHWPPV
DRNLVEMAVRSLTVDHSPSAVQQLWQAIGLAEGRLPTDMALINEVLDALPDAIANELVIDVFNALF

Specific function: Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine [H]

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31982936, Length=377, Percent_Identity=39.5225464190981, Blast_Score=274, Evalue=1e-73,
Organism=Escherichia coli, GI1789934, Length=336, Percent_Identity=24.4047619047619, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787769, Length=336, Percent_Identity=24.4047619047619, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17543922, Length=396, Percent_Identity=35.6060606060606, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17557272, Length=397, Percent_Identity=34.5088161209068, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI25148342, Length=406, Percent_Identity=32.2660098522167, Blast_Score=214, Evalue=9e-56,
Organism=Saccharomyces cerevisiae, GI6320500, Length=390, Percent_Identity=36.1538461538462, Blast_Score=236, Evalue=7e-63,
Organism=Drosophila melanogaster, GI21355963, Length=404, Percent_Identity=36.6336633663366, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24654344, Length=404, Percent_Identity=36.6336633663366, Blast_Score=277, Evalue=1e-74,

Paralogues:

None

Copy number: 3820 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115
- InterPro:   IPR020931 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.25 [H]

Molecular weight: Translated: 50692; Mature: 50560

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPAEILSALQRFKMADLDWQHGRVWAYVYQPDAAATDLMQQAYLHYLTENCLDPTTFPS
CCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
TAHLEQEVVRMVADLLGGDEETCGNVTSGGTESILLAVKTARDWARHQRPGIDQPEMVLS
HHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCHHHHHH
RTAHAAFHKAAHYLGVKPVVVDFDPLTFAADVAAMRAAINERTIMLVASAPSYAQGALDP
HHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHCCHHH
VADIAALAQEYGLLCHVDACVGGMYLPFLRQLGREIPPFDLSVPGVTSLSVDLHKYGYAA
HHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHCCCC
KGASVILYRHRALRRYQLFASTDTTAYTVINPTVLSSRSAGPLAAAWALLRYLGAVGYRQ
CCCCEEHHHHHHHHHHHHEECCCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHH
IVAVVQDATDRLIAGIAAIPDLQVLGQPVMSMVAVASPTINVFQLADAMRRRGWYVQPQL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEECCCC
SAPHSPRNIHFSVSYGVAGYVDALLADLAACVAEVRHWPPVDRNLVEMAVRSLTVDHSPS
CCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCH
AVQQLWQAIGLAEGRLPTDMALINEVLDALPDAIANELVIDVFNALF
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
APAEILSALQRFKMADLDWQHGRVWAYVYQPDAAATDLMQQAYLHYLTENCLDPTTFPS
CHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
TAHLEQEVVRMVADLLGGDEETCGNVTSGGTESILLAVKTARDWARHQRPGIDQPEMVLS
HHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCHHHHHH
RTAHAAFHKAAHYLGVKPVVVDFDPLTFAADVAAMRAAINERTIMLVASAPSYAQGALDP
HHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHCCHHH
VADIAALAQEYGLLCHVDACVGGMYLPFLRQLGREIPPFDLSVPGVTSLSVDLHKYGYAA
HHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHCCCC
KGASVILYRHRALRRYQLFASTDTTAYTVINPTVLSSRSAGPLAAAWALLRYLGAVGYRQ
CCCCEEHHHHHHHHHHHHEECCCCCEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHH
IVAVVQDATDRLIAGIAAIPDLQVLGQPVMSMVAVASPTINVFQLADAMRRRGWYVQPQL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEECCCC
SAPHSPRNIHFSVSYGVAGYVDALLADLAACVAEVRHWPPVDRNLVEMAVRSLTVDHSPS
CCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCH
AVQQLWQAIGLAEGRLPTDMALINEVLDALPDAIANELVIDVFNALF
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA