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The map label for this gene is msrA [H]

Identifier: 222525065

GI number: 222525065

Start: 2280140

End: 2280685

Strand: Direct

Name: msrA [H]

Synonym: Chy400_1802

Alternate gene names: 222525065

Gene position: 2280140-2280685 (Clockwise)

Preceding gene: 222525064

Following gene: 222525068

Centisome position: 43.28

GC content: 54.95

Gene sequence:

>546_bases
ATGCCTCTGGAGACAGCTACGCTGGCTGGTGGATGTTTCTGGTGTCTGGAAGCGGTGTACGATCAGGTGAGCGGCGTGAA
GGACGTGGTGTCGGGATATACCGGGGGGTATGTGCCCAACCCGACGTATCGCCGGGTGTGTGATGGCAATACCGGCCACG
CGGAAGCGGTACAAATCCAGTTTGATCCCGAACAGATCAGCTATCGCGAATTGCTGGAAATTTTCTTCAGTATTCACGAT
CCGACGACGCTGAACCGACAGGGAGCTGATGTCGGCACACAATACCGTTCAGCCATCTTCTACCACTCTGAGGAGCAGCG
TCAGGTGGCCGAGCAACTTGTGCGTGAGCTGACCGAACAACAGGTATTTCGCGATCCGATTGTGACGCAGATCGTCCCGG
CTACCACTTTTTATCCGGCTGAGGAGTATCACCAGGAGTATTTTGCCCGCAATCCCTATCAGCCCTATTGTCAGTTTGTG
GTGGCCCCGAAAGTGGCGAAGTTTCAGAAACTCTTTGCCCATCGGGTTGCCGGTGAGAAGAGCTGA

Upstream 100 bases:

>100_bases
ACAATCCGCTGTAGCACTCTTTGCCCGAAAACCCGCCATCCATCGCCAAACTGCGGTAGACTACAAAGAGGAAGCGATTA
CGTAGACAAGGAGATTCGGT

Downstream 100 bases:

>100_bases
TCGAAGGGGGGCGAACACTATCGCTCGCCCCCTACCGGGTGATCACCACACCTCTTCAAGCATAGCAAGTAACTCTTCAG
GCGTTGCCGGACGGGGATTG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MPLETATLAGGCFWCLEAVYDQVSGVKDVVSGYTGGYVPNPTYRRVCDGNTGHAEAVQIQFDPEQISYRELLEIFFSIHD
PTTLNRQGADVGTQYRSAIFYHSEEQRQVAEQLVRELTEQQVFRDPIVTQIVPATTFYPAEEYHQEYFARNPYQPYCQFV
VAPKVAKFQKLFAHRVAGEKS

Sequences:

>Translated_181_residues
MPLETATLAGGCFWCLEAVYDQVSGVKDVVSGYTGGYVPNPTYRRVCDGNTGHAEAVQIQFDPEQISYRELLEIFFSIHD
PTTLNRQGADVGTQYRSAIFYHSEEQRQVAEQLVRELTEQQVFRDPIVTQIVPATTFYPAEEYHQEYFARNPYQPYCQFV
VAPKVAKFQKLFAHRVAGEKS
>Mature_180_residues
PLETATLAGGCFWCLEAVYDQVSGVKDVVSGYTGGYVPNPTYRRVCDGNTGHAEAVQIQFDPEQISYRELLEIFFSIHDP
TTLNRQGADVGTQYRSAIFYHSEEQRQVAEQLVRELTEQQVFRDPIVTQIVPATTFYPAEEYHQEYFARNPYQPYCQFVV
APKVAKFQKLFAHRVAGEKS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=158, Percent_Identity=44.3037974683544, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI208609995, Length=158, Percent_Identity=44.3037974683544, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI208609993, Length=111, Percent_Identity=46.8468468468468, Blast_Score=95, Evalue=4e-20,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=49.0196078431373, Blast_Score=149, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17533973, Length=148, Percent_Identity=36.4864864864865, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=154, Percent_Identity=42.2077922077922, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24664627, Length=166, Percent_Identity=39.1566265060241, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI45553131, Length=160, Percent_Identity=38.75, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24664631, Length=166, Percent_Identity=37.3493975903614, Blast_Score=97, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20642; Mature: 20511

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLETATLAGGCFWCLEAVYDQVSGVKDVVSGYTGGYVPNPTYRRVCDGNTGHAEAVQIQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCEEEEEE
FDPEQISYRELLEIFFSIHDPTTLNRQGADVGTQYRSAIFYHSEEQRQVAEQLVRELTEQ
ECHHHCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QVFRDPIVTQIVPATTFYPAEEYHQEYFARNPYQPYCQFVVAPKVAKFQKLFAHRVAGEK
HHHHCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHCCCC
S
C
>Mature Secondary Structure 
PLETATLAGGCFWCLEAVYDQVSGVKDVVSGYTGGYVPNPTYRRVCDGNTGHAEAVQIQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCEEEEEE
FDPEQISYRELLEIFFSIHDPTTLNRQGADVGTQYRSAIFYHSEEQRQVAEQLVRELTEQ
ECHHHCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QVFRDPIVTQIVPATTFYPAEEYHQEYFARNPYQPYCQFVVAPKVAKFQKLFAHRVAGEK
HHHHCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHCCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA