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The map label for this gene is pth

Identifier: 222525064

GI number: 222525064

Start: 2279487

End: 2280053

Strand: Direct

Name: pth

Synonym: Chy400_1801

Alternate gene names: 222525064

Gene position: 2279487-2280053 (Clockwise)

Preceding gene: 222525061

Following gene: 222525065

Centisome position: 43.26

GC content: 55.73

Gene sequence:

>567_bases
ATGTGGCTCATTGTTGGTCTGGGAAATCCGGGGGAGCGCTATGCAAGAACCCGCCACAATATCGGTTTTCGGAGTGTGGA
CACGTTAGCCGAACGGCATGGTCTGACCTTTCGCCCACAACGGGCAAACAGTCAGCTTGCCGAAGGGAACATCTACGGTC
AGCGCGTGGTGCTGGCAAAACCCCAAACTTACATGAATCTCAGCGGGCAGGCAGTGGTGGCACTGTGTAACTGGTACAAA
ATCGATCCGGCTCGCGAGCTGTTGGTCATCTACGATGATCTCGATCTACCGTTCGCCAAACTGCGCATCCGTGAGCGTGG
CAGTGCCGGGACGCACAATGGCATGCGGTCGATAGTCGCCCAATTAGGAACGACCGAATTCCCCCGGTTACGGGTCGGGA
TCGGTCAGCCCCCTGGCAAGATGGATGCTGCCGATTATGTATTGGGACGGTTCACGCCTGATGAAGAGGCTGCTCTTCCC
GATCTGCTTGGGCGAATTGCCGATGCAGTTGAGGTGATCTTACGAGAAGGTTTAACAACAGCGATGAACCGCTACAATCC
GCTGTAG

Upstream 100 bases:

>100_bases
ATCTCCTATTTCCTATCTCCTATCTCCTTGACGCATACCGCAACCGCTTCTACCATGCGCATCTGATGCAAAGGAATAGT
ATCCGGTTAGGATGGATCAT

Downstream 100 bases:

>100_bases
CACTCTTTGCCCGAAAACCCGCCATCCATCGCCAAACTGCGGTAGACTACAAAGAGGAAGCGATTACGTAGACAAGGAGA
TTCGGTATGCCTCTGGAGAC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MWLIVGLGNPGERYARTRHNIGFRSVDTLAERHGLTFRPQRANSQLAEGNIYGQRVVLAKPQTYMNLSGQAVVALCNWYK
IDPARELLVIYDDLDLPFAKLRIRERGSAGTHNGMRSIVAQLGTTEFPRLRVGIGQPPGKMDAADYVLGRFTPDEEAALP
DLLGRIADAVEVILREGLTTAMNRYNPL

Sequences:

>Translated_188_residues
MWLIVGLGNPGERYARTRHNIGFRSVDTLAERHGLTFRPQRANSQLAEGNIYGQRVVLAKPQTYMNLSGQAVVALCNWYK
IDPARELLVIYDDLDLPFAKLRIRERGSAGTHNGMRSIVAQLGTTEFPRLRVGIGQPPGKMDAADYVLGRFTPDEEAALP
DLLGRIADAVEVILREGLTTAMNRYNPL
>Mature_188_residues
MWLIVGLGNPGERYARTRHNIGFRSVDTLAERHGLTFRPQRANSQLAEGNIYGQRVVLAKPQTYMNLSGQAVVALCNWYK
IDPARELLVIYDDLDLPFAKLRIRERGSAGTHNGMRSIVAQLGTTEFPRLRVGIGQPPGKMDAADYVLGRFTPDEEAALP
DLLGRIADAVEVILREGLTTAMNRYNPL

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=178, Percent_Identity=35.9550561797753, Blast_Score=108, Evalue=4e-24,
Organism=Escherichia coli, GI1787455, Length=186, Percent_Identity=39.7849462365591, Blast_Score=113, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6321983, Length=167, Percent_Identity=32.9341317365269, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_CHLAA (A9WBS1)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001635267.1
- ProteinModelPortal:   A9WBS1
- SMR:   A9WBS1
- GeneID:   5826109
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_1660
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20917; Mature: 20917

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWLIVGLGNPGERYARTRHNIGFRSVDTLAERHGLTFRPQRANSQLAEGNIYGQRVVLAK
CEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEC
PQTYMNLSGQAVVALCNWYKIDPARELLVIYDDLDLPFAKLRIRERGSAGTHNGMRSIVA
CCHHCCCCCCEEEEEECCEEECCCCEEEEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHH
QLGTTEFPRLRVGIGQPPGKMDAADYVLGRFTPDEEAALPDLLGRIADAVEVILREGLTT
HHCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHH
AMNRYNPL
HHHHCCCC
>Mature Secondary Structure
MWLIVGLGNPGERYARTRHNIGFRSVDTLAERHGLTFRPQRANSQLAEGNIYGQRVVLAK
CEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEC
PQTYMNLSGQAVVALCNWYKIDPARELLVIYDDLDLPFAKLRIRERGSAGTHNGMRSIVA
CCHHCCCCCCEEEEEECCEEECCCCEEEEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHH
QLGTTEFPRLRVGIGQPPGKMDAADYVLGRFTPDEEAALPDLLGRIADAVEVILREGLTT
HHCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHH
AMNRYNPL
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA