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The map label for this gene is rsbRA [H]

Identifier: 222524959

GI number: 222524959

Start: 2138916

End: 2140442

Strand: Direct

Name: rsbRA [H]

Synonym: Chy400_1694

Alternate gene names: 222524959

Gene position: 2138916-2140442 (Clockwise)

Preceding gene: 222524958

Following gene: 222524960

Centisome position: 40.59

GC content: 54.88

Gene sequence:

>1527_bases
ATGAACAACACATTCGTCGCAATTGCCGATGCACTACGAGCACATCTTCCGTCGCTTCCCCCAGCCGAACGTCCATTGCT
CGTCGCATTAGCCGATGCGTTGAGTACCGGTGATCCCTCGCACCTGTTGACTCTGCTGCGTAACGGCGGATCGATCAGTG
CCGGTTTCAACCGCCTTGATGCAGTCCGTCGCCAGGCAACCGGCTTACTGGCCGATAACCCGGCAGCAGCGGGGCCAATT
GCCGACATTGTGGCCGAGGCGCAACGAGTGTTAATCGCGGAAGAAGAGACGATGCTGCGACGCGAGCATATGCTCAATCA
GCGCCTTGAACAGAGTTTTCTGACCTCACCGCTGGCAACGCTCGAAGCTAATGAGTACGGTATCATTACCCGCTGGAATT
CGGCTGCCGAACGTATTTTTGGCTGGAGTGCAGCCGAAGCGGTTGGCAAAAATGCTATTGAACTGCTGGTCCCGAACATT
GCCCGCGAACACGTCGAAGCGATTGTCCAGGCTCTCCTGAGTGGTCAGGCAAAGAATAGCCGCAATGAAAACATCACGAA
AGATGGCCGCATTATCATTTGTCAGTGGTACAACGCGGTTTTGTACCATCCTGATGGAAGAGTTGCCGGCTGGTTGTCGC
AGACCGAAGATATTACCGAACAGATTCGTGCCGAAGAAGCCCTGCGCGAGAATCAACGCCGCCTCGATAGGTTAATGCGT
AATTTGCCCGGCATTGCATATCGATCCCGCAAGGATGGGCGCTGGACGGCTGAGTTTATGAGTGAAGGGGCGCTTGAGGT
TACTGGTTATCCGGCCAGCGATTTTATGCCGGACGGTGATCAACCGCTGCGCCGTTATTTTGGTGATCTCATCCTGCCTG
AAGACCGCGAGGCAGTGAAGGAGAGTGTGCAGACGGCAATTGCTCAGCAGCGCCAGTTTGAGATTACGTACCGGATCCGT
CACGCTGATGGCAGCATTCGTTGGGTGTGGGAACGCGGAACAGGTGTGTTTAATGAGACGGGTCAGTTGGAAGCTATCGA
AGGCTTCATTACTGATGTCACTGCTGAACGGCAGGCTGCTGAAGAGCGCCAGGCGTTAAACGAGCGTATTATTGCTGCGC
AAGAAGCCGCCCTCCGCGAATTAAGCACGCCAATTGTCCCGATCAGTCGAGGGGTGATTGCGATGCCGCTCATCGGCAGT
ATCGATAGCACTCGCGCCCAACAGGTGATCGAATCCTTGCTGGAAGGCGTGAATACAAGTGGGGCCCACATTGTGATCCT
CGATGTAACCGGTGTACCGGTGGTTGATACACAGGTTGCCAACACGCTGTTACGTTCGGCTCAGGCTGTACGTCTGCTCG
GTGCCGAAGTTCTCTTAACCGGCATCCGGCCAGAAGTTGCCCAAACCATTGTCGGATTGGGGCTTGATATGAGCCACATT
CGCACGCTGGCAACGTTGCAAGATGGCATTACATATGCACTTGGCCGGCAATCCCTCGGCCAGACCATAGTCCACCGCAT
AAGATAA

Upstream 100 bases:

>100_bases
ATTAGAGCAGCTATTTGACTTGTCACTAAAGCCCGGCAATATGTTATACTACGGCCAGCACCTGCATACAATTCCACTAC
GGTGACAGGAACTCGTTCCT

Downstream 100 bases:

>100_bases
AGGAGTCGATGATGATGCTCGAACGTGCCCAGGCGTTGGCGGATGAAATTATTCGCATCCGCCGTGACATTCATGCCCAT
CCCGAACTCGGCTTTCAGGA

Product: putative PAS/PAC sensor protein

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MNNTFVAIADALRAHLPSLPPAERPLLVALADALSTGDPSHLLTLLRNGGSISAGFNRLDAVRRQATGLLADNPAAAGPI
ADIVAEAQRVLIAEEETMLRREHMLNQRLEQSFLTSPLATLEANEYGIITRWNSAAERIFGWSAAEAVGKNAIELLVPNI
AREHVEAIVQALLSGQAKNSRNENITKDGRIIICQWYNAVLYHPDGRVAGWLSQTEDITEQIRAEEALRENQRRLDRLMR
NLPGIAYRSRKDGRWTAEFMSEGALEVTGYPASDFMPDGDQPLRRYFGDLILPEDREAVKESVQTAIAQQRQFEITYRIR
HADGSIRWVWERGTGVFNETGQLEAIEGFITDVTAERQAAEERQALNERIIAAQEAALRELSTPIVPISRGVIAMPLIGS
IDSTRAQQVIESLLEGVNTSGAHIVILDVTGVPVVDTQVANTLLRSAQAVRLLGAEVLLTGIRPEVAQTIVGLGLDMSHI
RTLATLQDGITYALGRQSLGQTIVHRIR

Sequences:

>Translated_508_residues
MNNTFVAIADALRAHLPSLPPAERPLLVALADALSTGDPSHLLTLLRNGGSISAGFNRLDAVRRQATGLLADNPAAAGPI
ADIVAEAQRVLIAEEETMLRREHMLNQRLEQSFLTSPLATLEANEYGIITRWNSAAERIFGWSAAEAVGKNAIELLVPNI
AREHVEAIVQALLSGQAKNSRNENITKDGRIIICQWYNAVLYHPDGRVAGWLSQTEDITEQIRAEEALRENQRRLDRLMR
NLPGIAYRSRKDGRWTAEFMSEGALEVTGYPASDFMPDGDQPLRRYFGDLILPEDREAVKESVQTAIAQQRQFEITYRIR
HADGSIRWVWERGTGVFNETGQLEAIEGFITDVTAERQAAEERQALNERIIAAQEAALRELSTPIVPISRGVIAMPLIGS
IDSTRAQQVIESLLEGVNTSGAHIVILDVTGVPVVDTQVANTLLRSAQAVRLLGAEVLLTGIRPEVAQTIVGLGLDMSHI
RTLATLQDGITYALGRQSLGQTIVHRIR
>Mature_508_residues
MNNTFVAIADALRAHLPSLPPAERPLLVALADALSTGDPSHLLTLLRNGGSISAGFNRLDAVRRQATGLLADNPAAAGPI
ADIVAEAQRVLIAEEETMLRREHMLNQRLEQSFLTSPLATLEANEYGIITRWNSAAERIFGWSAAEAVGKNAIELLVPNI
AREHVEAIVQALLSGQAKNSRNENITKDGRIIICQWYNAVLYHPDGRVAGWLSQTEDITEQIRAEEALRENQRRLDRLMR
NLPGIAYRSRKDGRWTAEFMSEGALEVTGYPASDFMPDGDQPLRRYFGDLILPEDREAVKESVQTAIAQQRQFEITYRIR
HADGSIRWVWERGTGVFNETGQLEAIEGFITDVTAERQAAEERQALNERIIAAQEAALRELSTPIVPISRGVIAMPLIGS
IDSTRAQQVIESLLEGVNTSGAHIVILDVTGVPVVDTQVANTLLRSAQAVRLLGAEVLLTGIRPEVAQTIVGLGLDMSHI
RTLATLQDGITYALGRQSLGQTIVHRIR

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 55831; Mature: 55831

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNTFVAIADALRAHLPSLPPAERPLLVALADALSTGDPSHLLTLLRNGGSISAGFNRLD
CCCCEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHH
AVRRQATGLLADNPAAAGPIADIVAEAQRVLIAEEETMLRREHMLNQRLEQSFLTSPLAT
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LEANEYGIITRWNSAAERIFGWSAAEAVGKNAIELLVPNIAREHVEAIVQALLSGQAKNS
CCCCCCEEEEECCHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RNENITKDGRIIICQWYNAVLYHPDGRVAGWLSQTEDITEQIRAEEALRENQRRLDRLMR
CCCCCCCCCCEEEEEECCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLPGIAYRSRKDGRWTAEFMSEGALEVTGYPASDFMPDGDQPLRRYFGDLILPEDREAVK
HCCCCEEECCCCCCCHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHH
ESVQTAIAQQRQFEITYRIRHADGSIRWVWERGTGVFNETGQLEAIEGFITDVTAERQAA
HHHHHHHHHHHEEEEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EERQALNERIIAAQEAALRELSTPIVPISRGVIAMPLIGSIDSTRAQQVIESLLEGVNTS
HHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCC
GAHIVILDVTGVPVVDTQVANTLLRSAQAVRLLGAEVLLTGIRPEVAQTIVGLGLDMSHI
CCEEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHH
RTLATLQDGITYALGRQSLGQTIVHRIR
HHHHHHHHCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNNTFVAIADALRAHLPSLPPAERPLLVALADALSTGDPSHLLTLLRNGGSISAGFNRLD
CCCCEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHH
AVRRQATGLLADNPAAAGPIADIVAEAQRVLIAEEETMLRREHMLNQRLEQSFLTSPLAT
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LEANEYGIITRWNSAAERIFGWSAAEAVGKNAIELLVPNIAREHVEAIVQALLSGQAKNS
CCCCCCEEEEECCHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RNENITKDGRIIICQWYNAVLYHPDGRVAGWLSQTEDITEQIRAEEALRENQRRLDRLMR
CCCCCCCCCCEEEEEECCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLPGIAYRSRKDGRWTAEFMSEGALEVTGYPASDFMPDGDQPLRRYFGDLILPEDREAVK
HCCCCEEECCCCCCCHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHH
ESVQTAIAQQRQFEITYRIRHADGSIRWVWERGTGVFNETGQLEAIEGFITDVTAERQAA
HHHHHHHHHHHEEEEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
EERQALNERIIAAQEAALRELSTPIVPISRGVIAMPLIGSIDSTRAQQVIESLLEGVNTS
HHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCC
GAHIVILDVTGVPVVDTQVANTLLRSAQAVRLLGAEVLLTGIRPEVAQTIVGLGLDMSHI
CCEEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHH
RTLATLQDGITYALGRQSLGQTIVHRIR
HHHHHHHHCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]