Click here to switch to the map view.

The map label for this gene is clpP2 [H]

Identifier: 222151830

GI number: 222151830

Start: 1713683

End: 1714237

Strand: Direct

Name: clpP2 [H]

Synonym: MCCL_1587

Alternate gene names: 222151830

Gene position: 1713683-1714237 (Clockwise)

Preceding gene: 222151828

Following gene: 222151832

Centisome position: 81.51

GC content: 34.95

Gene sequence:

>555_bases
ATGACAAACGAAAACAAAGATCTTATGTTAGAGAAAATGATAGAATCAAGAACAATCCTAATCTCTGGAGGTATTGATGA
CAAATCAGCGAAAGAAGTTGTCAATCAATTATTACTTTTAGATTCAATCAATCATGAACCAATTAAATTAATCATCTCTT
CTCCTGGTGGACATGTAGACTCTGGTTATTTAATTCACGATATGATTAATTTCATCGAATCAGAAGTGAAAATTATTGGT
GCAGGTTGGGTAGTTAGTGCGGGCGTATTAATTTACTTATCAGGTAAGAAAGAAAATCGTTACGCATTACCAAATACACG
CTTTATGATCCATCAGCCAAGTGGAGGCACTCAAGGACAAGCGTCAAATATGGAGATTACAGCGAAAGAAATTATCCGTA
CACGCCAAAAGTTAAATGAATTAATCGCACGTGAAACCGGTAAATCTGTAGAAGAAGTCGAGCAGCATACAGGCCGTGAC
TACTGGTTAAATACAGAAGAAGCAAAAGAATACGGTATCGTAAATAAAATTATTGAAAACCAAAAAGAAATCTAA

Upstream 100 bases:

>100_bases
GCATATATAAATGCATTATCATACCTAAACAATCCATATTCTTTGACTTAAATTGACCAAAACAATAAAATAATAATAAC
AAGCATATAGGAGGCTTATT

Downstream 100 bases:

>100_bases
AAAAATCTCAATGCACATTACGTTGCATTGAGATTTTTTGGAATTAAAGAAGTAACAAATATTTTAATGACGTAATAACC
TAGCTTATTAATGCTGTATA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2 [H]

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MTNENKDLMLEKMIESRTILISGGIDDKSAKEVVNQLLLLDSINHEPIKLIISSPGGHVDSGYLIHDMINFIESEVKIIG
AGWVVSAGVLIYLSGKKENRYALPNTRFMIHQPSGGTQGQASNMEITAKEIIRTRQKLNELIARETGKSVEEVEQHTGRD
YWLNTEEAKEYGIVNKIIENQKEI

Sequences:

>Translated_184_residues
MTNENKDLMLEKMIESRTILISGGIDDKSAKEVVNQLLLLDSINHEPIKLIISSPGGHVDSGYLIHDMINFIESEVKIIG
AGWVVSAGVLIYLSGKKENRYALPNTRFMIHQPSGGTQGQASNMEITAKEIIRTRQKLNELIARETGKSVEEVEQHTGRD
YWLNTEEAKEYGIVNKIIENQKEI
>Mature_183_residues
TNENKDLMLEKMIESRTILISGGIDDKSAKEVVNQLLLLDSINHEPIKLIISSPGGHVDSGYLIHDMINFIESEVKIIGA
GWVVSAGVLIYLSGKKENRYALPNTRFMIHQPSGGTQGQASNMEITAKEIIRTRQKLNELIARETGKSVEEVEQHTGRDY
WLNTEEAKEYGIVNKIIENQKEI

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=168, Percent_Identity=37.5, Blast_Score=131, Evalue=4e-31,
Organism=Escherichia coli, GI1786641, Length=171, Percent_Identity=41.5204678362573, Blast_Score=150, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17538017, Length=167, Percent_Identity=38.9221556886228, Blast_Score=129, Evalue=7e-31,
Organism=Drosophila melanogaster, GI20129427, Length=176, Percent_Identity=37.5, Blast_Score=132, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 20662; Mature: 20531

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNENKDLMLEKMIESRTILISGGIDDKSAKEVVNQLLLLDSINHEPIKLIISSPGGHVD
CCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCC
SGYLIHDMINFIESEVKIIGAGWVVSAGVLIYLSGKKENRYALPNTRFMIHQPSGGTQGQ
CCHHHHHHHHHHHHHHEEEECCHHHHCCEEEEEECCCCCCEECCCCEEEEECCCCCCCCC
ASNMEITAKEIIRTRQKLNELIARETGKSVEEVEQHTGRDYWLNTEEAKEYGIVNKIIEN
CCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEECCCHHHHHHHHHHHHHHH
QKEI
CCCC
>Mature Secondary Structure 
TNENKDLMLEKMIESRTILISGGIDDKSAKEVVNQLLLLDSINHEPIKLIISSPGGHVD
CCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCC
SGYLIHDMINFIESEVKIIGAGWVVSAGVLIYLSGKKENRYALPNTRFMIHQPSGGTQGQ
CCHHHHHHHHHHHHHHEEEECCHHHHCCEEEEEECCCCCCEECCCCEEEEECCCCCCCCC
ASNMEITAKEIIRTRQKLNELIARETGKSVEEVEQHTGRDYWLNTEEAKEYGIVNKIIEN
CCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEECCCHHHHHHHHHHHHHHH
QKEI
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]