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The map label for this gene is pyrE [H]

Identifier: 222151026

GI number: 222151026

Start: 838053

End: 838664

Strand: Direct

Name: pyrE [H]

Synonym: MCCL_0777

Alternate gene names: 222151026

Gene position: 838053-838664 (Clockwise)

Preceding gene: 222151025

Following gene: 222151027

Centisome position: 39.86

GC content: 39.38

Gene sequence:

>612_bases
ATGTTAAATAAAGAAATCGCAAAAGCATTACTTGAAATTGAAGCAGTATCACTACAGCCGAATGATATGTTTACATGGTC
TTCTGGTATTAAAAGCCCGATTTATTGTGATAACCGTTTAACGATGAGCTATCCGGAAGTTCGTGACCAAATTGCTGAAG
GTTTAAAGTCATTGATTGAAACACATTTCAGTAATGCGGAAGTGTTAGCAGGAACTGCTACAGCAGGTATTCCACACGCT
GCATTTACATCTCAGAAGATGAATCTCCCGATGAGTTACGTGCGTTCATCAAGCAAAAAACACGGTAAAGGAAATCAAAT
TGAAGGCCGTGTATTAGAAGGGCAGAAGGTTGTTGTCGTAGAAGATTTAATATCTACTGGGGGGTCAGCAATTGAAGCAG
CGGATGCATTACAAGCGCATGGTGCGGATGTATTAGGCATCGTTGCAATATTTACATACGGATTAAGCAAAGGGAAAGAA
AGATTAGCACAAGCTGGATATCCATACTATACGCTTTCTGATTTCGATAGTCTCGTTGAGGTTGCAAGTGAGACAGGAAA
GATTGAACAAAGTGATATTGAAGGATTAATTAACTGGCGTGATAACTTATAG

Upstream 100 bases:

>100_bases
GCAGAAAATGGTTCAACGCATATCGTTGTAGGACGTTCAATTACTAATGACGCAAATCCAGTGGAAAAATATAGACAAAT
TAAGAAAGCGTGGGAATCAA

Downstream 100 bases:

>100_bases
GCAAAAAGAAACTGTTTAATGTATACTATCATTAAACAGTTTTATTTTTTTGAGGTGAGAAAATGGGCAAATGGGACCAC
ATTAATAAGTTTATTAAAGA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MLNKEIAKALLEIEAVSLQPNDMFTWSSGIKSPIYCDNRLTMSYPEVRDQIAEGLKSLIETHFSNAEVLAGTATAGIPHA
AFTSQKMNLPMSYVRSSSKKHGKGNQIEGRVLEGQKVVVVEDLISTGGSAIEAADALQAHGADVLGIVAIFTYGLSKGKE
RLAQAGYPYYTLSDFDSLVEVASETGKIEQSDIEGLINWRDNL

Sequences:

>Translated_203_residues
MLNKEIAKALLEIEAVSLQPNDMFTWSSGIKSPIYCDNRLTMSYPEVRDQIAEGLKSLIETHFSNAEVLAGTATAGIPHA
AFTSQKMNLPMSYVRSSSKKHGKGNQIEGRVLEGQKVVVVEDLISTGGSAIEAADALQAHGADVLGIVAIFTYGLSKGKE
RLAQAGYPYYTLSDFDSLVEVASETGKIEQSDIEGLINWRDNL
>Mature_203_residues
MLNKEIAKALLEIEAVSLQPNDMFTWSSGIKSPIYCDNRLTMSYPEVRDQIAEGLKSLIETHFSNAEVLAGTATAGIPHA
AFTSQKMNLPMSYVRSSSKKHGKGNQIEGRVLEGQKVVVVEDLISTGGSAIEAADALQAHGADVLGIVAIFTYGLSKGKE
RLAQAGYPYYTLSDFDSLVEVASETGKIEQSDIEGLINWRDNL

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=166, Percent_Identity=24.0963855421687, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17508631, Length=128, Percent_Identity=31.25, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554964, Length=175, Percent_Identity=24.5714285714286, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17933654, Length=196, Percent_Identity=27.0408163265306, Blast_Score=74, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 21982; Mature: 21982

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKEIAKALLEIEAVSLQPNDMFTWSSGIKSPIYCDNRLTMSYPEVRDQIAEGLKSLIE
CCCHHHHHHHHHHHHEEECCCCCEEECCCCCCCEEECCCEEECCHHHHHHHHHHHHHHHH
THFSNAEVLAGTATAGIPHAAFTSQKMNLPMSYVRSSSKKHGKGNQIEGRVLEGQKVVVV
HHCCCCEEEECCCCCCCCCHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCEEECCCEEEEH
EDLISTGGSAIEAADALQAHGADVLGIVAIFTYGLSKGKERLAQAGYPYYTLSDFDSLVE
HHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHH
VASETGKIEQSDIEGLINWRDNL
HHHHCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MLNKEIAKALLEIEAVSLQPNDMFTWSSGIKSPIYCDNRLTMSYPEVRDQIAEGLKSLIE
CCCHHHHHHHHHHHHEEECCCCCEEECCCCCCCEEECCCEEECCHHHHHHHHHHHHHHHH
THFSNAEVLAGTATAGIPHAAFTSQKMNLPMSYVRSSSKKHGKGNQIEGRVLEGQKVVVV
HHCCCCEEEECCCCCCCCCHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCEEECCCEEEEH
EDLISTGGSAIEAADALQAHGADVLGIVAIFTYGLSKGKERLAQAGYPYYTLSDFDSLVE
HHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHH
VASETGKIEQSDIEGLINWRDNL
HHHHCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA