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The map label for this gene is gyrA [H]

Identifier: 222150259

GI number: 222150259

Start: 9858

End: 12497

Strand: Direct

Name: gyrA [H]

Synonym: MCCL_0009

Alternate gene names: 222150259

Gene position: 9858-12497 (Clockwise)

Preceding gene: 222150258

Following gene: 222150260

Centisome position: 0.47

GC content: 37.92

Gene sequence:

>2640_bases
ATGGCTTTAGACCATGATTCAAAATTGAAGGAGCAAAATATCGTCAAAGAAATGAAAGATTCATTTCTAGACTATGCAAT
GAGTGTCATAGTTTCTCGTGCATTACCGGATGTTCGTGACGGCATGAAGCCTGTCCATCGTCGAATACTGTACGGTATGA
ACAATCAAGGCATGACACCAGACAAACCATACAAGAAATCTGCGCGTATTGTCGGAGATGTAATGGGTAAATATCATCCG
CATGGAGATTCTTCCATATACGAAGCCATGGTGCGTATGGCGCAAGATTTCAGCTACCGTTACATGCTTGTCGATGGTCA
AGGTAACTTTGGTTCTATGGATGGCGACGGAGCGGCTGCAATGAGGTATACGGAAGCACGTATGTCAAAAATTGCAATGG
AACTTATGCGTGATATTAATAAGGATACAATTGACTTTACAGATAACTATGATGGAAATGAGCGTGAACCTGTTGTATTA
CCATCAAGATTTCCGAACCTACTTGTAAATGGTGCTTCAGGTATTGCGGTAGGTATGGCAACAAATATTCCACCACATAA
CCTAACAGAGGTCATTAATGGTGTGTTAGAACTAAGTAAGAATCCTGATATTTCTATTCCTGAATTAATGGAATTGATTC
AAGGACCAGATTTTCCTACGGCTGGTCTTATATTGGGACGAAGCGGTATACGTCGAGCATATGAAACAGGGCGTGGTTCT
GTAATTATGCGCGCAAAGACATTGATTGAGACACGTCCGAATGGTAAAGAGACGATTATTATTTCAGAAATCCCTTACCA
AGTAAATAAAGCGAGATTAGTAGAAAAAATTGCTGAATTAGCACGTGATAAAAAGGTGGACGGTATTACAGACCTTCGTG
ATGAAACAAGTTTAAAAGAAGGAGTACGTATTGTTATCGATGTACGACGTGATGCAAATGCAAACGTAATCCTTAACAAT
TTATATAAGCAGACACCACTTCAGACATCATTTGGCGTGAATATGCTGGCGCTTGTAGATGGCAAGCCACAAGTATTAAA
TATTAAACAAGCAATTTATCACTATCTCGAACATCAAAAGACTGTTGTTCGCCGACGAACTGCCTATAATTTAAAAAAAG
CAGAAGATCGTGCACATATTCTGGAAGGATTAAGAATTGCGCTTGATCATATCGATGAAATCATTGCTTTGATTAGAGCC
TCTAATAATGATGCTGAAGCATTACAAGGTTTACAAGAACAGTTTAAGCTATCAGAGCGTCAAGCACAGGCGATCCTTGA
TATGCGATTACGTCGATTAACAGGGCTAGAAAGAGATAAAATTGAATCTGAGTATCAAGAACTGCTGAAATATATCGATG
AACTTCGTGCAATATTAGCAGATGAAGAGAAGTTACTTCAGATTATTCGCGAGGAATTAATTGAGATCCGTGATAAATAT
GGAGATGAACGTCGTACTGAAATTGTTGCTGGAGGATTAGAGGATCTTGAAGATGAAGATTTAATTGATGAAGAAAATAT
CGTGATTACATTAAGTAGTAATAACTATATTAAACGTCTTCCAGCTTCAACTTATCGTGCACAGCATCGTGGTGGAAGAG
GGATTCAAGGTATGAATACTTTGGATGAAGACTTCGTCAGTCAAATGGTAACAACTTCTACGCATGATAATGTCCTGTTC
TTTACGAACAAAGGGCGTGTGTATAAAGTCAAAGGATACGAAATACCTGAACTTTCAAGACAATCAAAAGGTATTCCGAT
TGTTAATGTGATTGATTTGGACAAAGATGAATCCATCAGTACGATGATTGCGGTGAAAAATCTTGAGCGTGAAGATGCTT
ATATTGTTTTTGCAACGAAACATGGATTGATTAAACGATCTAATTTATCTCACTTCTCGCGTATTAACAAAAATGGTAAG
ATAGCTATTAACTTTAGAGAAGAAGATGAACTGATTGCTGTTAGATTAACAGATGGTAATAAACAATTGATTATAGGAAC
AAAACACGCTTCACTTATTCGTTTCGAAGAGAATAAATTACGTCCTTTAGGCCGTACAGCTGCGGGAGTTAAAGGTATCA
GTCTGCGTGAAGGTGACGAAGTTATCGGATTAGATGTAATAGAATCTAATGACGAACATGAAGTGCTGGTTGTTACTGAG
AATGGATATGGAAAACGTACTAAAGAAAGTGAATACCGAATTTCAAATCGTGGTGGTAAAGGAATTAAAACAGCAACGAT
TACTGAGAAGAATGGAAATCTTGTCTGTATTACTACCGTAAATGGTAACGAAGATATTATGATTGTAACAGACCACGGTG
TGATTATTCGACTTGATGTTGCTGAATTCTCACAAAACGGTCGTTCTGCACAAGGGGTACGCTTGATTCGACTTGATGAA
GGACAATTTGTTGCTACTGTCGCTAAAGTGGAAAAAGAAGAAGAAGTGATGGATGAGGATAAAGAACCAGGAGAAGTTAT
TGCAGAACAAGGTGCAGATTTGACTGAAGTAGCCAAAGAATCGATTGATGAAACTATAGAAGTTGAAGATGGTCATGTGA
TGGGAACCGTTGATGTGTCAGAGCAAAATCTATTAGAACGTTCTGAATTTGAATCAATATATAATGACAGTGAAGAATAA

Upstream 100 bases:

>100_bases
GATGGGAGATGTTGTAGAACATCGTCGTACGTTCATTGAAGAGAATGCAGAATACGCAAACGTTGATGTATAAAGATAGT
ATTTTAAGGAGGCGCCATCT

Downstream 100 bases:

>100_bases
AAATATGAAATAAAATTTCTTAGCTATTAAAAGTTTCAAAACTTTTAATAGTTATTTTTTTTAAAAAAACCCTTTATCAA
TAATATTTTATTTAAAAATA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 879; Mature: 878

Protein sequence:

>879_residues
MALDHDSKLKEQNIVKEMKDSFLDYAMSVIVSRALPDVRDGMKPVHRRILYGMNNQGMTPDKPYKKSARIVGDVMGKYHP
HGDSSIYEAMVRMAQDFSYRYMLVDGQGNFGSMDGDGAAAMRYTEARMSKIAMELMRDINKDTIDFTDNYDGNEREPVVL
PSRFPNLLVNGASGIAVGMATNIPPHNLTEVINGVLELSKNPDISIPELMELIQGPDFPTAGLILGRSGIRRAYETGRGS
VIMRAKTLIETRPNGKETIIISEIPYQVNKARLVEKIAELARDKKVDGITDLRDETSLKEGVRIVIDVRRDANANVILNN
LYKQTPLQTSFGVNMLALVDGKPQVLNIKQAIYHYLEHQKTVVRRRTAYNLKKAEDRAHILEGLRIALDHIDEIIALIRA
SNNDAEALQGLQEQFKLSERQAQAILDMRLRRLTGLERDKIESEYQELLKYIDELRAILADEEKLLQIIREELIEIRDKY
GDERRTEIVAGGLEDLEDEDLIDEENIVITLSSNNYIKRLPASTYRAQHRGGRGIQGMNTLDEDFVSQMVTTSTHDNVLF
FTNKGRVYKVKGYEIPELSRQSKGIPIVNVIDLDKDESISTMIAVKNLEREDAYIVFATKHGLIKRSNLSHFSRINKNGK
IAINFREEDELIAVRLTDGNKQLIIGTKHASLIRFEENKLRPLGRTAAGVKGISLREGDEVIGLDVIESNDEHEVLVVTE
NGYGKRTKESEYRISNRGGKGIKTATITEKNGNLVCITTVNGNEDIMIVTDHGVIIRLDVAEFSQNGRSAQGVRLIRLDE
GQFVATVAKVEKEEEVMDEDKEPGEVIAEQGADLTEVAKESIDETIEVEDGHVMGTVDVSEQNLLERSEFESIYNDSEE

Sequences:

>Translated_879_residues
MALDHDSKLKEQNIVKEMKDSFLDYAMSVIVSRALPDVRDGMKPVHRRILYGMNNQGMTPDKPYKKSARIVGDVMGKYHP
HGDSSIYEAMVRMAQDFSYRYMLVDGQGNFGSMDGDGAAAMRYTEARMSKIAMELMRDINKDTIDFTDNYDGNEREPVVL
PSRFPNLLVNGASGIAVGMATNIPPHNLTEVINGVLELSKNPDISIPELMELIQGPDFPTAGLILGRSGIRRAYETGRGS
VIMRAKTLIETRPNGKETIIISEIPYQVNKARLVEKIAELARDKKVDGITDLRDETSLKEGVRIVIDVRRDANANVILNN
LYKQTPLQTSFGVNMLALVDGKPQVLNIKQAIYHYLEHQKTVVRRRTAYNLKKAEDRAHILEGLRIALDHIDEIIALIRA
SNNDAEALQGLQEQFKLSERQAQAILDMRLRRLTGLERDKIESEYQELLKYIDELRAILADEEKLLQIIREELIEIRDKY
GDERRTEIVAGGLEDLEDEDLIDEENIVITLSSNNYIKRLPASTYRAQHRGGRGIQGMNTLDEDFVSQMVTTSTHDNVLF
FTNKGRVYKVKGYEIPELSRQSKGIPIVNVIDLDKDESISTMIAVKNLEREDAYIVFATKHGLIKRSNLSHFSRINKNGK
IAINFREEDELIAVRLTDGNKQLIIGTKHASLIRFEENKLRPLGRTAAGVKGISLREGDEVIGLDVIESNDEHEVLVVTE
NGYGKRTKESEYRISNRGGKGIKTATITEKNGNLVCITTVNGNEDIMIVTDHGVIIRLDVAEFSQNGRSAQGVRLIRLDE
GQFVATVAKVEKEEEVMDEDKEPGEVIAEQGADLTEVAKESIDETIEVEDGHVMGTVDVSEQNLLERSEFESIYNDSEE
>Mature_878_residues
ALDHDSKLKEQNIVKEMKDSFLDYAMSVIVSRALPDVRDGMKPVHRRILYGMNNQGMTPDKPYKKSARIVGDVMGKYHPH
GDSSIYEAMVRMAQDFSYRYMLVDGQGNFGSMDGDGAAAMRYTEARMSKIAMELMRDINKDTIDFTDNYDGNEREPVVLP
SRFPNLLVNGASGIAVGMATNIPPHNLTEVINGVLELSKNPDISIPELMELIQGPDFPTAGLILGRSGIRRAYETGRGSV
IMRAKTLIETRPNGKETIIISEIPYQVNKARLVEKIAELARDKKVDGITDLRDETSLKEGVRIVIDVRRDANANVILNNL
YKQTPLQTSFGVNMLALVDGKPQVLNIKQAIYHYLEHQKTVVRRRTAYNLKKAEDRAHILEGLRIALDHIDEIIALIRAS
NNDAEALQGLQEQFKLSERQAQAILDMRLRRLTGLERDKIESEYQELLKYIDELRAILADEEKLLQIIREELIEIRDKYG
DERRTEIVAGGLEDLEDEDLIDEENIVITLSSNNYIKRLPASTYRAQHRGGRGIQGMNTLDEDFVSQMVTTSTHDNVLFF
TNKGRVYKVKGYEIPELSRQSKGIPIVNVIDLDKDESISTMIAVKNLEREDAYIVFATKHGLIKRSNLSHFSRINKNGKI
AINFREEDELIAVRLTDGNKQLIIGTKHASLIRFEENKLRPLGRTAAGVKGISLREGDEVIGLDVIESNDEHEVLVVTEN
GYGKRTKESEYRISNRGGKGIKTATITEKNGNLVCITTVNGNEDIMIVTDHGVIIRLDVAEFSQNGRSAQGVRLIRLDEG
QFVATVAKVEKEEEVMDEDKEPGEVIAEQGADLTEVAKESIDETIEVEDGHVMGTVDVSEQNLLERSEFESIYNDSEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=319, Percent_Identity=27.5862068965517, Blast_Score=87, Evalue=8e-17,
Organism=Homo sapiens, GI19913406, Length=331, Percent_Identity=27.190332326284, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1788562, Length=863, Percent_Identity=50.6373117033604, Blast_Score=835, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=673, Percent_Identity=37.890044576523, Blast_Score=441, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17535065, Length=173, Percent_Identity=32.3699421965318, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=343, Percent_Identity=25.9475218658892, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI115534553, Length=169, Percent_Identity=30.1775147928994, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212645845, Length=203, Percent_Identity=28.0788177339901, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=170, Percent_Identity=31.1764705882353, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136538, Length=430, Percent_Identity=23.4883720930233, Blast_Score=76, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 98870; Mature: 98739

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALDHDSKLKEQNIVKEMKDSFLDYAMSVIVSRALPDVRDGMKPVHRRILYGMNNQGMTP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
DKPYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYMLVDGQGNFGSMDGDGAAA
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHH
MRYTEARMSKIAMELMRDINKDTIDFTDNYDGNEREPVVLPSRFPNLLVNGASGIAVGMA
HHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCEECCCCCCCCEEECCCCEEEEEE
TNIPPHNLTEVINGVLELSKNPDISIPELMELIQGPDFPTAGLILGRSGIRRAYETGRGS
CCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHEEECCHHHHHHHHCCCCC
VIMRAKTLIETRPNGKETIIISEIPYQVNKARLVEKIAELARDKKVDGITDLRDETSLKE
EEEEEHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHC
GVRIVIDVRRDANANVILNNLYKQTPLQTSFGVNMLALVDGKPQVLNIKQAIYHYLEHQK
CCEEEEEECCCCCCCEEEHHHHHCCCCCCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHH
TVVRRRTAYNLKKAEDRAHILEGLRIALDHIDEIIALIRASNNDAEALQGLQEQFKLSER
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QAQAILDMRLRRLTGLERDKIESEYQELLKYIDELRAILADEEKLLQIIREELIEIRDKY
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
GDERRTEIVAGGLEDLEDEDLIDEENIVITLSSNNYIKRLPASTYRAQHRGGRGIQGMNT
CCHHHHHHHCCCHHCCCCCCCCCCCCEEEEECCCCCEECCCCHHHHHHHCCCCCCCCCCH
LDEDFVSQMVTTSTHDNVLFFTNKGRVYKVKGYEIPELSRQSKGIPIVNVIDLDKDESIS
HHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCCCHHHHCCCCCEEEEEECCCCCCHH
TMIAVKNLEREDAYIVFATKHGLIKRSNLSHFSRINKNGKIAINFREEDELIAVRLTDGN
HHHEECCCCCCCCEEEEEECCCCEECCCCHHHHHCCCCCEEEEEEECCCCEEEEEEECCC
KQLIIGTKHASLIRFEENKLRPLGRTAAGVKGISLREGDEVIGLDVIESNDEHEVLVVTE
EEEEEEECCCEEEEECCCCCCCCCCHHCCCCCCEECCCCCEEEEEEEECCCCCEEEEEEC
NGYGKRTKESEYRISNRGGKGIKTATITEKNGNLVCITTVNGNEDIMIVTDHGVIIRLDV
CCCCCCCCCCCCEEECCCCCCCEEEEEEECCCCEEEEEEECCCCCEEEEECCCEEEEEEH
AEFSQNGRSAQGVRLIRLDEGQFVATVAKVEKEEEVMDEDKEPGEVIAEQGADLTEVAKE
HHHCCCCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHH
SIDETIEVEDGHVMGTVDVSEQNLLERSEFESIYNDSEE
HHCCEEEECCCEEEEEEECCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALDHDSKLKEQNIVKEMKDSFLDYAMSVIVSRALPDVRDGMKPVHRRILYGMNNQGMTP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
DKPYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYMLVDGQGNFGSMDGDGAAA
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHH
MRYTEARMSKIAMELMRDINKDTIDFTDNYDGNEREPVVLPSRFPNLLVNGASGIAVGMA
HHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCEECCCCCCCCEEECCCCEEEEEE
TNIPPHNLTEVINGVLELSKNPDISIPELMELIQGPDFPTAGLILGRSGIRRAYETGRGS
CCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHEEECCHHHHHHHHCCCCC
VIMRAKTLIETRPNGKETIIISEIPYQVNKARLVEKIAELARDKKVDGITDLRDETSLKE
EEEEEHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHC
GVRIVIDVRRDANANVILNNLYKQTPLQTSFGVNMLALVDGKPQVLNIKQAIYHYLEHQK
CCEEEEEECCCCCCCEEEHHHHHCCCCCCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHH
TVVRRRTAYNLKKAEDRAHILEGLRIALDHIDEIIALIRASNNDAEALQGLQEQFKLSER
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
QAQAILDMRLRRLTGLERDKIESEYQELLKYIDELRAILADEEKLLQIIREELIEIRDKY
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
GDERRTEIVAGGLEDLEDEDLIDEENIVITLSSNNYIKRLPASTYRAQHRGGRGIQGMNT
CCHHHHHHHCCCHHCCCCCCCCCCCCEEEEECCCCCEECCCCHHHHHHHCCCCCCCCCCH
LDEDFVSQMVTTSTHDNVLFFTNKGRVYKVKGYEIPELSRQSKGIPIVNVIDLDKDESIS
HHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCCCHHHHCCCCCEEEEEECCCCCCHH
TMIAVKNLEREDAYIVFATKHGLIKRSNLSHFSRINKNGKIAINFREEDELIAVRLTDGN
HHHEECCCCCCCCEEEEEECCCCEECCCCHHHHHCCCCCEEEEEEECCCCEEEEEEECCC
KQLIIGTKHASLIRFEENKLRPLGRTAAGVKGISLREGDEVIGLDVIESNDEHEVLVVTE
EEEEEEECCCEEEEECCCCCCCCCCHHCCCCCCEECCCCCEEEEEEEECCCCCEEEEEEC
NGYGKRTKESEYRISNRGGKGIKTATITEKNGNLVCITTVNGNEDIMIVTDHGVIIRLDV
CCCCCCCCCCCCEEECCCCCCCEEEEEEECCCCEEEEEEECCCCCEEEEECCCEEEEEEH
AEFSQNGRSAQGVRLIRLDEGQFVATVAKVEKEEEVMDEDKEPGEVIAEQGADLTEVAKE
HHHCCCCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHH
SIDETIEVEDGHVMGTVDVSEQNLLERSEFESIYNDSEE
HHCCEEEECCCEEEEEEECCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA