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The map label for this gene is pgsA [H]

Identifier: 222110393

GI number: 222110393

Start: 1244949

End: 1245515

Strand: Direct

Name: pgsA [H]

Synonym: Dtpsy_1186

Alternate gene names: 222110393

Gene position: 1244949-1245515 (Clockwise)

Preceding gene: 222110392

Following gene: 222110394

Centisome position: 32.79

GC content: 55.2

Gene sequence:

>567_bases
ATGTTTTTCACTATTCCCACCATCATGACTTGGACGCGCATTGTCGCGATACCCTTGATCGTGGGAGTGTTCTATGCGCC
GCTGGACCCTGCGATGCGCAACCTCATCGCCACGGTGATGTTCATCGTTTTTGCGGCCACCGATTGGCTCGATGGGTTTC
TTGCACGCAAGCTCAACCAGACCTCCGCGTTCGGGGCGTTTCTGGATCCCGTGGCTGACAAGTTCTTGGTATGTGCGTCG
CTATTGGTACTCGTGCATATGCAACGTGCCGATGTGTTCGTGGCACTCATCATCATCGGCCGCGAAATCGCTATCAGTGC
CTTGCGGGAATGGATGGCGCAGATCGGGGCGAGCAAGAGTGTGGCCGTGCACATGATCGGCAAGCTCAAGACCACGGTGC
AGATGATTGCCATTCCTTTCCTGTTGTATGACGGGCAGTTGTTTGGCGTCATTGACACGGGTGTGTGGGGTACCTGGCTG
ATCTGGGTCGCCGCAGTGCTGACGGTGTGGTCCATGGTTTATTACCTGCAAAAAGCACTGCCAGAAATTCGTGCGAGAGT
CCGTTAA

Upstream 100 bases:

>100_bases
CGAGGGCATATCTCACGACTTGGCTGAAGAGATCTATCGCGCGCTGCGCTGACCCGGTTGACGGCCCAGGGCATTGCCGC
GCGTGCCACAATTGGCACCC

Downstream 100 bases:

>100_bases
GTTTCTTGCTACTGCTGGGAGAGCCTTGTGTCAAAAGGGTTCATTGCTATATATAACATAGCAGGCAATCCGTGCCCACA
TGGAGAAGGCTGGTGGCGGC

Product: cdp-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MFFTIPTIMTWTRIVAIPLIVGVFYAPLDPAMRNLIATVMFIVFAATDWLDGFLARKLNQTSAFGAFLDPVADKFLVCAS
LLVLVHMQRADVFVALIIIGREIAISALREWMAQIGASKSVAVHMIGKLKTTVQMIAIPFLLYDGQLFGVIDTGVWGTWL
IWVAAVLTVWSMVYYLQKALPEIRARVR

Sequences:

>Translated_188_residues
MFFTIPTIMTWTRIVAIPLIVGVFYAPLDPAMRNLIATVMFIVFAATDWLDGFLARKLNQTSAFGAFLDPVADKFLVCAS
LLVLVHMQRADVFVALIIIGREIAISALREWMAQIGASKSVAVHMIGKLKTTVQMIAIPFLLYDGQLFGVIDTGVWGTWL
IWVAAVLTVWSMVYYLQKALPEIRARVR
>Mature_188_residues
MFFTIPTIMTWTRIVAIPLIVGVFYAPLDPAMRNLIATVMFIVFAATDWLDGFLARKLNQTSAFGAFLDPVADKFLVCAS
LLVLVHMQRADVFVALIIIGREIAISALREWMAQIGASKSVAVHMIGKLKTTVQMIAIPFLLYDGQLFGVIDTGVWGTWL
IWVAAVLTVWSMVYYLQKALPEIRARVR

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1788220, Length=185, Percent_Identity=49.1891891891892, Blast_Score=144, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 21008; Mature: 21008

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFTIPTIMTWTRIVAIPLIVGVFYAPLDPAMRNLIATVMFIVFAATDWLDGFLARKLNQ
CEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSAFGAFLDPVADKFLVCASLLVLVHMQRADVFVALIIIGREIAISALREWMAQIGASKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
VAVHMIGKLKTTVQMIAIPFLLYDGQLFGVIDTGVWGTWLIWVAAVLTVWSMVYYLQKAL
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
PEIRARVR
HHHHHCCC
>Mature Secondary Structure
MFFTIPTIMTWTRIVAIPLIVGVFYAPLDPAMRNLIATVMFIVFAATDWLDGFLARKLNQ
CEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSAFGAFLDPVADKFLVCASLLVLVHMQRADVFVALIIIGREIAISALREWMAQIGASKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
VAVHMIGKLKTTVQMIAIPFLLYDGQLFGVIDTGVWGTWLIWVAAVLTVWSMVYYLQKAL
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
PEIRARVR
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]