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The map label for this gene is uvrC [H]

Identifier: 222110392

GI number: 222110392

Start: 1242927

End: 1244900

Strand: Direct

Name: uvrC [H]

Synonym: Dtpsy_1185

Alternate gene names: 222110392

Gene position: 1242927-1244900 (Clockwise)

Preceding gene: 222110391

Following gene: 222110393

Centisome position: 32.74

GC content: 60.39

Gene sequence:

>1974_bases
ATGACCACAACCTATTCGGATGAGCTTCTGGCACAGGTGGCGGCGCTGCCACCTTTGCCCGGGGTGTACCGCTACTTCGA
TGCACAGAATGTCTTGCTATATGTCGGCAAGGCGCGCAACCTGAAAAAGCGGGTCAGCAGCTACTTCAGCAAGCAGCACG
GAGGCACGCGCATTGGCCATATGGTGGGCAGAATTGCGCGGCTGGAAACGACGGTGGTGCGCTCCGAGGCCGAGGCGCTC
CTGCTGGAAAACAATCTCATCAAGTCCCTGGGCCCGAAGTACAACATTCTTTTTCGGGACGACAAGAGCTACCCTTATCT
CAAGATCACCGGTGTCTCGGCAAAGGACGGTACGGGGGATGCTCCGGGGCAGTGCTACCCGCGCATGGCGTATTACCGCG
GGGCAGTGGATAAACGTCACCGATACTTCGGTCCTTACCCTGGCGCATGGGCCGTCAAAGAAAGCATTCAGCTACTGCAG
AAGGTTTTTCGGTTGCGTACTTGTGAAGACACGGTGTTTGCGAATCGCACGCGTCCCTGCTTGCTGTACCAGATCAAACG
CTGCTCCGCTCCGTGTGTGGGTTTGATTTCCCCAACGGCCTATGCCGCAGATGTGCGCAGTGCGGAGGCGATGCTGCTGG
GTGAAACCCAGGAACTGCTTCAAACGCTGGAAGAACGCATGCTCGCGTATGCCGAGAAGCTGGAGTTTGAACAGGCGGCC
GAGGTCCGCAACCAGATCACGGCACTCGCACGTGTGTTGCACCAACAAGCGGTGGAGACGGCATCGGACAAGGACGTGGA
CATACTCGCCGTTAAAGTGGCTGGCGGCCGTGCCTGCGTCAACCTGGCGATGGTGCGCGGTGGCCGGCACCTTGGCGACA
GGCCTTACTTTCCGGTTCACGTAGAGGAAGCGACAGGTGTCTTCCAACTGGAAACGCGCGAGGATGCCCCGGATAACTTG
ATGGTAGAGGAGGCTGGCGGACTTGAGCAGTCGGTGCCGGCGCAGATCCTTGCTGCGTTCATTGCGCAGCACTACCTGGG
GGTACCGTTGCCACCGACACTGATTACGAGCGAGCCAGTCGACCCCGCATTGCTTTGGGTGCTGGCACAGCAGACGGGGG
TGCGAGCGACAGTCGTCCACCAGCCGCGTGAACAACGGCGAATCTGGCTGGAAATGGCGGAGCAGAACGCACAGATCCAG
TTGGCACGGTTGCTGGCGGAGGAGGGTTCCCAGCGGGCGCGCACGCGTGCCCTGGCGGAAGCGCTGGATCTGGAGGCAGA
GAGCTTGGATGACCTCACCATCGAGTGTTTCGACATTTCGCACACTGCAGGGGAGGCGACCCAGGCTTCTTGCGTGGTTT
TTCATCACCACAAAATGCAAAGTGGCGAGTACCGCCGTTTCAAAATCGAGGGCATTACCCCGGGCGATGACTATGCAGCT
ATGCGTCAGGTACTCATGCGTCGCTACAGCAAGGTTGCCGAAGCACAGCGTGAGGCAGGGGGAGCGGAGGTGACAAATGC
CCCGCGCTTGCCGGACCTGGTGCTGGTGGACGGTGGCAAGGGGCAAGTAAGCATGGCGCGCGATGTGTTCCAGGAACTGG
GCCTGGATATCTCACGCATCGTTGGTGTCGAAAAGGGGGAGGGCCGCAAGGTGGGGCTGGAAGAACTGGTCTTTGCGGAT
GGACGCGACAAAGTCTATCTGGGGCGAGACTCGGCTGCGCTGATGCTCGTGGCGCAGATCCGTGACGAGGCCCACCGCTT
CGCCATCACCGGAATGCGCGCCGCTCGTGCAAAAGTACGCGTAGGCGGCAGCCGATTGGAAGATATACCCGGTGTGGGGC
CTAAAAAACGGGCAAGGCTGCTTCAGCGCTTTGGGGGCGTGCGCGGCGTGGCAGATGCCAGCGTGGACGACCTCGCCACG
GTCGAGGGCATATCTCACGACTTGGCTGAAGAGATCTATCGCGCGCTGCGCTGA

Upstream 100 bases:

>100_bases
CGTGCTCGACAAATCTTTGTGTCGGACACCATGGCGTGAGTTGCAGTGCTCCCCTCGCACGGTATAGAAGAGGCTTTCGA
CGCGTGCCCACAATAGCGTC

Downstream 100 bases:

>100_bases
CCCGGTTGACGGCCCAGGGCATTGCCGCGCGTGCCACAATTGGCACCCATGTTTTTCACTATTCCCACCATCATGACTTG
GACGCGCATTGTCGCGATAC

Product: excinuclease ABC subunit c

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MTTTYSDELLAQVAALPPLPGVYRYFDAQNVLLYVGKARNLKKRVSSYFSKQHGGTRIGHMVGRIARLETTVVRSEAEAL
LLENNLIKSLGPKYNILFRDDKSYPYLKITGVSAKDGTGDAPGQCYPRMAYYRGAVDKRHRYFGPYPGAWAVKESIQLLQ
KVFRLRTCEDTVFANRTRPCLLYQIKRCSAPCVGLISPTAYAADVRSAEAMLLGETQELLQTLEERMLAYAEKLEFEQAA
EVRNQITALARVLHQQAVETASDKDVDILAVKVAGGRACVNLAMVRGGRHLGDRPYFPVHVEEATGVFQLETREDAPDNL
MVEEAGGLEQSVPAQILAAFIAQHYLGVPLPPTLITSEPVDPALLWVLAQQTGVRATVVHQPREQRRIWLEMAEQNAQIQ
LARLLAEEGSQRARTRALAEALDLEAESLDDLTIECFDISHTAGEATQASCVVFHHHKMQSGEYRRFKIEGITPGDDYAA
MRQVLMRRYSKVAEAQREAGGAEVTNAPRLPDLVLVDGGKGQVSMARDVFQELGLDISRIVGVEKGEGRKVGLEELVFAD
GRDKVYLGRDSAALMLVAQIRDEAHRFAITGMRAARAKVRVGGSRLEDIPGVGPKKRARLLQRFGGVRGVADASVDDLAT
VEGISHDLAEEIYRALR

Sequences:

>Translated_657_residues
MTTTYSDELLAQVAALPPLPGVYRYFDAQNVLLYVGKARNLKKRVSSYFSKQHGGTRIGHMVGRIARLETTVVRSEAEAL
LLENNLIKSLGPKYNILFRDDKSYPYLKITGVSAKDGTGDAPGQCYPRMAYYRGAVDKRHRYFGPYPGAWAVKESIQLLQ
KVFRLRTCEDTVFANRTRPCLLYQIKRCSAPCVGLISPTAYAADVRSAEAMLLGETQELLQTLEERMLAYAEKLEFEQAA
EVRNQITALARVLHQQAVETASDKDVDILAVKVAGGRACVNLAMVRGGRHLGDRPYFPVHVEEATGVFQLETREDAPDNL
MVEEAGGLEQSVPAQILAAFIAQHYLGVPLPPTLITSEPVDPALLWVLAQQTGVRATVVHQPREQRRIWLEMAEQNAQIQ
LARLLAEEGSQRARTRALAEALDLEAESLDDLTIECFDISHTAGEATQASCVVFHHHKMQSGEYRRFKIEGITPGDDYAA
MRQVLMRRYSKVAEAQREAGGAEVTNAPRLPDLVLVDGGKGQVSMARDVFQELGLDISRIVGVEKGEGRKVGLEELVFAD
GRDKVYLGRDSAALMLVAQIRDEAHRFAITGMRAARAKVRVGGSRLEDIPGVGPKKRARLLQRFGGVRGVADASVDDLAT
VEGISHDLAEEIYRALR
>Mature_656_residues
TTTYSDELLAQVAALPPLPGVYRYFDAQNVLLYVGKARNLKKRVSSYFSKQHGGTRIGHMVGRIARLETTVVRSEAEALL
LENNLIKSLGPKYNILFRDDKSYPYLKITGVSAKDGTGDAPGQCYPRMAYYRGAVDKRHRYFGPYPGAWAVKESIQLLQK
VFRLRTCEDTVFANRTRPCLLYQIKRCSAPCVGLISPTAYAADVRSAEAMLLGETQELLQTLEERMLAYAEKLEFEQAAE
VRNQITALARVLHQQAVETASDKDVDILAVKVAGGRACVNLAMVRGGRHLGDRPYFPVHVEEATGVFQLETREDAPDNLM
VEEAGGLEQSVPAQILAAFIAQHYLGVPLPPTLITSEPVDPALLWVLAQQTGVRATVVHQPREQRRIWLEMAEQNAQIQL
ARLLAEEGSQRARTRALAEALDLEAESLDDLTIECFDISHTAGEATQASCVVFHHHKMQSGEYRRFKIEGITPGDDYAAM
RQVLMRRYSKVAEAQREAGGAEVTNAPRLPDLVLVDGGKGQVSMARDVFQELGLDISRIVGVEKGEGRKVGLEELVFADG
RDKVYLGRDSAALMLVAQIRDEAHRFAITGMRAARAKVRVGGSRLEDIPGVGPKKRARLLQRFGGVRGVADASVDDLATV
EGISHDLAEEIYRALR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=649, Percent_Identity=41.2942989214176, Blast_Score=460, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 72592; Mature: 72461

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTYSDELLAQVAALPPLPGVYRYFDAQNVLLYVGKARNLKKRVSSYFSKQHGGTRIGH
CCCCCHHHHHHHHHHCCCCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHH
MVGRIARLETTVVRSEAEALLLENNLIKSLGPKYNILFRDDKSYPYLKITGVSAKDGTGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCCCC
APGQCYPRMAYYRGAVDKRHRYFGPYPGAWAVKESIQLLQKVFRLRTCEDTVFANRTRPC
CCCCCCCHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCH
LLYQIKRCSAPCVGLISPTAYAADVRSAEAMLLGETQELLQTLEERMLAYAEKLEFEQAA
HHHHHHHCCCCEEECCCCCHHHHHHHCCHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHH
EVRNQITALARVLHQQAVETASDKDVDILAVKVAGGRACVNLAMVRGGRHLGDRPYFPVH
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEE
VEEATGVFQLETREDAPDNLMVEEAGGLEQSVPAQILAAFIAQHYLGVPLPPTLITSEPV
ECCCCCEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
DPALLWVLAQQTGVRATVVHQPREQRRIWLEMAEQNAQIQLARLLAEEGSQRARTRALAE
CHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHH
ALDLEAESLDDLTIECFDISHTAGEATQASCVVFHHHKMQSGEYRRFKIEGITPGDDYAA
HHCCCHHCCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCHHHH
MRQVLMRRYSKVAEAQREAGGAEVTNAPRLPDLVLVDGGKGQVSMARDVFQELGLDISRI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHH
VGVEKGEGRKVGLEELVFADGRDKVYLGRDSAALMLVAQIRDEAHRFAITGMRAARAKVR
HCCCCCCCCCCCHHHHHEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHEE
VGGSRLEDIPGVGPKKRARLLQRFGGVRGVADASVDDLATVEGISHDLAEEIYRALR
ECCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTTYSDELLAQVAALPPLPGVYRYFDAQNVLLYVGKARNLKKRVSSYFSKQHGGTRIGH
CCCCHHHHHHHHHHCCCCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHHH
MVGRIARLETTVVRSEAEALLLENNLIKSLGPKYNILFRDDKSYPYLKITGVSAKDGTGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCCCCC
APGQCYPRMAYYRGAVDKRHRYFGPYPGAWAVKESIQLLQKVFRLRTCEDTVFANRTRPC
CCCCCCCHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCH
LLYQIKRCSAPCVGLISPTAYAADVRSAEAMLLGETQELLQTLEERMLAYAEKLEFEQAA
HHHHHHHCCCCEEECCCCCHHHHHHHCCHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHH
EVRNQITALARVLHQQAVETASDKDVDILAVKVAGGRACVNLAMVRGGRHLGDRPYFPVH
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCEEE
VEEATGVFQLETREDAPDNLMVEEAGGLEQSVPAQILAAFIAQHYLGVPLPPTLITSEPV
ECCCCCEEEEECCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
DPALLWVLAQQTGVRATVVHQPREQRRIWLEMAEQNAQIQLARLLAEEGSQRARTRALAE
CHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHH
ALDLEAESLDDLTIECFDISHTAGEATQASCVVFHHHKMQSGEYRRFKIEGITPGDDYAA
HHCCCHHCCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCHHHH
MRQVLMRRYSKVAEAQREAGGAEVTNAPRLPDLVLVDGGKGQVSMARDVFQELGLDISRI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHH
VGVEKGEGRKVGLEELVFADGRDKVYLGRDSAALMLVAQIRDEAHRFAITGMRAARAKVR
HCCCCCCCCCCCHHHHHEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHEE
VGGSRLEDIPGVGPKKRARLLQRFGGVRGVADASVDDLATVEGISHDLAEEIYRALR
ECCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA