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The map label for this gene is hmuU [H]

Identifier: 222110230

GI number: 222110230

Start: 1056951

End: 1058033

Strand: Direct

Name: hmuU [H]

Synonym: Dtpsy_1016

Alternate gene names: 222110230

Gene position: 1056951-1058033 (Clockwise)

Preceding gene: 222110229

Following gene: 222110231

Centisome position: 27.84

GC content: 73.31

Gene sequence:

>1083_bases
ATGAGCGCGCGCCTCCCGCAGCCCTCTACCATGGTGGCGACCACCGCCATGCCAGCAACCTATGCCACCTCCTTGCACCC
CGACGCCAGCGGCCGCCGCGCGCGCTGGCTGGGCCTGTGGCTGCTGGCCGCCAGCGTGGCGCTGCTGCTGCTCGGCGCCA
GCGTCGGCAGCACGGGCTTTGGCAGCCTGCTGAACCTGCGCGGCGACCCGCTGGCGCAGCAGATCGTGTGGGACATCCGC
CTGCCGCGCACGCTGGGCGCATGGCTGGCCGGCGCGCTGCTGGGACTGGCGGGCGCCATTGCCCAGGGGCTCTTTCGCAA
CCCGCTGGCCGACCCGTACCTGCTGGGCAGTGCGTCGGGCGCGGCGCTGGGCGGCGCCGTGGCCATGGCCGTTCTGGGTG
TGTCGCCCAGCACGGCGAGCTGGCTGGCGCGACTGGGCGTGACGGGCTTGGCCTTCGCGGGTGCTGCGGGCGCCGTGCTG
CTGACGCTGGTGTTGGCCCGTGGTGTGCAACACACGCTGCGCCTGCTGCTGGCGGGCGTAATCGTGGGCGTGGTGCTTGG
CGCTGCGCGCGACCTGATCCAGGTGGCGCAGCCCGCCATTCTGGAGCCGATGCAGGTCTTCACCATGGGCAGCTCGGCCT
TCGTGGGCTGGCAGGCCTGCGCCATCATGGCTGGCGGCTGGCTGCTGTGCGCCGCCACGGCCTGGGCGTTGTCGCGCCTG
CTGGACGGGCTGATGCTGGGCGAAGCCACGGCCGCCAGCCTGGGCCTGCCCATCGTGCCCATGCGCGCGGGGCTGGTGCT
GGCGCTGGCCCTGGCCACCGGCACGGCCGTGGCGCACACTGGGCTGATTGCCTTCGTCGGGCTGGCGGCGCCGCACCTCG
TGCGCTCGATCGCGCGCGTCACCCACCAGTGGCATGTGTGGCTGTCCAGCCTGATGGGCGCGGTGCTGCTGCTGGCCGCC
GACATCCTGGCGCGTTGGGTGGTGGCGCCGCAGGAACTGCCCGTGGGCGTGCTCACCGCCGCGCTGGGCGGCAGCTACCT
GCTGTGGCTCATGCACCGCCGGGTGTTGGGAAGCTCGCTATGA

Upstream 100 bases:

>100_bases
GCGACTTCGGGCCCGAACTGTCAGACGTGGTGGTGCGCCCCGGCCCGCGCATGGCCGAGGCCGCGCGCATCATGGCCCGC
TGCCTGGCGGAGAAGTACGA

Downstream 100 bases:

>100_bases
AGAACATAGCTGTTAGCGCACGCCAGATAAGCGCCAGCATCGCAAATGCCTCTATCTTGCGCGGCATTGACCTGGACCTG
CCCGCTGGCCGCTGGACCAG

Product: transport system permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MSARLPQPSTMVATTAMPATYATSLHPDASGRRARWLGLWLLAASVALLLLGASVGSTGFGSLLNLRGDPLAQQIVWDIR
LPRTLGAWLAGALLGLAGAIAQGLFRNPLADPYLLGSASGAALGGAVAMAVLGVSPSTASWLARLGVTGLAFAGAAGAVL
LTLVLARGVQHTLRLLLAGVIVGVVLGAARDLIQVAQPAILEPMQVFTMGSSAFVGWQACAIMAGGWLLCAATAWALSRL
LDGLMLGEATAASLGLPIVPMRAGLVLALALATGTAVAHTGLIAFVGLAAPHLVRSIARVTHQWHVWLSSLMGAVLLLAA
DILARWVVAPQELPVGVLTAALGGSYLLWLMHRRVLGSSL

Sequences:

>Translated_360_residues
MSARLPQPSTMVATTAMPATYATSLHPDASGRRARWLGLWLLAASVALLLLGASVGSTGFGSLLNLRGDPLAQQIVWDIR
LPRTLGAWLAGALLGLAGAIAQGLFRNPLADPYLLGSASGAALGGAVAMAVLGVSPSTASWLARLGVTGLAFAGAAGAVL
LTLVLARGVQHTLRLLLAGVIVGVVLGAARDLIQVAQPAILEPMQVFTMGSSAFVGWQACAIMAGGWLLCAATAWALSRL
LDGLMLGEATAASLGLPIVPMRAGLVLALALATGTAVAHTGLIAFVGLAAPHLVRSIARVTHQWHVWLSSLMGAVLLLAA
DILARWVVAPQELPVGVLTAALGGSYLLWLMHRRVLGSSL
>Mature_359_residues
SARLPQPSTMVATTAMPATYATSLHPDASGRRARWLGLWLLAASVALLLLGASVGSTGFGSLLNLRGDPLAQQIVWDIRL
PRTLGAWLAGALLGLAGAIAQGLFRNPLADPYLLGSASGAALGGAVAMAVLGVSPSTASWLARLGVTGLAFAGAAGAVLL
TLVLARGVQHTLRLLLAGVIVGVVLGAARDLIQVAQPAILEPMQVFTMGSSAFVGWQACAIMAGGWLLCAATAWALSRLL
DGLMLGEATAASLGLPIVPMRAGLVLALALATGTAVAHTGLIAFVGLAAPHLVRSIARVTHQWHVWLSSLMGAVLLLAAD
ILARWVVAPQELPVGVLTAALGGSYLLWLMHRRVLGSSL

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=293, Percent_Identity=37.542662116041, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790740, Length=282, Percent_Identity=36.1702127659575, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786805, Length=286, Percent_Identity=38.1118881118881, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1790741, Length=290, Percent_Identity=32.7586206896552, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1786347, Length=281, Percent_Identity=32.0284697508897, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1786804, Length=282, Percent_Identity=34.7517730496454, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36780; Mature: 36649

Theoretical pI: Translated: 11.78; Mature: 11.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARLPQPSTMVATTAMPATYATSLHPDASGRRARWLGLWLLAASVALLLLGASVGSTGF
CCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCH
GSLLNLRGDPLAQQIVWDIRLPRTLGAWLAGALLGLAGAIAQGLFRNPLADPYLLGSASG
HHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCC
AALGGAVAMAVLGVSPSTASWLARLGVTGLAFAGAAGAVLLTLVLARGVQHTLRLLLAGV
HHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVGVVLGAARDLIQVAQPAILEPMQVFTMGSSAFVGWQACAIMAGGWLLCAATAWALSRL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHH
LDGLMLGEATAASLGLPIVPMRAGLVLALALATGTAVAHTGLIAFVGLAAPHLVRSIARV
HHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
THQWHVWLSSLMGAVLLLAADILARWVVAPQELPVGVLTAALGGSYLLWLMHRRVLGSSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SARLPQPSTMVATTAMPATYATSLHPDASGRRARWLGLWLLAASVALLLLGASVGSTGF
CCCCCCCCCEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCH
GSLLNLRGDPLAQQIVWDIRLPRTLGAWLAGALLGLAGAIAQGLFRNPLADPYLLGSASG
HHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCC
AALGGAVAMAVLGVSPSTASWLARLGVTGLAFAGAAGAVLLTLVLARGVQHTLRLLLAGV
HHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVGVVLGAARDLIQVAQPAILEPMQVFTMGSSAFVGWQACAIMAGGWLLCAATAWALSRL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHH
LDGLMLGEATAASLGLPIVPMRAGLVLALALATGTAVAHTGLIAFVGLAAPHLVRSIARV
HHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
THQWHVWLSSLMGAVLLLAADILARWVVAPQELPVGVLTAALGGSYLLWLMHRRVLGSSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]