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The map label for this gene is mas [H]

Identifier: 222110083

GI number: 222110083

Start: 894133

End: 895137

Strand: Direct

Name: mas [H]

Synonym: Dtpsy_0869

Alternate gene names: 222110083

Gene position: 894133-895137 (Clockwise)

Preceding gene: 222110082

Following gene: 222110084

Centisome position: 23.55

GC content: 68.76

Gene sequence:

>1005_bases
ATGAATGACGTGATGCAGGCCGTAGAGATTGCGGCGTTTGGCCCGCCTGAGGGGCTGCGTCTCGCCGAGCGCCCGGTGCC
GCAGCCGGGAGACGGCGAGTTGTTGATCCGCGTGGCGGCCAGCGGGGTGAACCGCCCCGACGTGCTGCAGCGCAAGGGCA
ACTACGCGCCACCCGCGGGCGTCTCCGATCTGCCGGGGCTGGAAGTGGCGGGCGTTGTCGAGTCCGGCGATGCCGCCGCC
ATGGCGCAGGCGGGCCTTCGCGTGGGCGACCGGGTGTGCGCTTTGGTTGCGGGCGGCGGTTATGCGCAGTGGTGCGTCGC
GCCTGTTGCGCAATGCCTGCCGGTGCCGCAGGGCTTGAGCGACGTGGAGGCGGCCTCGCTGCCGGAAACCTTCTTTACCG
TCTGGAGCAATGTGTTCGACCGCGGCCGCCTGCAGGCGGGAGAGGTCCTGCTGGTGCAGGGCGGCAGTAGCGGCATTGGC
GTTACGGCTATTCAGTTGGCGCGTGCACGCGGCGCCACGGTCATCGTCACGGCGGGTTCGGACGAAAAGTGCGCAGCCTG
CCTGGCGCTGGGTGCGCACCACGCGATCAACTACAAGACACAGGACTTCGTGGCCGAGGCGCGGCGCCTTACCGATGGGC
GCGGCGTGGACGTAGTGCTGGACATGGTGGCCGGCTCCTACGTGGCGCGCGAGGTTGAGTGTCTGGCCGAGGACGGCCGC
GTGGTCATCATCGCGGTGCAGGGCGGGCTGGATGCGCAGTTCAATGCGGGGCTGGTGCTGCGCAGGCGGCTGACCATCAC
GGGCTCCACGCTGAGGCCGCGTCCCGTGGCGTTCAAGGGCGCCATTGCGCAGGCATTGCGTGAGCATGTTTGGCCGCTGC
TGGCGTCGGGCGCGGTGAAGCCGGTCATCCACAGCACCTTCCCGGCCGCGCAGGCCGCGCAGGCGCATGCGCTCATGGAA
TCCAACCAGCACGTGGGCAAGATTGTTTTGACATGGACGACATGA

Upstream 100 bases:

>100_bases
AGCCGGGGGTGTTCCTTCGGGAATACCTGTTTGCTATTGAAATGAGAGCTGCTAACGCCCGATGGACGGGCGCTAGCGGC
TCAAATGATTCAAAACTGCC

Downstream 100 bases:

>100_bases
CACAGAAAAAGAAACTCATTGCCGGCAACTGGAAGATGAACGGTAGCCTGCAGGCGAATGCGGTGCTGCTGCAGGCATTG
CGCGATGGCTTGGGCGCGCC

Product: NAD(P)h quinone oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MNDVMQAVEIAAFGPPEGLRLAERPVPQPGDGELLIRVAASGVNRPDVLQRKGNYAPPAGVSDLPGLEVAGVVESGDAAA
MAQAGLRVGDRVCALVAGGGYAQWCVAPVAQCLPVPQGLSDVEAASLPETFFTVWSNVFDRGRLQAGEVLLVQGGSSGIG
VTAIQLARARGATVIVTAGSDEKCAACLALGAHHAINYKTQDFVAEARRLTDGRGVDVVLDMVAGSYVAREVECLAEDGR
VVIIAVQGGLDAQFNAGLVLRRRLTITGSTLRPRPVAFKGAIAQALREHVWPLLASGAVKPVIHSTFPAAQAAQAHALME
SNQHVGKIVLTWTT

Sequences:

>Translated_334_residues
MNDVMQAVEIAAFGPPEGLRLAERPVPQPGDGELLIRVAASGVNRPDVLQRKGNYAPPAGVSDLPGLEVAGVVESGDAAA
MAQAGLRVGDRVCALVAGGGYAQWCVAPVAQCLPVPQGLSDVEAASLPETFFTVWSNVFDRGRLQAGEVLLVQGGSSGIG
VTAIQLARARGATVIVTAGSDEKCAACLALGAHHAINYKTQDFVAEARRLTDGRGVDVVLDMVAGSYVAREVECLAEDGR
VVIIAVQGGLDAQFNAGLVLRRRLTITGSTLRPRPVAFKGAIAQALREHVWPLLASGAVKPVIHSTFPAAQAAQAHALME
SNQHVGKIVLTWTT
>Mature_334_residues
MNDVMQAVEIAAFGPPEGLRLAERPVPQPGDGELLIRVAASGVNRPDVLQRKGNYAPPAGVSDLPGLEVAGVVESGDAAA
MAQAGLRVGDRVCALVAGGGYAQWCVAPVAQCLPVPQGLSDVEAASLPETFFTVWSNVFDRGRLQAGEVLLVQGGSSGIG
VTAIQLARARGATVIVTAGSDEKCAACLALGAHHAINYKTQDFVAEARRLTDGRGVDVVLDMVAGSYVAREVECLAEDGR
VVIIAVQGGLDAQFNAGLVLRRRLTITGSTLRPRPVAFKGAIAQALREHVWPLLASGAVKPVIHSTFPAAQAAQAHALME
SNQHVGKIVLTWTT

Specific function: Catalyzes the elongation of N-fatty acyl-CoA with methylamalonyl-CoA (not malonyl-CoA) as the elongating agent to form mycocerosyl lipids [H]

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 acyl carrier domain [H]

Homologues:

Organism=Homo sapiens, GI22538446, Length=332, Percent_Identity=39.1566265060241, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI22538444, Length=332, Percent_Identity=39.1566265060241, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI194239674, Length=334, Percent_Identity=29.940119760479, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI13236495, Length=334, Percent_Identity=29.940119760479, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI24308257, Length=346, Percent_Identity=28.6127167630058, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI18379349, Length=314, Percent_Identity=29.2993630573248, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI194239676, Length=336, Percent_Identity=27.9761904761905, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI28557745, Length=225, Percent_Identity=34.6666666666667, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI41872631, Length=329, Percent_Identity=30.3951367781155, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI197927207, Length=188, Percent_Identity=28.7234042553192, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI47519420, Length=361, Percent_Identity=26.0387811634349, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790485, Length=331, Percent_Identity=29.607250755287, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17507255, Length=328, Percent_Identity=26.219512195122, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI212642053, Length=315, Percent_Identity=27.3015873015873, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319520, Length=335, Percent_Identity=26.865671641791, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6324486, Length=342, Percent_Identity=24.5614035087719, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=282, Percent_Identity=24.468085106383, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19920632, Length=257, Percent_Identity=31.1284046692607, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI221330659, Length=257, Percent_Identity=30.7392996108949, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24581345, Length=339, Percent_Identity=28.6135693215339, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR009081
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR000794
- InterPro:   IPR011032
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016036
- InterPro:   IPR016040
- InterPro:   IPR006163
- InterPro:   IPR020842
- InterPro:   IPR020801
- InterPro:   IPR020841
- InterPro:   IPR020807
- InterPro:   IPR020843
- InterPro:   IPR013968
- InterPro:   IPR006162
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF08240 ADH_N; PF00107 ADH_zinc_N; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF08659 KR; PF00550 PP-binding [H]

EC number: =2.3.1.111 [H]

Molecular weight: Translated: 34728; Mature: 34728

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDVMQAVEIAAFGPPEGLRLAERPVPQPGDGELLIRVAASGVNRPDVLQRKGNYAPPAG
CCHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCCC
VSDLPGLEVAGVVESGDAAAMAQAGLRVGDRVCALVAGGGYAQWCVAPVAQCLPVPQGLS
CCCCCCCEEEEEEECCCHHHHHHHCCHHCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCC
DVEAASLPETFFTVWSNVFDRGRLQAGEVLLVQGGSSGIGVTAIQLARARGATVIVTAGS
CCHHHCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEECCC
DEKCAACLALGAHHAINYKTQDFVAEARRLTDGRGVDVVLDMVAGSYVAREVECLAEDGR
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
VVIIAVQGGLDAQFNAGLVLRRRLTITGSTLRPRPVAFKGAIAQALREHVWPLLASGAVK
EEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
PVIHSTFPAAQAAQAHALMESNQHVGKIVLTWTT
HHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEEEC
>Mature Secondary Structure
MNDVMQAVEIAAFGPPEGLRLAERPVPQPGDGELLIRVAASGVNRPDVLQRKGNYAPPAG
CCHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCCC
VSDLPGLEVAGVVESGDAAAMAQAGLRVGDRVCALVAGGGYAQWCVAPVAQCLPVPQGLS
CCCCCCCEEEEEEECCCHHHHHHHCCHHCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCC
DVEAASLPETFFTVWSNVFDRGRLQAGEVLLVQGGSSGIGVTAIQLARARGATVIVTAGS
CCHHHCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEECCC
DEKCAACLALGAHHAINYKTQDFVAEARRLTDGRGVDVVLDMVAGSYVAREVECLAEDGR
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
VVIIAVQGGLDAQFNAGLVLRRRLTITGSTLRPRPVAFKGAIAQALREHVWPLLASGAVK
EEEEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
PVIHSTFPAAQAAQAHALMESNQHVGKIVLTWTT
HHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1527058; 12788972 [H]