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The map label for this gene is tpiA [H]

Identifier: 222110084

GI number: 222110084

Start: 895134

End: 895886

Strand: Direct

Name: tpiA [H]

Synonym: Dtpsy_0870

Alternate gene names: 222110084

Gene position: 895134-895886 (Clockwise)

Preceding gene: 222110083

Following gene: 222110085

Centisome position: 23.58

GC content: 65.87

Gene sequence:

>753_bases
ATGACACAGAAAAAGAAACTCATTGCCGGCAACTGGAAGATGAACGGTAGCCTGCAGGCGAATGCGGTGCTGCTGCAGGC
ATTGCGCGATGGCTTGGGCGCGCCCGGCTGTGGCGTGGCGGTGGCCGTGCCAGCGCCCTACCTGGCGCAGGTGCAGGCCT
TGGTCGCGGGCAGCGAAATCGCTCTGGCTGCCCAGGATGTATCGCAACATGAAACGGGCGCGTTCACCGGCGAGGTCTCT
GTGAGTATGTTGCGCGACTTTGGTGCACGCTACGCGCTTGTGGGGCACTCCGAGCGTCGCCAATACCATGGCGAAACCGA
TGCCGTGGTCGCGGCCAAGGCCCAGCGGGCGCTCTCGGGCGGCGTCACGCCGATCGTATGCGTGGGAGAAACTCTGGCCG
AGCGCGAGGCGGGCCAGACCGAGACCGTCGTCAAGCGCCAACTGGCGGCTGTAATCCATGCCGTGGGGCACTGCGTGAGC
GAGATCGTGGTGGCCTACGAGCCTGTCTGGGCCATCGGCACCGGCCGCACGGCAACGCCAGAGCAGGCGCAGCAGGTGCA
TGCGGTGCTGCGCGCTCAGCTCGCCGCCGCGACCGAGAGCGCGGACCGCGTGCTCATCCTGTATGGCGGCAGCATGAATG
CTGCCAACGCAGCCGAACTGCTGGCGCAGCCGGATATCGATGGGGGCCTGGTGGGCGGTGCGTCGCTCAAGGCCGCGGAT
TTCTTGAAAATTATCGCTGCAGCGCATAGCTGA

Upstream 100 bases:

>100_bases
CGGTCATCCACAGCACCTTCCCGGCCGCGCAGGCCGCGCAGGCGCATGCGCTCATGGAATCCAACCAGCACGTGGGCAAG
ATTGTTTTGACATGGACGAC

Downstream 100 bases:

>100_bases
CAAGCGCTGGTAGCTATTAAATTAGGAGTGATGGGATTATGGGACTGGTTGTGAACGTGATTCTGGCGGTGCAGATGCTG
ACCGCCCTCGGGATGATTGG

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MTQKKKLIAGNWKMNGSLQANAVLLQALRDGLGAPGCGVAVAVPAPYLAQVQALVAGSEIALAAQDVSQHETGAFTGEVS
VSMLRDFGARYALVGHSERRQYHGETDAVVAAKAQRALSGGVTPIVCVGETLAEREAGQTETVVKRQLAAVIHAVGHCVS
EIVVAYEPVWAIGTGRTATPEQAQQVHAVLRAQLAAATESADRVLILYGGSMNAANAAELLAQPDIDGGLVGGASLKAAD
FLKIIAAAHS

Sequences:

>Translated_250_residues
MTQKKKLIAGNWKMNGSLQANAVLLQALRDGLGAPGCGVAVAVPAPYLAQVQALVAGSEIALAAQDVSQHETGAFTGEVS
VSMLRDFGARYALVGHSERRQYHGETDAVVAAKAQRALSGGVTPIVCVGETLAEREAGQTETVVKRQLAAVIHAVGHCVS
EIVVAYEPVWAIGTGRTATPEQAQQVHAVLRAQLAAATESADRVLILYGGSMNAANAAELLAQPDIDGGLVGGASLKAAD
FLKIIAAAHS
>Mature_249_residues
TQKKKLIAGNWKMNGSLQANAVLLQALRDGLGAPGCGVAVAVPAPYLAQVQALVAGSEIALAAQDVSQHETGAFTGEVSV
SMLRDFGARYALVGHSERRQYHGETDAVVAAKAQRALSGGVTPIVCVGETLAEREAGQTETVVKRQLAAVIHAVGHCVSE
IVVAYEPVWAIGTGRTATPEQAQQVHAVLRAQLAAATESADRVLILYGGSMNAANAAELLAQPDIDGGLVGGASLKAADF
LKIIAAAHS

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI226529917, Length=246, Percent_Identity=45.1219512195122, Blast_Score=194, Evalue=5e-50,
Organism=Homo sapiens, GI4507645, Length=246, Percent_Identity=45.1219512195122, Blast_Score=194, Evalue=5e-50,
Organism=Escherichia coli, GI1790353, Length=250, Percent_Identity=51.6, Blast_Score=243, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17536593, Length=247, Percent_Identity=48.9878542510121, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6320255, Length=245, Percent_Identity=44.4897959183673, Blast_Score=201, Evalue=1e-52,
Organism=Drosophila melanogaster, GI28572004, Length=246, Percent_Identity=49.1869918699187, Blast_Score=221, Evalue=3e-58,
Organism=Drosophila melanogaster, GI28572008, Length=246, Percent_Identity=49.1869918699187, Blast_Score=221, Evalue=4e-58,
Organism=Drosophila melanogaster, GI28572006, Length=246, Percent_Identity=49.1869918699187, Blast_Score=221, Evalue=4e-58,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 25722; Mature: 25590

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKKKLIAGNWKMNGSLQANAVLLQALRDGLGAPGCGVAVAVPAPYLAQVQALVAGSEI
CCCCCCEEECCEEECCCCHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHCCCHH
ALAAQDVSQHETGAFTGEVSVSMLRDFGARYALVGHSERRQYHGETDAVVAAKAQRALSG
EEEHHHHHHHCCCCEEHHHHHHHHHHCCCCEEEECCHHHHHHCCCCHHHHHHHHHHHHHC
GVTPIVCVGETLAEREAGQTETVVKRQLAAVIHAVGHCVSEIVVAYEPVWAIGTGRTATP
CCCEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCH
EQAQQVHAVLRAQLAAATESADRVLILYGGSMNAANAAELLAQPDIDGGLVGGASLKAAD
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCEECCCCHHHHH
FLKIIAAAHS
HHHHHHHHCC
>Mature Secondary Structure 
TQKKKLIAGNWKMNGSLQANAVLLQALRDGLGAPGCGVAVAVPAPYLAQVQALVAGSEI
CCCCCEEECCEEECCCCHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHCCCHH
ALAAQDVSQHETGAFTGEVSVSMLRDFGARYALVGHSERRQYHGETDAVVAAKAQRALSG
EEEHHHHHHHCCCCEEHHHHHHHHHHCCCCEEEECCHHHHHHCCCCHHHHHHHHHHHHHC
GVTPIVCVGETLAEREAGQTETVVKRQLAAVIHAVGHCVSEIVVAYEPVWAIGTGRTATP
CCCEEEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCH
EQAQQVHAVLRAQLAAATESADRVLILYGGSMNAANAAELLAQPDIDGGLVGGASLKAAD
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCEECCCCHHHHH
FLKIIAAAHS
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA