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The map label for this gene is fadN [H]

Identifier: 222109789

GI number: 222109789

Start: 592651

End: 595053

Strand: Direct

Name: fadN [H]

Synonym: Dtpsy_0573

Alternate gene names: 222109789

Gene position: 592651-595053 (Clockwise)

Preceding gene: 222109788

Following gene: 222109790

Centisome position: 15.61

GC content: 67.46

Gene sequence:

>2403_bases
ATGTCCCGATTCCAAGTGAAGAAAGTCGCCGTGCTCGGCGCGGGCGTGATGGGCGCGCAGATCGCGGCCCACCTCGTCAA
TGTGAAGGTGCCGGTGGTGCTGTTCGATCTCCCCGCCAAGGAAGGTCCGAAGAACGGCATCGTCACCCGCGCGGTGGAGA
ACCTCAAGAAGCTCAAGCCCTCGCCCCTGGGCGTGGCGGACGACGCCGCGCTGATCCAGCAGGCGAACTACGAGGAGAAC
ATGGCGCTGCTGGGCGAGTGCGACCTCATCATCGAGGCCATCGCCGAGCGCATGGACTGGAAGCTCGATCTGTACAAGAA
GATCGCGCCGCACGTCGCACCGCACGCCATCGTGGCGTCCAACACCTCGGGCCTGTCGATCACCCAGCTGTCCGAAGCCC
TGCCCGACGCCATCAAGCCGCGCTTTTGCGGCATCCACTTCTTCAACCCGCCGCGCTACATGGTGCTGGTGGAGCTGATC
AACACCCCCACCACCCGCCCCGAGGTGCTCGACCAGCTCGAAGCCTTCGTGACCAGCGGCCTGGGCAAGGGCGTGGTGCG
CGCGCACGACACCCCCAACTTCATCGCCAACCGCGTGGGCATCGCCGGCATGCTTTCCACGATGAAGGAGGTGGAGAACT
TCGGCCTGACCTTCGACGTGGTGGACGACCTCACCGGCAAGAAGCTGGGCCGTGCCTCCAGCGGCACCTTCCGCACCGCC
GACGTGGTGGGCCTGGACACCATGGCCCACGTCATCAAGACGCTGCAGGACAACCTGAACGAGCAGACCGACCCGTTCTA
CGGCAGCTTCGGCACGCCCGCCGTGCTGCAAAAGCTGATCGAGCTGGGCAACCTGGGCCAGAAGGCCAAGGCGGGCTTCT
ACAAGAAGGTGGGGCGCGACATCCTGCGCTTCGAGCTGGAGAGCGAGGAATATGTGCCCGCCGGCGCCAAGGCCGACGAG
GTGTACGGCCGCATGCTCAAGAAGCCCGCTGCCGAGCGCCTGAAGCTGCTGCGCAACGCCGAGGGCGCGCAGGGCCGGTT
CCTGTGGGCGATCCTGCGCAACAGCTTCCACTACGCTGCGGTGCATCTGGCCACGATTGCCGACACCGCGCGCGACGTGG
ACCAGGCCATGCGCTGGGGCTTCGGCATGAGCCAGGGGCCGTTCGAGCTGTGGCAGGAGGCGGGCTGGCTGGAGGTGGCC
AGGATGGTCCAGGAGGACATTGACGCCGGCAAGGCACTGTCCAAGGCGCCGCTGCCCGAGTGGGTGTTCAAGGGCCCGGT
GGCGGATGCCGGCGGCGTGCACACGGCGCAGGGTTCGTGGAGCGCGCGCCAAGGCAAGTTCGTGCCGCGCCGCCAGTTGC
CGGTGTACGAGCGCCAGTACTTCCCCGAGAAACTGCTGGGCGAGGACAACCTGCCCGACTGGCGCAAGGCCGGCACCACC
ATCAGCGAGACCGATGCGCTGCGCACCTGGACGCTCGATGGCAAGGTATTGATCGCCTCCATCCAGAGCAAGATGCACGC
GATCAGCCCCGACGTGATGGAAGGCCTGATGGAGGCCGTGGACCTGGCCGAGCGCGAGTACGACGGCATGGTCATCTGGT
CGGGCGACGCGCCGTTCAGCGTGGGCGCCGACCTGCAGGCCACCATGCCTGCCTACGTGGTGGCCGGCATTGCCGCCATC
GAGGGCGTGGAGCATGAGCTGCAGAACCTGATGCTGCGCCTGCGCTACGCCCAGGTGCCGGTGGTCTCGGCCATCCATGG
CATGGCGCTGGGCGGCGGCTGCGAGCTGGCCGTGCACAGCGCACGCCGCGTGGCCCACATGGAAAGCTACATCGGCCTGG
TGGAAGTGGGCGTGGGCCTGGTGCCCGGCGCCGGCGGCCTGACCTACATCGCCCGCCGCGCGGCCGAGAACGCCGCCGCC
AGCACCGGCAAGGACCTTTTGCCCTTCCTGACCGAAGGCTTCACCGCCGCGGCCATGGCCAAGGTAGGCACCAGCGCCCT
TGAGTCGAAGAAGCTCGGCTACCTGCTCGACAGCGACCTCATCGTGCCGCACAAGGACGAGGTGCTGTTCGTCGCCATCA
ACGAAGCCAAGGCCATGGCCGCCGGCGGCTGGCGCGCGCCGCACAAGCGCCTGTTCCCCGTGGCGGGGCGCAGCGGCATT
GCCACCATCCGCGGCTCGCTGGTCAATATGCGCGACGGCGGCTTCATCAGCGAGCATGACCAGCACATCGCCACGCTGAT
CGCCGAAGTGGTGTGCGGCGGCGACGTGGACGCCGGCACGCTGGTGAGCGAGGAATACCTGATGGCGCTGGAGCGCAAGG
CGTTCTGCGCCCTGATCGAGCACCCCAAGACCCAGGAGCGCATCCTGGGCATGCTCAACACTGGCAAGCCGGTGCGTAAC
TGA

Upstream 100 bases:

>100_bases
GCAAAGCAGTGAGCGCCACGGCGCCGCAGCCGGCCCGCCCGCGTGGCACGGGGCCTGGCGCGCGGCCCCGTGCGCATCCC
ACCATCCAAGGAACAAGCAA

Downstream 100 bases:

>100_bases
GGCCGCCCGAGGAGAGAAACCATGAAACAGATCCAAGACGCCTACATCGTTGCCGCCACGCGCACGCCCATCGGCCGTTC
GCACAAGGGCTTTTTCCGCA

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 800; Mature: 799

Protein sequence:

>800_residues
MSRFQVKKVAVLGAGVMGAQIAAHLVNVKVPVVLFDLPAKEGPKNGIVTRAVENLKKLKPSPLGVADDAALIQQANYEEN
MALLGECDLIIEAIAERMDWKLDLYKKIAPHVAPHAIVASNTSGLSITQLSEALPDAIKPRFCGIHFFNPPRYMVLVELI
NTPTTRPEVLDQLEAFVTSGLGKGVVRAHDTPNFIANRVGIAGMLSTMKEVENFGLTFDVVDDLTGKKLGRASSGTFRTA
DVVGLDTMAHVIKTLQDNLNEQTDPFYGSFGTPAVLQKLIELGNLGQKAKAGFYKKVGRDILRFELESEEYVPAGAKADE
VYGRMLKKPAAERLKLLRNAEGAQGRFLWAILRNSFHYAAVHLATIADTARDVDQAMRWGFGMSQGPFELWQEAGWLEVA
RMVQEDIDAGKALSKAPLPEWVFKGPVADAGGVHTAQGSWSARQGKFVPRRQLPVYERQYFPEKLLGEDNLPDWRKAGTT
ISETDALRTWTLDGKVLIASIQSKMHAISPDVMEGLMEAVDLAEREYDGMVIWSGDAPFSVGADLQATMPAYVVAGIAAI
EGVEHELQNLMLRLRYAQVPVVSAIHGMALGGGCELAVHSARRVAHMESYIGLVEVGVGLVPGAGGLTYIARRAAENAAA
STGKDLLPFLTEGFTAAAMAKVGTSALESKKLGYLLDSDLIVPHKDEVLFVAINEAKAMAAGGWRAPHKRLFPVAGRSGI
ATIRGSLVNMRDGGFISEHDQHIATLIAEVVCGGDVDAGTLVSEEYLMALERKAFCALIEHPKTQERILGMLNTGKPVRN

Sequences:

>Translated_800_residues
MSRFQVKKVAVLGAGVMGAQIAAHLVNVKVPVVLFDLPAKEGPKNGIVTRAVENLKKLKPSPLGVADDAALIQQANYEEN
MALLGECDLIIEAIAERMDWKLDLYKKIAPHVAPHAIVASNTSGLSITQLSEALPDAIKPRFCGIHFFNPPRYMVLVELI
NTPTTRPEVLDQLEAFVTSGLGKGVVRAHDTPNFIANRVGIAGMLSTMKEVENFGLTFDVVDDLTGKKLGRASSGTFRTA
DVVGLDTMAHVIKTLQDNLNEQTDPFYGSFGTPAVLQKLIELGNLGQKAKAGFYKKVGRDILRFELESEEYVPAGAKADE
VYGRMLKKPAAERLKLLRNAEGAQGRFLWAILRNSFHYAAVHLATIADTARDVDQAMRWGFGMSQGPFELWQEAGWLEVA
RMVQEDIDAGKALSKAPLPEWVFKGPVADAGGVHTAQGSWSARQGKFVPRRQLPVYERQYFPEKLLGEDNLPDWRKAGTT
ISETDALRTWTLDGKVLIASIQSKMHAISPDVMEGLMEAVDLAEREYDGMVIWSGDAPFSVGADLQATMPAYVVAGIAAI
EGVEHELQNLMLRLRYAQVPVVSAIHGMALGGGCELAVHSARRVAHMESYIGLVEVGVGLVPGAGGLTYIARRAAENAAA
STGKDLLPFLTEGFTAAAMAKVGTSALESKKLGYLLDSDLIVPHKDEVLFVAINEAKAMAAGGWRAPHKRLFPVAGRSGI
ATIRGSLVNMRDGGFISEHDQHIATLIAEVVCGGDVDAGTLVSEEYLMALERKAFCALIEHPKTQERILGMLNTGKPVRN
>Mature_799_residues
SRFQVKKVAVLGAGVMGAQIAAHLVNVKVPVVLFDLPAKEGPKNGIVTRAVENLKKLKPSPLGVADDAALIQQANYEENM
ALLGECDLIIEAIAERMDWKLDLYKKIAPHVAPHAIVASNTSGLSITQLSEALPDAIKPRFCGIHFFNPPRYMVLVELIN
TPTTRPEVLDQLEAFVTSGLGKGVVRAHDTPNFIANRVGIAGMLSTMKEVENFGLTFDVVDDLTGKKLGRASSGTFRTAD
VVGLDTMAHVIKTLQDNLNEQTDPFYGSFGTPAVLQKLIELGNLGQKAKAGFYKKVGRDILRFELESEEYVPAGAKADEV
YGRMLKKPAAERLKLLRNAEGAQGRFLWAILRNSFHYAAVHLATIADTARDVDQAMRWGFGMSQGPFELWQEAGWLEVAR
MVQEDIDAGKALSKAPLPEWVFKGPVADAGGVHTAQGSWSARQGKFVPRRQLPVYERQYFPEKLLGEDNLPDWRKAGTTI
SETDALRTWTLDGKVLIASIQSKMHAISPDVMEGLMEAVDLAEREYDGMVIWSGDAPFSVGADLQATMPAYVVAGIAAIE
GVEHELQNLMLRLRYAQVPVVSAIHGMALGGGCELAVHSARRVAHMESYIGLVEVGVGLVPGAGGLTYIARRAAENAAAS
TGKDLLPFLTEGFTAAAMAKVGTSALESKKLGYLLDSDLIVPHKDEVLFVAINEAKAMAAGGWRAPHKRLFPVAGRSGIA
TIRGSLVNMRDGGFISEHDQHIATLIAEVVCGGDVDAGTLVSEEYLMALERKAFCALIEHPKTQERILGMLNTGKPVRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=299, Percent_Identity=33.4448160535117, Blast_Score=120, Evalue=6e-27,
Organism=Homo sapiens, GI296179427, Length=314, Percent_Identity=33.1210191082803, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI20127408, Length=297, Percent_Identity=29.2929292929293, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI68989263, Length=140, Percent_Identity=35, Blast_Score=72, Evalue=3e-12,
Organism=Homo sapiens, GI261878539, Length=329, Percent_Identity=26.1398176291793, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1787661, Length=296, Percent_Identity=29.7297297297297, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1790281, Length=213, Percent_Identity=29.1079812206573, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1788682, Length=215, Percent_Identity=28.8372093023256, Blast_Score=63, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17563036, Length=297, Percent_Identity=31.6498316498317, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17549919, Length=303, Percent_Identity=31.023102310231, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17553560, Length=295, Percent_Identity=30.1694915254237, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17508953, Length=293, Percent_Identity=30.7167235494881, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17558304, Length=291, Percent_Identity=29.553264604811, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25144276, Length=293, Percent_Identity=30.7167235494881, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17508951, Length=293, Percent_Identity=30.7167235494881, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71985923, Length=253, Percent_Identity=29.2490118577075, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19921000, Length=331, Percent_Identity=30.5135951661631, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583077, Length=331, Percent_Identity=30.5135951661631, Blast_Score=88, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24583079, Length=331, Percent_Identity=30.5135951661631, Blast_Score=88, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45549573, Length=227, Percent_Identity=28.6343612334802, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 86611; Mature: 86480

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFQVKKVAVLGAGVMGAQIAAHLVNVKVPVVLFDLPAKEGPKNGIVTRAVENLKKLKP
CCCHHHHHHHHHCCCHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCC
SPLGVADDAALIQQANYEENMALLGECDLIIEAIAERMDWKLDLYKKIAPHVAPHAIVAS
CCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEC
NTSGLSITQLSEALPDAIKPRFCGIHFFNPPRYMVLVELINTPTTRPEVLDQLEAFVTSG
CCCCCCHHHHHHHCHHHCCCCEEEEEEECCCHHEEHEEHHCCCCCCHHHHHHHHHHHHHC
LGKGVVRAHDTPNFIANRVGIAGMLSTMKEVENFGLTFDVVDDLTGKKLGRASSGTFRTA
CCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHCCCCHHCCCCCCCCEEEH
DVVGLDTMAHVIKTLQDNLNEQTDPFYGSFGTPAVLQKLIELGNLGQKAKAGFYKKVGRD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ILRFELESEEYVPAGAKADEVYGRMLKKPAAERLKLLRNAEGAQGRFLWAILRNSFHYAA
HHHEEECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHH
VHLATIADTARDVDQAMRWGFGMSQGPFELWQEAGWLEVARMVQEDIDAGKALSKAPLPE
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCH
WVFKGPVADAGGVHTAQGSWSARQGKFVPRRQLPVYERQYFPEKLLGEDNLPDWRKAGTT
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHCCCCCCCCHHHHCCC
ISETDALRTWTLDGKVLIASIQSKMHAISPDVMEGLMEAVDLAEREYDGMVIWSGDAPFS
CCCCCCEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
VGADLQATMPAYVVAGIAAIEGVEHELQNLMLRLRYAQVPVVSAIHGMALGGGCELAVHS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHH
ARRVAHMESYIGLVEVGVGLVPGAGGLTYIARRAAENAAASTGKDLLPFLTEGFTAAAMA
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHH
KVGTSALESKKLGYLLDSDLIVPHKDEVLFVAINEAKAMAAGGWRAPHKRLFPVAGRSGI
HHHHHHHHHCCCCEEECCCCCCCCCCCEEEEEECCCHHHHCCCCCCCCCCCCCCCCCCCH
ATIRGSLVNMRDGGFISEHDQHIATLIAEVVCGGDVDAGTLVSEEYLMALERKAFCALIE
HHHHCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
HPKTQERILGMLNTGKPVRN
CCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SRFQVKKVAVLGAGVMGAQIAAHLVNVKVPVVLFDLPAKEGPKNGIVTRAVENLKKLKP
CCHHHHHHHHHCCCHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCC
SPLGVADDAALIQQANYEENMALLGECDLIIEAIAERMDWKLDLYKKIAPHVAPHAIVAS
CCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEC
NTSGLSITQLSEALPDAIKPRFCGIHFFNPPRYMVLVELINTPTTRPEVLDQLEAFVTSG
CCCCCCHHHHHHHCHHHCCCCEEEEEEECCCHHEEHEEHHCCCCCCHHHHHHHHHHHHHC
LGKGVVRAHDTPNFIANRVGIAGMLSTMKEVENFGLTFDVVDDLTGKKLGRASSGTFRTA
CCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHCCCCHHCCCCCCCCEEEH
DVVGLDTMAHVIKTLQDNLNEQTDPFYGSFGTPAVLQKLIELGNLGQKAKAGFYKKVGRD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
ILRFELESEEYVPAGAKADEVYGRMLKKPAAERLKLLRNAEGAQGRFLWAILRNSFHYAA
HHHEEECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHH
VHLATIADTARDVDQAMRWGFGMSQGPFELWQEAGWLEVARMVQEDIDAGKALSKAPLPE
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCH
WVFKGPVADAGGVHTAQGSWSARQGKFVPRRQLPVYERQYFPEKLLGEDNLPDWRKAGTT
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHCCCCCCCCHHHHCCC
ISETDALRTWTLDGKVLIASIQSKMHAISPDVMEGLMEAVDLAEREYDGMVIWSGDAPFS
CCCCCCEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
VGADLQATMPAYVVAGIAAIEGVEHELQNLMLRLRYAQVPVVSAIHGMALGGGCELAVHS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHH
ARRVAHMESYIGLVEVGVGLVPGAGGLTYIARRAAENAAASTGKDLLPFLTEGFTAAAMA
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHH
KVGTSALESKKLGYLLDSDLIVPHKDEVLFVAINEAKAMAAGGWRAPHKRLFPVAGRSGI
HHHHHHHHHCCCCEEECCCCCCCCCCCEEEEEECCCHHHHCCCCCCCCCCCCCCCCCCCH
ATIRGSLVNMRDGGFISEHDQHIATLIAEVVCGGDVDAGTLVSEEYLMALERKAFCALIE
HHHHCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
HPKTQERILGMLNTGKPVRN
CCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]