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The map label for this gene is fadA [H]

Identifier: 222109790

GI number: 222109790

Start: 595075

End: 596271

Strand: Direct

Name: fadA [H]

Synonym: Dtpsy_0574

Alternate gene names: 222109790

Gene position: 595075-596271 (Clockwise)

Preceding gene: 222109789

Following gene: 222109791

Centisome position: 15.67

GC content: 70.51

Gene sequence:

>1197_bases
ATGAAACAGATCCAAGACGCCTACATCGTTGCCGCCACGCGCACGCCCATCGGCCGTTCGCACAAGGGCTTTTTCCGCAA
CTACCGCCCGGACGACCTGCTGGCCACCACGCTCAAGAGCGCGCTGGCCCAGGTGCCGGGGCTGGACCCCGCCTCGATCG
AGGACATCATCTGCGGCTGCGCCATCCCTGAGGCGCAGCAGGGCCTGAACGTGGCGCGCATCGGCGCCGTGCTGGCGGGC
CTGCCCACCAGCGTGGGCGGCATCACGGTGAACCGCTTCTGCGCTTCGGGCCTGTCGGCCGTGGCCATGGCGGCCGACCG
CATCCGCGTGGGCGAGGCCGAGGTGATGATCGCCGCCGGCGTGGAGAGCATGAGCATGGTGCCTATGATGGGCAACGCGC
CCAGCCTGTCGCCCAGCATCTTCGAGCGTGACGGCGACGTGGGCATCGCCTACGGCATGGGCCTCACCGCCGAGAAGGTG
GCCCAGCAGTGGAAGGTGAGCCGCGAGGCGCAGGACGCCTTCGCGCTGGAGTCGCACCGCCGCGCCATCGCCGCGCAGCA
GGCCGGCGAGTTTGCCGACGAGATCACGCCCATCGAGGTGACCGACCGCACGGCCCACCTGGAGACGGGCGAAGTCATTG
CCGGCACCCGCACCGTGAGCCTGGACGAGGGCGCCCGCCCCGACACCAGCCTGGAAGGCCTGGCCAAGCTGCGCACCGTG
TTTGCCGCGCGCGGCACGGTTACGGCCGGCAACAGCTCGCAGACCAGCGACGGCGCCGGCGCGCTGATCCTGGCCAGCGA
AGCCGCCGTCAAGCGCTTCGGCCTCACGCCGCTGGCGCGCTTCGTCAGCTTCGCCAGCAAGGGCGTGCCGCCGTCCATCA
TGGGCATCGGCCCGATCGAAGCCATCCCCGCCGCGCTGCGCTATGCCGGTCTGAAGCAGGACGACATCGGCTGGTACGAG
CTCAACGAAGCCTTCGCCGCCCAGTCGCTGGCCGTCATCAACACGCTGGGGCTGGACACGGCCAAGGTCAACCCCATGGG
CGGCGCCATCGCGCTGGGCCACCCGCTGGGCGCGACGGGCGCCATCCGCTCGGCCACCGTGGTGCATGCGCTGCGCCGCA
AGCAGCTCAAGTACGGCATGGTCACCATGTGCGTGGGCATGGGCCAGGGCGCGGCGGGTATCTTCGAGCGCGTGTAA

Upstream 100 bases:

>100_bases
CTGCGCCCTGATCGAGCACCCCAAGACCCAGGAGCGCATCCTGGGCATGCTCAACACTGGCAAGCCGGTGCGTAACTGAG
GCCGCCCGAGGAGAGAAACC

Downstream 100 bases:

>100_bases
GTAAGCGCCACTGCCGCGCGGCAGCGCGCGGGGATTGCAGCCGAGCCGGCGCAGACCGGCCGCCTTCATGGAGACAAGCC
ATGCAGAGTGAAACCCTGAT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKQIQDAYIVAATRTPIGRSHKGFFRNYRPDDLLATTLKSALAQVPGLDPASIEDIICGCAIPEAQQGLNVARIGAVLAG
LPTSVGGITVNRFCASGLSAVAMAADRIRVGEAEVMIAAGVESMSMVPMMGNAPSLSPSIFERDGDVGIAYGMGLTAEKV
AQQWKVSREAQDAFALESHRRAIAAQQAGEFADEITPIEVTDRTAHLETGEVIAGTRTVSLDEGARPDTSLEGLAKLRTV
FAARGTVTAGNSSQTSDGAGALILASEAAVKRFGLTPLARFVSFASKGVPPSIMGIGPIEAIPAALRYAGLKQDDIGWYE
LNEAFAAQSLAVINTLGLDTAKVNPMGGAIALGHPLGATGAIRSATVVHALRRKQLKYGMVTMCVGMGQGAAGIFERV

Sequences:

>Translated_398_residues
MKQIQDAYIVAATRTPIGRSHKGFFRNYRPDDLLATTLKSALAQVPGLDPASIEDIICGCAIPEAQQGLNVARIGAVLAG
LPTSVGGITVNRFCASGLSAVAMAADRIRVGEAEVMIAAGVESMSMVPMMGNAPSLSPSIFERDGDVGIAYGMGLTAEKV
AQQWKVSREAQDAFALESHRRAIAAQQAGEFADEITPIEVTDRTAHLETGEVIAGTRTVSLDEGARPDTSLEGLAKLRTV
FAARGTVTAGNSSQTSDGAGALILASEAAVKRFGLTPLARFVSFASKGVPPSIMGIGPIEAIPAALRYAGLKQDDIGWYE
LNEAFAAQSLAVINTLGLDTAKVNPMGGAIALGHPLGATGAIRSATVVHALRRKQLKYGMVTMCVGMGQGAAGIFERV
>Mature_398_residues
MKQIQDAYIVAATRTPIGRSHKGFFRNYRPDDLLATTLKSALAQVPGLDPASIEDIICGCAIPEAQQGLNVARIGAVLAG
LPTSVGGITVNRFCASGLSAVAMAADRIRVGEAEVMIAAGVESMSMVPMMGNAPSLSPSIFERDGDVGIAYGMGLTAEKV
AQQWKVSREAQDAFALESHRRAIAAQQAGEFADEITPIEVTDRTAHLETGEVIAGTRTVSLDEGARPDTSLEGLAKLRTV
FAARGTVTAGNSSQTSDGAGALILASEAAVKRFGLTPLARFVSFASKGVPPSIMGIGPIEAIPAALRYAGLKQDDIGWYE
LNEAFAAQSLAVINTLGLDTAKVNPMGGAIALGHPLGATGAIRSATVVHALRRKQLKYGMVTMCVGMGQGAAGIFERV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=43.8775510204082, Blast_Score=295, Evalue=5e-80,
Organism=Homo sapiens, GI167614485, Length=406, Percent_Identity=41.3793103448276, Blast_Score=289, Evalue=3e-78,
Organism=Homo sapiens, GI148539872, Length=402, Percent_Identity=40.2985074626866, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI4557237, Length=408, Percent_Identity=36.7647058823529, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=31.6326530612245, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI4504327, Length=440, Percent_Identity=32.0454545454545, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=45.5223880597015, Blast_Score=307, Evalue=7e-85,
Organism=Escherichia coli, GI1787663, Length=411, Percent_Identity=44.5255474452555, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=42.1182266009852, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=39.1089108910891, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=31.4420803782506, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=39.9002493765586, Blast_Score=267, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI25147385, Length=402, Percent_Identity=33.8308457711443, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=33.5802469135802, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17535917, Length=399, Percent_Identity=29.0726817042606, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17551802, Length=444, Percent_Identity=29.2792792792793, Blast_Score=150, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6322031, Length=405, Percent_Identity=39.7530864197531, Blast_Score=277, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6325229, Length=412, Percent_Identity=36.1650485436893, Blast_Score=222, Evalue=8e-59,
Organism=Drosophila melanogaster, GI24655093, Length=406, Percent_Identity=41.1330049261084, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI17648125, Length=405, Percent_Identity=40.2469135802469, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24640423, Length=405, Percent_Identity=35.5555555555556, Blast_Score=217, Evalue=9e-57,
Organism=Drosophila melanogaster, GI17137578, Length=442, Percent_Identity=32.579185520362, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI19921506, Length=369, Percent_Identity=24.9322493224932, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24585051, Length=369, Percent_Identity=24.9322493224932, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41363; Mature: 41363

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQIQDAYIVAATRTPIGRSHKGFFRNYRPDDLLATTLKSALAQVPGLDPASIEDIICGC
CCCCCCEEEEEEECCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHCC
AIPEAQQGLNVARIGAVLAGLPTSVGGITVNRFCASGLSAVAMAADRIRVGEAEVMIAAG
CCCHHHHCCCHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHEECCCCEEEEEEC
VESMSMVPMMGNAPSLSPSIFERDGDVGIAYGMGLTAEKVAQQWKVSREAQDAFALESHR
CCHHEECCCCCCCCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RAIAAQQAGEFADEITPIEVTDRTAHLETGEVIAGTRTVSLDEGARPDTSLEGLAKLRTV
HHHHHHHHHHHHHCCCCEEECCCEEECCCCCEEECEEEEECCCCCCCCCHHHHHHHHHHH
FAARGTVTAGNSSQTSDGAGALILASEAAVKRFGLTPLARFVSFASKGVPPSIMGIGPIE
HHHCCEEECCCCCCCCCCCCEEEEECHHHHHHHCCHHHHHHHHHHHCCCCCCEECCCCHH
AIPAALRYAGLKQDDIGWYELNEAFAAQSLAVINTLGLDTAKVNPMGGAIALGHPLGATG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCEEEECCCCCCCC
AIRSATVVHALRRKQLKYGMVTMCVGMGQGAAGIFERV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCC
>Mature Secondary Structure
MKQIQDAYIVAATRTPIGRSHKGFFRNYRPDDLLATTLKSALAQVPGLDPASIEDIICGC
CCCCCCEEEEEEECCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHCC
AIPEAQQGLNVARIGAVLAGLPTSVGGITVNRFCASGLSAVAMAADRIRVGEAEVMIAAG
CCCHHHHCCCHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHEECCCCEEEEEEC
VESMSMVPMMGNAPSLSPSIFERDGDVGIAYGMGLTAEKVAQQWKVSREAQDAFALESHR
CCHHEECCCCCCCCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RAIAAQQAGEFADEITPIEVTDRTAHLETGEVIAGTRTVSLDEGARPDTSLEGLAKLRTV
HHHHHHHHHHHHHCCCCEEECCCEEECCCCCEEECEEEEECCCCCCCCCHHHHHHHHHHH
FAARGTVTAGNSSQTSDGAGALILASEAAVKRFGLTPLARFVSFASKGVPPSIMGIGPIE
HHHCCEEECCCCCCCCCCCCEEEEECHHHHHHHCCHHHHHHHHHHHCCCCCCEECCCCHH
AIPAALRYAGLKQDDIGWYELNEAFAAQSLAVINTLGLDTAKVNPMGGAIALGHPLGATG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCEEEECCCCCCCC
AIRSATVVHALRRKQLKYGMVTMCVGMGQGAAGIFERV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]