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The map label for this gene is rfbB [H]

Identifier: 222109769

GI number: 222109769

Start: 571044

End: 572111

Strand: Direct

Name: rfbB [H]

Synonym: Dtpsy_0553

Alternate gene names: 222109769

Gene position: 571044-572111 (Clockwise)

Preceding gene: 222109766

Following gene: 222109770

Centisome position: 15.04

GC content: 63.76

Gene sequence:

>1068_bases
ATGATTCTGGTAACAGGCGGCGCAGGCTTCATTGGCGCCAACTTTGTGCTCGACTGGCTGGCTGTCGGTGACGAGCCGGT
GGTGAACCTGGACAAGCTCACCTACGCGGGCAACCTGCACAACCTGGACAGCCTGCAGGGCGATGCCAGCCACGTGTTCG
TGCAGGGCGACATCGGTGACCGCACGCTGTTGGATCGCCTGCTGGCCGAGCACCAGCCACGCGCCGTGATCAACTTCGCC
GCCGAATCCCACGTAGACCGCTCCATCCACGGCCCCGAGGACTTCATCCAGACCAACGTTGTCGGCACCTTCAGGCTTTT
GGAGGCCGTAAGGCACTACTGGCAAGCGCTGCCAGCTACACAAAAAGAAGCATTCCGCTTCCTGCACGTGAGCACCGACG
AGGTCTATGGCAGTCTGGCGCCGGCTGCTGCGGCCTTCACCGAAGAGCACAACTACGAGCCCAACAGCCCGTACTCCGCC
AGCAAGGCGGCCAGTGACCACCTGGTGCGCGCCTGGCATCACACCTACGGCCTGCCGGTACTCACCACCAACTGCAGCAA
CAACTACGGCCCGCTGCACTTTCCGGAAAAGCTCATCCCGCTGATGATCGTCAACGCCCTGGCAGGCAAGAGCCTGCCCG
TGTATGGCGACGGCATGCAGATCCGGGACTGGCTGTACGTCAAGGACCATTGCAGCGCCATCCGGCGCGTGCTGCAGGCG
GGCCGGCTGGGCGAGACCTACAACGTAGGCGGCTGGAACGAAAAGCCCAACATCGACATCGTCAACACCGTGTGCGCCCT
GCTGGACGAGTTGCGCCCGCGCAGCGACGGCCAGAGCTACACGACGCAGATCACCTACGTGACCGACCGCCCTGGCCACG
ACCGGCGCTACGCCATCGACGCGCGCAAGCTCGAGCGCGAACTGGGCTGGAAGCCCGCGGAAACCTTTGAGACCGGCATC
CGCAAGACCGTGCAGTGGTACCTGGACCACCCCGAATGGGTGGCCCAGGTGCAAAGCGGTGCCTACCGCGAGTGGGTGCA
AAAGCAATACGAAGGTGCTGCGGCATGA

Upstream 100 bases:

>100_bases
CCATGGGAGTTTGTTACATGCGGGTGTAAGCAAATGGGATAATCCAAGGTTTTGGCCCGCAGGCACGCTGCAGGCAGAAA
CTGCGAAGGATTTTCACCCC

Downstream 100 bases:

>100_bases
ACATCCTCTTGCTGGGCAAGAGCGGCCAGGTGGGCTGGGAACTGCAGCGCAGCCTGGCCGTGCTGGGCCGGGTCACCGCG
CTGGACCACGACAGCACCGA

Product: dtdp-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MILVTGGAGFIGANFVLDWLAVGDEPVVNLDKLTYAGNLHNLDSLQGDASHVFVQGDIGDRTLLDRLLAEHQPRAVINFA
AESHVDRSIHGPEDFIQTNVVGTFRLLEAVRHYWQALPATQKEAFRFLHVSTDEVYGSLAPAAAAFTEEHNYEPNSPYSA
SKAASDHLVRAWHHTYGLPVLTTNCSNNYGPLHFPEKLIPLMIVNALAGKSLPVYGDGMQIRDWLYVKDHCSAIRRVLQA
GRLGETYNVGGWNEKPNIDIVNTVCALLDELRPRSDGQSYTTQITYVTDRPGHDRRYAIDARKLERELGWKPAETFETGI
RKTVQWYLDHPEWVAQVQSGAYREWVQKQYEGAAA

Sequences:

>Translated_355_residues
MILVTGGAGFIGANFVLDWLAVGDEPVVNLDKLTYAGNLHNLDSLQGDASHVFVQGDIGDRTLLDRLLAEHQPRAVINFA
AESHVDRSIHGPEDFIQTNVVGTFRLLEAVRHYWQALPATQKEAFRFLHVSTDEVYGSLAPAAAAFTEEHNYEPNSPYSA
SKAASDHLVRAWHHTYGLPVLTTNCSNNYGPLHFPEKLIPLMIVNALAGKSLPVYGDGMQIRDWLYVKDHCSAIRRVLQA
GRLGETYNVGGWNEKPNIDIVNTVCALLDELRPRSDGQSYTTQITYVTDRPGHDRRYAIDARKLERELGWKPAETFETGI
RKTVQWYLDHPEWVAQVQSGAYREWVQKQYEGAAA
>Mature_355_residues
MILVTGGAGFIGANFVLDWLAVGDEPVVNLDKLTYAGNLHNLDSLQGDASHVFVQGDIGDRTLLDRLLAEHQPRAVINFA
AESHVDRSIHGPEDFIQTNVVGTFRLLEAVRHYWQALPATQKEAFRFLHVSTDEVYGSLAPAAAAFTEEHNYEPNSPYSA
SKAASDHLVRAWHHTYGLPVLTTNCSNNYGPLHFPEKLIPLMIVNALAGKSLPVYGDGMQIRDWLYVKDHCSAIRRVLQA
GRLGETYNVGGWNEKPNIDIVNTVCALLDELRPRSDGQSYTTQITYVTDRPGHDRRYAIDARKLERELGWKPAETFETGI
RKTVQWYLDHPEWVAQVQSGAYREWVQKQYEGAAA

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=332, Percent_Identity=35.2409638554217, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI42516563, Length=344, Percent_Identity=21.8023255813953, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI56237023, Length=362, Percent_Identity=25.9668508287293, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI56118217, Length=362, Percent_Identity=25.9668508287293, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI189083684, Length=362, Percent_Identity=25.9668508287293, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI4504031, Length=286, Percent_Identity=26.2237762237762, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1788353, Length=359, Percent_Identity=60.4456824512535, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI48994969, Length=344, Percent_Identity=61.6279069767442, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1786974, Length=357, Percent_Identity=27.1708683473389, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788366, Length=294, Percent_Identity=27.891156462585, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788365, Length=255, Percent_Identity=23.5294117647059, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17568069, Length=340, Percent_Identity=34.7058823529412, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI115532424, Length=331, Percent_Identity=32.3262839879154, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17539532, Length=331, Percent_Identity=22.0543806646526, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI133901788, Length=198, Percent_Identity=29.2929292929293, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI133901786, Length=198, Percent_Identity=29.2929292929293, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17539422, Length=198, Percent_Identity=29.2929292929293, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17539424, Length=198, Percent_Identity=29.2929292929293, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI133901790, Length=198, Percent_Identity=29.2929292929293, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17507723, Length=198, Percent_Identity=29.2929292929293, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319493, Length=363, Percent_Identity=25.068870523416, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21356223, Length=331, Percent_Identity=25.0755287009063, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19923002, Length=368, Percent_Identity=26.3586956521739, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24158427, Length=281, Percent_Identity=25.9786476868327, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 39780; Mature: 39780

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILVTGGAGFIGANFVLDWLAVGDEPVVNLDKLTYAGNLHNLDSLQGDASHVFVQGDIGD
CEEEECCCCHHHHHHHHHHHHCCCCCCEEHHHEEECCCCCCHHHCCCCCCEEEEECCCCC
RTLLDRLLAEHQPRAVINFAAESHVDRSIHGPEDFIQTNVVGTFRLLEAVRHYWQALPAT
HHHHHHHHHCCCCCCEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QKEAFRFLHVSTDEVYGSLAPAAAAFTEEHNYEPNSPYSASKAASDHLVRAWHHTYGLPV
HHHHHHEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCE
LTTNCSNNYGPLHFPEKLIPLMIVNALAGKSLPVYGDGMQIRDWLYVKDHCSAIRRVLQA
EEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCEEEHEEEHHHHHHHHHHHHHH
GRLGETYNVGGWNEKPNIDIVNTVCALLDELRPRSDGQSYTTQITYVTDRPGHDRRYAID
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCEEEHH
ARKLERELGWKPAETFETGIRKTVQWYLDHPEWVAQVQSGAYREWVQKQYEGAAA
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MILVTGGAGFIGANFVLDWLAVGDEPVVNLDKLTYAGNLHNLDSLQGDASHVFVQGDIGD
CEEEECCCCHHHHHHHHHHHHCCCCCCEEHHHEEECCCCCCHHHCCCCCCEEEEECCCCC
RTLLDRLLAEHQPRAVINFAAESHVDRSIHGPEDFIQTNVVGTFRLLEAVRHYWQALPAT
HHHHHHHHHCCCCCCEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QKEAFRFLHVSTDEVYGSLAPAAAAFTEEHNYEPNSPYSASKAASDHLVRAWHHTYGLPV
HHHHHHEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCE
LTTNCSNNYGPLHFPEKLIPLMIVNALAGKSLPVYGDGMQIRDWLYVKDHCSAIRRVLQA
EEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCEEEHEEEHHHHHHHHHHHHHH
GRLGETYNVGGWNEKPNIDIVNTVCALLDELRPRSDGQSYTTQITYVTDRPGHDRRYAID
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCEEEHH
ARKLERELGWKPAETFETGIRKTVQWYLDHPEWVAQVQSGAYREWVQKQYEGAAA
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8253667 [H]