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The map label for this gene is hom [H]

Identifier: 222109237

GI number: 222109237

Start: 10940

End: 12358

Strand: Direct

Name: hom [H]

Synonym: Dtpsy_0012

Alternate gene names: 222109237

Gene position: 10940-12358 (Clockwise)

Preceding gene: 222109236

Following gene: 222109239

Centisome position: 0.29

GC content: 75.12

Gene sequence:

>1419_bases
ATGTTCGTAGAACCCCAGTTCAGCCCCTCGCCCGAGGTGCACGCCAGTGCGCGCCGCGCCCCGGCCCCGCCCCCTGCCCT
GCGCGTGGGCATGATCGGCACCGGCACCGTGGGCAGCGGCGTGTGGCGGGTGCTGCGGCGCAACCGGGACCTCATCAACG
CACGCGCCGGGCGCGCCATCGAGATCGTCGCGGTCGCCGCGCGCAACACCGCGCGCGCCGCTACGGCGCTGGACGGCGCG
CCCGGCGTGCGCCTGCTGACCGACCCGCTGCAACTGGCCGCCGACCCCGGCGTGGACGTGGTGCTGGAGCTGGCCGGCGG
CACCGGCGCCGCACGCGACTGGGTGCAGGCCGCGCTGGCGCATGGCAAGCATGTGGTGACCGCCAACAAGGCCCTGCTGG
CCACGCACGGCGAGGCGCTGGCGCAGACTGCCGCGCGCCATGGCCGGGTGCTGGCCTACGAAGCGGCCGTGGCCGGCAGC
GTACCCGTGATCAAGGCGCTGCGCGAAGGGCTGGCGGCCAACCGCATCACCGCGCTGGCAGGCGTGCTCAACGGCACCAG
CAACTACATCCTCACGCGCATGCAGGCGGCGGGCCTCGGCTTTGCCGCCGCGCTCACCGAAGCCCAGGCACTGGGCTATG
CCGAGGCCGATCCGGCCTTCGACGTGGACGGCACCGACGCCGCGCACAAGCTGGCGCTGCTGGCCGCCAACGCGTTCGGC
ATGCCGGTGCGGCTGGACGCCGTGCACGTCGAGGGCATCCGCGACCTGCAGCGGGGCGACGTGGCCGCCGCCGCGCATCT
GGGCTACGCCGTCAAGCTGCTGGCCGTGGCCGAGCAGCAGGAGTGCGAGGGCCGCATGGCCATCCAGCTGCGCGTGCACC
CGGCCCTGGTGCCCGCGCGGCACCCGCTGGCGCTGCTGGACGGCGCGACCAACGGGCTGCTGGTGCGCGGCGACGCAGCC
GGCAGCGCCTTTTTCAGCGGCGCGGGCGCCGGCGGCGAGCCCACGGCGAGCGCCGTGCTGGCGGACCTGATCGACCTGGC
GCGCCTGCCGGCTGTTTCTTCCCCGACGCCCACGGGCCCTGGCGTGCCCACACTGGGCACCCACCGCCGCGCGGGCGACG
ACCCCGCCGTACTGCCGATGGCCCCAGTGAAGACGCCGCACCTGCTGCGCCTGCTGCCCGGTGCGGCCCTGTGCGAAACG
GCAGTGCTACGGGCGCTGGCGCGCGAGGGCGTCAGGGTGCGGCGCCGCACGTGGGCGGCACCCGTCACACCGGGCGGAGC
GCCCGAGTTACTGCTGCTCACCGCGCCGACGCCCGATGCGCTGGCCGCAGAGGCCACGGCGCATTTGCAGGCGTACACGG
GTGCGCAGGTGCGGCGGCTGCGCGTGGAGCTGTGCAGCGCCCTCACGGATGAACAATAA

Upstream 100 bases:

>100_bases
ACCGGCGGCCCCCTGGTGTCTTCTTCCCCCTCCGAACGAAACCCAGCCCCGGCCGCTGGGTTTTTTTGTGGGCTTTTGCA
GCCCGTGTTTGGAGAAAGAC

Downstream 100 bases:

>100_bases
AAACAGGTGCTAGCGCTTTACCAGCAAGCGCTACCAGCTACGTTTTTAATAGCTATTCCGAGTCCTTGAGCTTGCGATAG
GTACGGTCGGCGGGCGGTCC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MFVEPQFSPSPEVHASARRAPAPPPALRVGMIGTGTVGSGVWRVLRRNRDLINARAGRAIEIVAVAARNTARAATALDGA
PGVRLLTDPLQLAADPGVDVVLELAGGTGAARDWVQAALAHGKHVVTANKALLATHGEALAQTAARHGRVLAYEAAVAGS
VPVIKALREGLAANRITALAGVLNGTSNYILTRMQAAGLGFAAALTEAQALGYAEADPAFDVDGTDAAHKLALLAANAFG
MPVRLDAVHVEGIRDLQRGDVAAAAHLGYAVKLLAVAEQQECEGRMAIQLRVHPALVPARHPLALLDGATNGLLVRGDAA
GSAFFSGAGAGGEPTASAVLADLIDLARLPAVSSPTPTGPGVPTLGTHRRAGDDPAVLPMAPVKTPHLLRLLPGAALCET
AVLRALAREGVRVRRRTWAAPVTPGGAPELLLLTAPTPDALAAEATAHLQAYTGAQVRRLRVELCSALTDEQ

Sequences:

>Translated_472_residues
MFVEPQFSPSPEVHASARRAPAPPPALRVGMIGTGTVGSGVWRVLRRNRDLINARAGRAIEIVAVAARNTARAATALDGA
PGVRLLTDPLQLAADPGVDVVLELAGGTGAARDWVQAALAHGKHVVTANKALLATHGEALAQTAARHGRVLAYEAAVAGS
VPVIKALREGLAANRITALAGVLNGTSNYILTRMQAAGLGFAAALTEAQALGYAEADPAFDVDGTDAAHKLALLAANAFG
MPVRLDAVHVEGIRDLQRGDVAAAAHLGYAVKLLAVAEQQECEGRMAIQLRVHPALVPARHPLALLDGATNGLLVRGDAA
GSAFFSGAGAGGEPTASAVLADLIDLARLPAVSSPTPTGPGVPTLGTHRRAGDDPAVLPMAPVKTPHLLRLLPGAALCET
AVLRALAREGVRVRRRTWAAPVTPGGAPELLLLTAPTPDALAAEATAHLQAYTGAQVRRLRVELCSALTDEQ
>Mature_472_residues
MFVEPQFSPSPEVHASARRAPAPPPALRVGMIGTGTVGSGVWRVLRRNRDLINARAGRAIEIVAVAARNTARAATALDGA
PGVRLLTDPLQLAADPGVDVVLELAGGTGAARDWVQAALAHGKHVVTANKALLATHGEALAQTAARHGRVLAYEAAVAGS
VPVIKALREGLAANRITALAGVLNGTSNYILTRMQAAGLGFAAALTEAQALGYAEADPAFDVDGTDAAHKLALLAANAFG
MPVRLDAVHVEGIRDLQRGDVAAAAHLGYAVKLLAVAEQQECEGRMAIQLRVHPALVPARHPLALLDGATNGLLVRGDAA
GSAFFSGAGAGGEPTASAVLADLIDLARLPAVSSPTPTGPGVPTLGTHRRAGDDPAVLPMAPVKTPHLLRLLPGAALCET
AVLRALAREGVRVRRRTWAAPVTPGGAPELLLLTAPTPDALAAEATAHLQAYTGAQVRRLRVELCSALTDEQ

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=379, Percent_Identity=25.5936675461741, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786183, Length=267, Percent_Identity=30.3370786516854, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 48373; Mature: 48373

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVEPQFSPSPEVHASARRAPAPPPALRVGMIGTGTVGSGVWRVLRRNRDLINARAGRAI
CCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCHHHHHCCCCEE
EIVAVAARNTARAATALDGAPGVRLLTDPLQLAADPGVDVVLELAGGTGAARDWVQAALA
EEEEEECCCCHHHHHHCCCCCCCEEECCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHH
HGKHVVTANKALLATHGEALAQTAARHGRVLAYEAAVAGSVPVIKALREGLAANRITALA
CCCEEEEECCEEEEECCHHHHHHHHHCCCEEEEECHHCCCCHHHHHHHHHHHHHHHHHHH
GVLNGTSNYILTRMQAAGLGFAAALTEAQALGYAEADPAFDVDGTDAAHKLALLAANAFG
HHHCCCCHHHEEEHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHEECCCCC
MPVRLDAVHVEGIRDLQRGDVAAAAHLGYAVKLLAVAEQQECEGRMAIQLRVHPALVPAR
CCEEEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCC
HPLALLDGATNGLLVRGDAAGSAFFSGAGAGGEPTASAVLADLIDLARLPAVSSPTPTGP
CCEEEECCCCCCEEEECCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
GVPTLGTHRRAGDDPAVLPMAPVKTPHLLRLLPGAALCETAVLRALAREGVRVRRRTWAA
CCCCCCCCCCCCCCCCEEECCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHCCC
PVTPGGAPELLLLTAPTPDALAAEATAHLQAYTGAQVRRLRVELCSALTDEQ
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFVEPQFSPSPEVHASARRAPAPPPALRVGMIGTGTVGSGVWRVLRRNRDLINARAGRAI
CCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCHHHHHCCCCEE
EIVAVAARNTARAATALDGAPGVRLLTDPLQLAADPGVDVVLELAGGTGAARDWVQAALA
EEEEEECCCCHHHHHHCCCCCCCEEECCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHH
HGKHVVTANKALLATHGEALAQTAARHGRVLAYEAAVAGSVPVIKALREGLAANRITALA
CCCEEEEECCEEEEECCHHHHHHHHHCCCEEEEECHHCCCCHHHHHHHHHHHHHHHHHHH
GVLNGTSNYILTRMQAAGLGFAAALTEAQALGYAEADPAFDVDGTDAAHKLALLAANAFG
HHHCCCCHHHEEEHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHEECCCCC
MPVRLDAVHVEGIRDLQRGDVAAAAHLGYAVKLLAVAEQQECEGRMAIQLRVHPALVPAR
CCEEEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCC
HPLALLDGATNGLLVRGDAAGSAFFSGAGAGGEPTASAVLADLIDLARLPAVSSPTPTGP
CCEEEECCCCCCEEEECCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
GVPTLGTHRRAGDDPAVLPMAPVKTPHLLRLLPGAALCETAVLRALAREGVRVRRRTWAA
CCCCCCCCCCCCCCCCEEECCCCCCCHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHCCC
PVTPGGAPELLLLTAPTPDALAAEATAHLQAYTGAQVRRLRVELCSALTDEQ
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]