Click here to switch to the map view.

The map label for this gene is ywrD [H]

Identifier: 222109236

GI number: 222109236

Start: 8991

End: 10586

Strand: Direct

Name: ywrD [H]

Synonym: Dtpsy_0011

Alternate gene names: 222109236

Gene position: 8991-10586 (Clockwise)

Preceding gene: 222109235

Following gene: 222109237

Centisome position: 0.24

GC content: 74.19

Gene sequence:

>1596_bases
ATGACTTGGCAACTCCCCTACCCCTCCGGCCGCCAGCCCGTGCTGGCGCGCAACGTGGTCTCCACCTCCCAGCCGCTGGC
CGCGCAGGCCGGCGCGGCGGCGTTTGCGCGCGGCGGCAATGCGATCGACGCGGCCCTGGCCGCGGCCATCACGCTCACGG
TGGTGGAGCCGGTGATGAACGGGATTGGCGGCGACGCCTTCGCGCTGGTGTGGGACGGCGCCGCGCTGCACGGCCTGAAC
GCCTCGGGCCGCGCGCCGCGCGCCTGGTCGGCCGAGCGCTTTGCCCACTTGCCGCAAATGCCGCGCATCGGCTGGGACAC
GGTGACCACGCCCGGCGGCGTGGCGGGCTGGGTGGCGCTGTCCGAGCGCTTTGGCGCCCTGCCCTTCGAAGACCTGTTCG
CCGACGCCATCCGCCACGCGCGCGACGGCTTTCCCGTCAGCCCGGTGATCGCGCGCCAGTGGGCGCAGGCGGCCATCGAC
CTCAAGGGCCAGCCGGGCTTCGAGGCCTTCACGCCCGGCGGGCGCGCGCCGCAGGCGGGCGAGATCTGGCGCTTTGCCGA
CCAGGCGGACACGCTGGCGGACATCGCCCGCACGCGCGGCGCGTCGTTCTACCGCGGCCGGCTGGCGCAGGCCATGGCCG
ACTACGCGCGCCAGCACGGCGCAGGCCTGGCGCTGGAGGACCTGGCCGCGCACGCCGTGGAATGGGTGCAGTCCATCAGC
GTGCCCTTTGGCGACCGCACGGTGCATGAGATCCCGCCCAACGGCCAGGGCATCGCCGCGCTGATGGCGCTGGGCCTGCT
GGAACATCTGCCCTACCGCAGCACCGCAGCGGGCTCGGCCGCGCGCATGCACCTGGAGATCGAGGCCATGCGCGTGGCCT
TTGCCGACCTGTACGCCCACGTGGCCGACCCGGACCACATGCGCCTCACCTCCGCGCAGCTGCTGGACCCGGCCTACCTG
CGCCAGCGCGCCGCGCTCATCGACCCGCAGCGCGCCGGCCAGTACCCCGCCGGCCAGCCCGGCAGCGGCGGCACGGTGTA
TCTGTGCACGGCCGACAGCGAGGGGCGCATGGTGTCGTTCATCCAGTCCAACTTCAAGGGCTTCGGCTCGGGCGTGGTGG
TGCCGGGCACGGGCATCGCGCTGCACAACCGCGGCATGGGCTTCGTCACCACGCCGGGCCACCCCAACCAGGTGGCGGGC
GGCAAGCGGCCCATGCACAGCATCATTCCCGCCTTCGTCACGCGCGGCGGCCAGCCCCACATGGCCTTTGGCGTGATGGG
CGGCAACATGCAGGCCCAGGGCCATGTGCAGATGGTGCTGCGCGAGGCCGTGGAGGGCCTGAACCCCCAGGCCTGCTCCG
ACGCGCCGCGCTGGCGCATCAACGACGCGGGCGCGCTGACGCTGGAGCACACCGTGCCCGCCGCCGTGGTCGAGGGCCTG
CGCGCGCTGGGGCACGACCCGCAGGTGGCCGCGCCCGGCAGCCTGGAATTCGGCAGCGCACAGATCATCCGCCGGCTGGA
GGCCACGCCCGGCACCGGCTTCGCCTACGCCGCGGGCTCCGACCACCGGCGCGACGGCCAGGCCGTCGGCTGCTGA

Upstream 100 bases:

>100_bases
TTCGATGCGATCCGCATGGTGCGTAACTCCACGCAGTAGGGCGGCGCCTTCACGGCGGCACAATCGACCCGGCATTCCTT
CCCCTTCCAGATCGGCTTCC

Downstream 100 bases:

>100_bases
TTCTTATCCCTAGGCATTCAAACCAAAACCGCCTCTAGCGCTTGTCCATCAAGCGCTAGCAGCTATCAAAACAAGAGTAA
AGAACGCTGCACCGTCACCT

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MTWQLPYPSGRQPVLARNVVSTSQPLAAQAGAAAFARGGNAIDAALAAAITLTVVEPVMNGIGGDAFALVWDGAALHGLN
ASGRAPRAWSAERFAHLPQMPRIGWDTVTTPGGVAGWVALSERFGALPFEDLFADAIRHARDGFPVSPVIARQWAQAAID
LKGQPGFEAFTPGGRAPQAGEIWRFADQADTLADIARTRGASFYRGRLAQAMADYARQHGAGLALEDLAAHAVEWVQSIS
VPFGDRTVHEIPPNGQGIAALMALGLLEHLPYRSTAAGSAARMHLEIEAMRVAFADLYAHVADPDHMRLTSAQLLDPAYL
RQRAALIDPQRAGQYPAGQPGSGGTVYLCTADSEGRMVSFIQSNFKGFGSGVVVPGTGIALHNRGMGFVTTPGHPNQVAG
GKRPMHSIIPAFVTRGGQPHMAFGVMGGNMQAQGHVQMVLREAVEGLNPQACSDAPRWRINDAGALTLEHTVPAAVVEGL
RALGHDPQVAAPGSLEFGSAQIIRRLEATPGTGFAYAAGSDHRRDGQAVGC

Sequences:

>Translated_531_residues
MTWQLPYPSGRQPVLARNVVSTSQPLAAQAGAAAFARGGNAIDAALAAAITLTVVEPVMNGIGGDAFALVWDGAALHGLN
ASGRAPRAWSAERFAHLPQMPRIGWDTVTTPGGVAGWVALSERFGALPFEDLFADAIRHARDGFPVSPVIARQWAQAAID
LKGQPGFEAFTPGGRAPQAGEIWRFADQADTLADIARTRGASFYRGRLAQAMADYARQHGAGLALEDLAAHAVEWVQSIS
VPFGDRTVHEIPPNGQGIAALMALGLLEHLPYRSTAAGSAARMHLEIEAMRVAFADLYAHVADPDHMRLTSAQLLDPAYL
RQRAALIDPQRAGQYPAGQPGSGGTVYLCTADSEGRMVSFIQSNFKGFGSGVVVPGTGIALHNRGMGFVTTPGHPNQVAG
GKRPMHSIIPAFVTRGGQPHMAFGVMGGNMQAQGHVQMVLREAVEGLNPQACSDAPRWRINDAGALTLEHTVPAAVVEGL
RALGHDPQVAAPGSLEFGSAQIIRRLEATPGTGFAYAAGSDHRRDGQAVGC
>Mature_530_residues
TWQLPYPSGRQPVLARNVVSTSQPLAAQAGAAAFARGGNAIDAALAAAITLTVVEPVMNGIGGDAFALVWDGAALHGLNA
SGRAPRAWSAERFAHLPQMPRIGWDTVTTPGGVAGWVALSERFGALPFEDLFADAIRHARDGFPVSPVIARQWAQAAIDL
KGQPGFEAFTPGGRAPQAGEIWRFADQADTLADIARTRGASFYRGRLAQAMADYARQHGAGLALEDLAAHAVEWVQSISV
PFGDRTVHEIPPNGQGIAALMALGLLEHLPYRSTAAGSAARMHLEIEAMRVAFADLYAHVADPDHMRLTSAQLLDPAYLR
QRAALIDPQRAGQYPAGQPGSGGTVYLCTADSEGRMVSFIQSNFKGFGSGVVVPGTGIALHNRGMGFVTTPGHPNQVAGG
KRPMHSIIPAFVTRGGQPHMAFGVMGGNMQAQGHVQMVLREAVEGLNPQACSDAPRWRINDAGALTLEHTVPAAVVEGLR
ALGHDPQVAAPGSLEFGSAQIIRRLEATPGTGFAYAAGSDHRRDGQAVGC

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=544, Percent_Identity=25.1838235294118, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI73915090, Length=544, Percent_Identity=25.1838235294118, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI73915096, Length=544, Percent_Identity=25.1838235294118, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI73915094, Length=544, Percent_Identity=25.1838235294118, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI153266885, Length=546, Percent_Identity=24.3589743589744, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI153266901, Length=547, Percent_Identity=24.1316270566728, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI113429326, Length=548, Percent_Identity=24.0875912408759, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI113429324, Length=543, Percent_Identity=24.1252302025783, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI153266907, Length=540, Percent_Identity=23.7037037037037, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI109148539, Length=508, Percent_Identity=25.5905511811024, Blast_Score=90, Evalue=6e-18,
Organism=Escherichia coli, GI1789856, Length=475, Percent_Identity=27.7894736842105, Blast_Score=161, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17506189, Length=514, Percent_Identity=24.9027237354086, Blast_Score=115, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI72000294, Length=475, Percent_Identity=24.2105263157895, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI212646519, Length=470, Percent_Identity=24.468085106383, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI193208245, Length=496, Percent_Identity=25, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI193208247, Length=496, Percent_Identity=25, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17542894, Length=482, Percent_Identity=22.1991701244813, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24642670, Length=467, Percent_Identity=25.9100642398287, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24642666, Length=467, Percent_Identity=25.9100642398287, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161077880, Length=467, Percent_Identity=25.9100642398287, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45551474, Length=467, Percent_Identity=25.9100642398287, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161077878, Length=467, Percent_Identity=25.9100642398287, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI18859893, Length=510, Percent_Identity=24.1176470588235, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI18859741, Length=528, Percent_Identity=23.8636363636364, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI161077496, Length=489, Percent_Identity=24.7443762781186, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 55809; Mature: 55678

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWQLPYPSGRQPVLARNVVSTSQPLAAQAGAAAFARGGNAIDAALAAAITLTVVEPVMN
CCCCCCCCCCCCCHHHHHHHHCCCCHHHHHCHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GIGGDAFALVWDGAALHGLNASGRAPRAWSAERFAHLPQMPRIGWDTVTTPGGVAGWVAL
CCCCCEEEEEECCCCEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
SERFGALPFEDLFADAIRHARDGFPVSPVIARQWAQAAIDLKGQPGFEAFTPGGRAPQAG
HHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCC
EIWRFADQADTLADIARTRGASFYRGRLAQAMADYARQHGAGLALEDLAAHAVEWVQSIS
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
VPFGDRTVHEIPPNGQGIAALMALGLLEHLPYRSTAAGSAARMHLEIEAMRVAFADLYAH
CCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
VADPDHMRLTSAQLLDPAYLRQRAALIDPQRAGQYPAGQPGSGGTVYLCTADSEGRMVSF
HCCCCCEEEHHHHHCCHHHHHHHHHHCCHHHCCCCCCCCCCCCCEEEEEECCCCCCCHHH
IQSNFKGFGSGVVVPGTGIALHNRGMGFVTTPGHPNQVAGGKRPMHSIIPAFVTRGGQPH
HHHHHCCCCCCEEECCCCEEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
MAFGVMGGNMQAQGHVQMVLREAVEGLNPQACSDAPRWRINDAGALTLEHTVPAAVVEGL
EEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCEEEECCCCHHHHHHHH
RALGHDPQVAAPGSLEFGSAQIIRRLEATPGTGFAYAAGSDHRRDGQAVGC
HHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TWQLPYPSGRQPVLARNVVSTSQPLAAQAGAAAFARGGNAIDAALAAAITLTVVEPVMN
CCCCCCCCCCCCHHHHHHHHCCCCHHHHHCHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GIGGDAFALVWDGAALHGLNASGRAPRAWSAERFAHLPQMPRIGWDTVTTPGGVAGWVAL
CCCCCEEEEEECCCCEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
SERFGALPFEDLFADAIRHARDGFPVSPVIARQWAQAAIDLKGQPGFEAFTPGGRAPQAG
HHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCC
EIWRFADQADTLADIARTRGASFYRGRLAQAMADYARQHGAGLALEDLAAHAVEWVQSIS
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHC
VPFGDRTVHEIPPNGQGIAALMALGLLEHLPYRSTAAGSAARMHLEIEAMRVAFADLYAH
CCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHH
VADPDHMRLTSAQLLDPAYLRQRAALIDPQRAGQYPAGQPGSGGTVYLCTADSEGRMVSF
HCCCCCEEEHHHHHCCHHHHHHHHHHCCHHHCCCCCCCCCCCCCEEEEEECCCCCCCHHH
IQSNFKGFGSGVVVPGTGIALHNRGMGFVTTPGHPNQVAGGKRPMHSIIPAFVTRGGQPH
HHHHHCCCCCCEEECCCCEEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
MAFGVMGGNMQAQGHVQMVLREAVEGLNPQACSDAPRWRINDAGALTLEHTVPAAVVEGL
EEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCEEEECCCCHHHHHHHH
RALGHDPQVAAPGSLEFGSAQIIRRLEATPGTGFAYAAGSDHRRDGQAVGC
HHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]