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The map label for this gene is nikC [H]

Identifier: 222102877

GI number: 222102877

Start: 555935

End: 556810

Strand: Direct

Name: nikC [H]

Synonym: Avi_7616

Alternate gene names: 222102877

Gene position: 555935-556810 (Clockwise)

Preceding gene: 222102876

Following gene: 222102878

Centisome position: 88.0

GC content: 59.13

Gene sequence:

>876_bases
ATGAGCCAGACGTCAGCATTGCACTCACCCACGCGCCCGGCTGGCTTTTGGCGCTCCTCATCGCTGGGTGTCAAAGCCTG
TGGTGTCATCGTTCTGCTGCTGGTAGTGGCCACGATTGCGGGGCCATGGATTTCGCCGCATGATCCGAATTTTGTCGAAT
TATCGCAGCGGCTTCAACCGCCAGACCTGAGCCACTGGCTTGGAACTGATCACTTGGGCCGCGATATTTTCTCGCGACTG
GTTGCCGGTGCCCGCGTGTCGCTGGGCTCTGTTGCCATTGCGCTGGGCCTGATCATGGTCACCGGCATTGTCCTTGGCGG
AACCGCAGGCGTTATCGGCGGGCGCACCGATCAGCTGATCATGCGCATTGCCGATGTGTTTTTGACCTTTCCAACGCTGG
TGCTGGCGCTGTTTATGGTTGGAATGCTGGGCACGGGCCTTACCAATGTCATCCTCGCCATCGCTCTCTCCCACTGGGCC
TGGTATGCCCGGATTGTGCGCGGAATTGTGTTGTCCCTGCGCCATCGGGAGTTTCTGCTGGCGGCGCGCATGAGCGGCGC
AGGACCGATCAGAACCTTTATAGATCACCTGCTTCCCGCAACCCTGTCTCAGCTGGTGGTGCTGGCCACGTTGGATATTG
GCCATATCATGCTGCATGTCTCTGGCCTGTCTTTTCTGGGATTGGGCGTCACCGCGCCCACGGCGGAATGGGGCGTGATG
ATCAACGATGCCCGCCAATATGTCTGGACAGCGCCGTCGCTGATCCTGTGGCCGGGATTAACCCTGTTTATCAGCGTCAT
GGCCTTCAACATTCTGGGCGATGCCCTGCGCTACAGGCTCGATCCCCATTTGCGTGTGGAGCATGGTCACCAATGA

Upstream 100 bases:

>100_bases
CCTTGTTGATGGTGGGCATTTTCGTGACCTGTAATCTCCTTGTCGATATTGCCTATGCATGGGCAGACCCACGGATCAGG
CTGTCAGCGGGGCATGTCGA

Downstream 100 bases:

>100_bases
TTCAGACCCTCTCCATCCACAATCTCACGGTTTACCCATCACACGCCGATGGTCATCCTGCTCTTGTCGATCATCTCTCG
CTTGAGCTCAAACGTGGCCG

Product: nickel transporter permease NikC

Products: Ni2; [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSQTSALHSPTRPAGFWRSSSLGVKACGVIVLLLVVATIAGPWISPHDPNFVELSQRLQPPDLSHWLGTDHLGRDIFSRL
VAGARVSLGSVAIALGLIMVTGIVLGGTAGVIGGRTDQLIMRIADVFLTFPTLVLALFMVGMLGTGLTNVILAIALSHWA
WYARIVRGIVLSLRHREFLLAARMSGAGPIRTFIDHLLPATLSQLVVLATLDIGHIMLHVSGLSFLGLGVTAPTAEWGVM
INDARQYVWTAPSLILWPGLTLFISVMAFNILGDALRYRLDPHLRVEHGHQ

Sequences:

>Translated_291_residues
MSQTSALHSPTRPAGFWRSSSLGVKACGVIVLLLVVATIAGPWISPHDPNFVELSQRLQPPDLSHWLGTDHLGRDIFSRL
VAGARVSLGSVAIALGLIMVTGIVLGGTAGVIGGRTDQLIMRIADVFLTFPTLVLALFMVGMLGTGLTNVILAIALSHWA
WYARIVRGIVLSLRHREFLLAARMSGAGPIRTFIDHLLPATLSQLVVLATLDIGHIMLHVSGLSFLGLGVTAPTAEWGVM
INDARQYVWTAPSLILWPGLTLFISVMAFNILGDALRYRLDPHLRVEHGHQ
>Mature_290_residues
SQTSALHSPTRPAGFWRSSSLGVKACGVIVLLLVVATIAGPWISPHDPNFVELSQRLQPPDLSHWLGTDHLGRDIFSRLV
AGARVSLGSVAIALGLIMVTGIVLGGTAGVIGGRTDQLIMRIADVFLTFPTLVLALFMVGMLGTGLTNVILAIALSHWAW
YARIVRGIVLSLRHREFLLAARMSGAGPIRTFIDHLLPATLSQLVVLATLDIGHIMLHVSGLSFLGLGVTAPTAEWGVMI
NDARQYVWTAPSLILWPGLTLFISVMAFNILGDALRYRLDPHLRVEHGHQ

Specific function: Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane [H]

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789889, Length=276, Percent_Identity=64.8550724637681, Blast_Score=349, Evalue=1e-97,
Organism=Escherichia coli, GI1787054, Length=274, Percent_Identity=42.3357664233577, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1787760, Length=266, Percent_Identity=39.0977443609023, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1789964, Length=258, Percent_Identity=37.984496124031, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI1787498, Length=262, Percent_Identity=32.824427480916, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1787549, Length=289, Percent_Identity=30.7958477508651, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1788505, Length=246, Percent_Identity=25.2032520325203, Blast_Score=75, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515
- InterPro:   IPR014157 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 31389; Mature: 31257

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTSALHSPTRPAGFWRSSSLGVKACGVIVLLLVVATIAGPWISPHDPNFVELSQRLQP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCC
PDLSHWLGTDHLGRDIFSRLVAGARVSLGSVAIALGLIMVTGIVLGGTAGVIGGRTDQLI
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
MRIADVFLTFPTLVLALFMVGMLGTGLTNVILAIALSHWAWYARIVRGIVLSLRHREFLL
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARMSGAGPIRTFIDHLLPATLSQLVVLATLDIGHIMLHVSGLSFLGLGVTAPTAEWGVM
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHCCE
INDARQYVWTAPSLILWPGLTLFISVMAFNILGDALRYRLDPHLRVEHGHQ
ECCCHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCC
>Mature Secondary Structure 
SQTSALHSPTRPAGFWRSSSLGVKACGVIVLLLVVATIAGPWISPHDPNFVELSQRLQP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCC
PDLSHWLGTDHLGRDIFSRLVAGARVSLGSVAIALGLIMVTGIVLGGTAGVIGGRTDQLI
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
MRIADVFLTFPTLVLALFMVGMLGTGLTNVILAIALSHWAWYARIVRGIVLSLRHREFLL
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARMSGAGPIRTFIDHLLPATLSQLVVLATLDIGHIMLHVSGLSFLGLGVTAPTAEWGVM
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHCCE
INDARQYVWTAPSLILWPGLTLFISVMAFNILGDALRYRLDPHLRVEHGHQ
ECCCHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Ni2; [Periplasm]; ATP; H2O [C]

Specific reaction: Ni2+ [Periplasm] + ATP + H2O = Ni2+ [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]