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The map label for this gene is lgrD [H]

Identifier: 222102648

GI number: 222102648

Start: 271520

End: 276040

Strand: Reverse

Name: lgrD [H]

Synonym: Avi_7306

Alternate gene names: 222102648

Gene position: 276040-271520 (Counterclockwise)

Preceding gene: 222102655

Following gene: 222102647

Centisome position: 43.69

GC content: 61.09

Gene sequence:

>4521_bases
ATGACCGCTCCCGAAACGGTGGAAGCGCTGCTGTCGCGCCTGTCGGAAAAAGGCATCCGCATCACATGCGTCGATGGGCG
GCTGCGACTTTCCGGCTGCGAGAGCGTGCTCACGCAGGACATCACCGACGCGATCCGCGCCCGCAAGGCGGAGATCATTG
CGAATCTTTCCCTGGACGTCGCTTATCAAGACGCGACACATAGCGAGACAATCCCGGCCCGTCATGCGGACAGGCCGCCG
CTTTCCTTTGCCCAGCAGCGCTTGTGGTTTGTGGAACAGATGATGCCGGAGGCTGGCCTTCACCACATATCGCTGGCTGT
TGAGGCCCACGGCAGCATCGATCTTTCCGCATTGCAGGCAGCGCTTCAGGCCGTCGCAGAGCGCCACGCCATCCTGCGCA
CCCGCATCAATATGCGGGATGGCATGCCCTCTCAACGCATCATCGCCGACAGTGATATTCCGCTGCAATTGATCGACCGA
CAGGGTGATATGCCGGATGAGGCGGAAATCGACCGGATACGGCAAGAGGAAGCGCGGCGGCCATTTGATCTGGCCTTTGA
GTCGCCCCTCCGTCTCACGGCAATCCGCCTTGGCCCCGAGCGAACCCTTTTGCTGCTGACGCTGCACCACATTGCCGGGG
ACGGTTGGTCGATGGATGTGCTGCTTGGCGATCTCTCCGCGATCTATCAGGCCAAGGTGTCGGGCGTTGAGCTTGATCTG
CCAGCGCTTCCCATCCAATACGGCGACTTCGCCGCATGGCAGCGCGACCATCTGGCAGGCCCGGCGCTTGAGCGGTCTTT
AGCGTTCTGGACAGATCATCTGGAAGCTCCGCTTCCCGCCACGCAATTGCCGGGGGATTTCACCCGGCCACCTGTTCAGG
CCAATGCCGGAGCCTTGCATTCCATCGCCTTCGATGCGGCCACGACGGCCCGGCTGAAAGCGCTTGCGAAAGCAGAAGGT
GCCACCCTGTTCGCCACGCTGTTTACGGCCTTCAACACCCTCGTCTATCGCTATACCGGGCAAAGGGATCTGGTGATTGG
CACGCCCGTCGCCAACCGTCGTCACCGGGAAACGGAAGGGTTGATCGGCCTCTTCGTCAATCCGCTGCCGGTGCGCACAA
GGCTTCATCCCGCAGCGAGCTTTCGCGAGACGCTGCGCCAAAGCCAAGCGACCCTCTGGTCGGTGCTTGACCACCAAGAC
CTGCCTTTTGAGCAATTGGTGGAAGCACTGAAGCCGGAGCGCGATCCGAGCGTCCATCCGCTTTTCCAATTGAAGTTCCA
GCTCGATGCTCAGCCTTCGCAAAGGGTCGGACTTTCGGGCCTCGCGCTGACCCGCCTGCCACGACACGATGGTGTTGCGA
AACTCGATCTCAGCCTTAACCTGATCGATGCCGGAAACACGATCCATGGCACTTTCGAATATGACACAGCGCTTTTCCGC
TCTGAGACAATCGCCTCCCTCGCCGCCCATTTCGGTGTGCTGATCGAAGCAATTGCCATTGAGCCGGACACGGCCCTTGC
CATTCTTCCCTTGCTCGGAACCGAGGAGCGTCAGCGCCAGATCGTCGGCTGGAATGCAACGGCGAAACCTTTTGATGAGA
AGGCCTTTTTCCACACGGTGTTCGAGGCCCACGCCGCCCGCAAACCAGACGCGATTGCGCTTGTTCATGTCAGTGATGGC
AAGCGACGCACCCTGACCTATGACGCCCTCAACCGACGCGCCAACCAGATCGCGCACCACCTGCGCGGTCTGGGTGCGGG
TCCAGAGACCATCGTTGCCATCGCGCTTGAGCGCGGTTTCGATATGATTGCCGCTTGGCTCGGCGTGCTCAAGTCTGGCG
CTGCCTATCTGCCGCTGGATCCGGCCTATCCGCCGGAACGCCTCGCCATGATGCTCTCAGATTCGCAAGCCCGCTTGGTT
TTGACCGAAAGCCGCCGGACATTGCCGGAGACGGTAACCCGCATTGATCTCGATACCGATTGGCCACGGGATGCGGCGAC
GGGCAATCCTGATCTCGTCAATCGGCCCGATCACCTTGCCTATATCATCTACACCTCAGGATCGACCGGGCGGCCAAAAG
GCGTGCTCGTCGAGCACAGGGGCCTCGTCAACCTGACGCAACACAAGATCCGTATTGGCGGGGTGAAGCCGGGCGATTGT
GTGCTCCAGTTCTTCTCCTTCTCGTTTGATGCCTCGATTCCAGAACTCGTCATGGCGCTTGGCGCAGGCGCGTCATTGCT
GCTGCTGCCCGCCAGCGACCTTCTGCCCGGACCAGCGCTTGCCGAACACATGAAAACGCAAGCCGTAACACATGTGACAA
TGACACCCTCCGCGCTCATCGCGCTGCCATCGGGCGATTATCCAGCACTGCGCATGGTGCTAACCGGCGGCGAAGCCCCG
ACGCCCGAATTGATCGAACGTTGGGGAACGGGGCGGCTGTTCATCAACGCCTATGGCCCGACGGAAACAACGGTCAATGC
GAGCATGGTCCCCTGCGGCAACGGTCATCCCATTGAGGCAACCTTGCTGCCCGCTGCCAACAAGCAACTCTATGTGCTCG
ACGCCAATCTGGAGCCGGTTCCGGTCGGTCAACCGGGCGAACTGCATATCGGCGGGCTTGGCATTGCCCGGGGCTATCAC
GGTCGCCCGGCACTGACAGCCGAGCGCTTCGTGCCCGATCCATTTTCCGCGACGGGCGGCGTGCTCTATCGAACAGGCGA
CCGTGCCTGCCAACGGGCGGATGGCCGCATCCGGGTGCTTGGCCGCCTCGACGATCAGGTGAAAATCCGTGGCTATCGCA
TCGAGCCGGGTGAAATCGAGGCCATGGTGCTGACGCATCCCACCATAGTGGCTGCGGCAGTCGTGATCCACGAGATTGAT
GGTGAAAAGCGCGTCATTGCCTACGGCGTCGCCAAGGAGGCAACCACCATCAGCGCCGTGGACATGAAGGCATTCCTCGC
CGCACATCTGCCCCGCTACCTCGTGCCGGACGCCTTCGTCTGGCTTGATCGCTTGCCACTCACCGTCAATGGAAAGATCG
ACACAAAAGCACTTCCGCTTCTGGATCTGACACCACAGGCTGGCCGTCCGCCGCAAGGAGAGACGGAAAACGCAATCGCG
GCAATTTTCGCGCAAGTGCTCGGATGCCCGCCTGTCTCGGCCACTGATGATTTCTTCGTAATCGGCGGTCACTCGCTGCT
GGCCACGCGGCTATCGGCCCTTGCCAAATCGGCGTTCGGCCTCGACATCGCCATTATCGATCTCTTCGAGGCCCCGACGG
TCGAAGCACTGGCGGCAAGGATAAGCAACCGAAACCACAGCCTGATGACGGAAGAGGAGATGTGCCGGGCCGATACCGAG
CTTGATGCGGCCATCCGCATTCCGGCACAGATTGTGTCTACTCATCCTTTGAGCCATGTGTTTCTCACTGGAGCGACAGG
CTTTCTGGGCGCTTACCTGCTCAGCGAACTGCTCAAGGACAAGTCTCGCACGGTCTCCTGCCTCGTCCGGGGCGTGACCG
GGGCGGATCGCCTGCGCCAATCGCTTCAATCCTACGGTCTGTGGCGGGATGACCTTGCTGAACGCATCAGGCCGCTGCCG
GGCGATCTCTCACAGCAAAAATTCGGGCTTTCCGATGCCGTCTACACGGCACTTGGTGAAAGCATAGACGCCATCATCCA
CAATGGCGCGGAGGTTCATCATCTGCATCCCTATCAACGCCTTCGCGCTCCCAATGTCGGCGGCACGGTCGAGGCGATCC
GGCTGGCGGCGGTGGGCCGAGGACGGCCCTTGCATCTTATTTCCTCGCTCAGCGCCCTGACACGCCGAGGAGCCGGGGAA
ACGATAGGCGAAAGCGCCGTGATCGGGGACTTCCCCTTGCCTGCTGGCGGATACAACCAGACCAAGTGGGTTGCGGAGCA
TCTTGCGCAAGCCGCCAAAGAGCGTGGTCTCCCGGTGACAATCTACCGCCCCGGCGCGATTTCGGGCGATAGCCGCACCG
GCACTTTCAACAAAGCCGACATCCTGTGCCGGCTCATGCAGGGCTATCTGCGCTCAGGGCTTGCGCCAGAGGGTGACACC
CCGCTGGAAATGCTGCCGGTGGACACGGTCGCGCACGCGATCATTGCCCTTGCGGACGAACCCTCATCGATTGGCCAAAC
CTTCCATCTGGTCCATTCGTCGCCCGTCTCCTCCGCGCTGCTGTTTGAGGCGGCAGCGGCCGAAGGGCTCCATTTGCAAC
GCATTCCCCGGCTGGAATGGCGTGCCGAGCTTGATCGCATTGCGCGGGAAGAGACCGATCATCCGCTTTACCCGCTGATG
GGTCTTTTCGAACAAAAGCCAGCCAGTTCATCGCAGGGCACAATCCGCACCGTTGAGCGCCGTGAAACGCATCGCGCGCT
GGCGCTCGCATCGATTGTCGAGCCAGCGCTCGACCTTCGCCTTTTTCGCTCCTATCTGCGCGCCTTCATTCTCTCTGGCG
CGCTCAACCCTTCCAAAGAAAATGAGCAGAGATATGCTTGA

Upstream 100 bases:

>100_bases
CGTTCAAAATAGTCCCGGGCAAAGGCATCTCCAAGATGGTCGTTTCCACACATAAACTGTGTGTGCAACAGGTCCGGTGC
GCTCTGGTGGAGGCATGCCG

Downstream 100 bases:

>100_bases
ACAAGCAAGCAAATACGATCACTGGGCGTGGCTCTATAACCGCACGCTTGGGCCCCGCTACGGCGCATATAAGATCGGTC
CGATCGAGCGTGTGGTGCTG

Product: peptide synthetase

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent D-leucine adenylase; D-LeuA; D-Leucine activase; Leucine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent glycine adenylase; GlyA; Glycine activase; Linear gramicidin--PCP reductase [H]

Number of amino acids: Translated: 1506; Mature: 1505

Protein sequence:

>1506_residues
MTAPETVEALLSRLSEKGIRITCVDGRLRLSGCESVLTQDITDAIRARKAEIIANLSLDVAYQDATHSETIPARHADRPP
LSFAQQRLWFVEQMMPEAGLHHISLAVEAHGSIDLSALQAALQAVAERHAILRTRINMRDGMPSQRIIADSDIPLQLIDR
QGDMPDEAEIDRIRQEEARRPFDLAFESPLRLTAIRLGPERTLLLLTLHHIAGDGWSMDVLLGDLSAIYQAKVSGVELDL
PALPIQYGDFAAWQRDHLAGPALERSLAFWTDHLEAPLPATQLPGDFTRPPVQANAGALHSIAFDAATTARLKALAKAEG
ATLFATLFTAFNTLVYRYTGQRDLVIGTPVANRRHRETEGLIGLFVNPLPVRTRLHPAASFRETLRQSQATLWSVLDHQD
LPFEQLVEALKPERDPSVHPLFQLKFQLDAQPSQRVGLSGLALTRLPRHDGVAKLDLSLNLIDAGNTIHGTFEYDTALFR
SETIASLAAHFGVLIEAIAIEPDTALAILPLLGTEERQRQIVGWNATAKPFDEKAFFHTVFEAHAARKPDAIALVHVSDG
KRRTLTYDALNRRANQIAHHLRGLGAGPETIVAIALERGFDMIAAWLGVLKSGAAYLPLDPAYPPERLAMMLSDSQARLV
LTESRRTLPETVTRIDLDTDWPRDAATGNPDLVNRPDHLAYIIYTSGSTGRPKGVLVEHRGLVNLTQHKIRIGGVKPGDC
VLQFFSFSFDASIPELVMALGAGASLLLLPASDLLPGPALAEHMKTQAVTHVTMTPSALIALPSGDYPALRMVLTGGEAP
TPELIERWGTGRLFINAYGPTETTVNASMVPCGNGHPIEATLLPAANKQLYVLDANLEPVPVGQPGELHIGGLGIARGYH
GRPALTAERFVPDPFSATGGVLYRTGDRACQRADGRIRVLGRLDDQVKIRGYRIEPGEIEAMVLTHPTIVAAAVVIHEID
GEKRVIAYGVAKEATTISAVDMKAFLAAHLPRYLVPDAFVWLDRLPLTVNGKIDTKALPLLDLTPQAGRPPQGETENAIA
AIFAQVLGCPPVSATDDFFVIGGHSLLATRLSALAKSAFGLDIAIIDLFEAPTVEALAARISNRNHSLMTEEEMCRADTE
LDAAIRIPAQIVSTHPLSHVFLTGATGFLGAYLLSELLKDKSRTVSCLVRGVTGADRLRQSLQSYGLWRDDLAERIRPLP
GDLSQQKFGLSDAVYTALGESIDAIIHNGAEVHHLHPYQRLRAPNVGGTVEAIRLAAVGRGRPLHLISSLSALTRRGAGE
TIGESAVIGDFPLPAGGYNQTKWVAEHLAQAAKERGLPVTIYRPGAISGDSRTGTFNKADILCRLMQGYLRSGLAPEGDT
PLEMLPVDTVAHAIIALADEPSSIGQTFHLVHSSPVSSALLFEAAAAEGLHLQRIPRLEWRAELDRIAREETDHPLYPLM
GLFEQKPASSSQGTIRTVERRETHRALALASIVEPALDLRLFRSYLRAFILSGALNPSKENEQRYA

Sequences:

>Translated_1506_residues
MTAPETVEALLSRLSEKGIRITCVDGRLRLSGCESVLTQDITDAIRARKAEIIANLSLDVAYQDATHSETIPARHADRPP
LSFAQQRLWFVEQMMPEAGLHHISLAVEAHGSIDLSALQAALQAVAERHAILRTRINMRDGMPSQRIIADSDIPLQLIDR
QGDMPDEAEIDRIRQEEARRPFDLAFESPLRLTAIRLGPERTLLLLTLHHIAGDGWSMDVLLGDLSAIYQAKVSGVELDL
PALPIQYGDFAAWQRDHLAGPALERSLAFWTDHLEAPLPATQLPGDFTRPPVQANAGALHSIAFDAATTARLKALAKAEG
ATLFATLFTAFNTLVYRYTGQRDLVIGTPVANRRHRETEGLIGLFVNPLPVRTRLHPAASFRETLRQSQATLWSVLDHQD
LPFEQLVEALKPERDPSVHPLFQLKFQLDAQPSQRVGLSGLALTRLPRHDGVAKLDLSLNLIDAGNTIHGTFEYDTALFR
SETIASLAAHFGVLIEAIAIEPDTALAILPLLGTEERQRQIVGWNATAKPFDEKAFFHTVFEAHAARKPDAIALVHVSDG
KRRTLTYDALNRRANQIAHHLRGLGAGPETIVAIALERGFDMIAAWLGVLKSGAAYLPLDPAYPPERLAMMLSDSQARLV
LTESRRTLPETVTRIDLDTDWPRDAATGNPDLVNRPDHLAYIIYTSGSTGRPKGVLVEHRGLVNLTQHKIRIGGVKPGDC
VLQFFSFSFDASIPELVMALGAGASLLLLPASDLLPGPALAEHMKTQAVTHVTMTPSALIALPSGDYPALRMVLTGGEAP
TPELIERWGTGRLFINAYGPTETTVNASMVPCGNGHPIEATLLPAANKQLYVLDANLEPVPVGQPGELHIGGLGIARGYH
GRPALTAERFVPDPFSATGGVLYRTGDRACQRADGRIRVLGRLDDQVKIRGYRIEPGEIEAMVLTHPTIVAAAVVIHEID
GEKRVIAYGVAKEATTISAVDMKAFLAAHLPRYLVPDAFVWLDRLPLTVNGKIDTKALPLLDLTPQAGRPPQGETENAIA
AIFAQVLGCPPVSATDDFFVIGGHSLLATRLSALAKSAFGLDIAIIDLFEAPTVEALAARISNRNHSLMTEEEMCRADTE
LDAAIRIPAQIVSTHPLSHVFLTGATGFLGAYLLSELLKDKSRTVSCLVRGVTGADRLRQSLQSYGLWRDDLAERIRPLP
GDLSQQKFGLSDAVYTALGESIDAIIHNGAEVHHLHPYQRLRAPNVGGTVEAIRLAAVGRGRPLHLISSLSALTRRGAGE
TIGESAVIGDFPLPAGGYNQTKWVAEHLAQAAKERGLPVTIYRPGAISGDSRTGTFNKADILCRLMQGYLRSGLAPEGDT
PLEMLPVDTVAHAIIALADEPSSIGQTFHLVHSSPVSSALLFEAAAAEGLHLQRIPRLEWRAELDRIAREETDHPLYPLM
GLFEQKPASSSQGTIRTVERRETHRALALASIVEPALDLRLFRSYLRAFILSGALNPSKENEQRYA
>Mature_1505_residues
TAPETVEALLSRLSEKGIRITCVDGRLRLSGCESVLTQDITDAIRARKAEIIANLSLDVAYQDATHSETIPARHADRPPL
SFAQQRLWFVEQMMPEAGLHHISLAVEAHGSIDLSALQAALQAVAERHAILRTRINMRDGMPSQRIIADSDIPLQLIDRQ
GDMPDEAEIDRIRQEEARRPFDLAFESPLRLTAIRLGPERTLLLLTLHHIAGDGWSMDVLLGDLSAIYQAKVSGVELDLP
ALPIQYGDFAAWQRDHLAGPALERSLAFWTDHLEAPLPATQLPGDFTRPPVQANAGALHSIAFDAATTARLKALAKAEGA
TLFATLFTAFNTLVYRYTGQRDLVIGTPVANRRHRETEGLIGLFVNPLPVRTRLHPAASFRETLRQSQATLWSVLDHQDL
PFEQLVEALKPERDPSVHPLFQLKFQLDAQPSQRVGLSGLALTRLPRHDGVAKLDLSLNLIDAGNTIHGTFEYDTALFRS
ETIASLAAHFGVLIEAIAIEPDTALAILPLLGTEERQRQIVGWNATAKPFDEKAFFHTVFEAHAARKPDAIALVHVSDGK
RRTLTYDALNRRANQIAHHLRGLGAGPETIVAIALERGFDMIAAWLGVLKSGAAYLPLDPAYPPERLAMMLSDSQARLVL
TESRRTLPETVTRIDLDTDWPRDAATGNPDLVNRPDHLAYIIYTSGSTGRPKGVLVEHRGLVNLTQHKIRIGGVKPGDCV
LQFFSFSFDASIPELVMALGAGASLLLLPASDLLPGPALAEHMKTQAVTHVTMTPSALIALPSGDYPALRMVLTGGEAPT
PELIERWGTGRLFINAYGPTETTVNASMVPCGNGHPIEATLLPAANKQLYVLDANLEPVPVGQPGELHIGGLGIARGYHG
RPALTAERFVPDPFSATGGVLYRTGDRACQRADGRIRVLGRLDDQVKIRGYRIEPGEIEAMVLTHPTIVAAAVVIHEIDG
EKRVIAYGVAKEATTISAVDMKAFLAAHLPRYLVPDAFVWLDRLPLTVNGKIDTKALPLLDLTPQAGRPPQGETENAIAA
IFAQVLGCPPVSATDDFFVIGGHSLLATRLSALAKSAFGLDIAIIDLFEAPTVEALAARISNRNHSLMTEEEMCRADTEL
DAAIRIPAQIVSTHPLSHVFLTGATGFLGAYLLSELLKDKSRTVSCLVRGVTGADRLRQSLQSYGLWRDDLAERIRPLPG
DLSQQKFGLSDAVYTALGESIDAIIHNGAEVHHLHPYQRLRAPNVGGTVEAIRLAAVGRGRPLHLISSLSALTRRGAGET
IGESAVIGDFPLPAGGYNQTKWVAEHLAQAAKERGLPVTIYRPGAISGDSRTGTFNKADILCRLMQGYLRSGLAPEGDTP
LEMLPVDTVAHAIIALADEPSSIGQTFHLVHSSPVSSALLFEAAAAEGLHLQRIPRLEWRAELDRIAREETDHPLYPLMG
LFEQKPASSSQGTIRTVERRETHRALALASIVEPALDLRLFRSYLRAFILSGALNPSKENEQRYA

Specific function: Activates the 13th to the 16th (Trp, D-Leu, Trp and Gly) amino acids in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 14th (D-Leu) amino acid. It also catalyzes

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=501, Percent_Identity=25.9481037924152, Blast_Score=121, Evalue=5e-27,
Organism=Homo sapiens, GI28416953, Length=544, Percent_Identity=25.5514705882353, Blast_Score=101, Evalue=4e-21,
Organism=Homo sapiens, GI187761345, Length=471, Percent_Identity=24.8407643312102, Blast_Score=100, Evalue=1e-20,
Organism=Homo sapiens, GI187761343, Length=471, Percent_Identity=24.8407643312102, Blast_Score=100, Evalue=1e-20,
Organism=Homo sapiens, GI156151445, Length=569, Percent_Identity=24.2530755711775, Blast_Score=97, Evalue=8e-20,
Organism=Homo sapiens, GI122937307, Length=373, Percent_Identity=27.0777479892761, Blast_Score=91, Evalue=1e-17,
Organism=Homo sapiens, GI38505220, Length=390, Percent_Identity=27.4358974358974, Blast_Score=85, Evalue=7e-16,
Organism=Homo sapiens, GI58082049, Length=506, Percent_Identity=23.7154150197628, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI157311624, Length=357, Percent_Identity=26.3305322128852, Blast_Score=78, Evalue=6e-14,
Organism=Homo sapiens, GI157311622, Length=357, Percent_Identity=26.3305322128852, Blast_Score=78, Evalue=6e-14,
Organism=Homo sapiens, GI42544132, Length=306, Percent_Identity=25.1633986928105, Blast_Score=78, Evalue=7e-14,
Organism=Homo sapiens, GI115511026, Length=502, Percent_Identity=24.1035856573705, Blast_Score=77, Evalue=1e-13,
Organism=Escherichia coli, GI1786801, Length=1080, Percent_Identity=29.4444444444444, Blast_Score=295, Evalue=2e-80,
Organism=Escherichia coli, GI1788107, Length=538, Percent_Identity=25.6505576208178, Blast_Score=123, Evalue=8e-29,
Organism=Escherichia coli, GI1786810, Length=539, Percent_Identity=26.3450834879406, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1790505, Length=538, Percent_Identity=25.2788104089219, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI145693145, Length=514, Percent_Identity=25.4863813229572, Blast_Score=97, Evalue=7e-21,
Organism=Escherichia coli, GI221142682, Length=504, Percent_Identity=24.6031746031746, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17556356, Length=504, Percent_Identity=30.1587301587302, Blast_Score=184, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17557194, Length=548, Percent_Identity=25.3649635036496, Blast_Score=106, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=1003, Percent_Identity=21.2362911266201, Blast_Score=106, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17538037, Length=563, Percent_Identity=24.1563055062167, Blast_Score=102, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17560140, Length=475, Percent_Identity=24, Blast_Score=94, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17559526, Length=513, Percent_Identity=22.2222222222222, Blast_Score=90, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=356, Percent_Identity=26.9662921348315, Blast_Score=73, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=1276, Percent_Identity=27.9780564263323, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6319699, Length=482, Percent_Identity=22.4066390041494, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648676, Length=654, Percent_Identity=26.7584097859327, Blast_Score=175, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24581924, Length=545, Percent_Identity=25.8715596330275, Blast_Score=107, Evalue=5e-23,
Organism=Drosophila melanogaster, GI18859661, Length=473, Percent_Identity=25.5813953488372, Blast_Score=101, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21356441, Length=477, Percent_Identity=23.4800838574423, Blast_Score=73, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24582852, Length=378, Percent_Identity=24.8677248677249, Blast_Score=67, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR013120
- InterPro:   IPR016040
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR010080 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF07993 NAD_binding_4; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 163757; Mature: 163626

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPETVEALLSRLSEKGIRITCVDGRLRLSGCESVLTQDITDAIRARKAEIIANLSLDV
CCCHHHHHHHHHHHHHCCCEEEEECCEEEECHHHHHHHHHHHHHHHHHHHHHHEECEEEE
AYQDATHSETIPARHADRPPLSFAQQRLWFVEQMMPEAGLHHISLAVEAHGSIDLSALQA
EECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHH
ALQAVAERHAILRTRINMRDGMPSQRIIADSDIPLQLIDRQGDMPDEAEIDRIRQEEARR
HHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHHHCCC
PFDLAFESPLRLTAIRLGPERTLLLLTLHHIAGDGWSMDVLLGDLSAIYQAKVSGVELDL
CEEEECCCCCEEEEEEECCCCEEEEEEEHHHCCCCCEEHHHHHHHHHHHHHHCCCEEEEC
PALPIQYGDFAAWQRDHLAGPALERSLAFWTDHLEAPLPATQLPGDFTRPPVQANAGALH
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHH
SIAFDAATTARLKALAKAEGATLFATLFTAFNTLVYRYTGQRDLVIGTPVANRRHRETEG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCC
LIGLFVNPLPVRTRLHPAASFRETLRQSQATLWSVLDHQDLPFEQLVEALKPERDPSVHP
EEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCC
LFQLKFQLDAQPSQRVGLSGLALTRLPRHDGVAKLDLSLNLIDAGNTIHGTFEYDTALFR
EEEEEEEECCCCCHHCCCCCCCEECCCCCCCEEEEEEEEEEEECCCEEEEEEEHHHHHHH
SETIASLAAHFGVLIEAIAIEPDTALAILPLLGTEERQRQIVGWNATAKPFDEKAFFHTV
HHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCHHHCEEECCCCCCCCCCHHHHHHHH
FEAHAARKPDAIALVHVSDGKRRTLTYDALNRRANQIAHHLRGLGAGPETIVAIALERGF
HHHHHCCCCCEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHCCCCCHHHEEEEHHHHCH
DMIAAWLGVLKSGAAYLPLDPAYPPERLAMMLSDSQARLVLTESRRTLPETVTRIDLDTD
HHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHEEECCCC
WPRDAATGNPDLVNRPDHLAYIIYTSGSTGRPKGVLVEHRGLVNLTQHKIRIGGVKPGDC
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEECCCCEEEEEEEEEECCCCCHHH
VLQFFSFSFDASIPELVMALGAGASLLLLPASDLLPGPALAEHMKTQAVTHVTMTPSALI
HHHHHHCCCCCCHHHHHHHHCCCCEEEEEECHHCCCCHHHHHHHHHHHEEEEEECCCEEE
ALPSGDYPALRMVLTGGEAPTPELIERWGTGRLFINAYGPTETTVNASMVPCGNGHPIEA
EECCCCCCEEEEEEECCCCCCHHHHHHCCCCEEEEEEECCCCCEECEEEEECCCCCCEEE
TLLPAANKQLYVLDANLEPVPVGQPGELHIGGLGIARGYHGRPALTAERFVPDPFSATGG
EEECCCCCEEEEEECCCCCCCCCCCCCEEECCEEEECCCCCCCCCCHHHCCCCCCCCCCC
VLYRTGDRACQRADGRIRVLGRLDDQVKIRGYRIEPGEIEAMVLTHPTIVAAAVVIHEID
EEEECCHHHHHCCCCCEEEEECCCCEEEEEEEEECCCCEEEEEEECCHHHHHHHHHHCCC
GEKRVIAYGVAKEATTISAVDMKAFLAAHLPRYLVPDAFVWLDRLPLTVNGKIDTKALPL
CCCEEEEEECCCCCCEEEHHHHHHHHHHHCCHHHCCHHHHHHHCCCEEECCCCCCCCCCE
LDLTPQAGRPPQGETENAIAAIFAQVLGCPPVSATDDFFVIGGHSLLATRLSALAKSAFG
EECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCC
LDIAIIDLFEAPTVEALAARISNRNHSLMTEEEMCRADTELDAAIRIPAQIVSTHPLSHV
CEEEEEEECCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCEEECCHHHHCCCCCCEE
FLTGATGFLGAYLLSELLKDKSRTVSCLVRGVTGADRLRQSLQSYGLWRDDLAERIRPLP
EEECCHHHHHHHHHHHHHHHHHHEEEHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCC
GDLSQQKFGLSDAVYTALGESIDAIIHNGAEVHHLHPYQRLRAPNVGGTVEAIRLAAVGR
CCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHCCCCCCCHHHHHEEEECCC
GRPLHLISSLSALTRRGAGETIGESAVIGDFPLPAGGYNQTKWVAEHLAQAAKERGLPVT
CCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
IYRPGAISGDSRTGTFNKADILCRLMQGYLRSGLAPEGDTPLEMLPVDTVAHAIIALADE
EECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECHHHHHHHHHHCCCC
PSSIGQTFHLVHSSPVSSALLFEAAAAEGLHLQRIPRLEWRAELDRIAREETDHPLYPLM
CHHHCCEEEEEECCCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCHHHH
GLFEQKPASSSQGTIRTVERRETHRALALASIVEPALDLRLFRSYLRAFILSGALNPSKE
HHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NEQRYA
CCCCCC
>Mature Secondary Structure 
TAPETVEALLSRLSEKGIRITCVDGRLRLSGCESVLTQDITDAIRARKAEIIANLSLDV
CCHHHHHHHHHHHHHCCCEEEEECCEEEECHHHHHHHHHHHHHHHHHHHHHHEECEEEE
AYQDATHSETIPARHADRPPLSFAQQRLWFVEQMMPEAGLHHISLAVEAHGSIDLSALQA
EECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHH
ALQAVAERHAILRTRINMRDGMPSQRIIADSDIPLQLIDRQGDMPDEAEIDRIRQEEARR
HHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHHHCCC
PFDLAFESPLRLTAIRLGPERTLLLLTLHHIAGDGWSMDVLLGDLSAIYQAKVSGVELDL
CEEEECCCCCEEEEEEECCCCEEEEEEEHHHCCCCCEEHHHHHHHHHHHHHHCCCEEEEC
PALPIQYGDFAAWQRDHLAGPALERSLAFWTDHLEAPLPATQLPGDFTRPPVQANAGALH
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHH
SIAFDAATTARLKALAKAEGATLFATLFTAFNTLVYRYTGQRDLVIGTPVANRRHRETEG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCCCC
LIGLFVNPLPVRTRLHPAASFRETLRQSQATLWSVLDHQDLPFEQLVEALKPERDPSVHP
EEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCC
LFQLKFQLDAQPSQRVGLSGLALTRLPRHDGVAKLDLSLNLIDAGNTIHGTFEYDTALFR
EEEEEEEECCCCCHHCCCCCCCEECCCCCCCEEEEEEEEEEEECCCEEEEEEEHHHHHHH
SETIASLAAHFGVLIEAIAIEPDTALAILPLLGTEERQRQIVGWNATAKPFDEKAFFHTV
HHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCHHHCEEECCCCCCCCCCHHHHHHHH
FEAHAARKPDAIALVHVSDGKRRTLTYDALNRRANQIAHHLRGLGAGPETIVAIALERGF
HHHHHCCCCCEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHCCCCCHHHEEEEHHHHCH
DMIAAWLGVLKSGAAYLPLDPAYPPERLAMMLSDSQARLVLTESRRTLPETVTRIDLDTD
HHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHEEECCCC
WPRDAATGNPDLVNRPDHLAYIIYTSGSTGRPKGVLVEHRGLVNLTQHKIRIGGVKPGDC
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEECCCCEEEEEEEEEECCCCCHHH
VLQFFSFSFDASIPELVMALGAGASLLLLPASDLLPGPALAEHMKTQAVTHVTMTPSALI
HHHHHHCCCCCCHHHHHHHHCCCCEEEEEECHHCCCCHHHHHHHHHHHEEEEEECCCEEE
ALPSGDYPALRMVLTGGEAPTPELIERWGTGRLFINAYGPTETTVNASMVPCGNGHPIEA
EECCCCCCEEEEEEECCCCCCHHHHHHCCCCEEEEEEECCCCCEECEEEEECCCCCCEEE
TLLPAANKQLYVLDANLEPVPVGQPGELHIGGLGIARGYHGRPALTAERFVPDPFSATGG
EEECCCCCEEEEEECCCCCCCCCCCCCEEECCEEEECCCCCCCCCCHHHCCCCCCCCCCC
VLYRTGDRACQRADGRIRVLGRLDDQVKIRGYRIEPGEIEAMVLTHPTIVAAAVVIHEID
EEEECCHHHHHCCCCCEEEEECCCCEEEEEEEEECCCCEEEEEEECCHHHHHHHHHHCCC
GEKRVIAYGVAKEATTISAVDMKAFLAAHLPRYLVPDAFVWLDRLPLTVNGKIDTKALPL
CCCEEEEEECCCCCCEEEHHHHHHHHHHHCCHHHCCHHHHHHHCCCEEECCCCCCCCCCE
LDLTPQAGRPPQGETENAIAAIFAQVLGCPPVSATDDFFVIGGHSLLATRLSALAKSAFG
EECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCC
LDIAIIDLFEAPTVEALAARISNRNHSLMTEEEMCRADTELDAAIRIPAQIVSTHPLSHV
CEEEEEEECCCCCHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCEEECCHHHHCCCCCCEE
FLTGATGFLGAYLLSELLKDKSRTVSCLVRGVTGADRLRQSLQSYGLWRDDLAERIRPLP
EEECCHHHHHHHHHHHHHHHHHHEEEHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCC
GDLSQQKFGLSDAVYTALGESIDAIIHNGAEVHHLHPYQRLRAPNVGGTVEAIRLAAVGR
CCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHCCCCCCCHHHHHEEEECCC
GRPLHLISSLSALTRRGAGETIGESAVIGDFPLPAGGYNQTKWVAEHLAQAAKERGLPVT
CCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEE
IYRPGAISGDSRTGTFNKADILCRLMQGYLRSGLAPEGDTPLEMLPVDTVAHAIIALADE
EECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECHHHHHHHHHHCCCC
PSSIGQTFHLVHSSPVSSALLFEAAAAEGLHLQRIPRLEWRAELDRIAREETDHPLYPLM
CHHHCCEEEEEECCCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCHHHH
GLFEQKPASSSQGTIRTVERRETHRALALASIVEPALDLRLFRSYLRAFILSGALNPSKE
HHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NEQRYA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA