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The map label for this gene is 222102601

Identifier: 222102601

GI number: 222102601

Start: 208262

End: 209260

Strand: Reverse

Name: 222102601

Synonym: Avi_7251

Alternate gene names: NA

Gene position: 209260-208262 (Counterclockwise)

Preceding gene: 222102602

Following gene: 222102600

Centisome position: 33.12

GC content: 57.76

Gene sequence:

>999_bases
ATGCGGCACAGCTTCTTTTGTATCGACAGCCATACATGCGGCAATCCTGTCCGCCTCGTTGCCGGGGGCGGACCGCTTCT
GCCGCATTTGCCAATCGCTGAGCGTCGGGAACTGTTTGTCCGGGACCATGACTGGGTGCGAAAAGCCCTGATGTTCGAAC
CGCGCGGCCATGACGTCATGTCCGGTGCGATCATTTATCCGGCCTACCGCGACGACTGCGATTTCGCAGTCATTTTCATC
GAGGTCAGCGGATGCCTGCCGATGTGCGGAGCCGGTACGATTGGCTTGGTGACAGCCGGTATCGAGGAAGGCCTCATCAC
GCCTAGGGTCGAAGGACAGCTTTCCATCGAAACTCCGGCTGGTCGGGTGGATATACACTATGAAAAGCCTGGCGCATTCG
TGGAATCCGTTCGTATGTTCAACGTGCCGAGCTATCTCCACGCAGCAGATGTCGAGGTTGATATTCCCGGCATCGGGCGT
CTTATTGTCGATATTTCCTATGGCGGCAATTATTATGCCGTGGTGGAGCCGCAGGCATCATGGTCGGGGCTCGACGGCAT
GTCCGGCAGTGACATCGTAGACCTCAGCGTGAAGCTGCGAGACGCATTGGCAGACATCTGCGATCCCCAGCATCCGGATG
ATGAGCGGATTCGAGGCGTTCATCACGCTCTCTGGTGCGATAAGCCGACAAGCAATGCAGCAGACGGGCGTGGAGCCGTA
TTCTACGGCGACAAGGCCATCGATCGCTCCCCGGGCGGGACCGGCACTTCGGCAAGAATGGCCCAGCTTTACGGCAAGGG
TCGATTGAAGGTGGGTGAGGCGTTTCGCCAGGAAAGTATCATCGGCACTGTTTTCGAAGGACGGGTCGAGGAAGAGGTCG
TTGTCGGCACCTTGAAAGGGATCAGGCCGAGCGTTGGGGGATGGGCACGGATCATTGGTCACAACACGATCTTCGTGGAC
GATCGAGATCCTCTGGCTCACGGCTTCCAGATCAAATAA

Upstream 100 bases:

>100_bases
GTCGCGGTGGCGATTTTCCTCGATCGACTGTCACGCGGCGCATTGCAGCGAGGCCGGGCACCTGGCGCAGCCAGCACCTG
ACACTTGATAAGGAACGATC

Downstream 100 bases:

>100_bases
AGTAGGGCTTACAGGCACCTCGCGATACATGCCTGCCCCGATTGGAGTTTAGAATGACGCCCTCCGATACCAACGCCCCG
GTCGACCGCCTGAAAATCGG

Product: hydroxyproline-2-epimerase

Products: NA

Alternate protein names: Hydroxyproline-2-epimerase; HyPRE [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MRHSFFCIDSHTCGNPVRLVAGGGPLLPHLPIAERRELFVRDHDWVRKALMFEPRGHDVMSGAIIYPAYRDDCDFAVIFI
EVSGCLPMCGAGTIGLVTAGIEEGLITPRVEGQLSIETPAGRVDIHYEKPGAFVESVRMFNVPSYLHAADVEVDIPGIGR
LIVDISYGGNYYAVVEPQASWSGLDGMSGSDIVDLSVKLRDALADICDPQHPDDERIRGVHHALWCDKPTSNAADGRGAV
FYGDKAIDRSPGGTGTSARMAQLYGKGRLKVGEAFRQESIIGTVFEGRVEEEVVVGTLKGIRPSVGGWARIIGHNTIFVD
DRDPLAHGFQIK

Sequences:

>Translated_332_residues
MRHSFFCIDSHTCGNPVRLVAGGGPLLPHLPIAERRELFVRDHDWVRKALMFEPRGHDVMSGAIIYPAYRDDCDFAVIFI
EVSGCLPMCGAGTIGLVTAGIEEGLITPRVEGQLSIETPAGRVDIHYEKPGAFVESVRMFNVPSYLHAADVEVDIPGIGR
LIVDISYGGNYYAVVEPQASWSGLDGMSGSDIVDLSVKLRDALADICDPQHPDDERIRGVHHALWCDKPTSNAADGRGAV
FYGDKAIDRSPGGTGTSARMAQLYGKGRLKVGEAFRQESIIGTVFEGRVEEEVVVGTLKGIRPSVGGWARIIGHNTIFVD
DRDPLAHGFQIK
>Mature_332_residues
MRHSFFCIDSHTCGNPVRLVAGGGPLLPHLPIAERRELFVRDHDWVRKALMFEPRGHDVMSGAIIYPAYRDDCDFAVIFI
EVSGCLPMCGAGTIGLVTAGIEEGLITPRVEGQLSIETPAGRVDIHYEKPGAFVESVRMFNVPSYLHAADVEVDIPGIGR
LIVDISYGGNYYAVVEPQASWSGLDGMSGSDIVDLSVKLRDALADICDPQHPDDERIRGVHHALWCDKPTSNAADGRGAV
FYGDKAIDRSPGGTGTSARMAQLYGKGRLKVGEAFRQESIIGTVFEGRVEEEVVVGTLKGIRPSVGGWARIIGHNTIFVD
DRDPLAHGFQIK

Specific function: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4- hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell

COG id: COG3938

COG function: function code E; Proline racemase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the proline racemase family. 4- hydroxyproline epimerase subfamily [H]

Homologues:

Organism=Homo sapiens, GI21389361, Length=344, Percent_Identity=34.593023255814, Blast_Score=169, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008794 [H]

Pfam domain/function: PF05544 Pro_racemase [H]

EC number: =5.1.1.8 [H]

Molecular weight: Translated: 36065; Mature: 36065

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHSFFCIDSHTCGNPVRLVAGGGPLLPHLPIAERRELFVRDHDWVRKALMFEPRGHDVM
CCCEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHEEECCHHHHHHHHEECCCCCCEE
SGAIIYPAYRDDCDFAVIFIEVSGCLPMCGAGTIGLVTAGIEEGLITPRVEGQLSIETPA
CCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCEEEEEECHHCCCCCCCCCCEEEEECCC
GRVDIHYEKPGAFVESVRMFNVPSYLHAADVEVDIPGIGRLIVDISYGGNYYAVVEPQAS
CEEEEEECCCCHHHHHHHEECCCCHHEECCCEEECCCCCEEEEEEEECCCEEEEECCCCC
WSGLDGMSGSDIVDLSVKLRDALADICDPQHPDDERIRGVHHALWCDKPTSNAADGRGAV
CCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHEECCCCCCCCCCCCEEE
FYGDKAIDRSPGGTGTSARMAQLYGKGRLKVGEAFRQESIIGTVFEGRVEEEVVVGTLKG
EECCCCCCCCCCCCCCHHHHHHHHCCCCEEHHHHHHHCCEEEEECCCCCCCEEEEEECCC
IRPSVGGWARIIGHNTIFVDDRDPLAHGFQIK
CCCCCCCEEEEEECCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MRHSFFCIDSHTCGNPVRLVAGGGPLLPHLPIAERRELFVRDHDWVRKALMFEPRGHDVM
CCCEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHEEECCHHHHHHHHEECCCCCCEE
SGAIIYPAYRDDCDFAVIFIEVSGCLPMCGAGTIGLVTAGIEEGLITPRVEGQLSIETPA
CCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCEEEEEECHHCCCCCCCCCCEEEEECCC
GRVDIHYEKPGAFVESVRMFNVPSYLHAADVEVDIPGIGRLIVDISYGGNYYAVVEPQAS
CEEEEEECCCCHHHHHHHEECCCCHHEECCCEEECCCCCEEEEEEEECCCEEEEECCCCC
WSGLDGMSGSDIVDLSVKLRDALADICDPQHPDDERIRGVHHALWCDKPTSNAADGRGAV
CCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHEECCCCCCCCCCCCEEE
FYGDKAIDRSPGGTGTSARMAQLYGKGRLKVGEAFRQESIIGTVFEGRVEEEVVVGTLKG
EECCCCCCCCCCCCCCHHHHHHHHCCCCEEHHHHHHHCCEEEEECCCCCCCEEEEEECCC
IRPSVGGWARIIGHNTIFVDDRDPLAHGFQIK
CCCCCCCEEEEEECCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA