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The map label for this gene is pyrD [H]

Identifier: 221636028

GI number: 221636028

Start: 611884

End: 613008

Strand: Reverse

Name: pyrD [H]

Synonym: trd_A0622

Alternate gene names: 221636028

Gene position: 613008-611884 (Counterclockwise)

Preceding gene: 221636030

Following gene: 221636026

Centisome position: 66.8

GC content: 67.02

Gene sequence:

>1125_bases
ATGGAGAGCGGGGAGGATCGGGGAGAGGTCGCGCGCATGGGCTGGTATCGGCGGATCGTCACACCGCTCCTCTTTCGGCT
GGATCCGGAAGATGCCCACCGGCTGGTACTCGGGGTACTCAGCAGGCTGTCCCGCTGCCCTGGGTCGGAACGGGTGCTGC
GGCGCGTGTTCCGGGTGCCCGATGACGAGCGGCTGCGGGTGGAAGTGGGCGACCTGACGTTTCCGAATCCGATCGGCTTG
GCCGCTGGTGTAGACAAGAATGCGGAAGCGGTGGCAGCCTGGTTCGGCCTCGGCTTCGGTTCGGTCGAAGTCGGGACGGT
TACCCCTTGCCCACAGGAAGGGAATCCCCGTCCCCGACTGTGGCGTTTCCCGGAGGACGAGACCTTGGTCAATGCGCTGG
GCTTCCCCAGCGACGGTGTGGCAGCCGTGCGGGCGCGACTCGTCGGCCGCTGGTTTCCCGGGCCAGTCGGCATCAATCTC
GGCAAGAATGCGTGGACCCCGCTGGAGCAGGCGGTCGTGGATTACTGCGCGACGCTGGTGGCGCTGTGGGACGTCGCCGA
TTACGTGGTGGTGAACGTGAGTTCGCCCAATACGCCGGGACTCCGGGAATTGCAGCGGGGTGAGCGACTCGAGCAGGTGC
TAGCCGCGGTTCAGGAAACCAACCGAACACTGGCGGCACTCCAGCGTGCCCGACCGCGCCCACTCTTCGTCAAGGTCTCG
CTGGACCTGGACGCTGGGGCACTGGCTGACGCCATCGAGATCGCGGTGGCAGTGGGAGCGGACGGCCTGATCCTCGGCAA
TACGAGCATCGATCCGTCGCTCCGCCCAGCTGGTGCAGGAGCATTGCCGGGTGGGGTGAGTGGGCGTCCGCTCCGCAAGA
GAGCGGTCGAGCTCTTGAGCAACGCTGCGGATCGCGCCGGGGGACGTCTCGCTCTGATCAGCGTGGGTGGAGTGCTGGAG
ACGGACGACGTGATCCAGCGCCTGCGCCTGGGTGCCGATCTGGTGCAGGTCTATACCGGTCTGGTGTTTCGAGGTCCGGC
TCTGCCGGCCGTGCTGTTGCGTGGGCTCCTCCGGTATCTCGACGAACAGGGGCTGCCGTCGGTACGGGCGCTCCGCGGGC
GTTGA

Upstream 100 bases:

>100_bases
GGTAGCTCCAAATCGAGCACGAGCACGTCGTCGGCCGGATCGTAGCAGAGTCGCATCGGTCATCGTCTCCCGGGTTCCGC
AGGCACGAAGAAAGGGTAGC

Downstream 100 bases:

>100_bases
GCGCGTTTCCGTTCGCGCGCTGCCGTGTCCGTTCGCCGTGGGGCCGCTTTCATGCCGTTGAGCGCGTTTCCGTCAGCGTG
CGAGCTGTGCTGGCGTCGGG

Product: dihydroorotate oxidase

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MESGEDRGEVARMGWYRRIVTPLLFRLDPEDAHRLVLGVLSRLSRCPGSERVLRRVFRVPDDERLRVEVGDLTFPNPIGL
AAGVDKNAEAVAAWFGLGFGSVEVGTVTPCPQEGNPRPRLWRFPEDETLVNALGFPSDGVAAVRARLVGRWFPGPVGINL
GKNAWTPLEQAVVDYCATLVALWDVADYVVVNVSSPNTPGLRELQRGERLEQVLAAVQETNRTLAALQRARPRPLFVKVS
LDLDAGALADAIEIAVAVGADGLILGNTSIDPSLRPAGAGALPGGVSGRPLRKRAVELLSNAADRAGGRLALISVGGVLE
TDDVIQRLRLGADLVQVYTGLVFRGPALPAVLLRGLLRYLDEQGLPSVRALRGR

Sequences:

>Translated_374_residues
MESGEDRGEVARMGWYRRIVTPLLFRLDPEDAHRLVLGVLSRLSRCPGSERVLRRVFRVPDDERLRVEVGDLTFPNPIGL
AAGVDKNAEAVAAWFGLGFGSVEVGTVTPCPQEGNPRPRLWRFPEDETLVNALGFPSDGVAAVRARLVGRWFPGPVGINL
GKNAWTPLEQAVVDYCATLVALWDVADYVVVNVSSPNTPGLRELQRGERLEQVLAAVQETNRTLAALQRARPRPLFVKVS
LDLDAGALADAIEIAVAVGADGLILGNTSIDPSLRPAGAGALPGGVSGRPLRKRAVELLSNAADRAGGRLALISVGGVLE
TDDVIQRLRLGADLVQVYTGLVFRGPALPAVLLRGLLRYLDEQGLPSVRALRGR
>Mature_374_residues
MESGEDRGEVARMGWYRRIVTPLLFRLDPEDAHRLVLGVLSRLSRCPGSERVLRRVFRVPDDERLRVEVGDLTFPNPIGL
AAGVDKNAEAVAAWFGLGFGSVEVGTVTPCPQEGNPRPRLWRFPEDETLVNALGFPSDGVAAVRARLVGRWFPGPVGINL
GKNAWTPLEQAVVDYCATLVALWDVADYVVVNVSSPNTPGLRELQRGERLEQVLAAVQETNRTLAALQRARPRPLFVKVS
LDLDAGALADAIEIAVAVGADGLILGNTSIDPSLRPAGAGALPGGVSGRPLRKRAVELLSNAADRAGGRLALISVGGVLE
TDDVIQRLRLGADLVQVYTGLVFRGPALPAVLLRGLLRYLDEQGLPSVRALRGR

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=382, Percent_Identity=40.0523560209424, Blast_Score=223, Evalue=2e-58,
Organism=Escherichia coli, GI1787177, Length=338, Percent_Identity=39.6449704142012, Blast_Score=232, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17509475, Length=371, Percent_Identity=34.2318059299191, Blast_Score=194, Evalue=5e-50,
Organism=Drosophila melanogaster, GI281361352, Length=341, Percent_Identity=39.2961876832845, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI17137316, Length=341, Percent_Identity=39.2961876832845, Blast_Score=222, Evalue=4e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 40208; Mature: 40208

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS00911 DHODEHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESGEDRGEVARMGWYRRIVTPLLFRLDPEDAHRLVLGVLSRLSRCPGSERVLRRVFRVP
CCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
DDERLRVEVGDLTFPNPIGLAAGVDKNAEAVAAWFGLGFGSVEVGTVTPCPQEGNPRPRL
CCCEEEEEECCCCCCCCCCHHCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCE
WRFPEDETLVNALGFPSDGVAAVRARLVGRWFPGPVGINLGKNAWTPLEQAVVDYCATLV
ECCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
ALWDVADYVVVNVSSPNTPGLRELQRGERLEQVLAAVQETNRTLAALQRARPRPLFVKVS
HHHHHHCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
LDLDAGALADAIEIAVAVGADGLILGNTSIDPSLRPAGAGALPGGVSGRPLRKRAVELLS
ECCCCCHHHHHHHHHHEECCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
NAADRAGGRLALISVGGVLETDDVIQRLRLGADLVQVYTGLVFRGPALPAVLLRGLLRYL
HHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DEQGLPSVRALRGR
HHCCCCHHHHHCCC
>Mature Secondary Structure
MESGEDRGEVARMGWYRRIVTPLLFRLDPEDAHRLVLGVLSRLSRCPGSERVLRRVFRVP
CCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
DDERLRVEVGDLTFPNPIGLAAGVDKNAEAVAAWFGLGFGSVEVGTVTPCPQEGNPRPRL
CCCEEEEEECCCCCCCCCCHHCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCE
WRFPEDETLVNALGFPSDGVAAVRARLVGRWFPGPVGINLGKNAWTPLEQAVVDYCATLV
ECCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
ALWDVADYVVVNVSSPNTPGLRELQRGERLEQVLAAVQETNRTLAALQRARPRPLFVKVS
HHHHHHCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
LDLDAGALADAIEIAVAVGADGLILGNTSIDPSLRPAGAGALPGGVSGRPLRKRAVELLS
ECCCCCHHHHHHHHHHEECCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
NAADRAGGRLALISVGGVLETDDVIQRLRLGADLVQVYTGLVFRGPALPAVLLRGLLRYL
HHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
DEQGLPSVRALRGR
HHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA