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The map label for this gene is echA8 [H]

Identifier: 221635740

GI number: 221635740

Start: 321677

End: 322393

Strand: Reverse

Name: echA8 [H]

Synonym: trd_A0334

Alternate gene names: 221635740

Gene position: 322393-321677 (Counterclockwise)

Preceding gene: 221635741

Following gene: 221635739

Centisome position: 35.13

GC content: 59.14

Gene sequence:

>717_bases
ATGAATAATCATTTTCCCTATCAGAAGATCCGAATTCAGCAAGAGAATAATGTCACCGTGCTCACGCTTGCAGATCCCGA
CACCCATAATGCTCTTTCCAATGAGTTGCTCGGGGAATTGTGCGACGCCCTTTCGCGCGTGAGCAGCACAGTCCTCCTCC
TGAACGCAGAGGGGGATCATTTCTCGATCGGTCGACCGCCCCAATCGTACAGCGCAGCCCCTGAGACCTGGATGAAGGGG
TACTACCTCGTGATGCGCGCCAATGAACTTTTGATGGGGTTTCCGGGTGTGACGATCGCAGCAGTTCAAGGGCACGCAAG
GGGTGCCGGCTGCAGCCTCGCCGGACGCTGTGATCTGGTCCTCGCTGCCGAGACCGCAACGTTCTCCTTCCCGGAGCTGC
GCGCAGGAGTGCCGCCGGTCATCGTCGCATCCTATTACTCCCGCAAGTTACCGTGGCACGCCTTTCTCCGGCTCGCTCTG
ACTGGGCAGGAAGTGAGCGCAGCGGAGGCTTGTCGGCTCGCTCTGGTTACCGAAGTGGTACCCGACCACGAACTCTTCCA
GCGCGCCCGAGAACTAGCTGATGATCTCGCCAAGATCGATGCTGGCGCTCTGGCCACCTTGAAGCATTTCCTGCTCTCGA
GTGAAAGTGCGAGCACACCCCAGGCGAACCGCCTCGCCTATGCCGCTTTGCTGGAAACCCTTGCCTCCCGAGTGTAG

Upstream 100 bases:

>100_bases
TTGCAGCCGTCATCATCGATGGTGCGATCCGGACACGCCGAAGCCGCAATACACCCCCCTCACGTCGTGAGGTGCTCGTG
AAGGAGAGAGGAAGTAACCC

Downstream 100 bases:

>100_bases
TCAGCCTGAGGAGGAGACCGATGAGTGATCTGCTGGTCACGCTCCAGACTTTGGACGACACAGCGATCGTCACGCTCAAT
CGTCCAGAAAAGCTCAACGC

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MNNHFPYQKIRIQQENNVTVLTLADPDTHNALSNELLGELCDALSRVSSTVLLLNAEGDHFSIGRPPQSYSAAPETWMKG
YYLVMRANELLMGFPGVTIAAVQGHARGAGCSLAGRCDLVLAAETATFSFPELRAGVPPVIVASYYSRKLPWHAFLRLAL
TGQEVSAAEACRLALVTEVVPDHELFQRARELADDLAKIDAGALATLKHFLLSSESASTPQANRLAYAALLETLASRV

Sequences:

>Translated_238_residues
MNNHFPYQKIRIQQENNVTVLTLADPDTHNALSNELLGELCDALSRVSSTVLLLNAEGDHFSIGRPPQSYSAAPETWMKG
YYLVMRANELLMGFPGVTIAAVQGHARGAGCSLAGRCDLVLAAETATFSFPELRAGVPPVIVASYYSRKLPWHAFLRLAL
TGQEVSAAEACRLALVTEVVPDHELFQRARELADDLAKIDAGALATLKHFLLSSESASTPQANRLAYAALLETLASRV
>Mature_238_residues
MNNHFPYQKIRIQQENNVTVLTLADPDTHNALSNELLGELCDALSRVSSTVLLLNAEGDHFSIGRPPQSYSAAPETWMKG
YYLVMRANELLMGFPGVTIAAVQGHARGAGCSLAGRCDLVLAAETATFSFPELRAGVPPVIVASYYSRKLPWHAFLRLAL
TGQEVSAAEACRLALVTEVVPDHELFQRARELADDLAKIDAGALATLKHFLLSSESASTPQANRLAYAALLETLASRV

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI45643119, Length=219, Percent_Identity=28.310502283105, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI260275230, Length=219, Percent_Identity=28.310502283105, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI260274832, Length=219, Percent_Identity=28.310502283105, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI31542718, Length=234, Percent_Identity=26.0683760683761, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI194097323, Length=231, Percent_Identity=25.5411255411255, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787659, Length=219, Percent_Identity=28.310502283105, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI221142681, Length=150, Percent_Identity=32.6666666666667, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17549921, Length=214, Percent_Identity=26.6355140186916, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25145438, Length=227, Percent_Identity=29.5154185022026, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20129971, Length=208, Percent_Identity=30.2884615384615, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24653477, Length=208, Percent_Identity=30.2884615384615, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19922422, Length=237, Percent_Identity=26.1603375527426, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 25762; Mature: 25762

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNHFPYQKIRIQQENNVTVLTLADPDTHNALSNELLGELCDALSRVSSTVLLLNAEGDH
CCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCE
FSIGRPPQSYSAAPETWMKGYYLVMRANELLMGFPGVTIAAVQGHARGAGCSLAGRCDLV
EECCCCCCCCCCCCHHHHCCEEEEEEECHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEE
LAAETATFSFPELRAGVPPVIVASYYSRKLPWHAFLRLALTGQEVSAAEACRLALVTEVV
EEECCCCCCCHHHHCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
PDHELFQRARELADDLAKIDAGALATLKHFLLSSESASTPQANRLAYAALLETLASRV
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNNHFPYQKIRIQQENNVTVLTLADPDTHNALSNELLGELCDALSRVSSTVLLLNAEGDH
CCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCE
FSIGRPPQSYSAAPETWMKGYYLVMRANELLMGFPGVTIAAVQGHARGAGCSLAGRCDLV
EECCCCCCCCCCCCHHHHCCEEEEEEECHHHCCCCCCEEEEECCCCCCCCCCCCCCCCEE
LAAETATFSFPELRAGVPPVIVASYYSRKLPWHAFLRLALTGQEVSAAEACRLALVTEVV
EEECCCCCCCHHHHCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
PDHELFQRARELADDLAKIDAGALATLKHFLLSSESASTPQANRLAYAALLETLASRV
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]