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The map label for this gene is serA [H]

Identifier: 221633825

GI number: 221633825

Start: 1863994

End: 1864995

Strand: Reverse

Name: serA [H]

Synonym: trd_1852

Alternate gene names: 221633825

Gene position: 1864995-1863994 (Counterclockwise)

Preceding gene: 221633827

Following gene: 221633824

Centisome position: 93.11

GC content: 63.37

Gene sequence:

>1002_bases
ATGAGCGGAAGGGAACAGCAGCCGACAATGGGGAAGGATGTTCTGGTTCTGACGTGGAAGTATTTCTCGGCGCGCGAGGA
GATCGCGCGTTTTCTCGAAGAGCGCGGTTGCCGTTTCGTCGAGAAGGAGATTCGCTATCCGGTCGACGAGGAGCAGCTGT
GCGAGTTGGTCCGTGACGTCGACGGCTTGGTCGTGGGACTCGAGCCGATCACGGCACGCGTCCTCGCCCACGCGAACCGG
CTCAAGGTGATCAGCACGAGCGGCGTCGGCTTCGACAACATCGACGTTGCCGAGGCGACCCGGCGCGGCATCGTCGTCGC
CAACTGCCACGGTGCCAACGAGCATTCGGTCGCCGAACTCGCCTTCGGGCTCATGCTCGCGCTGGCGCGTGGGATCCATC
GCTCGGACCGACTGATGCGCGAGGGTCGCTGGGAGCCCTATTTCGGGGTAGAGTTGTGGGGAAAGACGCTCGGCGTCATC
GGTCTGGGTCGGGCTGGCCGCGCGGTCGCACTGCTCGGTCGCGGGTTCGGGATGCGCGTCCTTGCACACGATATCGTTTG
GGATACCACGTTCGCCAATGCCCACGAGATCAGCTATGTCCCACTCGAGAAGCTCCTCCGCGAGTCGGACTTCGTCTCGC
TCCATGTCCCGCTCACTCCGGATACCCGGTACCTGATCGACGAGCGAGCCCTCTCGCTCATGAAGCCGACCGCCTTCCTC
ATCAACCTGGCCCGCGGCCCGGTCGTCAAGCAATCGGCACTGGTCGAGGCTCTGCGCCGCGGTCAGATCGCTGGGGCCGG
TCTGGACGTCTTCGAGGTCGAGCCGATTCGCGATAATCCGTTCGTCGAGTTCGAGAATGTCGTCATGACGCCGCACCTCG
GCGGCTCGACCGAGGAGGCACGCGAGCGGACACTCTATCTCGCTTTGACGAACGTCTGCAACGTGTTGAACGGACGACCA
CCGCACCATCAGGTCAATACGGACGTTCGTATCGGCAACTGA

Upstream 100 bases:

>100_bases
GTTCTCTCAACTTGCTCAAGCGTACTCCCCAGCGAGGCCAGCGTCAAATCGAGTCGTTTCGCGTAGAATAGCGCGGGTGT
GCCGACGGAAGTGCTGTCCG

Downstream 100 bases:

>100_bases
GGAGGCAGGGATGCTGCGCGACGAGCAGAAATCGTTCTTGCTGCGGTTGCTGGAGGCCCCCAGCCCCTCCGGTTTCGAGG
AAGCGGCAGCGCGCATCTGG

Product: glyoxylate reductase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MSGREQQPTMGKDVLVLTWKYFSAREEIARFLEERGCRFVEKEIRYPVDEEQLCELVRDVDGLVVGLEPITARVLAHANR
LKVISTSGVGFDNIDVAEATRRGIVVANCHGANEHSVAELAFGLMLALARGIHRSDRLMREGRWEPYFGVELWGKTLGVI
GLGRAGRAVALLGRGFGMRVLAHDIVWDTTFANAHEISYVPLEKLLRESDFVSLHVPLTPDTRYLIDERALSLMKPTAFL
INLARGPVVKQSALVEALRRGQIAGAGLDVFEVEPIRDNPFVEFENVVMTPHLGGSTEEARERTLYLALTNVCNVLNGRP
PHHQVNTDVRIGN

Sequences:

>Translated_333_residues
MSGREQQPTMGKDVLVLTWKYFSAREEIARFLEERGCRFVEKEIRYPVDEEQLCELVRDVDGLVVGLEPITARVLAHANR
LKVISTSGVGFDNIDVAEATRRGIVVANCHGANEHSVAELAFGLMLALARGIHRSDRLMREGRWEPYFGVELWGKTLGVI
GLGRAGRAVALLGRGFGMRVLAHDIVWDTTFANAHEISYVPLEKLLRESDFVSLHVPLTPDTRYLIDERALSLMKPTAFL
INLARGPVVKQSALVEALRRGQIAGAGLDVFEVEPIRDNPFVEFENVVMTPHLGGSTEEARERTLYLALTNVCNVLNGRP
PHHQVNTDVRIGN
>Mature_332_residues
SGREQQPTMGKDVLVLTWKYFSAREEIARFLEERGCRFVEKEIRYPVDEEQLCELVRDVDGLVVGLEPITARVLAHANRL
KVISTSGVGFDNIDVAEATRRGIVVANCHGANEHSVAELAFGLMLALARGIHRSDRLMREGRWEPYFGVELWGKTLGVIG
LGRAGRAVALLGRGFGMRVLAHDIVWDTTFANAHEISYVPLEKLLRESDFVSLHVPLTPDTRYLIDERALSLMKPTAFLI
NLARGPVVKQSALVEALRRGQIAGAGLDVFEVEPIRDNPFVEFENVVMTPHLGGSTEEARERTLYLALTNVCNVLNGRPP
HHQVNTDVRIGN

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=277, Percent_Identity=39.7111913357401, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI6912396, Length=293, Percent_Identity=34.1296928327645, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI61743967, Length=253, Percent_Identity=35.1778656126482, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI4557497, Length=253, Percent_Identity=35.1778656126482, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI145580578, Length=253, Percent_Identity=33.9920948616601, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI4557499, Length=253, Percent_Identity=33.9920948616601, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI145580575, Length=253, Percent_Identity=33.9920948616601, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1789279, Length=266, Percent_Identity=39.0977443609023, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI87082289, Length=290, Percent_Identity=35.1724137931034, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1787645, Length=296, Percent_Identity=32.7702702702703, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1788660, Length=250, Percent_Identity=29.2, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081824, Length=173, Percent_Identity=31.2138728323699, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=282, Percent_Identity=35.8156028368794, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI25147481, Length=273, Percent_Identity=30.03663003663, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=288, Percent_Identity=35.4166666666667, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6322116, Length=269, Percent_Identity=35.3159851301115, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324055, Length=249, Percent_Identity=32.9317269076305, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=324, Percent_Identity=28.0864197530864, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321253, Length=175, Percent_Identity=32.5714285714286, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=122, Percent_Identity=33.6065573770492, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921140, Length=300, Percent_Identity=38, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI45551003, Length=304, Percent_Identity=35.1973684210526, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI45552429, Length=304, Percent_Identity=35.1973684210526, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24585514, Length=304, Percent_Identity=35.1973684210526, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI28574282, Length=304, Percent_Identity=35.1973684210526, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI28574284, Length=304, Percent_Identity=35.1973684210526, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24585516, Length=282, Percent_Identity=30.4964539007092, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28574286, Length=300, Percent_Identity=32.6666666666667, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI28571528, Length=300, Percent_Identity=32.3333333333333, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24646446, Length=269, Percent_Identity=33.457249070632, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646448, Length=269, Percent_Identity=33.457249070632, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646452, Length=269, Percent_Identity=33.457249070632, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646450, Length=269, Percent_Identity=33.457249070632, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI62472511, Length=264, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=7e-28,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 37082; Mature: 36951

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGREQQPTMGKDVLVLTWKYFSAREEIARFLEERGCRFVEKEIRYPVDEEQLCELVRDV
CCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHCC
DGLVVGLEPITARVLAHANRLKVISTSGVGFDNIDVAEATRRGIVVANCHGANEHSVAEL
CCEEECCHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHCCEEEEECCCCCCHHHHHH
AFGLMLALARGIHRSDRLMREGRWEPYFGVELWGKTLGVIGLGRAGRAVALLGRGFGMRV
HHHHHHHHHHCCCHHHHHHHHCCCCCEECHHHHCCHHCEEEECCCCCEEEEECCCCCHHH
LAHDIVWDTTFANAHEISYVPLEKLLRESDFVSLHVPLTPDTRYLIDERALSLMKPTAFL
HHHHHHHCCCCCCCCCEEECCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCHHHH
INLARGPVVKQSALVEALRRGQIAGAGLDVFEVEPIRDNPFVEFENVVMTPHLGGSTEEA
HHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCEEECCEEEECCCCCCCHHH
RERTLYLALTNVCNVLNGRPPHHQVNTDVRIGN
HHHHHEEHHHHHHHHHCCCCCCCCCCCCEEECC
>Mature Secondary Structure 
SGREQQPTMGKDVLVLTWKYFSAREEIARFLEERGCRFVEKEIRYPVDEEQLCELVRDV
CCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHCC
DGLVVGLEPITARVLAHANRLKVISTSGVGFDNIDVAEATRRGIVVANCHGANEHSVAEL
CCEEECCHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHCCEEEEECCCCCCHHHHHH
AFGLMLALARGIHRSDRLMREGRWEPYFGVELWGKTLGVIGLGRAGRAVALLGRGFGMRV
HHHHHHHHHHCCCHHHHHHHHCCCCCEECHHHHCCHHCEEEECCCCCEEEEECCCCCHHH
LAHDIVWDTTFANAHEISYVPLEKLLRESDFVSLHVPLTPDTRYLIDERALSLMKPTAFL
HHHHHHHCCCCCCCCCEEECCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCHHHH
INLARGPVVKQSALVEALRRGQIAGAGLDVFEVEPIRDNPFVEFENVVMTPHLGGSTEEA
HHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCEEECCEEEECCCCCCCHHH
RERTLYLALTNVCNVLNGRPPHHQVNTDVRIGN
HHHHHEEHHHHHHHHHCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]