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The map label for this gene is coxL [H]

Identifier: 221633820

GI number: 221633820

Start: 1856205

End: 1858532

Strand: Reverse

Name: coxL [H]

Synonym: trd_1847

Alternate gene names: 221633820

Gene position: 1858532-1856205 (Counterclockwise)

Preceding gene: 221633821

Following gene: 221633814

Centisome position: 92.79

GC content: 65.29

Gene sequence:

>2328_bases
ATGGTCATCAGTCATTATGTCGGTGCGCGAGTGCGGCGCAAGGAGGATCCGCGCCTCATCACCGGCTCCTCGCAATACGT
CGACGATCTCAAGCTGCCAGGCATGCTGCACGTCGCCTTCGTCCGCAGCAGTTATCCACACGCCCGGATCCGCGGTATCG
ACGCCTCCGCCGCCAAGGCTATGCCAGGCGTCGTCGATGTCTTCACTGGTCGCGATCTGGCAGCGCGTCTCAAGGGGAAG
CCAGAACTCATCCCCGGGGAGGCACCGCATCCTGAAGAGCAGAAACCGGAAGGGATCCCGGTTCCCCCGGAAGAGCCGAT
CGCGGTCGAACGCGCCCTCTATGTCGGCCAACCCATCGCCGTCGTCGTCGCCACGTCAGCGGCAGTCGCTCGCGATGCGG
CTGAAGCGGTCGTGGTCGACTACGAACCCCTTCCCGCCATCATCGATCCAGAGGTGGCGATGCAGGACGGCGCTCCGCAA
CTCTATCCGAATATCCCCAACAACATCGGGGAGCGCTGGGAGCGCGTCCACGGCGACATCGAGGCAGCCTTCGCTCAGGC
CCACGTCGTCGTCAGGCAACGCTTCCGCCAGCAGCGTTTGGCCGGTATCCCGATGGAGACGCGCGCCATCGTCGCGGCCC
CTGACCCCTTGACGCAAGGCGTCACGGTCTGGAGTTCCACCCAGGCACCGCACTGGAACCGGAACGCGCTCGCGGCGGCG
CTCGGGCTGGCACACGGCCAGGTTCGCATCATCGCTCCGGAAGTCGGGGGCGGCTTCGGAGTCAAGATCGGCGCGTACCA
GGAAGACTTCATTCTCGCCGCGCTGGCCTTGCACCTCCATCGCCCGGTCAAGTGGGTCGAGACACGTTCCGAGCATCTCA
TGGCCACCAACCACGGCCGCGATCAGGTGGTGGACTACGAACTCGCCGCCGATGCTGAGGGACGCATCCTCGGATTGCGT
GCCCGCATCGTCCAGAATCTCGGTGCCTACCCGCGTGGGCTCTATCTCCCCTCGACGACCGGTCTCATGGCCTGCGGCTG
CTACGACATCCCGGCTGTGGATATCAAAGCGTACGGCGTCTACACCAACACGATGGCAGTCGGCGCCTACCGCGGCGCTG
GTCGACCCGAGGCAGCCTACTACATCGAACGGATGATGGACCTCTTGGCCCGCAAGCTCGGCAAGGATCCCGCTGAGGTC
CGGCGCCTGAACTACATCCCACCAGAGAAGTTCCCCTACACGACTGCAGCCGGTGAGAAGTACGATACGGGCGACTACGC
CAAAGCACTCGACAAGGCTCTCGAGATCTCGAGATATCACGAGTGGCGCCAGAAGCAGCAGGAACTCCGCCAGCAGGGTC
GCTTCGTCGGGGTTGGTCTCGCCAGCTACGTGGAGATCTGCGGCTTCGGCCCCTACGAGAGCGCAGTCGTCCGCGTCGAG
CCGAGCGGCGCGGTCACCGTCTATACCGGTACCTCGCCGCACGGTCAGGGGCTGGAGACGGCACTGGCCCAGCTCGTCGC
CGATCGCCTCGGAGCCGATTTCGACCAGATCGTCGTGCTGCACGGTGATACGCAAAGCGTCCCCGAGGGGCATGGCACGA
TGGGGAGCCGCAGCCTGGTCGTCGGCGGCGGCGCGGTCCTCATGGCCATCGACCGCATCAAGGAGAAGGCCACGCAGATC
GCCGCGCACCTGCTCGAAGCGGCGGCAGAGGACATCGAATTCGTCGACGGGAAATGGCGCGTCAAGGGTGCTCCTGACCG
CGCCGTCACGCTGGCCGAGATCGCCCAGGCGGCCTATGGCGGTAATCTCCCGGAGGGGATGGAACCAGGGCTGGTCGCGA
CCGACTTCTTTGCACCCCCTGACGAGGTCTTCCCCTTCGGGACGCATGTGGCAGTGGTCGAAGTCTTCCCCGAGACAGGC
GAGGTTGAGATCCTCGAGTACTACTCGGTCGATGACTGTGGCCCCCGCATCAACCCGCTCCTCGTCGAGGGCCAGGTGCA
CGGTGGCTTGGCCCAGGGGATCGCCCAGGCCCTCTGGGAAGAGGTCCGCTACGACGAGAACGGCCAGCTCCTCACCGGCA
CGCTCATGGACTACGCCATGCCCAAGGCGGCGATGTTGCTTTCCTTCACCACCGACCACACCGAGACGCCAACTCCGCTC
AACCCGCTCGGTGCCAAGGGGATCGGTGAGGCGGCGACGATCGGTTCCACCCCGACCATCGCCAACGCGGTCATGGATGC
CCTAGCTCCCTTCGGGATCGAGCACCTCGACATCCCGCTCACCCCGCAGAAGATCTGGCAAGCGATCCAACGGGCCAAGC
AAGCCTGA

Upstream 100 bases:

>100_bases
TTTCCTTTTCCCCTTGACGACAGTGTCAAACACGTTCACGCTAGTTTGTGGACAGGGCCACCGGACCTCGCGTTGGTACA
AAACGGAAAGGAGTTGTCTC

Downstream 100 bases:

>100_bases
CCGATGAACGCGATGACCGACCGGCAGCACCCACCGGTAGGTGCTGCCGGTCTTGCTTTTCCTCGCCGGAACCGCGACGA
CGTGCCGCCACGCGGCAGTT

Product: carbon monoxide dehydrogenase large chain

Products: NA

Alternate protein names: CO dehydrogenase subunit L; CO-DH L [H]

Number of amino acids: Translated: 775; Mature: 775

Protein sequence:

>775_residues
MVISHYVGARVRRKEDPRLITGSSQYVDDLKLPGMLHVAFVRSSYPHARIRGIDASAAKAMPGVVDVFTGRDLAARLKGK
PELIPGEAPHPEEQKPEGIPVPPEEPIAVERALYVGQPIAVVVATSAAVARDAAEAVVVDYEPLPAIIDPEVAMQDGAPQ
LYPNIPNNIGERWERVHGDIEAAFAQAHVVVRQRFRQQRLAGIPMETRAIVAAPDPLTQGVTVWSSTQAPHWNRNALAAA
LGLAHGQVRIIAPEVGGGFGVKIGAYQEDFILAALALHLHRPVKWVETRSEHLMATNHGRDQVVDYELAADAEGRILGLR
ARIVQNLGAYPRGLYLPSTTGLMACGCYDIPAVDIKAYGVYTNTMAVGAYRGAGRPEAAYYIERMMDLLARKLGKDPAEV
RRLNYIPPEKFPYTTAAGEKYDTGDYAKALDKALEISRYHEWRQKQQELRQQGRFVGVGLASYVEICGFGPYESAVVRVE
PSGAVTVYTGTSPHGQGLETALAQLVADRLGADFDQIVVLHGDTQSVPEGHGTMGSRSLVVGGGAVLMAIDRIKEKATQI
AAHLLEAAAEDIEFVDGKWRVKGAPDRAVTLAEIAQAAYGGNLPEGMEPGLVATDFFAPPDEVFPFGTHVAVVEVFPETG
EVEILEYYSVDDCGPRINPLLVEGQVHGGLAQGIAQALWEEVRYDENGQLLTGTLMDYAMPKAAMLLSFTTDHTETPTPL
NPLGAKGIGEAATIGSTPTIANAVMDALAPFGIEHLDIPLTPQKIWQAIQRAKQA

Sequences:

>Translated_775_residues
MVISHYVGARVRRKEDPRLITGSSQYVDDLKLPGMLHVAFVRSSYPHARIRGIDASAAKAMPGVVDVFTGRDLAARLKGK
PELIPGEAPHPEEQKPEGIPVPPEEPIAVERALYVGQPIAVVVATSAAVARDAAEAVVVDYEPLPAIIDPEVAMQDGAPQ
LYPNIPNNIGERWERVHGDIEAAFAQAHVVVRQRFRQQRLAGIPMETRAIVAAPDPLTQGVTVWSSTQAPHWNRNALAAA
LGLAHGQVRIIAPEVGGGFGVKIGAYQEDFILAALALHLHRPVKWVETRSEHLMATNHGRDQVVDYELAADAEGRILGLR
ARIVQNLGAYPRGLYLPSTTGLMACGCYDIPAVDIKAYGVYTNTMAVGAYRGAGRPEAAYYIERMMDLLARKLGKDPAEV
RRLNYIPPEKFPYTTAAGEKYDTGDYAKALDKALEISRYHEWRQKQQELRQQGRFVGVGLASYVEICGFGPYESAVVRVE
PSGAVTVYTGTSPHGQGLETALAQLVADRLGADFDQIVVLHGDTQSVPEGHGTMGSRSLVVGGGAVLMAIDRIKEKATQI
AAHLLEAAAEDIEFVDGKWRVKGAPDRAVTLAEIAQAAYGGNLPEGMEPGLVATDFFAPPDEVFPFGTHVAVVEVFPETG
EVEILEYYSVDDCGPRINPLLVEGQVHGGLAQGIAQALWEEVRYDENGQLLTGTLMDYAMPKAAMLLSFTTDHTETPTPL
NPLGAKGIGEAATIGSTPTIANAVMDALAPFGIEHLDIPLTPQKIWQAIQRAKQA
>Mature_775_residues
MVISHYVGARVRRKEDPRLITGSSQYVDDLKLPGMLHVAFVRSSYPHARIRGIDASAAKAMPGVVDVFTGRDLAARLKGK
PELIPGEAPHPEEQKPEGIPVPPEEPIAVERALYVGQPIAVVVATSAAVARDAAEAVVVDYEPLPAIIDPEVAMQDGAPQ
LYPNIPNNIGERWERVHGDIEAAFAQAHVVVRQRFRQQRLAGIPMETRAIVAAPDPLTQGVTVWSSTQAPHWNRNALAAA
LGLAHGQVRIIAPEVGGGFGVKIGAYQEDFILAALALHLHRPVKWVETRSEHLMATNHGRDQVVDYELAADAEGRILGLR
ARIVQNLGAYPRGLYLPSTTGLMACGCYDIPAVDIKAYGVYTNTMAVGAYRGAGRPEAAYYIERMMDLLARKLGKDPAEV
RRLNYIPPEKFPYTTAAGEKYDTGDYAKALDKALEISRYHEWRQKQQELRQQGRFVGVGLASYVEICGFGPYESAVVRVE
PSGAVTVYTGTSPHGQGLETALAQLVADRLGADFDQIVVLHGDTQSVPEGHGTMGSRSLVVGGGAVLMAIDRIKEKATQI
AAHLLEAAAEDIEFVDGKWRVKGAPDRAVTLAEIAQAAYGGNLPEGMEPGLVATDFFAPPDEVFPFGTHVAVVEVFPETG
EVEILEYYSVDDCGPRINPLLVEGQVHGGLAQGIAQALWEEVRYDENGQLLTGTLMDYAMPKAAMLLSFTTDHTETPTPL
NPLGAKGIGEAATIGSTPTIANAVMDALAPFGIEHLDIPLTPQKIWQAIQRAKQA

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI71773480, Length=778, Percent_Identity=25.8354755784062, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI91823271, Length=780, Percent_Identity=24.6153846153846, Blast_Score=151, Evalue=2e-36,
Organism=Escherichia coli, GI1789230, Length=778, Percent_Identity=28.7917737789203, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI1789246, Length=813, Percent_Identity=26.8142681426814, Blast_Score=233, Evalue=4e-62,
Organism=Escherichia coli, GI1786478, Length=768, Percent_Identity=27.0833333333333, Blast_Score=133, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17539860, Length=760, Percent_Identity=23.6842105263158, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17540638, Length=793, Percent_Identity=24.2118537200504, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI32566215, Length=596, Percent_Identity=23.993288590604, Blast_Score=118, Evalue=9e-27,
Organism=Drosophila melanogaster, GI17737937, Length=747, Percent_Identity=27.041499330656, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24647199, Length=741, Percent_Identity=26.5856950067476, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24647201, Length=780, Percent_Identity=24.2307692307692, Blast_Score=137, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24647193, Length=795, Percent_Identity=23.7735849056604, Blast_Score=135, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24647195, Length=779, Percent_Identity=23.4916559691913, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24647197, Length=770, Percent_Identity=23.5064935064935, Blast_Score=111, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012780 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 83639; Mature: 83639

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVISHYVGARVRRKEDPRLITGSSQYVDDLKLPGMLHVAFVRSSYPHARIRGIDASAAKA
CEECCCCCCHHHCCCCCCEEECCHHHHHHCCCCCCEEEEEHHCCCCCCEEECCCCHHHHC
MPGVVDVFTGRDLAARLKGKPELIPGEAPHPEEQKPEGIPVPPEEPIAVERALYVGQPIA
CCCEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEE
VVVATSAAVARDAAEAVVVDYEPLPAIIDPEVAMQDGAPQLYPNIPNNIGERWERVHGDI
EEEECHHHHHHHCCCEEEEECCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHCHH
EAAFAQAHVVVRQRFRQQRLAGIPMETRAIVAAPDPLTQGVTVWSSTQAPHWNRNALAAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCEEEEECCCCCCCCHHHHHHH
LGLAHGQVRIIAPEVGGGFGVKIGAYQEDFILAALALHLHRPVKWVETRSEHLMATNHGR
HHHCCCEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCC
DQVVDYELAADAEGRILGLRARIVQNLGAYPRGLYLPSTTGLMACGCYDIPAVDIKAYGV
CCEEEEEECCCCCCCEEHHHHHHHHHCCCCCCCEECCCCCCEEEECCCCCCCEEEEEEEE
YTNTMAVGAYRGAGRPEAAYYIERMMDLLARKLGKDPAEVRRLNYIPPEKFPYTTAAGEK
EECEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCC
YDTGDYAKALDKALEISRYHEWRQKQQELRQQGRFVGVGLASYVEICGFGPYESAVVRVE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCCCCCCEEEEC
PSGAVTVYTGTSPHGQGLETALAQLVADRLGADFDQIVVLHGDTQSVPEGHGTMGSRSLV
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCEEE
VGGGAVLMAIDRIKEKATQIAAHLLEAAAEDIEFVDGKWRVKGAPDRAVTLAEIAQAAYG
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHC
GNLPEGMEPGLVATDFFAPPDEVFPFGTHVAVVEVFPETGEVEILEYYSVDDCGPRINPL
CCCCCCCCCCCEEECCCCCCHHCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCE
LVEGQVHGGLAQGIAQALWEEVRYDENGQLLTGTLMDYAMPKAAMLLSFTTDHTETPTPL
EEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHCCCCEEEEEEECCCCCCCCCC
NPLGAKGIGEAATIGSTPTIANAVMDALAPFGIEHLDIPLTPQKIWQAIQRAKQA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MVISHYVGARVRRKEDPRLITGSSQYVDDLKLPGMLHVAFVRSSYPHARIRGIDASAAKA
CEECCCCCCHHHCCCCCCEEECCHHHHHHCCCCCCEEEEEHHCCCCCCEEECCCCHHHHC
MPGVVDVFTGRDLAARLKGKPELIPGEAPHPEEQKPEGIPVPPEEPIAVERALYVGQPIA
CCCEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEE
VVVATSAAVARDAAEAVVVDYEPLPAIIDPEVAMQDGAPQLYPNIPNNIGERWERVHGDI
EEEECHHHHHHHCCCEEEEECCCCCCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHCHH
EAAFAQAHVVVRQRFRQQRLAGIPMETRAIVAAPDPLTQGVTVWSSTQAPHWNRNALAAA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCEEEEECCCCCCCCHHHHHHH
LGLAHGQVRIIAPEVGGGFGVKIGAYQEDFILAALALHLHRPVKWVETRSEHLMATNHGR
HHHCCCEEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCC
DQVVDYELAADAEGRILGLRARIVQNLGAYPRGLYLPSTTGLMACGCYDIPAVDIKAYGV
CCEEEEEECCCCCCCEEHHHHHHHHHCCCCCCCEECCCCCCEEEECCCCCCCEEEEEEEE
YTNTMAVGAYRGAGRPEAAYYIERMMDLLARKLGKDPAEVRRLNYIPPEKFPYTTAAGEK
EECEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCC
YDTGDYAKALDKALEISRYHEWRQKQQELRQQGRFVGVGLASYVEICGFGPYESAVVRVE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCCCCCCEEEEC
PSGAVTVYTGTSPHGQGLETALAQLVADRLGADFDQIVVLHGDTQSVPEGHGTMGSRSLV
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCEEE
VGGGAVLMAIDRIKEKATQIAAHLLEAAAEDIEFVDGKWRVKGAPDRAVTLAEIAQAAYG
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHC
GNLPEGMEPGLVATDFFAPPDEVFPFGTHVAVVEVFPETGEVEILEYYSVDDCGPRINPL
CCCCCCCCCCCEEECCCCCCHHCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCE
LVEGQVHGGLAQGIAQALWEEVRYDENGQLLTGTLMDYAMPKAAMLLSFTTDHTETPTPL
EEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHCCCCEEEEEEECCCCCCCCCC
NPLGAKGIGEAATIGSTPTIANAVMDALAPFGIEHLDIPLTPQKIWQAIQRAKQA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721710; 2818128; 12515558; 10430865; 12475995 [H]