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The map label for this gene is lysA [H]

Identifier: 221633687

GI number: 221633687

Start: 1717928

End: 1719277

Strand: Reverse

Name: lysA [H]

Synonym: trd_1714

Alternate gene names: 221633687

Gene position: 1719277-1717928 (Counterclockwise)

Preceding gene: 221633692

Following gene: 221633686

Centisome position: 85.83

GC content: 64.89

Gene sequence:

>1350_bases
ATGTGCGGTTTCGTGGCCGAACGAGCGCATATCTTGCCGGAAACGGCGCGGCGTGACGAGTCTGGCCAGCTGTGGACCGG
GGGTGTTCCGCTGCCCCGACTCGCGGAGCAGTACGGCACCCCGCTCTACCTGTACGATGTCGCGACGATCCGCGCTGCCA
TCGCGGCGTACCGGCACGGCCTGGAGAGCTATCCAGGGGAGACTGCTCTCGTCTATGCGGCCAAAGCCTTTGCTGCGGTG
GGGCTGCTCCGCTTGCTGGCGAGCGAGGGGCTCGGCGTGGACTGTGTCTCCGAGGGGGAACTCGCGTTGGCACGAGCAGC
CGGTGTCCCCGCCGAGCGACTGGTGTTGCACGGCAACAACAAGTCGGAGGAAGAGCTCCGCTTCGCGCTCGAACTGGGAG
TTGGGCGGATCGTGGTCGATAACCACGATGAGCTCGAGCGGTTGGTAGCGATCGCCCGGAGTACTGGAAAGACTGTTCCG
ATTCTCCTGCGCCTGAATCCGGGGGTCGAACCACACGATACCCACGCTTATCGGCGCACCGGCCAACTCGATTCCAAGTT
CGGTCTGCCCATCGTCACTGGGGACGCGGAGGCAGCAGTCGCGCGCTGCCTCTCGACACCGGAACTCGCACTGCTCGGGT
TCCATGTCCATATCGGCTCGCAGTTGTTCGATCTCATCCCCTACCAGCGAGCGATCGAGCAGGTCTTCGCTTTCGCGGGT
GAGCTCTCCCGGCGATTCGCTTTCTCCCTTCGCGAATTCTCGCCAGGTGGTGGCTTCGGGATTCCCTACACGACCGAAGA
CCCGGTCCTGGATCTGGCCGAGGCGACAGCGCAGGTCAGCCGATGGGTGGCGGAAGCAGCGAGCATGGCCGGGTTGCCGC
TCCCCCGCCTCGTGCTCGAGCCGGGCCGCTCGCTGGTCGGACGTGCTGGCATGGCGCTCTACCGGGTGGGGAGTGTCAAG
CGTCTTCCCGGGATCCGCACCTACGTGGCAGTGGACGGTGGGATGGCGGACAATATCCGGCCGGCGCTGTATGGGGCGCG
CTATCTCGCACTTCCGGTCATCGAGCGAGCGGATCGACGTCGCGAGCGTGTCACCCTGGTGGGCAAGTATTGCGAGTCGG
GCGATGTATTGGTGAGGGACGCGGTGCTTCCGGAACCGGTTCCGGGGGATCTGGTGGCCATTCCCGTGGCTGGAGCGTAC
TGCTTGGCGATGGCGAGCAATTACAACCTCGCTCGCCGACCAGTTGTGGTCGCGTTGGAGGCGGGAAGAGTGGAACTCTG
GCAGCGTCGGGAAACGATCGCCGATCTTTTGGCACGGGAAGCGGGAATCGAAGGGGCGCGATACCGTTGA

Upstream 100 bases:

>100_bases
GATCGCGTCTTTCCCATCTGCTGGCGCCGAAAACCTTGGCGCGCTTCCAAAATGGCAACTATACTCACCGCCGTGCCCAC
TGTGGCCCGAAAGGTTGGAC

Downstream 100 bases:

>100_bases
ATTTTGCTCTGCTCCGTAGTATTACTGGGATGCCGCACGAGCAGGCGCTGGTTTCCTCGAAGGCCGTGAGGAGTGCGCGC
GGTGACCAAGGCGGAACGGC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MCGFVAERAHILPETARRDESGQLWTGGVPLPRLAEQYGTPLYLYDVATIRAAIAAYRHGLESYPGETALVYAAKAFAAV
GLLRLLASEGLGVDCVSEGELALARAAGVPAERLVLHGNNKSEEELRFALELGVGRIVVDNHDELERLVAIARSTGKTVP
ILLRLNPGVEPHDTHAYRRTGQLDSKFGLPIVTGDAEAAVARCLSTPELALLGFHVHIGSQLFDLIPYQRAIEQVFAFAG
ELSRRFAFSLREFSPGGGFGIPYTTEDPVLDLAEATAQVSRWVAEAASMAGLPLPRLVLEPGRSLVGRAGMALYRVGSVK
RLPGIRTYVAVDGGMADNIRPALYGARYLALPVIERADRRRERVTLVGKYCESGDVLVRDAVLPEPVPGDLVAIPVAGAY
CLAMASNYNLARRPVVVALEAGRVELWQRRETIADLLAREAGIEGARYR

Sequences:

>Translated_449_residues
MCGFVAERAHILPETARRDESGQLWTGGVPLPRLAEQYGTPLYLYDVATIRAAIAAYRHGLESYPGETALVYAAKAFAAV
GLLRLLASEGLGVDCVSEGELALARAAGVPAERLVLHGNNKSEEELRFALELGVGRIVVDNHDELERLVAIARSTGKTVP
ILLRLNPGVEPHDTHAYRRTGQLDSKFGLPIVTGDAEAAVARCLSTPELALLGFHVHIGSQLFDLIPYQRAIEQVFAFAG
ELSRRFAFSLREFSPGGGFGIPYTTEDPVLDLAEATAQVSRWVAEAASMAGLPLPRLVLEPGRSLVGRAGMALYRVGSVK
RLPGIRTYVAVDGGMADNIRPALYGARYLALPVIERADRRRERVTLVGKYCESGDVLVRDAVLPEPVPGDLVAIPVAGAY
CLAMASNYNLARRPVVVALEAGRVELWQRRETIADLLAREAGIEGARYR
>Mature_449_residues
MCGFVAERAHILPETARRDESGQLWTGGVPLPRLAEQYGTPLYLYDVATIRAAIAAYRHGLESYPGETALVYAAKAFAAV
GLLRLLASEGLGVDCVSEGELALARAAGVPAERLVLHGNNKSEEELRFALELGVGRIVVDNHDELERLVAIARSTGKTVP
ILLRLNPGVEPHDTHAYRRTGQLDSKFGLPIVTGDAEAAVARCLSTPELALLGFHVHIGSQLFDLIPYQRAIEQVFAFAG
ELSRRFAFSLREFSPGGGFGIPYTTEDPVLDLAEATAQVSRWVAEAASMAGLPLPRLVLEPGRSLVGRAGMALYRVGSVK
RLPGIRTYVAVDGGMADNIRPALYGARYLALPVIERADRRRERVTLVGKYCESGDVLVRDAVLPEPVPGDLVAIPVAGAY
CLAMASNYNLARRPVVVALEAGRVELWQRRETIADLLAREAGIEGARYR

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=377, Percent_Identity=25.9946949602122, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI22538418, Length=368, Percent_Identity=23.3695652173913, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI21361583, Length=368, Percent_Identity=23.3695652173913, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789203, Length=423, Percent_Identity=31.9148936170213, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17562780, Length=373, Percent_Identity=23.8605898123324, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 48551; Mature: 48551

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGFVAERAHILPETARRDESGQLWTGGVPLPRLAEQYGTPLYLYDVATIRAAIAAYRHG
CCCCHHHHHHHCCHHHCCCCCCCEEECCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHH
LESYPGETALVYAAKAFAAVGLLRLLASEGLGVDCVSEGELALARAAGVPAERLVLHGNN
HHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEHHHCCCCHHHEEEECCC
KSEEELRFALELGVGRIVVDNHDELERLVAIARSTGKTVPILLRLNPGVEPHDTHAYRRT
CCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHC
GQLDSKFGLPIVTGDAEAAVARCLSTPELALLGFHVHIGSQLFDLIPYQRAIEQVFAFAG
CCCCCCCCCEEEECCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHCCHHHHHHHHHHHHH
ELSRRFAFSLREFSPGGGFGIPYTTEDPVLDLAEATAQVSRWVAEAASMAGLPLPRLVLE
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHC
PGRSLVGRAGMALYRVGSVKRLPGIRTYVAVDGGMADNIRPALYGARYLALPVIERADRR
CCHHHHHHCCHHHHCCCCHHHCCCCEEEEEECCCCCCCCCHHHHCCHHHHHHHHHHHHHH
RERVTLVGKYCESGDVLVRDAVLPEPVPGDLVAIPVAGAYCLAMASNYNLARRPVVVALE
HHHEEHEEHHCCCCCEEEECCCCCCCCCCCEEEECCHHHHHHHHHCCCCCCCCCEEEEEE
AGRVELWQRRETIADLLAREAGIEGARYR
CCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MCGFVAERAHILPETARRDESGQLWTGGVPLPRLAEQYGTPLYLYDVATIRAAIAAYRHG
CCCCHHHHHHHCCHHHCCCCCCCEEECCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHH
LESYPGETALVYAAKAFAAVGLLRLLASEGLGVDCVSEGELALARAAGVPAERLVLHGNN
HHHCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEHHHCCCCHHHEEEECCC
KSEEELRFALELGVGRIVVDNHDELERLVAIARSTGKTVPILLRLNPGVEPHDTHAYRRT
CCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHC
GQLDSKFGLPIVTGDAEAAVARCLSTPELALLGFHVHIGSQLFDLIPYQRAIEQVFAFAG
CCCCCCCCCEEEECCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHCCHHHHHHHHHHHHH
ELSRRFAFSLREFSPGGGFGIPYTTEDPVLDLAEATAQVSRWVAEAASMAGLPLPRLVLE
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHC
PGRSLVGRAGMALYRVGSVKRLPGIRTYVAVDGGMADNIRPALYGARYLALPVIERADRR
CCHHHHHHCCHHHHCCCCHHHCCCCEEEEEECCCCCCCCCHHHHCCHHHHHHHHHHHHHH
RERVTLVGKYCESGDVLVRDAVLPEPVPGDLVAIPVAGAYCLAMASNYNLARRPVVVALE
HHHEEHEEHHCCCCCEEEECCCCCCCCCCCEEEECCHHHHHHHHHCCCCCCCCCEEEEEE
AGRVELWQRRETIADLLAREAGIEGARYR
CCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]