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The map label for this gene is thrB [H]

Identifier: 221633233

GI number: 221633233

Start: 1234976

End: 1235923

Strand: Reverse

Name: thrB [H]

Synonym: trd_1251

Alternate gene names: 221633233

Gene position: 1235923-1234976 (Counterclockwise)

Preceding gene: 221633234

Following gene: 221633232

Centisome position: 61.7

GC content: 65.72

Gene sequence:

>948_bases
GTGCGTTGTGAAGTGCGTGTTCCCGCTTCGAGTGCCAATCTCGGACCCGGTTTCGACGTGCTGGCGGTGGCCCTCGGCCG
CTATCTTTCGGCTCGCTACGAGCCGGACGAGACGATCGGCGAGCTTCGGGTAGTTGTTCGACCAGAACTCCACGGCGGGC
GCAACCTCGTCGCCGAGGCGATGCGCTATTACGCGTCATCGACTGGTCGATCGCTCCCTGGTGGCACGCTCACCGTTGAC
TCCGACATTCCCGTGGCTCGGGGGTTGGGGAGTTCGGCGGCAGCGATCGTAGCCGGATTAGTTCTCGCCAATGAGCTGTG
CGGGGAGCCGCTCGGGCGCTCGGAATTGTTCCGCATGGCGTGCGAGCTCGAGGGTCATGGCGACAACGTCGGTGCAGCGC
TCTTCGGTGGGGTCGTGCTCGCGGTCGTTGACGAGGAAGGGCCGCAGGCAGTTGCGGTACCGGTCGAGTTCCCGCTCGTG
GCGGTCGTTTTGGTACCAGATGCTCTCGGCTACACGAGCGATGCGCGTGCTGTCCTGCCGCGGCGGGTGCGCCGGGTCAC
TGCCGTGCGGACTGCAGCGCACACCGCGCTTTTGGTCCTGGCTCTGGCGACTGGGCAGCCGGACCTTTTGCGGACAGCAA
TGACCGACGAGCTCCATCAACCTTATCGCGCGGTCTTGTACCCGCATCTGGAGGAGGCAATCGATCGCGCACTGGTGGCT
GGCGCCTACGGCGCAGCGCTGTCCGGGGCGGGGCCATCGGTCCTCGCGTTCTGTTCTCCGGAGCGAGCGTCGGCGGTGCA
AAGGGCGTTTGCTGATCTCCTGGCGCGACGCGCGATGGATGGGGAAGCGCTCGTACTACCGATCGATCGGCAAGGTGCAC
AGATTCTCCGCGCCGACGAACGCGGTCCGGTGAGCGCGCCCGAAGCGATTTCCAGCCATCACGAGTAA

Upstream 100 bases:

>100_bases
GCAGTCTTGGCGTATCATCTCGGGGATCCTCCACGACCGCTTGCGAACCGGCCGGTGACGATCGCGCCCACCCTCGACGC
ACTGGCAGGAGTATTGGCTC

Downstream 100 bases:

>100_bases
GTAACCGCACGATTTGCTTCGTTCCTGGTTCATCTCTGTGAACGGAAGTGATCCCCCGTCTGGAGCCGCCTCGCCCGGCG
CTCGACGCGTTCGACGGCGA

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MRCEVRVPASSANLGPGFDVLAVALGRYLSARYEPDETIGELRVVVRPELHGGRNLVAEAMRYYASSTGRSLPGGTLTVD
SDIPVARGLGSSAAAIVAGLVLANELCGEPLGRSELFRMACELEGHGDNVGAALFGGVVLAVVDEEGPQAVAVPVEFPLV
AVVLVPDALGYTSDARAVLPRRVRRVTAVRTAAHTALLVLALATGQPDLLRTAMTDELHQPYRAVLYPHLEEAIDRALVA
GAYGAALSGAGPSVLAFCSPERASAVQRAFADLLARRAMDGEALVLPIDRQGAQILRADERGPVSAPEAISSHHE

Sequences:

>Translated_315_residues
MRCEVRVPASSANLGPGFDVLAVALGRYLSARYEPDETIGELRVVVRPELHGGRNLVAEAMRYYASSTGRSLPGGTLTVD
SDIPVARGLGSSAAAIVAGLVLANELCGEPLGRSELFRMACELEGHGDNVGAALFGGVVLAVVDEEGPQAVAVPVEFPLV
AVVLVPDALGYTSDARAVLPRRVRRVTAVRTAAHTALLVLALATGQPDLLRTAMTDELHQPYRAVLYPHLEEAIDRALVA
GAYGAALSGAGPSVLAFCSPERASAVQRAFADLLARRAMDGEALVLPIDRQGAQILRADERGPVSAPEAISSHHE
>Mature_315_residues
MRCEVRVPASSANLGPGFDVLAVALGRYLSARYEPDETIGELRVVVRPELHGGRNLVAEAMRYYASSTGRSLPGGTLTVD
SDIPVARGLGSSAAAIVAGLVLANELCGEPLGRSELFRMACELEGHGDNVGAALFGGVVLAVVDEEGPQAVAVPVEFPLV
AVVLVPDALGYTSDARAVLPRRVRRVTAVRTAAHTALLVLALATGQPDLLRTAMTDELHQPYRAVLYPHLEEAIDRALVA
GAYGAALSGAGPSVLAFCSPERASAVQRAFADLLARRAMDGEALVLPIDRQGAQILRADERGPVSAPEAISSHHE

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=312, Percent_Identity=31.0897435897436, Blast_Score=130, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321814, Length=351, Percent_Identity=28.7749287749288, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 32977; Mature: 32977

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCEVRVPASSANLGPGFDVLAVALGRYLSARYEPDETIGELRVVVRPELHGGRNLVAEA
CCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHEEEEECCCCCCCHHHHHHH
MRYYASSTGRSLPGGTLTVDSDIPVARGLGSSAAAIVAGLVLANELCGEPLGRSELFRMA
HHHHHHHCCCCCCCCEEEECCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
CELEGHGDNVGAALFGGVVLAVVDEEGPQAVAVPVEFPLVAVVLVPDALGYTSDARAVLP
HHCCCCCCCHHHHHHCCEEEEEEECCCCCEEEEECCCCEEEEEEECHHCCCCCCHHHHHH
RRVRRVTAVRTAAHTALLVLALATGQPDLLRTAMTDELHQPYRAVLYPHLEEAIDRALVA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
GAYGAALSGAGPSVLAFCSPERASAVQRAFADLLARRAMDGEALVLPIDRQGAQILRADE
HHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHEECCC
RGPVSAPEAISSHHE
CCCCCCCHHHHCCCC
>Mature Secondary Structure
MRCEVRVPASSANLGPGFDVLAVALGRYLSARYEPDETIGELRVVVRPELHGGRNLVAEA
CCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHEEEEECCCCCCCHHHHHHH
MRYYASSTGRSLPGGTLTVDSDIPVARGLGSSAAAIVAGLVLANELCGEPLGRSELFRMA
HHHHHHHCCCCCCCCEEEECCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
CELEGHGDNVGAALFGGVVLAVVDEEGPQAVAVPVEFPLVAVVLVPDALGYTSDARAVLP
HHCCCCCCCHHHHHHCCEEEEEEECCCCCEEEEECCCCEEEEEEECHHCCCCCCHHHHHH
RRVRRVTAVRTAAHTALLVLALATGQPDLLRTAMTDELHQPYRAVLYPHLEEAIDRALVA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
GAYGAALSGAGPSVLAFCSPERASAVQRAFADLLARRAMDGEALVLPIDRQGAQILRADE
HHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHEECCC
RGPVSAPEAISSHHE
CCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]