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The map label for this gene is thrC [H]

Identifier: 221633234

GI number: 221633234

Start: 1235913

End: 1237187

Strand: Reverse

Name: thrC [H]

Synonym: trd_1252

Alternate gene names: 221633234

Gene position: 1237187-1235913 (Counterclockwise)

Preceding gene: 221633235

Following gene: 221633233

Centisome position: 61.77

GC content: 65.02

Gene sequence:

>1275_bases
GTGGGAGCGCTCGCTCAGATGACTCTCGTTTGTGACCGTTGTAGTGCGAGGTTCGAGCCTGCGGGATCACCTGGGCGCTG
CCAGTGCGGTGGGCTCCTCCATGTCGAATTCCCACTCGCGGAGGTGGTCGAGCGAACCAACTTCGATGTCCGCTTGTCGA
GTTGGCAGGCGCTCGATCGGAGCGGCGTCTGGCGCTACCGGGAGTTGCTGCCGCCTCTGCCAGCCGCCGCCATCGTGACG
CGTCCCGAAGGCAATACTGCCCTGTACCAGCATCCCCAACTCACCGACTGGACGGGGTGCGAAGAGCTCTTCCTCAAGCA
CGAGGGGGAAAATCCGACCGGCTCGTTCAAAGACCGGGGGATGACGGTCGCGATTTCCCATGCGCGAACGATCGGTGCGC
AGGCGGTGGCCTGTGCCTCGACGGGAAACACGGCCGCCTCAGTTGCGGCCTATGCAGCCCTGGCAGGTCTTCCCAGTGTG
GTGTTCCTCCCCGCGGGAAAGATCGCGGCAGGGAAGCTGGGCCAGGCGATCGCGTATGGAGCACGGATCGTCCAGGTGGA
GGGCGACTTCGATGCCGCCATGCGCCTGGTCGAGGAGGCGAGCCGGGAACTCGGGCTCTACCTGCTCAATTCGGTGAACC
CGTTTCGCCTGGAGGGGCAAAAGACGATCGTGTTCGAGCTGCTGCATCAGCTCGGGTGGAGCGTCCCGGACTGGATCGTG
CTGCCCGGCGGGAATCTCGGCAACACCGCGGCCTTTGGGGCAGCACTGGCTCAGTTGCGTGACGTGGGATGGCTCGAGCG
CCTGCCGCGCCTGGCAGTGATCCAGGCCGCGGGGGCTGCGCCGTTTTACGCAGCCTACCGGAGTGGCTTCCGGGAGTTTC
GTCCCGTTACCGCTGAGACCATCGCGACGGCGATCCGGATCGGAAATCCGGTGAGTTACGAGCGTGCTCGCCGTGCGATC
GAGCTGACCGACGGTCTCGTGGACACGGTCAGCGACGAGGAGATCCTGGAGGCGAAGGCACGCGTCGATCGAACGGGAAT
CGGGTGCGAACCGGCATCAGCTGCCTCGGTCGCCGGCGTTCGCAAGCTCGTCGCGCGAGGGGTCATTCGGCCAGGCGATC
GAGTTGTGGCGATTCTCACTGGTCATGTCTTGAAGGATCCGGATGCAGTCTTGGCGTATCATCTCGGGGATCCTCCACGA
CCGCTTGCGAACCGGCCGGTGACGATCGCGCCCACCCTCGACGCACTGGCAGGAGTATTGGCTCGTGCGTTGTGA

Upstream 100 bases:

>100_bases
TCGGTGATGGACTCCGGGACGCACTCGATCCACGGCGCATGTTCGCGATCTGAGGGGTAGCATGACGACGCGTGGCCGGG
CGAGCGCACGGGAGAAAACG

Downstream 100 bases:

>100_bases
AGTGCGTGTTCCCGCTTCGAGTGCCAATCTCGGACCCGGTTTCGACGTGCTGGCGGTGGCCCTCGGCCGCTATCTTTCGG
CTCGCTACGAGCCGGACGAG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MGALAQMTLVCDRCSARFEPAGSPGRCQCGGLLHVEFPLAEVVERTNFDVRLSSWQALDRSGVWRYRELLPPLPAAAIVT
RPEGNTALYQHPQLTDWTGCEELFLKHEGENPTGSFKDRGMTVAISHARTIGAQAVACASTGNTAASVAAYAALAGLPSV
VFLPAGKIAAGKLGQAIAYGARIVQVEGDFDAAMRLVEEASRELGLYLLNSVNPFRLEGQKTIVFELLHQLGWSVPDWIV
LPGGNLGNTAAFGAALAQLRDVGWLERLPRLAVIQAAGAAPFYAAYRSGFREFRPVTAETIATAIRIGNPVSYERARRAI
ELTDGLVDTVSDEEILEAKARVDRTGIGCEPASAASVAGVRKLVARGVIRPGDRVVAILTGHVLKDPDAVLAYHLGDPPR
PLANRPVTIAPTLDALAGVLARAL

Sequences:

>Translated_424_residues
MGALAQMTLVCDRCSARFEPAGSPGRCQCGGLLHVEFPLAEVVERTNFDVRLSSWQALDRSGVWRYRELLPPLPAAAIVT
RPEGNTALYQHPQLTDWTGCEELFLKHEGENPTGSFKDRGMTVAISHARTIGAQAVACASTGNTAASVAAYAALAGLPSV
VFLPAGKIAAGKLGQAIAYGARIVQVEGDFDAAMRLVEEASRELGLYLLNSVNPFRLEGQKTIVFELLHQLGWSVPDWIV
LPGGNLGNTAAFGAALAQLRDVGWLERLPRLAVIQAAGAAPFYAAYRSGFREFRPVTAETIATAIRIGNPVSYERARRAI
ELTDGLVDTVSDEEILEAKARVDRTGIGCEPASAASVAGVRKLVARGVIRPGDRVVAILTGHVLKDPDAVLAYHLGDPPR
PLANRPVTIAPTLDALAGVLARAL
>Mature_423_residues
GALAQMTLVCDRCSARFEPAGSPGRCQCGGLLHVEFPLAEVVERTNFDVRLSSWQALDRSGVWRYRELLPPLPAAAIVTR
PEGNTALYQHPQLTDWTGCEELFLKHEGENPTGSFKDRGMTVAISHARTIGAQAVACASTGNTAASVAAYAALAGLPSVV
FLPAGKIAAGKLGQAIAYGARIVQVEGDFDAAMRLVEEASRELGLYLLNSVNPFRLEGQKTIVFELLHQLGWSVPDWIVL
PGGNLGNTAAFGAALAQLRDVGWLERLPRLAVIQAAGAAPFYAAYRSGFREFRPVTAETIATAIRIGNPVSYERARRAIE
LTDGLVDTVSDEEILEAKARVDRTGIGCEPASAASVAGVRKLVARGVIRPGDRVVAILTGHVLKDPDAVLAYHLGDPPRP
LANRPVTIAPTLDALAGVLARAL

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786185, Length=332, Percent_Identity=28.0120481927711, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790207, Length=311, Percent_Identity=27.6527331189711, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 45124; Mature: 44993

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00037 MYB_1 ; PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGALAQMTLVCDRCSARFEPAGSPGRCQCGGLLHVEFPLAEVVERTNFDVRLSSWQALDR
CCCHHHHHHHHHHHCCCCCCCCCCCCEECCCEEEEECCHHHHHHHCCCCEEECCHHHHHH
SGVWRYRELLPPLPAAAIVTRPEGNTALYQHPQLTDWTGCEELFLKHEGENPTGSFKDRG
CCCHHHHHHCCCCCCEEEEECCCCCCEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCC
MTVAISHARTIGAQAVACASTGNTAASVAAYAALAGLPSVVFLPAGKIAAGKLGQAIAYG
EEEEEECHHHHCCHHEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCC
ARIVQVEGDFDAAMRLVEEASRELGLYLLNSVNPFRLEGQKTIVFELLHQLGWSVPDWIV
EEEEEECCCHHHHHHHHHHHHHHHCHHHCCCCCCEEECCCHHHHHHHHHHHCCCCCCEEE
LPGGNLGNTAAFGAALAQLRDVGWLERLPRLAVIQAAGAAPFYAAYRSGFREFRPVTAET
ECCCCCCCHHHHHHHHHHHHHCHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHH
IATAIRIGNPVSYERARRAIELTDGLVDTVSDEEILEAKARVDRTGIGCEPASAASVAGV
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
RKLVARGVIRPGDRVVAILTGHVLKDPDAVLAYHLGDPPRPLANRPVTIAPTLDALAGVL
HHHHHHCCCCCCCCEEEEEECCHHCCCCCEEEEECCCCCCCCCCCCEEEECCHHHHHHHH
ARAL
HHCC
>Mature Secondary Structure 
GALAQMTLVCDRCSARFEPAGSPGRCQCGGLLHVEFPLAEVVERTNFDVRLSSWQALDR
CCHHHHHHHHHHHCCCCCCCCCCCCEECCCEEEEECCHHHHHHHCCCCEEECCHHHHHH
SGVWRYRELLPPLPAAAIVTRPEGNTALYQHPQLTDWTGCEELFLKHEGENPTGSFKDRG
CCCHHHHHHCCCCCCEEEEECCCCCCEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCC
MTVAISHARTIGAQAVACASTGNTAASVAAYAALAGLPSVVFLPAGKIAAGKLGQAIAYG
EEEEEECHHHHCCHHEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCC
ARIVQVEGDFDAAMRLVEEASRELGLYLLNSVNPFRLEGQKTIVFELLHQLGWSVPDWIV
EEEEEECCCHHHHHHHHHHHHHHHCHHHCCCCCCEEECCCHHHHHHHHHHHCCCCCCEEE
LPGGNLGNTAAFGAALAQLRDVGWLERLPRLAVIQAAGAAPFYAAYRSGFREFRPVTAET
ECCCCCCCHHHHHHHHHHHHHCHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCHHHH
IATAIRIGNPVSYERARRAIELTDGLVDTVSDEEILEAKARVDRTGIGCEPASAASVAGV
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
RKLVARGVIRPGDRVVAILTGHVLKDPDAVLAYHLGDPPRPLANRPVTIAPTLDALAGVL
HHHHHHCCCCCCCCEEEEEECCHHCCCCCEEEEECCCCCCCCCCCCEEEECCHHHHHHHH
ARAL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]