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The map label for this gene is hemL

Identifier: 221633107

GI number: 221633107

Start: 1107241

End: 1108533

Strand: Reverse

Name: hemL

Synonym: trd_1123

Alternate gene names: 221633107

Gene position: 1108533-1107241 (Counterclockwise)

Preceding gene: 221633108

Following gene: 221633106

Centisome position: 55.34

GC content: 62.65

Gene sequence:

>1293_bases
GTGATGATGGAAAATTCCGGTTCTCTCTGGGACGCTGCTCGGCAATTCTTTCCAGGTGGAGTGAACAGCCCAGTGCGAGC
TTTTCGGGCAGTCGGTGAGGAACCGGTCGTCGCAGTGCGCGGTGAGGGTGCCTACCTCATCGATGCGGACGGACGGCGAT
TCCTCGATTACATCTGCTCGTGGGGTGCTCTGCTCGCCGGGCACGCCCATCCGCATGTCGTCGATCGTCTTTCGGAAGCC
ATCCAGCGGGGGACGAGTTTCGGTCTTTTGTCGCCGTACGAGGTGGAGTTGGCACGGGCGATCGTCGCGTCCGTTCCCGC
GATCGAGCTCGTACGCTTCGTCAATTCGGGAACGGAAGCGACGATGAGCGCGATTCGCCTGGCTCGGGCGGTCACCGGCC
GGAATCTCGTCGTGAAGTTCGCCGGCTGCTATCACGGCCATGTCGACGGCTTGCTGGTCGCTGCCGGTTCAGGCGTTCTG
ACATTCGGATTGCCAGGGACGCCCGGCGTCACGGAAGGGACTGCGCGTGACACCCTCGTTCTACCCTACAACGATCAGGA
AGCCGTGGAAGACGCGTTCGCTCAGCATGGTGAGCGTATCGCGGCGGTCATCGTGGAGCCGGTTGCCGGGAACATGGGAG
TGGTTCCACCGGCTGCTGGCTTTTTGTCGCGCCTGCGCGAGTTAACGCGGCAGGCTGGGGCACTCCTCATCTTCGATGAA
GTAATCACCGGTTTTCGATTAGGACTCGGTGGGGCTCAGGAACGGTTCGGTATCCTGCCAGACCTTACCTGTTTGGGGAA
GGTCATCGGTGGAGGTCTTCCGGTCGGTGCCTACGGTGGCCGGCGCGACCTCATGGAGCAGGTGGCCCCGAATGGTCCAG
TGTATCAAGCGGGGACGCTGGCGGGTAACCCACTCTCCATGGTGGCAGGACTTGCGACGCTCGAACTGGCTCGTGAACCA
GGGGTTTACGGTCGTCTGGAGACTTTGGCTGCTTGGCTCCAGCGAGGACTCGAGGAAACGATCCAGGAGTCTGGTCTCCC
GGCGCACGTCCAGCGTGTCGGCTCGATGCTCACGCTTTTCTTCAGCCAGCAGCCGGTCACGGATGCGCAAACGGCTGAGC
GATGCGATACGGCCCGCTTCGCTGCGTTTCACCGGGCCATGCGTGCGCAAGGCATTCTGCTGCCGCCCTCCCAGTTCGAA
GCCTGGTTCGTCTCACTCGCTCACCGGGAGGAGGATATCGATCGCACGATCGAGGCGGCGCGGAAGGCATTGGCTGAGGT
GGCACGGGGGTGA

Upstream 100 bases:

>100_bases
CAGATGATCATTACCTATCACGCGAAGGATGTGGCGCGCTGGCTGCGGAGCGGACGGATCGGAACTGCACTCGAGCAGGC
TCTCCTCGGCTGAGAAAGGG

Downstream 100 bases:

>100_bases
CGATGACGCTTTCCGTGGTCGCTGTAACGCATCGAACAGCGCCGGTCACGATCCGCGAGCGATTGAGTTTGCCGGTAGAG
CAGCAGTGCCAATGGCTCCA

Product: glutamate-1-semialdehyde-2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MMMENSGSLWDAARQFFPGGVNSPVRAFRAVGEEPVVAVRGEGAYLIDADGRRFLDYICSWGALLAGHAHPHVVDRLSEA
IQRGTSFGLLSPYEVELARAIVASVPAIELVRFVNSGTEATMSAIRLARAVTGRNLVVKFAGCYHGHVDGLLVAAGSGVL
TFGLPGTPGVTEGTARDTLVLPYNDQEAVEDAFAQHGERIAAVIVEPVAGNMGVVPPAAGFLSRLRELTRQAGALLIFDE
VITGFRLGLGGAQERFGILPDLTCLGKVIGGGLPVGAYGGRRDLMEQVAPNGPVYQAGTLAGNPLSMVAGLATLELAREP
GVYGRLETLAAWLQRGLEETIQESGLPAHVQRVGSMLTLFFSQQPVTDAQTAERCDTARFAAFHRAMRAQGILLPPSQFE
AWFVSLAHREEDIDRTIEAARKALAEVARG

Sequences:

>Translated_430_residues
MMMENSGSLWDAARQFFPGGVNSPVRAFRAVGEEPVVAVRGEGAYLIDADGRRFLDYICSWGALLAGHAHPHVVDRLSEA
IQRGTSFGLLSPYEVELARAIVASVPAIELVRFVNSGTEATMSAIRLARAVTGRNLVVKFAGCYHGHVDGLLVAAGSGVL
TFGLPGTPGVTEGTARDTLVLPYNDQEAVEDAFAQHGERIAAVIVEPVAGNMGVVPPAAGFLSRLRELTRQAGALLIFDE
VITGFRLGLGGAQERFGILPDLTCLGKVIGGGLPVGAYGGRRDLMEQVAPNGPVYQAGTLAGNPLSMVAGLATLELAREP
GVYGRLETLAAWLQRGLEETIQESGLPAHVQRVGSMLTLFFSQQPVTDAQTAERCDTARFAAFHRAMRAQGILLPPSQFE
AWFVSLAHREEDIDRTIEAARKALAEVARG
>Mature_430_residues
MMMENSGSLWDAARQFFPGGVNSPVRAFRAVGEEPVVAVRGEGAYLIDADGRRFLDYICSWGALLAGHAHPHVVDRLSEA
IQRGTSFGLLSPYEVELARAIVASVPAIELVRFVNSGTEATMSAIRLARAVTGRNLVVKFAGCYHGHVDGLLVAAGSGVL
TFGLPGTPGVTEGTARDTLVLPYNDQEAVEDAFAQHGERIAAVIVEPVAGNMGVVPPAAGFLSRLRELTRQAGALLIFDE
VITGFRLGLGGAQERFGILPDLTCLGKVIGGGLPVGAYGGRRDLMEQVAPNGPVYQAGTLAGNPLSMVAGLATLELAREP
GVYGRLETLAAWLQRGLEETIQESGLPAHVQRVGSMLTLFFSQQPVTDAQTAERCDTARFAAFHRAMRAQGILLPPSQFE
AWFVSLAHREEDIDRTIEAARKALAEVARG

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI37574042, Length=340, Percent_Identity=29.1176470588235, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI4557809, Length=320, Percent_Identity=31.25, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI13994255, Length=442, Percent_Identity=26.4705882352941, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI226442705, Length=339, Percent_Identity=28.3185840707965, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI24119277, Length=338, Percent_Identity=28.4023668639053, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI226442709, Length=307, Percent_Identity=29.3159609120521, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI284507298, Length=235, Percent_Identity=31.9148936170213, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=53.0516431924883, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1789016, Length=353, Percent_Identity=31.728045325779, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI145693181, Length=310, Percent_Identity=32.9032258064516, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788044, Length=337, Percent_Identity=31.4540059347181, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1789759, Length=338, Percent_Identity=28.698224852071, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1787560, Length=376, Percent_Identity=30.5851063829787, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786991, Length=298, Percent_Identity=30.8724832214765, Blast_Score=99, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=306, Percent_Identity=30.718954248366, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71992977, Length=429, Percent_Identity=25.8741258741259, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25144274, Length=141, Percent_Identity=36.1702127659575, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323470, Length=410, Percent_Identity=26.3414634146341, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324432, Length=360, Percent_Identity=24.4444444444444, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21356575, Length=337, Percent_Identity=30.2670623145401, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI161085790, Length=362, Percent_Identity=27.6243093922652, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28574759, Length=362, Percent_Identity=27.6243093922652, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21357415, Length=303, Percent_Identity=29.042904290429, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_THERP (B9L0Q2)

Other databases:

- EMBL:   CP001275
- RefSeq:   YP_002522332.1
- ProteinModelPortal:   B9L0Q2
- GeneID:   7355638
- GenomeReviews:   CP001275_GR
- KEGG:   tro:trd_1123
- OMA:   HANEKIV
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 45750; Mature: 45750

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMENSGSLWDAARQFFPGGVNSPVRAFRAVGEEPVVAVRGEGAYLIDADGRRFLDYICS
CCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCEEEECCCCHHHHHHHHH
WGALLAGHAHPHVVDRLSEAIQRGTSFGLLSPYEVELARAIVASVPAIELVRFVNSGTEA
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHH
TMSAIRLARAVTGRNLVVKFAGCYHGHVDGLLVAAGSGVLTFGLPGTPGVTEGTARDTLV
HHHHHHHHHHHCCCCEEEEEECHHCCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCEEE
LPYNDQEAVEDAFAQHGERIAAVIVEPVAGNMGVVPPAAGFLSRLRELTRQAGALLIFDE
ECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEHHH
VITGFRLGLGGAQERFGILPDLTCLGKVIGGGLPVGAYGGRRDLMEQVAPNGPVYQAGTL
HHHHHHHCCCCCHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCC
AGNPLSMVAGLATLELAREPGVYGRLETLAAWLQRGLEETIQESGLPAHVQRVGSMLTLF
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
FSQQPVTDAQTAERCDTARFAAFHRAMRAQGILLPPSQFEAWFVSLAHREEDIDRTIEAA
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RKALAEVARG
HHHHHHHHCC
>Mature Secondary Structure
MMMENSGSLWDAARQFFPGGVNSPVRAFRAVGEEPVVAVRGEGAYLIDADGRRFLDYICS
CCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCEEEECCCCHHHHHHHHH
WGALLAGHAHPHVVDRLSEAIQRGTSFGLLSPYEVELARAIVASVPAIELVRFVNSGTEA
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHH
TMSAIRLARAVTGRNLVVKFAGCYHGHVDGLLVAAGSGVLTFGLPGTPGVTEGTARDTLV
HHHHHHHHHHHCCCCEEEEEECHHCCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCEEE
LPYNDQEAVEDAFAQHGERIAAVIVEPVAGNMGVVPPAAGFLSRLRELTRQAGALLIFDE
ECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEHHH
VITGFRLGLGGAQERFGILPDLTCLGKVIGGGLPVGAYGGRRDLMEQVAPNGPVYQAGTL
HHHHHHHCCCCCHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCC
AGNPLSMVAGLATLELAREPGVYGRLETLAAWLQRGLEETIQESGLPAHVQRVGSMLTLF
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
FSQQPVTDAQTAERCDTARFAAFHRAMRAQGILLPPSQFEAWFVSLAHREEDIDRTIEAA
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RKALAEVARG
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA