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The map label for this gene is hemB [H]

Identifier: 221633108

GI number: 221633108

Start: 1108541

End: 1109563

Strand: Reverse

Name: hemB [H]

Synonym: trd_1124

Alternate gene names: 221633108

Gene position: 1109563-1108541 (Counterclockwise)

Preceding gene: 221633109

Following gene: 221633107

Centisome position: 55.39

GC content: 61.19

Gene sequence:

>1023_bases
GTGAGCATCGAGCGAGGGCGGTTTCGCCGGTTGCGTCGGCTGCGACAGACGGAGGGACTCCGTCGTCTGGTCCGCGAGAC
GCGTTTGAACGTGGAGGACTTCATTTATCCCTTGTTCGTCGTTCATGGTCGAGGCGTCCGGCGTGAAGTGGGGTCGATGC
CGGGCGTTTACCAGTTGAGTGTCGATCAGCTGGGGGCAGAAGTCGAAGAGTTACTGGAACTCGGTATCGGTGCGGTTCTC
GTCTTCGGTATTCCTGCTCAGAAGGATGAACTGGCTAGTGAAGCCTACGATCCGGATGGCATCGTGCAGCGCACAGTCAG
GGAACTGAAAAAGCGCGCGCCCGATCTCGTGGTGATCACCGATGTCTGTAATTGCGAATACACCTCACACGGGCACTGTG
GGATCGTGCGTGATGGACGGATCGTGAACGATCCCACACTGGAACTTTTGGCACGGACCGCGGTCTCGCATGCCGAGGCG
GGAGCCGACATGGTGGCTCCGTCCGATATGATGGACGGACGAGTCCTCGCTATCCGTGAAGCCCTCGATCGGGCCGGCTT
CATCGAAGTTCCGATTCTCTCCTATGCGGCCAAGTACGCATCGGCCTTTTATGGACCGTTTCGTGAGGCGGCGGAGTCGG
CCCCGGCGTTCGGCGATCGCCGTTCCCACCAGATGGACCCCGGCAACCGGCGGGAGGCCCTGCGCGAAATCGAGACCGAC
ATCGAAGAGGGGGCGGACGCGATCATCGTCAAACCAGCTCTTGCCTACCTGGATGTGATCGCCGCGGCGCGTGAACGGTT
CGAGGTACCGATCGCAGCCTACAACGTGAGCGGTGAGTATGCGATGGTCAAGGCGGCTGCCCGCAACGGTTGGATCGACG
AGCAGCGAGTGGTTCTCGAACTGTTGACGGGGATCCGTCGAGCCGGTGCGCAGATGATCATTACCTATCACGCGAAGGAT
GTGGCGCGCTGGCTGCGGAGCGGACGGATCGGAACTGCACTCGAGCAGGCTCTCCTCGGCTGA

Upstream 100 bases:

>100_bases
GGACCGCTCGAGAGCTCGGATTACGCGTCGATGTCGTTGCCGATACCTACACGGCTGAGGGGTTGATCGAAGCGGTGGTG
CGAGCGGAAAGGAGCAGGGG

Downstream 100 bases:

>100_bases
GAAAGGGGTGATGATGGAAAATTCCGGTTCTCTCTGGGACGCTGCTCGGCAATTCTTTCCAGGTGGAGTGAACAGCCCAG
TGCGAGCTTTTCGGGCAGTC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MSIERGRFRRLRRLRQTEGLRRLVRETRLNVEDFIYPLFVVHGRGVRREVGSMPGVYQLSVDQLGAEVEELLELGIGAVL
VFGIPAQKDELASEAYDPDGIVQRTVRELKKRAPDLVVITDVCNCEYTSHGHCGIVRDGRIVNDPTLELLARTAVSHAEA
GADMVAPSDMMDGRVLAIREALDRAGFIEVPILSYAAKYASAFYGPFREAAESAPAFGDRRSHQMDPGNRREALREIETD
IEEGADAIIVKPALAYLDVIAAARERFEVPIAAYNVSGEYAMVKAAARNGWIDEQRVVLELLTGIRRAGAQMIITYHAKD
VARWLRSGRIGTALEQALLG

Sequences:

>Translated_340_residues
MSIERGRFRRLRRLRQTEGLRRLVRETRLNVEDFIYPLFVVHGRGVRREVGSMPGVYQLSVDQLGAEVEELLELGIGAVL
VFGIPAQKDELASEAYDPDGIVQRTVRELKKRAPDLVVITDVCNCEYTSHGHCGIVRDGRIVNDPTLELLARTAVSHAEA
GADMVAPSDMMDGRVLAIREALDRAGFIEVPILSYAAKYASAFYGPFREAAESAPAFGDRRSHQMDPGNRREALREIETD
IEEGADAIIVKPALAYLDVIAAARERFEVPIAAYNVSGEYAMVKAAARNGWIDEQRVVLELLTGIRRAGAQMIITYHAKD
VARWLRSGRIGTALEQALLG
>Mature_339_residues
SIERGRFRRLRRLRQTEGLRRLVRETRLNVEDFIYPLFVVHGRGVRREVGSMPGVYQLSVDQLGAEVEELLELGIGAVLV
FGIPAQKDELASEAYDPDGIVQRTVRELKKRAPDLVVITDVCNCEYTSHGHCGIVRDGRIVNDPTLELLARTAVSHAEAG
ADMVAPSDMMDGRVLAIREALDRAGFIEVPILSYAAKYASAFYGPFREAAESAPAFGDRRSHQMDPGNRREALREIETDI
EEGADAIIVKPALAYLDVIAAARERFEVPIAAYNVSGEYAMVKAAARNGWIDEQRVVLELLTGIRRAGAQMIITYHAKDV
ARWLRSGRIGTALEQALLG

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=329, Percent_Identity=43.161094224924, Blast_Score=264, Evalue=9e-71,
Organism=Escherichia coli, GI87081728, Length=314, Percent_Identity=51.2738853503185, Blast_Score=304, Evalue=4e-84,
Organism=Saccharomyces cerevisiae, GI6321398, Length=312, Percent_Identity=43.2692307692308, Blast_Score=248, Evalue=1e-66,
Organism=Drosophila melanogaster, GI21358291, Length=313, Percent_Identity=42.1725239616613, Blast_Score=258, Evalue=4e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 37670; Mature: 37538

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIERGRFRRLRRLRQTEGLRRLVRETRLNVEDFIYPLFVVHGRGVRREVGSMPGVYQLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHCCCCCEEEEE
VDQLGAEVEELLELGIGAVLVFGIPAQKDELASEAYDPDGIVQRTVRELKKRAPDLVVIT
HHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEE
DVCNCEYTSHGHCGIVRDGRIVNDPTLELLARTAVSHAEAGADMVAPSDMMDGRVLAIRE
ECCCCCCCCCCCEEEEECCEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHH
ALDRAGFIEVPILSYAAKYASAFYGPFREAAESAPAFGDRRSHQMDPGNRREALREIETD
HHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IEEGADAIIVKPALAYLDVIAAARERFEVPIAAYNVSGEYAMVKAAARNGWIDEQRVVLE
HHCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHH
LLTGIRRAGAQMIITYHAKDVARWLRSGRIGTALEQALLG
HHHHHHHCCCEEEEEECHHHHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure 
SIERGRFRRLRRLRQTEGLRRLVRETRLNVEDFIYPLFVVHGRGVRREVGSMPGVYQLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHCCCCCEEEEE
VDQLGAEVEELLELGIGAVLVFGIPAQKDELASEAYDPDGIVQRTVRELKKRAPDLVVIT
HHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEE
DVCNCEYTSHGHCGIVRDGRIVNDPTLELLARTAVSHAEAGADMVAPSDMMDGRVLAIRE
ECCCCCCCCCCCEEEEECCEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHH
ALDRAGFIEVPILSYAAKYASAFYGPFREAAESAPAFGDRRSHQMDPGNRREALREIETD
HHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IEEGADAIIVKPALAYLDVIAAARERFEVPIAAYNVSGEYAMVKAAARNGWIDEQRVVLE
HHCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHH
LLTGIRRAGAQMIITYHAKDVARWLRSGRIGTALEQALLG
HHHHHHHCCCEEEEEECHHHHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]