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The map label for this gene is hemA

Identifier: 221633106

GI number: 221633106

Start: 1106024

End: 1107244

Strand: Reverse

Name: hemA

Synonym: trd_1122

Alternate gene names: 221633106

Gene position: 1107244-1106024 (Counterclockwise)

Preceding gene: 221633107

Following gene: 221633105

Centisome position: 55.28

GC content: 63.31

Gene sequence:

>1221_bases
GTGACGATGACGCTTTCCGTGGTCGCTGTAACGCATCGAACAGCGCCGGTCACGATCCGCGAGCGATTGAGTTTGCCGGT
AGAGCAGCAGTGCCAATGGCTCCAGCGCTGGGGAAACCAGGTGCCTGAAATCGTGCTCCTGGTCACGTGTCACCGTACCG
AGGTTTATTGGCTCGACGGCGAGGAAACTGCCCATCGAGGAGTGGAATGGTTGGCTGAACTGGGTGGACTGACGGTCGAG
GAACTCGAGCGTTGGGTCTTGCAGCGTAGCGGCGCAGAGGCGGTTCGTCATGCGTTTTGTGTCGCTGCTGGGCTCGACTC
GCGGGTCGTCGGTGAGCCGCAGATCCTCGGACAGGTACGTCGTGCGCGGGATCTCGCTCGGGCAGCGGGAACGCTCGGCC
CAATCCTCGACCGGCTGTTCTCTTGCAGTCTGGCAACGGGGCGAATGGTCCGGGTTCGTGCCGGCTGGTCGACCGGCAAG
CGGTCGCTCGCGCGCGTGGCGGTGCGCGAGGCAGCGCGGCTCTGCAGTGATCTCCAGTCGGCACGGGTTCTCGTGCTGGG
AGCAGGCGAAACTGGTCGAGACGTCATCGCTGCATTGTGCCGTTGCCAGCCGGCAGTGGTGTGGTGGACCAATCGGTCAC
CGGGGCGACTCGCCCAGATCCCATCTGAGGAACCTGTGCGGATTGTCGACTGGAGCGAGTGGCCTCGACTCGTCACCGAA
GCGGATGTCGTTTTTGTCGCGACGAATGCGCCGGAACCGATCGTTCGACTGGAGCACGTCACTCGCCATGCTCGCCTCCC
ACGCCTACTGGTCGATCTCGCCGTGCCACGCAATGTCGATCCAGCCATCAGCGACGTGCCTGGGATTCGGGTGGTGACGA
TCGACGATCTTCCAGCTGATCCCGTTCCTGTCGCGGCATGGGATGGCGTAGCGGTCGAGCCGTACGTCGAACGCGCTGTA
CAGCGCTATCTTCGTTGGTTGGAGGCCCGCTCGATAGCCGCGGAGATCCGTGCCGCGCATGAAACGCTCCAGTCGATGTT
GGAGCGCGAACTCGAGAAGGTGTTGCGGTTGGCTCTTCGCGATCCTGCACGGACTGGCGAGGTGAAACGTGTGGCGGCGG
CGAGCATGGCTCGCAAGACATTATTTCCTCTTTTCCGAGCGCTCGAGTCGGAACCTCAGCGAGTCGCGCTGGCCTTGCGT
CTGCTCGCCTATGACCGCTGA

Upstream 100 bases:

>100_bases
CCCAGTTCGAAGCCTGGTTCGTCTCACTCGCTCACCGGGAGGAGGATATCGATCGCACGATCGAGGCGGCGCGGAAGGCA
TTGGCTGAGGTGGCACGGGG

Downstream 100 bases:

>100_bases
CTAGCCCGCTTTTCCTGCTCCCCGGTAGGATAACCGACCAGACACGATGAGGACGGGGGTCTCTCGGCGACCCTCGTCGC
TCTGTCGATGATTGCCGGTG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MTMTLSVVAVTHRTAPVTIRERLSLPVEQQCQWLQRWGNQVPEIVLLVTCHRTEVYWLDGEETAHRGVEWLAELGGLTVE
ELERWVLQRSGAEAVRHAFCVAAGLDSRVVGEPQILGQVRRARDLARAAGTLGPILDRLFSCSLATGRMVRVRAGWSTGK
RSLARVAVREAARLCSDLQSARVLVLGAGETGRDVIAALCRCQPAVVWWTNRSPGRLAQIPSEEPVRIVDWSEWPRLVTE
ADVVFVATNAPEPIVRLEHVTRHARLPRLLVDLAVPRNVDPAISDVPGIRVVTIDDLPADPVPVAAWDGVAVEPYVERAV
QRYLRWLEARSIAAEIRAAHETLQSMLERELEKVLRLALRDPARTGEVKRVAAASMARKTLFPLFRALESEPQRVALALR
LLAYDR

Sequences:

>Translated_406_residues
MTMTLSVVAVTHRTAPVTIRERLSLPVEQQCQWLQRWGNQVPEIVLLVTCHRTEVYWLDGEETAHRGVEWLAELGGLTVE
ELERWVLQRSGAEAVRHAFCVAAGLDSRVVGEPQILGQVRRARDLARAAGTLGPILDRLFSCSLATGRMVRVRAGWSTGK
RSLARVAVREAARLCSDLQSARVLVLGAGETGRDVIAALCRCQPAVVWWTNRSPGRLAQIPSEEPVRIVDWSEWPRLVTE
ADVVFVATNAPEPIVRLEHVTRHARLPRLLVDLAVPRNVDPAISDVPGIRVVTIDDLPADPVPVAAWDGVAVEPYVERAV
QRYLRWLEARSIAAEIRAAHETLQSMLERELEKVLRLALRDPARTGEVKRVAAASMARKTLFPLFRALESEPQRVALALR
LLAYDR
>Mature_405_residues
TMTLSVVAVTHRTAPVTIRERLSLPVEQQCQWLQRWGNQVPEIVLLVTCHRTEVYWLDGEETAHRGVEWLAELGGLTVEE
LERWVLQRSGAEAVRHAFCVAAGLDSRVVGEPQILGQVRRARDLARAAGTLGPILDRLFSCSLATGRMVRVRAGWSTGKR
SLARVAVREAARLCSDLQSARVLVLGAGETGRDVIAALCRCQPAVVWWTNRSPGRLAQIPSEEPVRIVDWSEWPRLVTEA
DVVFVATNAPEPIVRLEHVTRHARLPRLLVDLAVPRNVDPAISDVPGIRVVTIDDLPADPVPVAAWDGVAVEPYVERAVQ
RYLRWLEARSIAAEIRAAHETLQSMLERELEKVLRLALRDPARTGEVKRVAAASMARKTLFPLFRALESEPQRVALALRL
LAYDR

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=347, Percent_Identity=31.4121037463977, Blast_Score=141, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_THERP (B9L0Q1)

Other databases:

- EMBL:   CP001275
- RefSeq:   YP_002522331.1
- ProteinModelPortal:   B9L0Q1
- GeneID:   7355377
- GenomeReviews:   CP001275_GR
- KEGG:   tro:trd_1122
- OMA:   GPILNRL
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 45247; Mature: 45116

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 107-107 BINDING 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMTLSVVAVTHRTAPVTIRERLSLPVEQQCQWLQRWGNQVPEIVLLVTCHRTEVYWLDG
CCEEEEEEEEECCCCCEEHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCEEEEEECC
EETAHRGVEWLAELGGLTVEELERWVLQRSGAEAVRHAFCVAAGLDSRVVGEPQILGQVR
CHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
RARDLARAAGTLGPILDRLFSCSLATGRMVRVRAGWSTGKRSLARVAVREAARLCSDLQS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ARVLVLGAGETGRDVIAALCRCQPAVVWWTNRSPGRLAQIPSEEPVRIVDWSEWPRLVTE
CEEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCHHHCC
ADVVFVATNAPEPIVRLEHVTRHARLPRLLVDLAVPRNVDPAISDVPGIRVVTIDDLPAD
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCEEEEEECCCCCC
PVPVAAWDGVAVEPYVERAVQRYLRWLEARSIAAEIRAAHETLQSMLERELEKVLRLALR
CCCEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DPARTGEVKRVAAASMARKTLFPLFRALESEPQRVALALRLLAYDR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TMTLSVVAVTHRTAPVTIRERLSLPVEQQCQWLQRWGNQVPEIVLLVTCHRTEVYWLDG
CEEEEEEEEECCCCCEEHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCEEEEEECC
EETAHRGVEWLAELGGLTVEELERWVLQRSGAEAVRHAFCVAAGLDSRVVGEPQILGQVR
CHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
RARDLARAAGTLGPILDRLFSCSLATGRMVRVRAGWSTGKRSLARVAVREAARLCSDLQS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ARVLVLGAGETGRDVIAALCRCQPAVVWWTNRSPGRLAQIPSEEPVRIVDWSEWPRLVTE
CEEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCHHHCC
ADVVFVATNAPEPIVRLEHVTRHARLPRLLVDLAVPRNVDPAISDVPGIRVVTIDDLPAD
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCEEEEEECCCCCC
PVPVAAWDGVAVEPYVERAVQRYLRWLEARSIAAEIRAAHETLQSMLERELEKVLRLALR
CCCEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DPARTGEVKRVAAASMARKTLFPLFRALESEPQRVALALRLLAYDR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA