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The map label for this gene is hisG [H]

Identifier: 221632655

GI number: 221632655

Start: 626497

End: 627516

Strand: Reverse

Name: hisG [H]

Synonym: trd_0638

Alternate gene names: 221632655

Gene position: 627516-626497 (Counterclockwise)

Preceding gene: 221632656

Following gene: 221632654

Centisome position: 31.33

GC content: 62.65

Gene sequence:

>1020_bases
ATGGCCGAACCGCTCCGAATCGCCATCGCTTCCAAAGGAGAATACGAGCAAGCAACCTTGCGTTTCCTCGAGAGTGCTGG
CCTCAGCGTGTGGCGGCCCAACCCACGTCAGTACGTCGGGCGACTGGCTGGCTTCGAGGACGTCGAGATTCTTTTTCAGC
GTACGGCCGATATCGTCCAGCAGGTCGCCAGCGGGGGCGCTGACTTCGGTATCACCGGTTACGATCTTGTCGCCGAACTC
GCCGGCGACGATCCCGATGTCCTCGTTGTCTTCGACGATCTCGGCTTCCGGCGCTGTCAGCTCGTCCTCGCCGTCCCCGA
AAGCTGGCTGGACGTTACGACACTGGCTGACCTGGCCGACCTCGCTGTCGAGTGGAAGCGACGTGGGCGCACCATGCGTA
TCGCCACGAAGTTTCCCAATCTGACACGCGAATTCCTGTTGCGCAACGGCGTCAATTACTTCACGCTCGTCGAGGGACAC
GGCGCGCTCGAAATCGCTCCCGCGCTCGGCTACGCTGATTTGATCGCCGATCTCACCGAAACAGGCGTCACCTTGCGCGA
AAATCGGCTCAGGGTACTGGAGGGTGGAGTCATTCTCCGCGCCCAGGCCTGCCTCATCGCGAGTCGGCGAGCGCTGCGGG
CAGCACCGCAAAAACTGCAGCAGGCTCGCTCCATCATCGAGCTGATCGAGGCGCGTCTCCGCTCGCGACGCTATCGCCTC
ATCACAGCGAACATTCGCGGATCGAGCGAGGACGAGGTCGTCCGTCACGTCACGGCACACGCGGCAACGACCGGCGAGCG
CGGACCGACCGTTGCGCGCGTCTACCCGAAGTTGGGTGAGGACGGTCCGGGTTGGTACGAAGTGACGATCATCGTTCCAC
AGCACCTCTTGCTGGAGGCTGTCGACCATCTGCGCTTGGCCGGAAGCTCGGGGATCACCGTGACTTCTCCCGAGTACGTT
TTCGATTCCCGCTCCCATGCCTTCGCCCGCCTCTGCCAGGCCTTGGAGGAGAAAGCATGA

Upstream 100 bases:

>100_bases
AACCGTCGTTACGCCCGTCGGCGCGGCGTCACTGAAATCCTGATCGTCGACGCGACGGGTTCCGTTCGCCGTATCGATCT
CTCCACCGAGGAATGACCTG

Downstream 100 bases:

>100_bases
CGCGCACCATTCGCGTGATCGAGAGCATCGCTGAAGCCGAACGCTTCCTGTCCCGCTCCCGTCAAATGCCAACCCACCTC
CCTGCCGCCGTGCAGGAACG

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MAEPLRIAIASKGEYEQATLRFLESAGLSVWRPNPRQYVGRLAGFEDVEILFQRTADIVQQVASGGADFGITGYDLVAEL
AGDDPDVLVVFDDLGFRRCQLVLAVPESWLDVTTLADLADLAVEWKRRGRTMRIATKFPNLTREFLLRNGVNYFTLVEGH
GALEIAPALGYADLIADLTETGVTLRENRLRVLEGGVILRAQACLIASRRALRAAPQKLQQARSIIELIEARLRSRRYRL
ITANIRGSSEDEVVRHVTAHAATTGERGPTVARVYPKLGEDGPGWYEVTIIVPQHLLLEAVDHLRLAGSSGITVTSPEYV
FDSRSHAFARLCQALEEKA

Sequences:

>Translated_339_residues
MAEPLRIAIASKGEYEQATLRFLESAGLSVWRPNPRQYVGRLAGFEDVEILFQRTADIVQQVASGGADFGITGYDLVAEL
AGDDPDVLVVFDDLGFRRCQLVLAVPESWLDVTTLADLADLAVEWKRRGRTMRIATKFPNLTREFLLRNGVNYFTLVEGH
GALEIAPALGYADLIADLTETGVTLRENRLRVLEGGVILRAQACLIASRRALRAAPQKLQQARSIIELIEARLRSRRYRL
ITANIRGSSEDEVVRHVTAHAATTGERGPTVARVYPKLGEDGPGWYEVTIIVPQHLLLEAVDHLRLAGSSGITVTSPEYV
FDSRSHAFARLCQALEEKA
>Mature_338_residues
AEPLRIAIASKGEYEQATLRFLESAGLSVWRPNPRQYVGRLAGFEDVEILFQRTADIVQQVASGGADFGITGYDLVAELA
GDDPDVLVVFDDLGFRRCQLVLAVPESWLDVTTLADLADLAVEWKRRGRTMRIATKFPNLTREFLLRNGVNYFTLVEGHG
ALEIAPALGYADLIADLTETGVTLRENRLRVLEGGVILRAQACLIASRRALRAAPQKLQQARSIIELIEARLRSRRYRLI
TANIRGSSEDEVVRHVTAHAATTGERGPTVARVYPKLGEDGPGWYEVTIIVPQHLLLEAVDHLRLAGSSGITVTSPEYVF
DSRSHAFARLCQALEEKA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=326, Percent_Identity=27.6073619631902, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 37458; Mature: 37327

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEPLRIAIASKGEYEQATLRFLESAGLSVWRPNPRQYVGRLAGFEDVEILFQRTADIVQ
CCCCEEEEEECCCCHHHHHHHHHHHCCCCEECCCHHHHHHHHCCCHHHHHHHHHHHHHHH
QVASGGADFGITGYDLVAELAGDDPDVLVVFDDLGFRRCQLVLAVPESWLDVTTLADLAD
HHHCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHH
LAVEWKRRGRTMRIATKFPNLTREFLLRNGVNYFTLVEGHGALEIAPALGYADLIADLTE
HHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCEEEEEECCCCEEEEHHCCHHHHHHHHHH
TGVTLRENRLRVLEGGVILRAQACLIASRRALRAAPQKLQQARSIIELIEARLRSRRYRL
CCCEECCCCEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
ITANIRGSSEDEVVRHVTAHAATTGERGPTVARVYPKLGEDGPGWYEVTIIVPQHLLLEA
EEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEEEECCHHHHHHH
VDHLRLAGSSGITVTSPEYVFDSRSHAFARLCQALEEKA
HHHHHCCCCCCEEECCCHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AEPLRIAIASKGEYEQATLRFLESAGLSVWRPNPRQYVGRLAGFEDVEILFQRTADIVQ
CCCEEEEEECCCCHHHHHHHHHHHCCCCEECCCHHHHHHHHCCCHHHHHHHHHHHHHHH
QVASGGADFGITGYDLVAELAGDDPDVLVVFDDLGFRRCQLVLAVPESWLDVTTLADLAD
HHHCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHH
LAVEWKRRGRTMRIATKFPNLTREFLLRNGVNYFTLVEGHGALEIAPALGYADLIADLTE
HHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCEEEEEECCCCEEEEHHCCHHHHHHHHHH
TGVTLRENRLRVLEGGVILRAQACLIASRRALRAAPQKLQQARSIIELIEARLRSRRYRL
CCCEECCCCEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
ITANIRGSSEDEVVRHVTAHAATTGERGPTVARVYPKLGEDGPGWYEVTIIVPQHLLLEA
EEEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEEEECCHHHHHHH
VDHLRLAGSSGITVTSPEYVFDSRSHAFARLCQALEEKA
HHHHHCCCCCCEEECCCHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]