| Definition | Thermomicrobium roseum DSM 5159 chromosome, complete genome. |
|---|---|
| Accession | NC_011959 |
| Length | 2,003,006 |
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The map label for this gene is hisD [H]
Identifier: 221632654
GI number: 221632654
Start: 625154
End: 626500
Strand: Reverse
Name: hisD [H]
Synonym: trd_0637
Alternate gene names: 221632654
Gene position: 626500-625154 (Counterclockwise)
Preceding gene: 221632655
Following gene: 221632650
Centisome position: 31.28
GC content: 63.33
Gene sequence:
>1347_bases ATGACGCGCACCATTCGCGTGATCGAGAGCATCGCTGAAGCCGAACGCTTCCTGTCCCGCTCCCGTCAAATGCCAACCCA CCTCCCTGCCGCCGTGCAGGAACGCATCCGCGCCGTCTTCGGTGGCGATCTGACGCCGCTTCAGGTCGTCGAGCGAATCA TCGACGATGTTCGTTCCCAGGGAGACGATGCTGTCCGCCGTTATACGCTCGCCTTCGATGGTGCTCATCTCGATACGTTT CTCGCCACTCCGGAAGAGTTCCTGCGAGCACGTCGAGCGATCACGCCTGAGCTCGAGGCAGCGCTCCGCTTCGCCCGCGA CCGCATCGTGGCGTTTCATCGGCGAGCGATCCCGCGCTCCTGGATCGAGTTCGACGAAACGGGCGCCTTCGGACAGCTCG TGCGACCGGTCGATCGCGTCGGCATTTACGTGCCAGGCGGCCGAGCTCCGCTCCCCTCCTCGCTCCTCATGACCGCAATC CCGGCCCAACTAGCTGGTGTTCGTGACATTGTCGTCTGCACGCCACCAGGCCGCGACGGGACGATCTCGCCTGCTGTACT GGCCGCAGCGGAACTTCTCGGGATCGAACGCGTCTTCAAGATCGGCGGTGCCCAGGCGATCGCTGCACTGGCCTATGGCA CACAGACGGTTCCAGCTGTCGATATCGTCGCCGGCCCGGGCAATCTCTTCGTCGTCCTCGCCAAAAGACTCGTGTACGGC GACGTCGGGATCGATCAGCTACCAGGGCCAACAGAAACATTGCTGATCGCTGACGAGCAGGCTGATCCGGTGCTCTGTGC GGCTGACTTGCTTGCCCAGGCTGAACACGATCCCCTGGCCTGCGCGATCTTGATCACTCCAGCGCGCACGCTTGCCCACA AAGTGGCGCAGGAACTGGAACGGCAGCTCCAGCAGCTGGACCGGAGCGAGATCGCTCGTGCTGCCTTGGAAGCGAATGGA GCCATCATCATCGTTCCTGATCTCGAGCGCGCCTTCGACCTGGCCAATCTCTTCGCGCCGGAACACCTCTGTCTGCTTGT CCGCGATCCCTGGCGCTATCTCGACCGGGTCCGTCATGCTGGTGGTGTCTTTCTCGGCGAGACTTCACCCGAGGTCATCG GCGATTACACCGCCGGCCCCAGTCACGTCATGCCGACCGGCCGGACCGCACGCTTCGCTTCACCTGTGACCGTACAGACG TTTCTGAAGGTGACGAGTCTCGTCGCGGTCGCACCGAAGGCGCTGGAACAGCTCGGAAGCCCCGCTCTTCAACTGGCCAT GAGCGAGGGGCTCACTGCACATGCAGCTGCCATCGAGCATCGCCTGGAGCGCACGCGGCCTGATTGA
Upstream 100 bases:
>100_bases TGGCCGGAAGCTCGGGGATCACCGTGACTTCTCCCGAGTACGTTTTCGATTCCCGCTCCCATGCCTTCGCCCGCCTCTGC CAGGCCTTGGAGGAGAAAGC
Downstream 100 bases:
>100_bases TTCAGGGTGGTGCCAACTGACGGAGCGCAGCGACGATACGCTCCTCGAGGGACGGGGCACGCCGCACCTCGGGATGCGTT GCGGCTTGCCGTGCCTCCTG
Product: histidinol dehydrogenase
Products: NA
Alternate protein names: HDH [H]
Number of amino acids: Translated: 448; Mature: 447
Protein sequence:
>448_residues MTRTIRVIESIAEAERFLSRSRQMPTHLPAAVQERIRAVFGGDLTPLQVVERIIDDVRSQGDDAVRRYTLAFDGAHLDTF LATPEEFLRARRAITPELEAALRFARDRIVAFHRRAIPRSWIEFDETGAFGQLVRPVDRVGIYVPGGRAPLPSSLLMTAI PAQLAGVRDIVVCTPPGRDGTISPAVLAAAELLGIERVFKIGGAQAIAALAYGTQTVPAVDIVAGPGNLFVVLAKRLVYG DVGIDQLPGPTETLLIADEQADPVLCAADLLAQAEHDPLACAILITPARTLAHKVAQELERQLQQLDRSEIARAALEANG AIIIVPDLERAFDLANLFAPEHLCLLVRDPWRYLDRVRHAGGVFLGETSPEVIGDYTAGPSHVMPTGRTARFASPVTVQT FLKVTSLVAVAPKALEQLGSPALQLAMSEGLTAHAAAIEHRLERTRPD
Sequences:
>Translated_448_residues MTRTIRVIESIAEAERFLSRSRQMPTHLPAAVQERIRAVFGGDLTPLQVVERIIDDVRSQGDDAVRRYTLAFDGAHLDTF LATPEEFLRARRAITPELEAALRFARDRIVAFHRRAIPRSWIEFDETGAFGQLVRPVDRVGIYVPGGRAPLPSSLLMTAI PAQLAGVRDIVVCTPPGRDGTISPAVLAAAELLGIERVFKIGGAQAIAALAYGTQTVPAVDIVAGPGNLFVVLAKRLVYG DVGIDQLPGPTETLLIADEQADPVLCAADLLAQAEHDPLACAILITPARTLAHKVAQELERQLQQLDRSEIARAALEANG AIIIVPDLERAFDLANLFAPEHLCLLVRDPWRYLDRVRHAGGVFLGETSPEVIGDYTAGPSHVMPTGRTARFASPVTVQT FLKVTSLVAVAPKALEQLGSPALQLAMSEGLTAHAAAIEHRLERTRPD >Mature_447_residues TRTIRVIESIAEAERFLSRSRQMPTHLPAAVQERIRAVFGGDLTPLQVVERIIDDVRSQGDDAVRRYTLAFDGAHLDTFL ATPEEFLRARRAITPELEAALRFARDRIVAFHRRAIPRSWIEFDETGAFGQLVRPVDRVGIYVPGGRAPLPSSLLMTAIP AQLAGVRDIVVCTPPGRDGTISPAVLAAAELLGIERVFKIGGAQAIAALAYGTQTVPAVDIVAGPGNLFVVLAKRLVYGD VGIDQLPGPTETLLIADEQADPVLCAADLLAQAEHDPLACAILITPARTLAHKVAQELERQLQQLDRSEIARAALEANGA IIIVPDLERAFDLANLFAPEHLCLLVRDPWRYLDRVRHAGGVFLGETSPEVIGDYTAGPSHVMPTGRTARFASPVTVQTF LKVTSLVAVAPKALEQLGSPALQLAMSEGLTAHAAAIEHRLERTRPD
Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]
COG id: COG0141
COG function: function code E; Histidinol dehydrogenase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the histidinol dehydrogenase family [H]
Homologues:
Organism=Escherichia coli, GI1788331, Length=400, Percent_Identity=40.75, Blast_Score=289, Evalue=3e-79, Organism=Saccharomyces cerevisiae, GI6319819, Length=412, Percent_Identity=37.8640776699029, Blast_Score=272, Evalue=6e-74,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR016161 - InterPro: IPR022695 - InterPro: IPR001692 - InterPro: IPR012131 [H]
Pfam domain/function: PF00815 Histidinol_dh [H]
EC number: =1.1.1.23 [H]
Molecular weight: Translated: 48451; Mature: 48320
Theoretical pI: Translated: 6.02; Mature: 6.02
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 2.0 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 0.9 %Met (Mature Protein) 1.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTRTIRVIESIAEAERFLSRSRQMPTHLPAAVQERIRAVFGGDLTPLQVVERIIDDVRSQ CCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC GDDAVRRYTLAFDGAHLDTFLATPEEFLRARRAITPELEAALRFARDRIVAFHRRAIPRS CCHHHHEEEEEECCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHH WIEFDETGAFGQLVRPVDRVGIYVPGGRAPLPSSLLMTAIPAQLAGVRDIVVCTPPGRDG HHCCCCCCCHHHHHHHHHHCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCC TISPAVLAAAELLGIERVFKIGGAQAIAALAYGTQTVPAVDIVAGPGNLFVVLAKRLVYG CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHC DVGIDQLPGPTETLLIADEQADPVLCAADLLAQAEHDPLACAILITPARTLAHKVAQELE CCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHH RQLQQLDRSEIARAALEANGAIIIVPDLERAFDLANLFAPEHLCLLVRDPWRYLDRVRHA HHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHC GGVFLGETSPEVIGDYTAGPSHVMPTGRTARFASPVTVQTFLKVTSLVAVAPKALEQLGS CCEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC PALQLAMSEGLTAHAAAIEHRLERTRPD HHHHHHHHCCCHHHHHHHHHHHHHCCCC >Mature Secondary Structure TRTIRVIESIAEAERFLSRSRQMPTHLPAAVQERIRAVFGGDLTPLQVVERIIDDVRSQ CHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC GDDAVRRYTLAFDGAHLDTFLATPEEFLRARRAITPELEAALRFARDRIVAFHRRAIPRS CCHHHHEEEEEECCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHH WIEFDETGAFGQLVRPVDRVGIYVPGGRAPLPSSLLMTAIPAQLAGVRDIVVCTPPGRDG HHCCCCCCCHHHHHHHHHHCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCC TISPAVLAAAELLGIERVFKIGGAQAIAALAYGTQTVPAVDIVAGPGNLFVVLAKRLVYG CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHC DVGIDQLPGPTETLLIADEQADPVLCAADLLAQAEHDPLACAILITPARTLAHKVAQELE CCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHH RQLQQLDRSEIARAALEANGAIIIVPDLERAFDLANLFAPEHLCLLVRDPWRYLDRVRHA HHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHC GGVFLGETSPEVIGDYTAGPSHVMPTGRTARFASPVTVQTFLKVTSLVAVAPKALEQLGS CCEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC PALQLAMSEGLTAHAAAIEHRLERTRPD HHHHHHHHCCCHHHHHHHHHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10567266 [H]