Click here to switch to the map view.

The map label for this gene is hsdR [H]

Identifier: 220932855

GI number: 220932855

Start: 2181897

End: 2184209

Strand: Reverse

Name: hsdR [H]

Synonym: Hore_20230

Alternate gene names: 220932855

Gene position: 2184209-2181897 (Counterclockwise)

Preceding gene: 220932856

Following gene: 220932854

Centisome position: 84.72

GC content: 35.41

Gene sequence:

>2313_bases
GTGGCTCTTACAGAAACTGAAGTTTGTATGCGGTATATTACACCTGCTATTCAGAATGCAGGCTGGGATATAAATAAACA
GGTGCTTAGAGAGTATAGCTTTACTGATGGACGGGTGATTGTTCGTGGTAAGCTTGTTAATAGGGCTAAGCCCAAAAGAG
CAGACTATATTCTTCAATATAAAAGTAATATACCCCTTGCAATTATTGAAGCTAAAAAAGACACCCTTCCTATAGGTGCA
GGAATGCAACAGGCGTTGGAGTATGCTGAAATTTTAGATATTCCCTTTGTTTATTCTAGCAATGGCAAAGGTTTCATTGA
GCATGACCGCAATAGTGGTAGAGAAAAAGAAATTGCTCTGGAAGATTTTCCTTCTCCAGAGGAATTGTGGGGTCGTTTTA
GTAAGCAGAAAGAATTTACCAGAGAACAGGAGCAGTTGTACTTACAAGATTATTTTTATCAAATAAATTATAAAACCCCT
AGATACTACCAGAGGGTGGCCATAAATAGGGCAGTTGAGGCAATTGCCAAAGGGCAAAAACGTATTCTGCTTGTTATGGC
TACTGGAACCGGTAAGACCTTTACAGCCTTTCAAATTATCCATAGATTGTGGAAAGCGGGTAAAAAGAAAAGAATCCTCT
TTCTTGCAGACCGTAACATTTTAGTTGACCAGACAATAACGGGTGACTTTAGTCCTTTTGGTGACAAGATGATTAAGATT
CAAAGAGGAAATGTTTCTCATGCCCATGAGATTTATCTTGCCCTATATCAGTCAATGACGGGTCCTGAAGAATGGCAAAA
GACCTTTGAGGAATACAGTCCTGATTTTTTTGATCTTGTTGTAATAGATGAGTGTCATCGAGGAAGTGCCAGGGCAAATA
GTGCCTGGAGAGTGGTTTTAGAGTATTTTGATCAGGCAACACATCTTGGATTAACTGCTACTCCAAAAGAGGATGCTGAT
GTATCAACTCAAGGTTATTTTGGAGAACCAATTTATACATATTCGTTGAAGCAGGGGATTGAGGATGGCTTTTTAGCACC
ATATAAGGTAGTAAGAATGGGACTAGATAAGGATTTAATGGGATTTAGACCAATTAAAGGTCAGACTGACAAGTATGGGC
GAGTTATGGAAGATAGAGAGTATTATGTTAATGATTTTGATAGAGAATTAATTTTAGAAAAAAGACATGAATTAGTTGCA
AAAGAAATTACAAGGTATTTAAAAGAGGAGTTGCAAGACAGATTTGCTAAAACTATTGTGTTTTGCCAGGATATTGAACA
TGCTGAGAATATGAGACAGGCATTAGTGAATGAAAATGCAGATCTTGTAAAGCAAAATTATAAATATGTAATGCGTATTA
CCGGGGATAATCCAGAGGCTAAAATTCAGCTGGATAATTTTATTGAACCTTCTGAGACTTATCCAGTTATTGCGACTACA
TCTAAATTAATGACAACTGGCGTTGATGCTCAAACCTGTAAGCTTATTGTTCTTGATATGACGATCAATTCTATGTCTGA
GTTTAAACAAATAATAGGGCGGGGGACACGTTTAAGGCCTGATTATGGTAAATATTATTTTACTATTTTAGATTTTAGGG
GAGCTACAAGGTTATTTGCTGACCCTGACTTTGATGGATATCCAATACCTGACGATGAAGATGGTGATAACTACCCAGGA
AATGATGTTAATGGTGGTAATAGAATACCTGGAAATGATGAAGGTGGGGATGAAGAAGGAAGAGTAAAATACTATGTGGA
TGATGTCGAGGTTAATTTAATTAATAAAAGGGTTCAGTATCTTGATGCTAATGGTAAACTTGTTTCTGAATCCTATGTAG
ACTATACAAAGAAAAATATTAGAAAACAATATGCTACACTTGACGATTTTATAAGGAGATGGACTGAAGAAGAAAAAAAA
CAGGTTATATATGATGAGTTACTGGAACAGGGAATTATACTTGATGAACTTAGAAAAGAGGTAGGCAAAGAGGATATAGA
TGATTTTGATTTAATTTGTCATATAGTTTTTGATGCCAAGCCTTTAACAAAGTCAGAAAGAATAAATAATGTTAAAAAGC
GAAATTATTTCACTAAATATGGAGAGCAAGCAAGAAAAGTCCTTGAGATTCTTCTTGATAAGTATAAAAACAGCAACATT
ACAGAAATAGAAGATATAAAAATCCTTAAACTTGATGAATTTAAGCAAATAGGTATGCCAGGAAGAATATTTAAACTCTT
TGGCGGAAAGAAAAAATATTTAGAAGCGATTAAGGAATTAGAAGCAGAAATATATAAAGGAGAGGTAAGTTGA

Upstream 100 bases:

>100_bases
AATTATTGGAGAAAATTATTAATTAAAGGATACAAGAATATAAATGATAGATGAATATGTAAACGTGTAAATTTATATTT
AAAATAGGGAGGTGAAAATT

Downstream 100 bases:

>100_bases
AATGACTTTAACAAATTTTGTAAAAAATGTTCAAGATATAATGAGAATGGATTCTGGTGTTGATGGGGATGCTCAAAGAA
TTAGTCAACTCACCTGGATG

Product: EcoEI R domain-containing protein

Products: NA

Alternate protein names: R.EcoEI [H]

Number of amino acids: Translated: 770; Mature: 769

Protein sequence:

>770_residues
MALTETEVCMRYITPAIQNAGWDINKQVLREYSFTDGRVIVRGKLVNRAKPKRADYILQYKSNIPLAIIEAKKDTLPIGA
GMQQALEYAEILDIPFVYSSNGKGFIEHDRNSGREKEIALEDFPSPEELWGRFSKQKEFTREQEQLYLQDYFYQINYKTP
RYYQRVAINRAVEAIAKGQKRILLVMATGTGKTFTAFQIIHRLWKAGKKKRILFLADRNILVDQTITGDFSPFGDKMIKI
QRGNVSHAHEIYLALYQSMTGPEEWQKTFEEYSPDFFDLVVIDECHRGSARANSAWRVVLEYFDQATHLGLTATPKEDAD
VSTQGYFGEPIYTYSLKQGIEDGFLAPYKVVRMGLDKDLMGFRPIKGQTDKYGRVMEDREYYVNDFDRELILEKRHELVA
KEITRYLKEELQDRFAKTIVFCQDIEHAENMRQALVNENADLVKQNYKYVMRITGDNPEAKIQLDNFIEPSETYPVIATT
SKLMTTGVDAQTCKLIVLDMTINSMSEFKQIIGRGTRLRPDYGKYYFTILDFRGATRLFADPDFDGYPIPDDEDGDNYPG
NDVNGGNRIPGNDEGGDEEGRVKYYVDDVEVNLINKRVQYLDANGKLVSESYVDYTKKNIRKQYATLDDFIRRWTEEEKK
QVIYDELLEQGIILDELRKEVGKEDIDDFDLICHIVFDAKPLTKSERINNVKKRNYFTKYGEQARKVLEILLDKYKNSNI
TEIEDIKILKLDEFKQIGMPGRIFKLFGGKKKYLEAIKELEAEIYKGEVS

Sequences:

>Translated_770_residues
MALTETEVCMRYITPAIQNAGWDINKQVLREYSFTDGRVIVRGKLVNRAKPKRADYILQYKSNIPLAIIEAKKDTLPIGA
GMQQALEYAEILDIPFVYSSNGKGFIEHDRNSGREKEIALEDFPSPEELWGRFSKQKEFTREQEQLYLQDYFYQINYKTP
RYYQRVAINRAVEAIAKGQKRILLVMATGTGKTFTAFQIIHRLWKAGKKKRILFLADRNILVDQTITGDFSPFGDKMIKI
QRGNVSHAHEIYLALYQSMTGPEEWQKTFEEYSPDFFDLVVIDECHRGSARANSAWRVVLEYFDQATHLGLTATPKEDAD
VSTQGYFGEPIYTYSLKQGIEDGFLAPYKVVRMGLDKDLMGFRPIKGQTDKYGRVMEDREYYVNDFDRELILEKRHELVA
KEITRYLKEELQDRFAKTIVFCQDIEHAENMRQALVNENADLVKQNYKYVMRITGDNPEAKIQLDNFIEPSETYPVIATT
SKLMTTGVDAQTCKLIVLDMTINSMSEFKQIIGRGTRLRPDYGKYYFTILDFRGATRLFADPDFDGYPIPDDEDGDNYPG
NDVNGGNRIPGNDEGGDEEGRVKYYVDDVEVNLINKRVQYLDANGKLVSESYVDYTKKNIRKQYATLDDFIRRWTEEEKK
QVIYDELLEQGIILDELRKEVGKEDIDDFDLICHIVFDAKPLTKSERINNVKKRNYFTKYGEQARKVLEILLDKYKNSNI
TEIEDIKILKLDEFKQIGMPGRIFKLFGGKKKYLEAIKELEAEIYKGEVS
>Mature_769_residues
ALTETEVCMRYITPAIQNAGWDINKQVLREYSFTDGRVIVRGKLVNRAKPKRADYILQYKSNIPLAIIEAKKDTLPIGAG
MQQALEYAEILDIPFVYSSNGKGFIEHDRNSGREKEIALEDFPSPEELWGRFSKQKEFTREQEQLYLQDYFYQINYKTPR
YYQRVAINRAVEAIAKGQKRILLVMATGTGKTFTAFQIIHRLWKAGKKKRILFLADRNILVDQTITGDFSPFGDKMIKIQ
RGNVSHAHEIYLALYQSMTGPEEWQKTFEEYSPDFFDLVVIDECHRGSARANSAWRVVLEYFDQATHLGLTATPKEDADV
STQGYFGEPIYTYSLKQGIEDGFLAPYKVVRMGLDKDLMGFRPIKGQTDKYGRVMEDREYYVNDFDRELILEKRHELVAK
EITRYLKEELQDRFAKTIVFCQDIEHAENMRQALVNENADLVKQNYKYVMRITGDNPEAKIQLDNFIEPSETYPVIATTS
KLMTTGVDAQTCKLIVLDMTINSMSEFKQIIGRGTRLRPDYGKYYFTILDFRGATRLFADPDFDGYPIPDDEDGDNYPGN
DVNGGNRIPGNDEGGDEEGRVKYYVDDVEVNLINKRVQYLDANGKLVSESYVDYTKKNIRKQYATLDDFIRRWTEEEKKQ
VIYDELLEQGIILDELRKEVGKEDIDDFDLICHIVFDAKPLTKSERINNVKKRNYFTKYGEQARKVLEILLDKYKNSNIT
EIEDIKILKLDEFKQIGMPGRIFKLFGGKKKYLEAIKELEAEIYKGEVS

Specific function: The EcoEI enzyme recognizes 5'-GAGN(7)ATGC-3'. Subunit R is required for both nuclease and ATPase activities, but not for modification [H]

COG id: COG4096

COG function: function code V; Type I site-specific restriction-modification system, R (restriction) subunit and related helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI226510991, Length=625, Percent_Identity=28.32, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1788511, Length=402, Percent_Identity=25.3731343283582, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320539, Length=493, Percent_Identity=23.5294117647059, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR013670
- InterPro:   IPR007409 [H]

Pfam domain/function: PF08463 EcoEI_R_C; PF04313 HSDR_N; PF04851 ResIII [H]

EC number: =3.1.21.3 [H]

Molecular weight: Translated: 89313; Mature: 89181

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTETEVCMRYITPAIQNAGWDINKQVLREYSFTDGRVIVRGKLVNRAKPKRADYILQY
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEEEEECCCCCCCCCCEEEEE
KSNIPLAIIEAKKDTLPIGAGMQQALEYAEILDIPFVYSSNGKGFIEHDRNSGREKEIAL
CCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCCCEEEC
EDFPSPEELWGRFSKQKEFTREQEQLYLQDYFYQINYKTPRYYQRVAINRAVEAIAKGQK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCC
RILLVMATGTGKTFTAFQIIHRLWKAGKKKRILFLADRNILVDQTITGDFSPFGDKMIKI
EEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCCCCCEEEEE
QRGNVSHAHEIYLALYQSMTGPEEWQKTFEEYSPDFFDLVVIDECHRGSARANSAWRVVL
ECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHH
EYFDQATHLGLTATPKEDADVSTQGYFGEPIYTYSLKQGIEDGFLAPYKVVRMGLDKDLM
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHCCCCCCCCHHHHHHHCCCCCCC
GFRPIKGQTDKYGRVMEDREYYVNDFDRELILEKRHELVAKEITRYLKEELQDRFAKTIV
CCCCCCCCCCHHCCHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FCQDIEHAENMRQALVNENADLVKQNYKYVMRITGDNPEAKIQLDNFIEPSETYPVIATT
HHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEEEECCCCCEEEEECCCCCCCCCCCEEEEC
SKLMTTGVDAQTCKLIVLDMTINSMSEFKQIIGRGTRLRPDYGKYYFTILDFRGATRLFA
HHHHHCCCCCHHEEEEEEEECHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCEEECC
DPDFDGYPIPDDEDGDNYPGNDVNGGNRIPGNDEGGDEEGRVKYYVDDVEVNLINKRVQY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECEEEHHHHHHHHH
LDANGKLVSESYVDYTKKNIRKQYATLDDFIRRWTEEEKKQVIYDELLEQGIILDELRKE
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VGKEDIDDFDLICHIVFDAKPLTKSERINNVKKRNYFTKYGEQARKVLEILLDKYKNSNI
HCCCCCCCHHHHEEHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TEIEDIKILKLDEFKQIGMPGRIFKLFGGKKKYLEAIKELEAEIYKGEVS
CEECCEEEEEEHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALTETEVCMRYITPAIQNAGWDINKQVLREYSFTDGRVIVRGKLVNRAKPKRADYILQY
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEEEEECCCCCCCCCCEEEEE
KSNIPLAIIEAKKDTLPIGAGMQQALEYAEILDIPFVYSSNGKGFIEHDRNSGREKEIAL
CCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCCCEEEC
EDFPSPEELWGRFSKQKEFTREQEQLYLQDYFYQINYKTPRYYQRVAINRAVEAIAKGQK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHCCCC
RILLVMATGTGKTFTAFQIIHRLWKAGKKKRILFLADRNILVDQTITGDFSPFGDKMIKI
EEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCCCCCEEEEE
QRGNVSHAHEIYLALYQSMTGPEEWQKTFEEYSPDFFDLVVIDECHRGSARANSAWRVVL
ECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHH
EYFDQATHLGLTATPKEDADVSTQGYFGEPIYTYSLKQGIEDGFLAPYKVVRMGLDKDLM
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHCCCCCCCCHHHHHHHCCCCCCC
GFRPIKGQTDKYGRVMEDREYYVNDFDRELILEKRHELVAKEITRYLKEELQDRFAKTIV
CCCCCCCCCCHHCCHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FCQDIEHAENMRQALVNENADLVKQNYKYVMRITGDNPEAKIQLDNFIEPSETYPVIATT
HHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEEEECCCCCEEEEECCCCCCCCCCCEEEEC
SKLMTTGVDAQTCKLIVLDMTINSMSEFKQIIGRGTRLRPDYGKYYFTILDFRGATRLFA
HHHHHCCCCCHHEEEEEEEECHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCEEECC
DPDFDGYPIPDDEDGDNYPGNDVNGGNRIPGNDEGGDEEGRVKYYVDDVEVNLINKRVQY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECEEEHHHHHHHHH
LDANGKLVSESYVDYTKKNIRKQYATLDDFIRRWTEEEKKQVIYDELLEQGIILDELRKE
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VGKEDIDDFDLICHIVFDAKPLTKSERINNVKKRNYFTKYGEQARKVLEILLDKYKNSNI
HCCCCCCCHHHHEEHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TEIEDIKILKLDEFKQIGMPGRIFKLFGGKKKYLEAIKELEAEIYKGEVS
CEECCEEEEEEHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8412658 [H]