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The map label for this gene is uvrC [H]

Identifier: 220932457

GI number: 220932457

Start: 1738819

End: 1740642

Strand: Reverse

Name: uvrC [H]

Synonym: Hore_16210

Alternate gene names: 220932457

Gene position: 1740642-1738819 (Counterclockwise)

Preceding gene: 220932458

Following gene: 220932456

Centisome position: 67.52

GC content: 42.38

Gene sequence:

>1824_bases
ATGAGATATATTGAAGAACAACTAAAGAGGTTACCTGATCGGCCAGGGGTATACCTGATGAAAGATGAGACAGGTGAGGT
TATTTATGTCGGTAAAGCAAAATCCCTGCGCAGGAGAGTCAGATCATACTTTCGTAAGGGTAATCATACCTTTAAAACAA
AAATCATGGTTAAGCATATTGCCGACTTTGATTATATTGTAACCGATACCGAGGTAGAGGCTTTTATCCTTGAGGCCAAT
TTAATAAAAAAATATAACCCCAAGTTTAATATCAGGTTAAAGGATGATAAAACTTACCCCTATATTAAAGTAACGGTTCA
GGAGGATTTTCCCAGGATATTCAAGACCCGCCTTGTAAAAAATGACGGGAATCGTTATTTCGGTCCTTTTACAGATGTTA
ATGCCATTTATAAGACCATTGATGTCCTAAAGGATTTATTTTCTTTAAGAACCTGTAAAAAAAATCTTGAAGCTGGAAAA
CCGGAAAAAAGGCCCTGTCTTAATTATCATATTGGAAAATGTGTCGGTCCCTGTATTGGGGCCATTGACAGGAATTCATA
TCGGGAACTGGTAGATCGTGTTTGTTTATTTTTATCGGGAAAGCAGGATGAATTAATAAATGAAGTTGAAAAAGAGATGT
ATCAGGCTGCTGAAAAGAAAAATTTTGAAAAAGCAGCCCGGTTCCGGGATGCGGTCCGGGCCCTGAAAAATATTTCAGCC
CAGCAGAAGGTTATGTCCAGTAAAAATATCAATCAGGATATTATTGCCCTGGTCGAAGAAGAGGGTGAGGCCTGTGTTCA
GGTCCTGTTCATCAGGAATGGGAGATTGATCGGGCAGGAATACTTCCTGATGGAGGGGGTTGATGAGGAGAGTAATACTG
ATATAATGGTGTCCTTTTTACAGCAATATTATGAACAGGCTCCTGAAATTCCTCAGGAAATAGTTATAAATACCCATGTC
AGTCAAACGGAACTCCTGGAGGACTGGTTACAACAGAAAAAGGGAAAAAAGGTTAAGATTTTAATCCCCCTTAAGGGTGA
GAAGAAGAGGCTGGTGGAGATGGCCTCTAAAAATGCTTCCCAGAACCTTAAAAAGGAATTAATACGACGGAAATACCAGA
AACAGAGGAATGAGAAAGCCCTGGACCAGCTAGTTGAGTATCTTGTACTTTCCAGTAAGCCGGTTCATATCGAAGGGTTT
GATATATCCAATATTCAGGGGAGTGACCCGGTAGCCTCGATGGTTGTCTTTAAAGATGGTGTCCCCTCTAAAGCTGATTA
CCGCCGTTTCAGGATTAAAACAGTTAGTGGCCCCAATGATTTTGCCATGATGCAGGAAGTGGTTAAAAGACGGTATAGTC
GTCTTCTGGAAGAAGAGGGTGATTTACCGGATTTAATTCTGATCGATGGAGGGAAGGGCCAGCTCAATGCAGCCCTGGAG
GTTTTGAAAGAAATGAATCTTGATTACCTGGATATAGCCGGTCTGGCTAAACGGGAAGAAGAGGTATTTCTCCCGGGGCA
AAAGGAACCGGTCATTATACCACGGAAATCGCCAGCTCTTCATTTATTACAGCGGGTCAGGGATGAGGCCCACCGGTTTG
CGGTAAGTTATCACCGGAAACTCCGTTCCCGACGTTTAACCCATACCATGTTAGATGAAATTCCAGGGGTTGGCCCCAAA
AGAAGGAAGGCTTTATTAAGCCATTTCGGGTCCCTCGGGGCAATAAGAAAGGCAACTATTGGTCAGCTAAAAGAAGTGGA
CGGTATCAGTAATAAAACGGCCCGGGTGATATATGATTATCTCCGGGAACATACCCGGCCGTAA

Upstream 100 bases:

>100_bases
AGGTTATTGCTACCGGAACCCCGGAAGAGGTTGCAGCCAACCCTGAATCTTATACGGGACAGTTTTTAAGTAAATATCTC
AATAATAAATGGTGATGCCC

Downstream 100 bases:

>100_bases
TTTTTTTATGTGAAATTATCAGAAAAATGTGAAGATGCTAAAATATCTTGACACATTCTTTTTAAAATTTTATAATATAT
AAGGAGGAATATTCCATACC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MRYIEEQLKRLPDRPGVYLMKDETGEVIYVGKAKSLRRRVRSYFRKGNHTFKTKIMVKHIADFDYIVTDTEVEAFILEAN
LIKKYNPKFNIRLKDDKTYPYIKVTVQEDFPRIFKTRLVKNDGNRYFGPFTDVNAIYKTIDVLKDLFSLRTCKKNLEAGK
PEKRPCLNYHIGKCVGPCIGAIDRNSYRELVDRVCLFLSGKQDELINEVEKEMYQAAEKKNFEKAARFRDAVRALKNISA
QQKVMSSKNINQDIIALVEEEGEACVQVLFIRNGRLIGQEYFLMEGVDEESNTDIMVSFLQQYYEQAPEIPQEIVINTHV
SQTELLEDWLQQKKGKKVKILIPLKGEKKRLVEMASKNASQNLKKELIRRKYQKQRNEKALDQLVEYLVLSSKPVHIEGF
DISNIQGSDPVASMVVFKDGVPSKADYRRFRIKTVSGPNDFAMMQEVVKRRYSRLLEEEGDLPDLILIDGGKGQLNAALE
VLKEMNLDYLDIAGLAKREEEVFLPGQKEPVIIPRKSPALHLLQRVRDEAHRFAVSYHRKLRSRRLTHTMLDEIPGVGPK
RRKALLSHFGSLGAIRKATIGQLKEVDGISNKTARVIYDYLREHTRP

Sequences:

>Translated_607_residues
MRYIEEQLKRLPDRPGVYLMKDETGEVIYVGKAKSLRRRVRSYFRKGNHTFKTKIMVKHIADFDYIVTDTEVEAFILEAN
LIKKYNPKFNIRLKDDKTYPYIKVTVQEDFPRIFKTRLVKNDGNRYFGPFTDVNAIYKTIDVLKDLFSLRTCKKNLEAGK
PEKRPCLNYHIGKCVGPCIGAIDRNSYRELVDRVCLFLSGKQDELINEVEKEMYQAAEKKNFEKAARFRDAVRALKNISA
QQKVMSSKNINQDIIALVEEEGEACVQVLFIRNGRLIGQEYFLMEGVDEESNTDIMVSFLQQYYEQAPEIPQEIVINTHV
SQTELLEDWLQQKKGKKVKILIPLKGEKKRLVEMASKNASQNLKKELIRRKYQKQRNEKALDQLVEYLVLSSKPVHIEGF
DISNIQGSDPVASMVVFKDGVPSKADYRRFRIKTVSGPNDFAMMQEVVKRRYSRLLEEEGDLPDLILIDGGKGQLNAALE
VLKEMNLDYLDIAGLAKREEEVFLPGQKEPVIIPRKSPALHLLQRVRDEAHRFAVSYHRKLRSRRLTHTMLDEIPGVGPK
RRKALLSHFGSLGAIRKATIGQLKEVDGISNKTARVIYDYLREHTRP
>Mature_607_residues
MRYIEEQLKRLPDRPGVYLMKDETGEVIYVGKAKSLRRRVRSYFRKGNHTFKTKIMVKHIADFDYIVTDTEVEAFILEAN
LIKKYNPKFNIRLKDDKTYPYIKVTVQEDFPRIFKTRLVKNDGNRYFGPFTDVNAIYKTIDVLKDLFSLRTCKKNLEAGK
PEKRPCLNYHIGKCVGPCIGAIDRNSYRELVDRVCLFLSGKQDELINEVEKEMYQAAEKKNFEKAARFRDAVRALKNISA
QQKVMSSKNINQDIIALVEEEGEACVQVLFIRNGRLIGQEYFLMEGVDEESNTDIMVSFLQQYYEQAPEIPQEIVINTHV
SQTELLEDWLQQKKGKKVKILIPLKGEKKRLVEMASKNASQNLKKELIRRKYQKQRNEKALDQLVEYLVLSSKPVHIEGF
DISNIQGSDPVASMVVFKDGVPSKADYRRFRIKTVSGPNDFAMMQEVVKRRYSRLLEEEGDLPDLILIDGGKGQLNAALE
VLKEMNLDYLDIAGLAKREEEVFLPGQKEPVIIPRKSPALHLLQRVRDEAHRFAVSYHRKLRSRRLTHTMLDEIPGVGPK
RRKALLSHFGSLGAIRKATIGQLKEVDGISNKTARVIYDYLREHTRP

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=610, Percent_Identity=36.7213114754098, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1788037, Length=174, Percent_Identity=28.1609195402299, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 70174; Mature: 70174

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYIEEQLKRLPDRPGVYLMKDETGEVIYVGKAKSLRRRVRSYFRKGNHTFKTKIMVKHI
CCHHHHHHHHCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
ADFDYIVTDTEVEAFILEANLIKKYNPKFNIRLKDDKTYPYIKVTVQEDFPRIFKTRLVK
CCCCEEEECCCHHHEEEHHHHHHHCCCCEEEEEECCCCCCEEEEEECHHHHHHHHHHHHH
NDGNRYFGPFTDVNAIYKTIDVLKDLFSLRTCKKNLEAGKPEKRPCLNYHIGKCVGPCIG
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
AIDRNSYRELVDRVCLFLSGKQDELINEVEKEMYQAAEKKNFEKAARFRDAVRALKNISA
HCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHH
QQKVMSSKNINQDIIALVEEEGEACVQVLFIRNGRLIGQEYFLMEGVDEESNTDIMVSFL
HHHHHHHCCCCHHHHHHHHHCCHHHHHHHHEECCEEECCHHHHHCCCCCCCCCHHHHHHH
QQYYEQAPEIPQEIVINTHVSQTELLEDWLQQKKGKKVKILIPLKGEKKRLVEMASKNAS
HHHHHHCCCCCHHHEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCHH
QNLKKELIRRKYQKQRNEKALDQLVEYLVLSSKPVHIEGFDISNIQGSDPVASMVVFKDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCHHEEEEEECC
VPSKADYRRFRIKTVSGPNDFAMMQEVVKRRYSRLLEEEGDLPDLILIDGGKGQLNAALE
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
VLKEMNLDYLDIAGLAKREEEVFLPGQKEPVIIPRKSPALHLLQRVRDEAHRFAVSYHRK
HHHHCCCCEEEHHHHHCCCCCEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
LRSRRLTHTMLDEIPGVGPKRRKALLSHFGSLGAIRKATIGQLKEVDGISNKTARVIYDY
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LREHTRP
HHHHCCC
>Mature Secondary Structure
MRYIEEQLKRLPDRPGVYLMKDETGEVIYVGKAKSLRRRVRSYFRKGNHTFKTKIMVKHI
CCHHHHHHHHCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
ADFDYIVTDTEVEAFILEANLIKKYNPKFNIRLKDDKTYPYIKVTVQEDFPRIFKTRLVK
CCCCEEEECCCHHHEEEHHHHHHHCCCCEEEEEECCCCCCEEEEEECHHHHHHHHHHHHH
NDGNRYFGPFTDVNAIYKTIDVLKDLFSLRTCKKNLEAGKPEKRPCLNYHIGKCVGPCIG
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
AIDRNSYRELVDRVCLFLSGKQDELINEVEKEMYQAAEKKNFEKAARFRDAVRALKNISA
HCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHH
QQKVMSSKNINQDIIALVEEEGEACVQVLFIRNGRLIGQEYFLMEGVDEESNTDIMVSFL
HHHHHHHCCCCHHHHHHHHHCCHHHHHHHHEECCEEECCHHHHHCCCCCCCCCHHHHHHH
QQYYEQAPEIPQEIVINTHVSQTELLEDWLQQKKGKKVKILIPLKGEKKRLVEMASKNAS
HHHHHHCCCCCHHHEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCHH
QNLKKELIRRKYQKQRNEKALDQLVEYLVLSSKPVHIEGFDISNIQGSDPVASMVVFKDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCHHEEEEEECC
VPSKADYRRFRIKTVSGPNDFAMMQEVVKRRYSRLLEEEGDLPDLILIDGGKGQLNAALE
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
VLKEMNLDYLDIAGLAKREEEVFLPGQKEPVIIPRKSPALHLLQRVRDEAHRFAVSYHRK
HHHHCCCCEEEHHHHHCCCCCEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
LRSRRLTHTMLDEIPGVGPKRRKALLSHFGSLGAIRKATIGQLKEVDGISNKTARVIYDY
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LREHTRP
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA