Click here to switch to the map view.

The map label for this gene is malR [H]

Identifier: 220932456

GI number: 220932456

Start: 1737445

End: 1738455

Strand: Reverse

Name: malR [H]

Synonym: Hore_16200

Alternate gene names: 220932456

Gene position: 1738455-1737445 (Counterclockwise)

Preceding gene: 220932457

Following gene: 220932455

Centisome position: 67.43

GC content: 43.03

Gene sequence:

>1011_bases
ATGAAAAATGTTACCATTAAGGATGTTGCAAAATATGCAGATGTATCTCCTTCAACAGTTTCCAGGGTAATTTCAAACAG
TCCGAGCATAAGTCCTGAAACCCAGCAGCGCGTCCGGGAAGCCATGAAAAAACTGGGTTACCATCCCAATGTGATTGCCC
GGAGTCTGGTCAAGCAGAAGACCAACACTATTGGGCTTGTTTTATCAAGACCAACTAAAGCTGCTTTTGCCAACCCATTT
TTTCCGGGAATAATCCAGGGTATTGCTTCAGTGGCCCAGGAAGAACATTTTAGCCTGGTACTGGCTGCCGCCAAAGATTA
CCGGGAAGAACATGCTGAGGCTTTGAAGATGTTGAGAAATAGACGGGTTGATGGTATTATCCTGATGGCTTCCAGGGTTA
ACGATGACCTGATAAAACAATTACAGGATAACAGGTCAAAGTTTATATTAATCGGGCGTAGCCTGGAAATAAAGGACATT
CCCCTGGTTAACAATGATAACATCGAAGCAGCCTATAAGGCAGTTAAGTACCTGCACAAGAGAGGGTATGAGAAAGTAGC
CCTGATCTGTGGTCCTGAAGAATATGTTGTTAGTCAGGACAGATTAACAGGTTATAAGAAGGCTTTAGAAGAGGCCGGTC
AAGGCTTTGATAAAAGTCTGGTTATGTATACTAACTTCACTTTTGAAGATGGTTATGATGCTACTAAAAAGCTTATGGCA
AAAAAGGATTTTGATGCTATATTCGCTGTTGATGACCTACTGGCCCTCGGGGCTTTAAGGGCAGCTCAGGACTCCGGTTT
AAAGGTCCCTGATGATATGGGTATAGTAGGATTTAACGACGATCCCATGGTGTCCTATGTTAAACCTGCCTTAACTACTG
TCAGGATTCCTATTGTAGAGATGGGTGAAAAGGCTGCCCGGATGCTAATCAGGATTATAACCGAAGAAGATTACAATGGA
GAAGAACAAATTATACCTACCGAAATATTGCCGAGGGGATCAACCAGGTAA

Upstream 100 bases:

>100_bases
CTTTTTAATTGGACTGGCATACTATTTATTTTTAAAAGGTGTGCAAACGTTTTACTGTTAAACACAATCATATCCAGGAA
TAAACAGGGTGGTTATAATA

Downstream 100 bases:

>100_bases
AGGCGTACATAAAATATATGTCTGAATTAGTTATGAAAGTTATATTTAGTTTCAAAAGAACTATTAATCGAAAACCATTT
GCGAAGAAAATAACTGTGTT

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: Maltose operon transcriptional repressor [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKNVTIKDVAKYADVSPSTVSRVISNSPSISPETQQRVREAMKKLGYHPNVIARSLVKQKTNTIGLVLSRPTKAAFANPF
FPGIIQGIASVAQEEHFSLVLAAAKDYREEHAEALKMLRNRRVDGIILMASRVNDDLIKQLQDNRSKFILIGRSLEIKDI
PLVNNDNIEAAYKAVKYLHKRGYEKVALICGPEEYVVSQDRLTGYKKALEEAGQGFDKSLVMYTNFTFEDGYDATKKLMA
KKDFDAIFAVDDLLALGALRAAQDSGLKVPDDMGIVGFNDDPMVSYVKPALTTVRIPIVEMGEKAARMLIRIITEEDYNG
EEQIIPTEILPRGSTR

Sequences:

>Translated_336_residues
MKNVTIKDVAKYADVSPSTVSRVISNSPSISPETQQRVREAMKKLGYHPNVIARSLVKQKTNTIGLVLSRPTKAAFANPF
FPGIIQGIASVAQEEHFSLVLAAAKDYREEHAEALKMLRNRRVDGIILMASRVNDDLIKQLQDNRSKFILIGRSLEIKDI
PLVNNDNIEAAYKAVKYLHKRGYEKVALICGPEEYVVSQDRLTGYKKALEEAGQGFDKSLVMYTNFTFEDGYDATKKLMA
KKDFDAIFAVDDLLALGALRAAQDSGLKVPDDMGIVGFNDDPMVSYVKPALTTVRIPIVEMGEKAARMLIRIITEEDYNG
EEQIIPTEILPRGSTR
>Mature_336_residues
MKNVTIKDVAKYADVSPSTVSRVISNSPSISPETQQRVREAMKKLGYHPNVIARSLVKQKTNTIGLVLSRPTKAAFANPF
FPGIIQGIASVAQEEHFSLVLAAAKDYREEHAEALKMLRNRRVDGIILMASRVNDDLIKQLQDNRSKFILIGRSLEIKDI
PLVNNDNIEAAYKAVKYLHKRGYEKVALICGPEEYVVSQDRLTGYKKALEEAGQGFDKSLVMYTNFTFEDGYDATKKLMA
KKDFDAIFAVDDLLALGALRAAQDSGLKVPDDMGIVGFNDDPMVSYVKPALTTVRIPIVEMGEKAARMLIRIITEEDYNG
EEQIIPTEILPRGSTR

Specific function: Transcriptional repressor of the maltosaccharide utilization operons malxCD and malMP [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=333, Percent_Identity=31.2312312312312, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1787948, Length=332, Percent_Identity=34.0361445783133, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789202, Length=301, Percent_Identity=32.2259136212625, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1789068, Length=317, Percent_Identity=31.8611987381703, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1790194, Length=332, Percent_Identity=29.8192771084337, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1787580, Length=312, Percent_Identity=27.8846153846154, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI1788474, Length=309, Percent_Identity=30.0970873786408, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1787906, Length=341, Percent_Identity=26.099706744868, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1786540, Length=340, Percent_Identity=27.6470588235294, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790715, Length=328, Percent_Identity=27.7439024390244, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI48994940, Length=330, Percent_Identity=27.8787878787879, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1790689, Length=340, Percent_Identity=25, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789456, Length=348, Percent_Identity=26.7241379310345, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37426; Mature: 37426

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVTIKDVAKYADVSPSTVSRVISNSPSISPETQQRVREAMKKLGYHPNVIARSLVKQK
CCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
TNTIGLVLSRPTKAAFANPFFPGIIQGIASVAQEEHFSLVLAAAKDYREEHAEALKMLRN
CCCEEEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRVDGIILMASRVNDDLIKQLQDNRSKFILIGRSLEIKDIPLVNNDNIEAAYKAVKYLHK
CCCCEEEEEECCCCHHHHHHHHCCCCEEEEEECCCEECCCCEECCCCHHHHHHHHHHHHH
RGYEKVALICGPEEYVVSQDRLTGYKKALEEAGQGFDKSLVMYTNFTFEDGYDATKKLMA
CCCCEEEEEECCHHHHHCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHH
KKDFDAIFAVDDLLALGALRAAQDSGLKVPDDMGIVGFNDDPMVSYVKPALTTVRIPIVE
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHEEECHHHH
MGEKAARMLIRIITEEDYNGEEQIIPTEILPRGSTR
HCHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCC
>Mature Secondary Structure
MKNVTIKDVAKYADVSPSTVSRVISNSPSISPETQQRVREAMKKLGYHPNVIARSLVKQK
CCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
TNTIGLVLSRPTKAAFANPFFPGIIQGIASVAQEEHFSLVLAAAKDYREEHAEALKMLRN
CCCEEEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRVDGIILMASRVNDDLIKQLQDNRSKFILIGRSLEIKDIPLVNNDNIEAAYKAVKYLHK
CCCCEEEEEECCCCHHHHHHHHCCCCEEEEEECCCEECCCCEECCCCHHHHHHHHHHHHH
RGYEKVALICGPEEYVVSQDRLTGYKKALEEAGQGFDKSLVMYTNFTFEDGYDATKKLMA
CCCCEEEEEECCHHHHHCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHH
KKDFDAIFAVDDLLALGALRAAQDSGLKVPDDMGIVGFNDDPMVSYVKPALTTVRIPIVE
HCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHEEECHHHH
MGEKAARMLIRIITEEDYNGEEQIIPTEILPRGSTR
HCHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]