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The map label for this gene is era

Identifier: 220932088

GI number: 220932088

Start: 1344997

End: 1345881

Strand: Reverse

Name: era

Synonym: Hore_12510

Alternate gene names: 220932088

Gene position: 1345881-1344997 (Counterclockwise)

Preceding gene: 220932089

Following gene: 220932087

Centisome position: 52.2

GC content: 38.64

Gene sequence:

>885_bases
ATGAGCTATAAATCCGGTTTTGTTTCTGTAATCGGGAGACCGAATGTGGGAAAATCGACCCTGATCAATAATTTAATTGG
GCAGAAAGTTGTTATCACATCTCCCAGACCCCAGACTACAAGAAATAGTGTCAGGGGAATATATACCAGGCCAGAGGGCC
AGATTGTTTTTGTAGATACTCCAGGAATTCATAAGGCCAGGAATAAACTCGATAATTATATGCTGGAGAAGGCATATGAG
AGTCTTGAAGACATAGATGTTATTATTTTTATGGTAGATGGAAACTATTCCTTTGGTAAAGGAGACGAATTTATCTATAA
TCAGATTAAAGGTGTCAGAGTCCCTGTCATTGTTGCCATGAATAAAATTGACAGGATCAATAAGGAGATAGTTATGGAAC
GTCAAAAGAATTATGAAGAAAGAACAGGTTTTCCGGTTATACCTATATCTGCCTCCCGGGGAACCAATCTGGATACCCTG
GTTGAGGAAATTTTTACATTTTTACCTGAAGGCCCCCAGTATTATCCTGAGGATATGGTTACAGATCAGATTGAACAGTT
TGTGGTGGCTGAACTAATAAGGGAGAAGGTTTTTATTTTAACGAGGGAAGAAGTTCCTTATGGGGTAGCTGTTAAAATAG
AGGAGATGAAAGAACGGGACAACAGTACTATGTATATAAGAGCCAATATTTACGCAGAAAAGAAGTCCCACAAAAAAATT
ATTATCGGTCATAAGGGAAAAATGATTAAAAAAATCGGGCGACTGGCCAGAGAAGAAATAGAAAAACTCCTTCAGACAAA
AGTGTATCTGGATTTATGGGTCAAGATTGAAAAAGACTGGAGGGAAAAAGAAGGACTGGTTAAGCGTATGGGCTACAAGG
GGTGA

Upstream 100 bases:

>100_bases
CTGATATGAAGGTGATCATGGGTAATTTGTCAGGAAATACTGTAGAAACAACCGCTAAAGAACTCCTTCCGGGTGCCTTT
AACAGGGGGGATCTGGATTC

Downstream 100 bases:

>100_bases
AATAGAAATGGAGAAATTAAAAGAGCAATTACCTGATGGTTTTGAATCGCTGGAACTTTTTTTAGAGGAATCGTATCCGG
CTGATATTGCTGATTTTTTA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSYKSGFVSVIGRPNVGKSTLINNLIGQKVVITSPRPQTTRNSVRGIYTRPEGQIVFVDTPGIHKARNKLDNYMLEKAYE
SLEDIDVIIFMVDGNYSFGKGDEFIYNQIKGVRVPVIVAMNKIDRINKEIVMERQKNYEERTGFPVIPISASRGTNLDTL
VEEIFTFLPEGPQYYPEDMVTDQIEQFVVAELIREKVFILTREEVPYGVAVKIEEMKERDNSTMYIRANIYAEKKSHKKI
IIGHKGKMIKKIGRLAREEIEKLLQTKVYLDLWVKIEKDWREKEGLVKRMGYKG

Sequences:

>Translated_294_residues
MSYKSGFVSVIGRPNVGKSTLINNLIGQKVVITSPRPQTTRNSVRGIYTRPEGQIVFVDTPGIHKARNKLDNYMLEKAYE
SLEDIDVIIFMVDGNYSFGKGDEFIYNQIKGVRVPVIVAMNKIDRINKEIVMERQKNYEERTGFPVIPISASRGTNLDTL
VEEIFTFLPEGPQYYPEDMVTDQIEQFVVAELIREKVFILTREEVPYGVAVKIEEMKERDNSTMYIRANIYAEKKSHKKI
IIGHKGKMIKKIGRLAREEIEKLLQTKVYLDLWVKIEKDWREKEGLVKRMGYKG
>Mature_293_residues
SYKSGFVSVIGRPNVGKSTLINNLIGQKVVITSPRPQTTRNSVRGIYTRPEGQIVFVDTPGIHKARNKLDNYMLEKAYES
LEDIDVIIFMVDGNYSFGKGDEFIYNQIKGVRVPVIVAMNKIDRINKEIVMERQKNYEERTGFPVIPISASRGTNLDTLV
EEIFTFLPEGPQYYPEDMVTDQIEQFVVAELIREKVFILTREEVPYGVAVKIEEMKERDNSTMYIRANIYAEKKSHKKII
IGHKGKMIKKIGRLAREEIEKLLQTKVYLDLWVKIEKDWREKEGLVKRMGYKG

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=322, Percent_Identity=27.0186335403727, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI1788919, Length=291, Percent_Identity=37.1134020618557, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI87082120, Length=181, Percent_Identity=27.0718232044199, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI2367268, Length=156, Percent_Identity=28.8461538461538, Blast_Score=70, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646434, Length=298, Percent_Identity=24.496644295302, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_HALOH (B8CXI2)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002508996.1
- ProteinModelPortal:   B8CXI2
- SMR:   B8CXI2
- GeneID:   7313572
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_12510
- HOGENOM:   HBG561652
- OMA:   AKDWQRD
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PRINTS:   PR00326
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 33989; Mature: 33858

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYKSGFVSVIGRPNVGKSTLINNLIGQKVVITSPRPQTTRNSVRGIYTRPEGQIVFVDT
CCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEECCCCCCCHHHCCEEEECCCCEEEEEEC
PGIHKARNKLDNYMLEKAYESLEDIDVIIFMVDGNYSFGKGDEFIYNQIKGVRVPVIVAM
CCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHCCCEEEEEEEE
NKIDRINKEIVMERQKNYEERTGFPVIPISASRGTNLDTLVEEIFTFLPEGPQYYPEDMV
HHHHHHHHHHHHHHHHCHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCHHHH
TDQIEQFVVAELIREKVFILTREEVPYGVAVKIEEMKERDNSTMYIRANIYAEKKSHKKI
HHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEEHHHHCCCCCEEEEEEEEEECCCCCCEE
IIGHKGKMIKKIGRLAREEIEKLLQTKVYLDLWVKIEKDWREKEGLVKRMGYKG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SYKSGFVSVIGRPNVGKSTLINNLIGQKVVITSPRPQTTRNSVRGIYTRPEGQIVFVDT
CCCCCEEEEECCCCCCHHHHHHHHHCCEEEEECCCCCCCHHHCCEEEECCCCEEEEEEC
PGIHKARNKLDNYMLEKAYESLEDIDVIIFMVDGNYSFGKGDEFIYNQIKGVRVPVIVAM
CCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHCCCEEEEEEEE
NKIDRINKEIVMERQKNYEERTGFPVIPISASRGTNLDTLVEEIFTFLPEGPQYYPEDMV
HHHHHHHHHHHHHHHHCHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCHHHH
TDQIEQFVVAELIREKVFILTREEVPYGVAVKIEEMKERDNSTMYIRANIYAEKKSHKKI
HHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEEHHHHCCCCCEEEEEEEEEECCCCCCEE
IIGHKGKMIKKIGRLAREEIEKLLQTKVYLDLWVKIEKDWREKEGLVKRMGYKG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA