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The map label for this gene is tdcB [H]

Identifier: 220931774

GI number: 220931774

Start: 1003787

End: 1004998

Strand: Direct

Name: tdcB [H]

Synonym: Hore_09310

Alternate gene names: 220931774

Gene position: 1003787-1004998 (Clockwise)

Preceding gene: 220931773

Following gene: 220931775

Centisome position: 38.93

GC content: 38.7

Gene sequence:

>1212_bases
ATGGAAATAACCCTAGAGGATGTAAAGAAAGCATCTGAACGGTTAAAGGGGGTAATTCACCGTACTAATTTAATTTATTC
ATATACTTTTAGCAAACTGACGGGTAATAAAGTCTATATGAAACCTGAAAATTTTCAAAAAACCGGTTCATTCAAAATCA
GGGGGGCCTTTAATAAAATTGCCTGTCTCAGTGATGAGGAAAAACGCCATGGGGTAATTGCTTCTTCAGCCGGAAACCAC
GCTCAGGGGGTGGCTTTCGGAGCCAGTCAAAATGGCATTAAATCCACTATTGTTATGCCCAAGAGGGCTCCGATGGCTAA
AGTAACCGCTACCAAAAATTATGGAGCTAAAGTTGTGTTATATGGAAATAATTATGATGAAGCTTATGAAAAGGCAAAAG
AGATTCAGGAGGAAACTAAAGCCACCTTTGTTCATCCCTTTAACGATCCTTATGTTATTGCCGGTCAGGGGACACTTGCT
CTTGAAATAATTGAGGAGTTACCCGATGCTGATATTATAGTTACCCCCGTCGGTGGTGGGGGATTAATATCGGGAATAGC
TCTTGCTGCCAAGGCCCTTAATCCCTCTATCAAAATAGTTGGAGTTGAAGCCTGTCAGGCTGCATCAATGGCTAATTCAT
TAAACAAAGGGAAGCTTGCAACACTGACTGAAGTAAATACTATAGCTGATGGAATTTGTGTAAAAACTCCGGGGGATTTA
ACATTTAATATCTGCCGGGAATATGTAGATGATGTAGTAGCTGTCAGTGAAGAGGAAATTGCTAATGCCATATTAATGTT
AATGGAAAGGGCTAAAATGGTTGTAGAAGGAGCGGGAGCAACCTCGATAGCAGCCCTTATATACAAAAAACTCGGCGTTC
AAAATAAAAAAATAGTTCCGGTGCTGAGCGGTGGTAATATTGACTTTAATATTATTTCCCGTATTATTGAAAGGGGTTTA
GCCAAGGCCGGCCGAAAAACAATTATTAAAACATACCTGGAAGACAGACCGGGTAGTTTGCAAAAACTACTTAGTTTGAT
TGCCGAGCTTGATTCCAATATTATTTCTATAAATCATAATCATTATAACCCCGATATTTCTATAGATAAGGCGGAAGTAG
AACTTGAACTTGAAACAAAACACCGGGACCATGTTAATGATATAATCAAGAAGTTAAAGGAAAATAATTATAAAGTTATC
CGTCTTTTGTAA

Upstream 100 bases:

>100_bases
TTTTATATATAACCCTTACTTAAGGAATTGACATAATTAAAGTCCCGGGGAAATTATATTTTGTATTATAAATTTAAAAA
TATAGAGGGAGGGGTAATGT

Downstream 100 bases:

>100_bases
CCTGACCGTAACCCGGACATATTTATATTATATATATTTTATAGGACAGGAAGATTGGGAAAAAAGTTATTAATTTATAA
AGCAGTTATTGCCATCGATT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MEITLEDVKKASERLKGVIHRTNLIYSYTFSKLTGNKVYMKPENFQKTGSFKIRGAFNKIACLSDEEKRHGVIASSAGNH
AQGVAFGASQNGIKSTIVMPKRAPMAKVTATKNYGAKVVLYGNNYDEAYEKAKEIQEETKATFVHPFNDPYVIAGQGTLA
LEIIEELPDADIIVTPVGGGGLISGIALAAKALNPSIKIVGVEACQAASMANSLNKGKLATLTEVNTIADGICVKTPGDL
TFNICREYVDDVVAVSEEEIANAILMLMERAKMVVEGAGATSIAALIYKKLGVQNKKIVPVLSGGNIDFNIISRIIERGL
AKAGRKTIIKTYLEDRPGSLQKLLSLIAELDSNIISINHNHYNPDISIDKAEVELELETKHRDHVNDIIKKLKENNYKVI
RLL

Sequences:

>Translated_403_residues
MEITLEDVKKASERLKGVIHRTNLIYSYTFSKLTGNKVYMKPENFQKTGSFKIRGAFNKIACLSDEEKRHGVIASSAGNH
AQGVAFGASQNGIKSTIVMPKRAPMAKVTATKNYGAKVVLYGNNYDEAYEKAKEIQEETKATFVHPFNDPYVIAGQGTLA
LEIIEELPDADIIVTPVGGGGLISGIALAAKALNPSIKIVGVEACQAASMANSLNKGKLATLTEVNTIADGICVKTPGDL
TFNICREYVDDVVAVSEEEIANAILMLMERAKMVVEGAGATSIAALIYKKLGVQNKKIVPVLSGGNIDFNIISRIIERGL
AKAGRKTIIKTYLEDRPGSLQKLLSLIAELDSNIISINHNHYNPDISIDKAEVELELETKHRDHVNDIIKKLKENNYKVI
RLL
>Mature_403_residues
MEITLEDVKKASERLKGVIHRTNLIYSYTFSKLTGNKVYMKPENFQKTGSFKIRGAFNKIACLSDEEKRHGVIASSAGNH
AQGVAFGASQNGIKSTIVMPKRAPMAKVTATKNYGAKVVLYGNNYDEAYEKAKEIQEETKATFVHPFNDPYVIAGQGTLA
LEIIEELPDADIIVTPVGGGGLISGIALAAKALNPSIKIVGVEACQAASMANSLNKGKLATLTEVNTIADGICVKTPGDL
TFNICREYVDDVVAVSEEEIANAILMLMERAKMVVEGAGATSIAALIYKKLGVQNKKIVPVLSGGNIDFNIISRIIERGL
AKAGRKTIIKTYLEDRPGSLQKLLSLIAELDSNIISINHNHYNPDISIDKAEVELELETKHRDHVNDIIKKLKENNYKVI
RLL

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=316, Percent_Identity=41.4556962025316, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI19923959, Length=313, Percent_Identity=28.7539936102236, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI33469958, Length=290, Percent_Identity=28.6206896551724, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1789505, Length=317, Percent_Identity=48.5804416403785, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1790207, Length=370, Percent_Identity=36.2162162162162, Blast_Score=219, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI71991565, Length=398, Percent_Identity=36.9346733668342, Blast_Score=230, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI17537387, Length=393, Percent_Identity=37.1501272264631, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI17508781, Length=315, Percent_Identity=33.968253968254, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6320930, Length=346, Percent_Identity=39.3063583815029, Blast_Score=223, Evalue=6e-59,
Organism=Saccharomyces cerevisiae, GI6322631, Length=314, Percent_Identity=41.4012738853503, Blast_Score=209, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6319788, Length=286, Percent_Identity=27.6223776223776, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322024, Length=161, Percent_Identity=30.4347826086957, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21355833, Length=400, Percent_Identity=40, Blast_Score=221, Evalue=8e-58,
Organism=Drosophila melanogaster, GI24645328, Length=304, Percent_Identity=39.8026315789474, Blast_Score=155, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 43867; Mature: 43867

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS00063 ALDOKETO_REDUCTASE_3 ; PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEITLEDVKKASERLKGVIHRTNLIYSYTFSKLTGNKVYMKPENFQKTGSFKIRGAFNKI
CCCCHHHHHHHHHHHHHHHHHHEEEEEEEEHHCCCCEEEECCCCCCCCCCEEEEECCCEE
ACLSDEEKRHGVIASSAGNHAQGVAFGASQNGIKSTIVMPKRAPMAKVTATKNYGAKVVL
EECCCCHHHCCEEEECCCCCCCCEEECCCCCCCEEEEECCCCCCCEEEEEECCCCCEEEE
YGNNYDEAYEKAKEIQEETKATFVHPFNDPYVIAGQGTLALEIIEELPDADIIVTPVGGG
ECCCHHHHHHHHHHHHHHHHCEEEECCCCCEEEECCCCHHHHHHHHCCCCCEEEEECCCC
GLISGIALAAKALNPSIKIVGVEACQAASMANSLNKGKLATLTEVNTIADGICVKTPGDL
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCEEEECCCCC
TFNICREYVDDVVAVSEEEIANAILMLMERAKMVVEGAGATSIAALIYKKLGVQNKKIVP
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHCCCCCEEEE
VLSGGNIDFNIISRIIERGLAKAGRKTIIKTYLEDRPGSLQKLLSLIAELDSNIISINHN
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECC
HYNPDISIDKAEVELELETKHRDHVNDIIKKLKENNYKVIRLL
CCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHCCCEEEEEEC
>Mature Secondary Structure
MEITLEDVKKASERLKGVIHRTNLIYSYTFSKLTGNKVYMKPENFQKTGSFKIRGAFNKI
CCCCHHHHHHHHHHHHHHHHHHEEEEEEEEHHCCCCEEEECCCCCCCCCCEEEEECCCEE
ACLSDEEKRHGVIASSAGNHAQGVAFGASQNGIKSTIVMPKRAPMAKVTATKNYGAKVVL
EECCCCHHHCCEEEECCCCCCCCEEECCCCCCCEEEEECCCCCCCEEEEEECCCCCEEEE
YGNNYDEAYEKAKEIQEETKATFVHPFNDPYVIAGQGTLALEIIEELPDADIIVTPVGGG
ECCCHHHHHHHHHHHHHHHHCEEEECCCCCEEEECCCCHHHHHHHHCCCCCEEEEECCCC
GLISGIALAAKALNPSIKIVGVEACQAASMANSLNKGKLATLTEVNTIADGICVKTPGDL
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCEEEECCCCC
TFNICREYVDDVVAVSEEEIANAILMLMERAKMVVEGAGATSIAALIYKKLGVQNKKIVP
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHCCCCCEEEE
VLSGGNIDFNIISRIIERGLAKAGRKTIIKTYLEDRPGSLQKLLSLIAELDSNIISINHN
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECC
HYNPDISIDKAEVELELETKHRDHVNDIIKKLKENNYKVIRLL
CCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]