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The map label for this gene is lspA

Identifier: 220931775

GI number: 220931775

Start: 1005136

End: 1005573

Strand: Direct

Name: lspA

Synonym: Hore_09320

Alternate gene names: 220931775

Gene position: 1005136-1005573 (Clockwise)

Preceding gene: 220931774

Following gene: 220931776

Centisome position: 38.99

GC content: 35.16

Gene sequence:

>438_bases
ATGGTATATATTGTTGTTTTAATAGTTATATTACTTGATCAGATGGTTAAATTATTAGTCATGGAAAAAATGAAGGTTTC
AGAATCTATACCGATTATAAAGGATGTTTTTCATCTTACCTATGTTCAAAACCGGGGGGCAGCCTTCGGGATTTTACCCG
GCCGGAGGTATTTATTTATAGTCATTACTGTAGTTGTAATCTCTTTTCTGTTAATTTATTATTATAAAACCAGGGGCTCT
GGAATGGTTACCCTGTCTACAGGATTAATAATTGGTGGTGCCCTGGGTAATTTAATTGACCGTATTAGATTTGGTTATGT
GGTTGATTACCTTGATTTTAGAATATGGCCTGTTTTTAATCTGGCTGATTCTTCTGTTGTAATTGGGGCGGCACTTTTAA
TACTGTATCTCTGGCAGCAGGAAAAAGTAGGTGATTAA

Upstream 100 bases:

>100_bases
TTTATAGGACAGGAAGATTGGGAAAAAAGTTATTAATTTATAAAGCAGTTATTGCCATCGATTACTGGCTATGCTACAAT
GAGGTAAGGGGCCTGGAATA

Downstream 100 bases:

>100_bases
GCTATGGATGTGGATGAAAAAGTTTATGAAGTTTCTTCTGAAGAAGAGGGGAAGAGGATAGATAAATATCTTAGTAAGTT
AAATAAAGATTTATCACGTT

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MVYIVVLIVILLDQMVKLLVMEKMKVSESIPIIKDVFHLTYVQNRGAAFGILPGRRYLFIVITVVVISFLLIYYYKTRGS
GMVTLSTGLIIGGALGNLIDRIRFGYVVDYLDFRIWPVFNLADSSVVIGAALLILYLWQQEKVGD

Sequences:

>Translated_145_residues
MVYIVVLIVILLDQMVKLLVMEKMKVSESIPIIKDVFHLTYVQNRGAAFGILPGRRYLFIVITVVVISFLLIYYYKTRGS
GMVTLSTGLIIGGALGNLIDRIRFGYVVDYLDFRIWPVFNLADSSVVIGAALLILYLWQQEKVGD
>Mature_145_residues
MVYIVVLIVILLDQMVKLLVMEKMKVSESIPIIKDVFHLTYVQNRGAAFGILPGRRYLFIVITVVVISFLLIYYYKTRGS
GMVTLSTGLIIGGALGNLIDRIRFGYVVDYLDFRIWPVFNLADSSVVIGAALLILYLWQQEKVGD

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=140, Percent_Identity=34.2857142857143, Blast_Score=83, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_HALOH (B8CWL9)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002508683.1
- MEROPS:   A08.001
- GeneID:   7313425
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_09320
- HOGENOM:   HBG724422
- OMA:   FFYITSH
- ProtClustDB:   CLSK2806338
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 16393; Mature: 16393

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 100-100 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

HASH(0x207a509c)-; HASH(0x1fca0fcc)-; HASH(0x209a1aec)-; HASH(0x209db7f4)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYIVVLIVILLDQMVKLLVMEKMKVSESIPIIKDVFHLTYVQNRGAAFGILPGRRYLFI
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHH
VITVVVISFLLIYYYKTRGSGMVTLSTGLIIGGALGNLIDRIRFGYVVDYLDFRIWPVFN
HHHHHHHHHHHHHHHHCCCCCEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHHEEEEEE
LADSSVVIGAALLILYLWQQEKVGD
CCCCHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure
MVYIVVLIVILLDQMVKLLVMEKMKVSESIPIIKDVFHLTYVQNRGAAFGILPGRRYLFI
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHH
VITVVVISFLLIYYYKTRGSGMVTLSTGLIIGGALGNLIDRIRFGYVVDYLDFRIWPVFN
HHHHHHHHHHHHHHHHCCCCCEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHHEEEEEE
LADSSVVIGAALLILYLWQQEKVGD
CCCCHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA