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The map label for this gene is map [H]

Identifier: 220930986

GI number: 220930986

Start: 147176

End: 147931

Strand: Direct

Name: map [H]

Synonym: Hore_01380

Alternate gene names: 220930986

Gene position: 147176-147931 (Clockwise)

Preceding gene: 220930985

Following gene: 220930987

Centisome position: 5.71

GC content: 44.71

Gene sequence:

>756_bases
ATGATTATTTTAAAATCACCCCGTGAAATTAATATTATGCGTGAAGCAAATCGAATAGTTGCTGAAGTACACGCCCGCCT
GGCTGAAGAAATCTCCCCGGGTATTACGACTGCTGATATTGATAAGCTGGGGGAAGAGTTAATTAGAAAAAAAGGTGGAA
TTCCTTCTTTTAAAGGGTATCGTGGTTATCCAGCTTCAGTATGTGTCTCCATTAATGACGAAGTGGTGCACGGGATTCCC
AGTAAAAAACGGGTTATTGAATCAGGGGACGTAGTTAGCCTTGATATCGGTGTTATCTATGAAGGGTTTCACGGGGATGC
TGCCAGGACTCTGGGGGTCGGAGAGGTTAGCAAGGAGGCCTCCCGACTTATTGAGATAACGGAGCAGTCATTCTTTCATG
GTATAGAACAGGCAAAGCCAGGAAACAGGTTATCTGACATCTCTCATGCTGTACAGAACTATGTTGAGAAAAATGGTTTT
TCAGTGGTCCGGGAATATGTCGGTCATGGTATTGGACGTGATATGCATGAGGACCCCCAGATTCCCAATTTTGGACCGCC
CGGAAGAGGCCCATTATTAAAGGAAGGAATGACCCTGGCTATTGAACCTATGGTTAATGCGGGAGGCTATATGGTTAAAA
CCCTGGCAGATGGCTGGACTGTAGTAACAAAAGATGGTAGTCTATCAGCCCATTACGAAAACACAATTGCTGTAACAAAA
GATGGTCCTGTTATTCTGAGCTGTCTGGAGTCCTGA

Upstream 100 bases:

>100_bases
ATATTACCGGAACCAGGGTAATTTAAAGACAGTGGAAAGTACCGGTGGGATTGACGAGGTGTTTAATAAAATACAAGAAA
TTATCGGGGCTGGTGTCTAA

Downstream 100 bases:

>100_bases
TTGCATTTTTCTGTTTTGTTGTGATATAATAATTTGGAGGTTTTGCAGGAAATATCCTCCTGGAAAAGGGGGGGTTTTAT
GTGTGGTAAGTTTCAGTTGG

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MIILKSPREINIMREANRIVAEVHARLAEEISPGITTADIDKLGEELIRKKGGIPSFKGYRGYPASVCVSINDEVVHGIP
SKKRVIESGDVVSLDIGVIYEGFHGDAARTLGVGEVSKEASRLIEITEQSFFHGIEQAKPGNRLSDISHAVQNYVEKNGF
SVVREYVGHGIGRDMHEDPQIPNFGPPGRGPLLKEGMTLAIEPMVNAGGYMVKTLADGWTVVTKDGSLSAHYENTIAVTK
DGPVILSCLES

Sequences:

>Translated_251_residues
MIILKSPREINIMREANRIVAEVHARLAEEISPGITTADIDKLGEELIRKKGGIPSFKGYRGYPASVCVSINDEVVHGIP
SKKRVIESGDVVSLDIGVIYEGFHGDAARTLGVGEVSKEASRLIEITEQSFFHGIEQAKPGNRLSDISHAVQNYVEKNGF
SVVREYVGHGIGRDMHEDPQIPNFGPPGRGPLLKEGMTLAIEPMVNAGGYMVKTLADGWTVVTKDGSLSAHYENTIAVTK
DGPVILSCLES
>Mature_251_residues
MIILKSPREINIMREANRIVAEVHARLAEEISPGITTADIDKLGEELIRKKGGIPSFKGYRGYPASVCVSINDEVVHGIP
SKKRVIESGDVVSLDIGVIYEGFHGDAARTLGVGEVSKEASRLIEITEQSFFHGIEQAKPGNRLSDISHAVQNYVEKNGF
SVVREYVGHGIGRDMHEDPQIPNFGPPGRGPLLKEGMTLAIEPMVNAGGYMVKTLADGWTVVTKDGSLSAHYENTIAVTK
DGPVILSCLES

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=246, Percent_Identity=38.2113821138211, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI40385867, Length=248, Percent_Identity=33.8709677419355, Blast_Score=153, Evalue=1e-37,
Organism=Escherichia coli, GI1786364, Length=247, Percent_Identity=44.9392712550607, Blast_Score=231, Evalue=4e-62,
Organism=Escherichia coli, GI1788728, Length=212, Percent_Identity=29.2452830188679, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71996291, Length=236, Percent_Identity=36.864406779661, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6323273, Length=240, Percent_Identity=37.0833333333333, Blast_Score=175, Evalue=6e-45,
Organism=Drosophila melanogaster, GI21355531, Length=239, Percent_Identity=37.6569037656904, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27175; Mature: 27175

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILKSPREINIMREANRIVAEVHARLAEEISPGITTADIDKLGEELIRKKGGIPSFKGY
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
RGYPASVCVSINDEVVHGIPSKKRVIESGDVVSLDIGVIYEGFHGDAARTLGVGEVSKEA
CCCCCEEEEEECHHHHHCCCCHHHEECCCCEEEEEEEEEEECCCCCCHHHCCCCHHHHHH
SRLIEITEQSFFHGIEQAKPGNRLSDISHAVQNYVEKNGFSVVREYVGHGIGRDMHEDPQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCC
IPNFGPPGRGPLLKEGMTLAIEPMVNAGGYMVKTLADGWTVVTKDGSLSAHYENTIAVTK
CCCCCCCCCCCHHHCCCEEEEECCCCCCCEEEEEECCCEEEEEECCCCEEECCCEEEEEC
DGPVILSCLES
CCCEEEEEECC
>Mature Secondary Structure
MIILKSPREINIMREANRIVAEVHARLAEEISPGITTADIDKLGEELIRKKGGIPSFKGY
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
RGYPASVCVSINDEVVHGIPSKKRVIESGDVVSLDIGVIYEGFHGDAARTLGVGEVSKEA
CCCCCEEEEEECHHHHHCCCCHHHEECCCCEEEEEEEEEEECCCCCCHHHCCCCHHHHHH
SRLIEITEQSFFHGIEQAKPGNRLSDISHAVQNYVEKNGFSVVREYVGHGIGRDMHEDPQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCC
IPNFGPPGRGPLLKEGMTLAIEPMVNAGGYMVKTLADGWTVVTKDGSLSAHYENTIAVTK
CCCCCCCCCCCHHHCCCEEEEECCCCCCCEEEEEECCCEEEEEECCCCEEECCCEEEEEC
DGPVILSCLES
CCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]