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The map label for this gene is adk [H]

Identifier: 220930985

GI number: 220930985

Start: 146525

End: 147175

Strand: Direct

Name: adk [H]

Synonym: Hore_01370

Alternate gene names: 220930985

Gene position: 146525-147175 (Clockwise)

Preceding gene: 220930984

Following gene: 220930986

Centisome position: 5.68

GC content: 41.63

Gene sequence:

>651_bases
ATGAATATTGTATTATTGGGTCTACCAGGGGCAGGTAAAGGAACCCAGGCCAAGAAAATGAGTCAGGAATACAACCTGCC
CCATATTGCCACCGGGGATATCTTTCGGCAGGCTATCCGGGAGGAAACCCCTCTGGGAAAAGAGGCAAAAAAATATCTTG
ATTCCGGGGAACTGGTTCCGGATGAGATTACTATTGGTATAGTAAGGGAACGTATCCAGAAAGATGATTGTGATAATGGT
TTTATTCTTGATGGTTTTCCCAGGACCTTAAATCAGGCCCGTGCTTTAACCGGTATGCTCGAAGATATGGGACGGAAAAT
AGATGTTGCCCTCTATATTAAAGTAAAGGAAGAGGAACTAATAAAGAGATTATCAGGACGACGTGTCTGCCAGGAATGTG
GTGCCGCCTATCATGTCGTCTATAACCCTCCGAAAGAAGAGGGTATCTGTGACCTCTGTAAGGGAAAACTCATTCAACGT
AGTGATGATAAAGAAGAAACAGTAAAAAATAGAATTAGAATTAATAAAGAAAAGATGGAAGACCTTATTGAATATTACCG
GAACCAGGGTAATTTAAAGACAGTGGAAAGTACCGGTGGGATTGACGAGGTGTTTAATAAAATACAAGAAATTATCGGGG
CTGGTGTCTAA

Upstream 100 bases:

>100_bases
ATTATGACCGGTGTTGCCTTACAGACAATGCAGCAGATTGAATCCCAGTTATTGATGAGGCACTATGAAGGATTTATGAA
ATAAAAAAGGGGGTTTTTGG

Downstream 100 bases:

>100_bases
ATGATTATTTTAAAATCACCCCGTGAAATTAATATTATGCGTGAAGCAAATCGAATAGTTGCTGAAGTACACGCCCGCCT
GGCTGAAGAAATCTCCCCGG

Product: Adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MNIVLLGLPGAGKGTQAKKMSQEYNLPHIATGDIFRQAIREETPLGKEAKKYLDSGELVPDEITIGIVRERIQKDDCDNG
FILDGFPRTLNQARALTGMLEDMGRKIDVALYIKVKEEELIKRLSGRRVCQECGAAYHVVYNPPKEEGICDLCKGKLIQR
SDDKEETVKNRIRINKEKMEDLIEYYRNQGNLKTVESTGGIDEVFNKIQEIIGAGV

Sequences:

>Translated_216_residues
MNIVLLGLPGAGKGTQAKKMSQEYNLPHIATGDIFRQAIREETPLGKEAKKYLDSGELVPDEITIGIVRERIQKDDCDNG
FILDGFPRTLNQARALTGMLEDMGRKIDVALYIKVKEEELIKRLSGRRVCQECGAAYHVVYNPPKEEGICDLCKGKLIQR
SDDKEETVKNRIRINKEKMEDLIEYYRNQGNLKTVESTGGIDEVFNKIQEIIGAGV
>Mature_216_residues
MNIVLLGLPGAGKGTQAKKMSQEYNLPHIATGDIFRQAIREETPLGKEAKKYLDSGELVPDEITIGIVRERIQKDDCDNG
FILDGFPRTLNQARALTGMLEDMGRKIDVALYIKVKEEELIKRLSGRRVCQECGAAYHVVYNPPKEEGICDLCKGKLIQR
SDDKEETVKNRIRINKEKMEDLIEYYRNQGNLKTVESTGGIDEVFNKIQEIIGAGV

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=205, Percent_Identity=39.0243902439024, Blast_Score=164, Evalue=4e-41,
Organism=Homo sapiens, GI4502013, Length=205, Percent_Identity=39.0243902439024, Blast_Score=164, Evalue=4e-41,
Organism=Homo sapiens, GI19923437, Length=198, Percent_Identity=35.8585858585859, Blast_Score=140, Evalue=7e-34,
Organism=Homo sapiens, GI310110345, Length=198, Percent_Identity=34.3434343434343, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI53832003, Length=198, Percent_Identity=34.3434343434343, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI8051579, Length=198, Percent_Identity=34.3434343434343, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI53832001, Length=198, Percent_Identity=34.3434343434343, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI4502011, Length=210, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI22749187, Length=194, Percent_Identity=27.8350515463918, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI7706497, Length=217, Percent_Identity=28.110599078341, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI28144897, Length=210, Percent_Identity=26.1904761904762, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI28144899, Length=210, Percent_Identity=26.1904761904762, Blast_Score=81, Evalue=6e-16,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=44.0366972477064, Blast_Score=181, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17552384, Length=217, Percent_Identity=35.4838709677419, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17567503, Length=205, Percent_Identity=27.8048780487805, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17537943, Length=213, Percent_Identity=30.9859154929577, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320432, Length=214, Percent_Identity=38.3177570093458, Blast_Score=167, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6321018, Length=194, Percent_Identity=35.0515463917526, Blast_Score=125, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6322828, Length=213, Percent_Identity=28.169014084507, Blast_Score=87, Evalue=1e-18,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=35.377358490566, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI17737899, Length=193, Percent_Identity=35.7512953367876, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24645822, Length=193, Percent_Identity=35.7512953367876, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI221459597, Length=215, Percent_Identity=26.5116279069767, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21356893, Length=215, Percent_Identity=26.5116279069767, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24663208, Length=211, Percent_Identity=23.696682464455, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17647141, Length=211, Percent_Identity=23.696682464455, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24299; Mature: 24299

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00113 ADENYLATE_KINASE ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIVLLGLPGAGKGTQAKKMSQEYNLPHIATGDIFRQAIREETPLGKEAKKYLDSGELVP
CCEEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
DEITIGIVRERIQKDDCDNGFILDGFPRTLNQARALTGMLEDMGRKIDVALYIKVKEEEL
HHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEECHHHH
IKRLSGRRVCQECGAAYHVVYNPPKEEGICDLCKGKLIQRSDDKEETVKNRIRINKEKME
HHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCHHHCCCCCHHHHHHHHHHCCHHHHH
DLIEYYRNQGNLKTVESTGGIDEVFNKIQEIIGAGV
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNIVLLGLPGAGKGTQAKKMSQEYNLPHIATGDIFRQAIREETPLGKEAKKYLDSGELVP
CCEEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
DEITIGIVRERIQKDDCDNGFILDGFPRTLNQARALTGMLEDMGRKIDVALYIKVKEEEL
HHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEECHHHH
IKRLSGRRVCQECGAAYHVVYNPPKEEGICDLCKGKLIQRSDDKEETVKNRIRINKEKME
HHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCHHHCCCCCHHHHHHHHHHCCHHHHH
DLIEYYRNQGNLKTVESTGGIDEVFNKIQEIIGAGV
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA