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The map label for this gene is nadC [H]

Identifier: 220930912

GI number: 220930912

Start: 75053

End: 75895

Strand: Direct

Name: nadC [H]

Synonym: Hore_00640

Alternate gene names: 220930912

Gene position: 75053-75895 (Clockwise)

Preceding gene: 220930911

Following gene: 220930914

Centisome position: 2.91

GC content: 42.94

Gene sequence:

>843_bases
ATGAAGTTAAATAATATTTATCTGGAGAAAGTCATTATTGAAGCCCTTGAAGAGGATATAGGGTTTGGCGATTTAACAAC
AGATTATTTAATACCATCCACTCACAGGTCCTCCGGAAAGATAATTGTTAAGGAGGATGGTGTTGTTGCTGGAGTGGGGG
TGGCCCGCTCTGTATTTGAAGCAGTGAACAGTAAAATAGAATTTAAGGCCATGGTGAGGGATGGTGATCAGGTCAGGGCC
GGTGATGTAATAATAAAAATAACTGGACCGACAGCAGGTATACTGAAAGGTGAGAGGACAGCCCTTAATTTTATGCAGAG
GTTATCGGGAATTGCTACCAAGACCTGTCGGTTGGTTACAAAAGTTAAAGATTTTCCGGTACGGGTAGTTGATACCCGGA
AAACGACTCCAACATTACGTCAACTGGAGAAATACGCTGTCAGGGTTGGTGGTGGTTATAACCATCGATTCGGGCTTTAC
GATGCGGTGATGGTTAAAGATAACCATATTAAGGCAGCCGGTGGTATTAAAAAAGCTGTAACCACTTTACGAAGGAATAT
CCCCCATACTACAAAAATTGAAGTAGAAGTCACTACTTTAACTGAAGTTGAAGAGGCGCTGGAGGCTGGTGCTGATATAA
TAATGCTGGATAATATGGACATTGAGACCATGGCTGAAGCGGTCAAACAGATTGAAGGGAAGGCTTTAGTAGAGGCATCC
GGGGGTATAGATGAGAATACCATTATAGAGGTTGCCAGGACCGGGGTAGATGTTATTTCAGTCGGGGCTTTAACCCATCA
GATTGAGTCCCTGGATATTAGCCTTAACCTGGATAGTGATTAA

Upstream 100 bases:

>100_bases
AGCCGGGGTGGGCATTTCAGGGAAGATTATCCGGAAATAAAACCTGGCTGGGGGAATAAACATGTCCTGGTAGATAAACT
TAGTCCGGAGGGGAGGATTC

Downstream 100 bases:

>100_bases
TTAGATACACTGGACAAAATTAAGCAAAACTATGTTACGGTTTCTGGCCTGCACAATAATCTGGTAAATCTGGTAGGCAC
AAAAACCCCCTGTCGGTTTT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKLNNIYLEKVIIEALEEDIGFGDLTTDYLIPSTHRSSGKIIVKEDGVVAGVGVARSVFEAVNSKIEFKAMVRDGDQVRA
GDVIIKITGPTAGILKGERTALNFMQRLSGIATKTCRLVTKVKDFPVRVVDTRKTTPTLRQLEKYAVRVGGGYNHRFGLY
DAVMVKDNHIKAAGGIKKAVTTLRRNIPHTTKIEVEVTTLTEVEEALEAGADIIMLDNMDIETMAEAVKQIEGKALVEAS
GGIDENTIIEVARTGVDVISVGALTHQIESLDISLNLDSD

Sequences:

>Translated_280_residues
MKLNNIYLEKVIIEALEEDIGFGDLTTDYLIPSTHRSSGKIIVKEDGVVAGVGVARSVFEAVNSKIEFKAMVRDGDQVRA
GDVIIKITGPTAGILKGERTALNFMQRLSGIATKTCRLVTKVKDFPVRVVDTRKTTPTLRQLEKYAVRVGGGYNHRFGLY
DAVMVKDNHIKAAGGIKKAVTTLRRNIPHTTKIEVEVTTLTEVEEALEAGADIIMLDNMDIETMAEAVKQIEGKALVEAS
GGIDENTIIEVARTGVDVISVGALTHQIESLDISLNLDSD
>Mature_280_residues
MKLNNIYLEKVIIEALEEDIGFGDLTTDYLIPSTHRSSGKIIVKEDGVVAGVGVARSVFEAVNSKIEFKAMVRDGDQVRA
GDVIIKITGPTAGILKGERTALNFMQRLSGIATKTCRLVTKVKDFPVRVVDTRKTTPTLRQLEKYAVRVGGGYNHRFGLY
DAVMVKDNHIKAAGGIKKAVTTLRRNIPHTTKIEVEVTTLTEVEEALEAGADIIMLDNMDIETMAEAVKQIEGKALVEAS
GGIDENTIIEVARTGVDVISVGALTHQIESLDISLNLDSD

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=282, Percent_Identity=35.4609929078014, Blast_Score=155, Evalue=4e-38,
Organism=Escherichia coli, GI1786299, Length=282, Percent_Identity=42.5531914893617, Blast_Score=202, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6321162, Length=280, Percent_Identity=36.0714285714286, Blast_Score=157, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30419; Mature: 30419

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNNIYLEKVIIEALEEDIGFGDLTTDYLIPSTHRSSGKIIVKEDGVVAGVGVARSVFE
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEHHHHHHHHH
AVNSKIEFKAMVRDGDQVRAGDVIIKITGPTAGILKGERTALNFMQRLSGIATKTCRLVT
HHCCCEEEEEEECCCCEEEECCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KVKDFPVRVVDTRKTTPTLRQLEKYAVRVGGGYNHRFGLYDAVMVKDNHIKAAGGIKKAV
HHCCCCEEEEECCCCCHHHHHHHHHHEEECCCCCCCCCCEEEEEEECCCEECCCCHHHHH
TTLRRNIPHTTKIEVEVTTLTEVEEALEAGADIIMLDNMDIETMAEAVKQIEGKALVEAS
HHHHHCCCCCEEEEEEEEHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCEEEEEC
GGIDENTIIEVARTGVDVISVGALTHQIESLDISLNLDSD
CCCCCHHHHHHHHCCCCEEEHHHHHHHHEEEEEEEEECCC
>Mature Secondary Structure
MKLNNIYLEKVIIEALEEDIGFGDLTTDYLIPSTHRSSGKIIVKEDGVVAGVGVARSVFE
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEHHHHHHHHH
AVNSKIEFKAMVRDGDQVRAGDVIIKITGPTAGILKGERTALNFMQRLSGIATKTCRLVT
HHCCCEEEEEEECCCCEEEECCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KVKDFPVRVVDTRKTTPTLRQLEKYAVRVGGGYNHRFGLYDAVMVKDNHIKAAGGIKKAV
HHCCCCEEEEECCCCCHHHHHHHHHHEEECCCCCCCCCCEEEEEEECCCEECCCCHHHHH
TTLRRNIPHTTKIEVEVTTLTEVEEALEAGADIIMLDNMDIETMAEAVKQIEGKALVEAS
HHHHHCCCCCEEEEEEEEHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCEEEEEC
GGIDENTIIEVARTGVDVISVGALTHQIESLDISLNLDSD
CCCCCHHHHHHHHCCCCEEEHHHHHHHHEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]