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The map label for this gene is cytR [H]

Identifier: 220930889

GI number: 220930889

Start: 46539

End: 47552

Strand: Direct

Name: cytR [H]

Synonym: Hore_00410

Alternate gene names: 220930889

Gene position: 46539-47552 (Clockwise)

Preceding gene: 220930888

Following gene: 220930890

Centisome position: 1.81

GC content: 38.76

Gene sequence:

>1014_bases
ATGAGTGTTACCATAAAGGATATTGCCAAAAGACTCGGGGTATCAGCTACAGCTGTATCCAAGGCCCTTAATGATAGGGA
TGATGTCAGTGAAGAATTAAAACGAAAGGTTCTTAAAGTTGCAGAAGAATTGGACTATTCTGCCAACACTATTGCTAAAA
GGCTGGTTACAAATAAAAGTAATACCATCGGGGTTTTTATGCTTAGTAGAAGAGAATCAGAGCAGAGGGAAACAGTTGGC
TTTCAATTTTTGAGTGGAATTCTGGAAGAAGCCAATAAAAATGGATATGATATAGTCCTGTTTTCAACTAATAGCGATCT
ACTGGATGAAAAATCCTACATAAAGCTCTGTAAAGAGAGAAGGGTTGAAGGAGCTATTTTTACTGGCTTAAGGCTTGATG
ACCCCCATATACCTGAAATAAAGAAAGCTAAATTCCCTATAACTATTATTGATACGGAACTGGATGATGCTGAGAATGTA
GGATTTATAACTACTGACAATCTAAGTGGAGTTCATAAAGCTCTGGAGTATTTATGGAAGCTGGGTCACAGGAGGATTGC
CATGATTAATGGGCATCACCAGGCCCAGGTCTCTAAAAGGAGATACCAGGCCTTTAAAGAATTTTTGACCCAGAAAGGTG
TTTTTGATGAAGACCTCGTCTTTTATGGTGATTTTACCAAAAATAGTGGTTATAAAGCTGCCCTGAAAATACTTGAATTA
AATGAACCTCCAACTGCTGTTTTTTCAGCCAGTGACCTTATGGCCCTGGGAGCTATTAAGGCTTTTAAGGATAAGGGTTT
AATACTTCCCCGGGATATGTCAATTATTGGTTATGATAATATAACTTCAAGTGAGTACACCGACCCCAGTCTAACTACTG
TAGCTCAGGATTCTGTTAATATGGGAAGAGAAGCAGTAAGATTGGTCCTTGATGGACTGGATGGGGGGACCATGAAGAAA
AAAGTTTTAGAAGCAAAATTAGTTATTCGAGATTCATGTGCCCGGTGTTGTTAA

Upstream 100 bases:

>100_bases
TGCATCGGAGAATAAAGTTGGTTATAATAAACTTAAACGTTAAAGTGTTTTGGTTTATTTTAGTTTGCTTTATTTAAACA
GGGGAAAGAGGGTAGCTAAA

Downstream 100 bases:

>100_bases
TTTGTAAATCACATTTAAAGAAGTTTCTGATTGACTATGTTTAGAAACCTGGATCAAATTTTCAGGAATAATAATTCTGG
AAACCTGGTCGGGTTAGATA

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MSVTIKDIAKRLGVSATAVSKALNDRDDVSEELKRKVLKVAEELDYSANTIAKRLVTNKSNTIGVFMLSRRESEQRETVG
FQFLSGILEEANKNGYDIVLFSTNSDLLDEKSYIKLCKERRVEGAIFTGLRLDDPHIPEIKKAKFPITIIDTELDDAENV
GFITTDNLSGVHKALEYLWKLGHRRIAMINGHHQAQVSKRRYQAFKEFLTQKGVFDEDLVFYGDFTKNSGYKAALKILEL
NEPPTAVFSASDLMALGAIKAFKDKGLILPRDMSIIGYDNITSSEYTDPSLTTVAQDSVNMGREAVRLVLDGLDGGTMKK
KVLEAKLVIRDSCARCC

Sequences:

>Translated_337_residues
MSVTIKDIAKRLGVSATAVSKALNDRDDVSEELKRKVLKVAEELDYSANTIAKRLVTNKSNTIGVFMLSRRESEQRETVG
FQFLSGILEEANKNGYDIVLFSTNSDLLDEKSYIKLCKERRVEGAIFTGLRLDDPHIPEIKKAKFPITIIDTELDDAENV
GFITTDNLSGVHKALEYLWKLGHRRIAMINGHHQAQVSKRRYQAFKEFLTQKGVFDEDLVFYGDFTKNSGYKAALKILEL
NEPPTAVFSASDLMALGAIKAFKDKGLILPRDMSIIGYDNITSSEYTDPSLTTVAQDSVNMGREAVRLVLDGLDGGTMKK
KVLEAKLVIRDSCARCC
>Mature_336_residues
SVTIKDIAKRLGVSATAVSKALNDRDDVSEELKRKVLKVAEELDYSANTIAKRLVTNKSNTIGVFMLSRRESEQRETVGF
QFLSGILEEANKNGYDIVLFSTNSDLLDEKSYIKLCKERRVEGAIFTGLRLDDPHIPEIKKAKFPITIIDTELDDAENVG
FITTDNLSGVHKALEYLWKLGHRRIAMINGHHQAQVSKRRYQAFKEFLTQKGVFDEDLVFYGDFTKNSGYKAALKILELN
EPPTAVFSASDLMALGAIKAFKDKGLILPRDMSIIGYDNITSSEYTDPSLTTVAQDSVNMGREAVRLVLDGLDGGTMKKK
VLEAKLVIRDSCARCC

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=335, Percent_Identity=33.134328358209, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1787948, Length=339, Percent_Identity=29.7935103244838, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1790194, Length=328, Percent_Identity=26.8292682926829, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1788474, Length=318, Percent_Identity=28.9308176100629, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1787580, Length=320, Percent_Identity=26.5625, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789068, Length=336, Percent_Identity=27.6785714285714, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786540, Length=341, Percent_Identity=27.8592375366569, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1789456, Length=315, Percent_Identity=29.5238095238095, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1789202, Length=311, Percent_Identity=27.0096463022508, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI48994940, Length=333, Percent_Identity=25.5255255255255, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790689, Length=325, Percent_Identity=21.5384615384615, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790715, Length=314, Percent_Identity=21.0191082802548, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786268, Length=315, Percent_Identity=21.5873015873016, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37614; Mature: 37482

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTIKDIAKRLGVSATAVSKALNDRDDVSEELKRKVLKVAEELDYSANTIAKRLVTNKS
CCEEHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
NTIGVFMLSRRESEQRETVGFQFLSGILEEANKNGYDIVLFSTNSDLLDEKSYIKLCKER
CEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHH
RVEGAIFTGLRLDDPHIPEIKKAKFPITIIDTELDDAENVGFITTDNLSGVHKALEYLWK
CCCCEEEECEECCCCCCCCHHHCCCCEEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHH
LGHRRIAMINGHHQAQVSKRRYQAFKEFLTQKGVFDEDLVFYGDFTKNSGYKAALKILEL
HCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEEEEC
NEPPTAVFSASDLMALGAIKAFKDKGLILPRDMSIIGYDNITSSEYTDPSLTTVAQDSVN
CCCCCCEECHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHH
MGREAVRLVLDGLDGGTMKKKVLEAKLVIRDSCARCC
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVTIKDIAKRLGVSATAVSKALNDRDDVSEELKRKVLKVAEELDYSANTIAKRLVTNKS
CEEHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
NTIGVFMLSRRESEQRETVGFQFLSGILEEANKNGYDIVLFSTNSDLLDEKSYIKLCKER
CEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHH
RVEGAIFTGLRLDDPHIPEIKKAKFPITIIDTELDDAENVGFITTDNLSGVHKALEYLWK
CCCCEEEECEECCCCCCCCHHHCCCCEEEEECCCCCCCCCCEEEECCHHHHHHHHHHHHH
LGHRRIAMINGHHQAQVSKRRYQAFKEFLTQKGVFDEDLVFYGDFTKNSGYKAALKILEL
HCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEEEEC
NEPPTAVFSASDLMALGAIKAFKDKGLILPRDMSIIGYDNITSSEYTDPSLTTVAQDSVN
CCCCCCEECHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHH
MGREAVRLVLDGLDGGTMKKKVLEAKLVIRDSCARCC
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]