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The map label for this gene is prrA [H]

Identifier: 221230616

GI number: 221230616

Start: 2524075

End: 2524776

Strand: Direct

Name: prrA [H]

Synonym: MLBr_02123

Alternate gene names: 221230616

Gene position: 2524075-2524776 (Clockwise)

Preceding gene: 221230610

Following gene: 221230617

Centisome position: 77.23

GC content: 62.54

Gene sequence:

>702_bases
ATGGACACTGGTGTAAGCTCACCTCGAGTGTTGGTCGTCGACGACGATTCCGATGTGCTTGCCTCGCTGGAGCGAGGCCT
ACGGCTATCCGGATTCGAGGTATCGACTGCTATCGACGGTGCCGAGGCGTTGCGCAACGCCACCGAGACCCGGCCGGATG
CAATCGTGCTCGACATCAATATGCCGGTACTGGACGGTGTAAGCGTCGTCACGGCATTAAGAGCCATGGACAACGACGTC
CCAGTCTGCGTGCTGTCCGCACGCAGTTCGGTCGACGATCGAGTGGCGGGCCTGGAGGCCGGCGCCGATGATTACCTGGT
CAAACCGTTCGTGCTGGCCGAGCTGGTGGCACGAGTGAAAGCGCTGCTGCGCCGCCGCGGCGCTACCGCAACGTCTTCCT
CGGAAACCATAGCCGTGGGCCCGCTGGAGGTAGACATCCCCGGTCGGCGGGCCCGAGTCAATGGCGTCGATGTCGACCTG
ACCAAGCGAGAGTTCGATCTGCTGGCAGTGCTGGCTGAGCACAAGACCACCGTCTTGTCACGCGCCCAGCTGCTGGAGCT
GGTGTGGGGCTATGATTTCGCCGCCGACACGAATGTCGTCGACGTGTTCATCGGGTACCTGCGCCGCAAGTTGGAGGCCA
ACAGCGGGCCCAGGCTACTGCACACCGTTCGAGGAGTTGGGTTCGTACTGCGCATGCAGTAA

Upstream 100 bases:

>100_bases
GCAGACAATGCTTGGAGCAGCCGTGCAGTGGAGCACTCCCCCGTGACCCGGCGACTGGTACTCCCACCGCCGTCGAAAAA
GATCCGGCAAAATAGGCCGC

Downstream 100 bases:

>100_bases
CCGGATCGAAGCAGGCCATGAATATCCTGTCGCGAATCTTCGCCCGTACGCCGTCGTTGCGAACCCGGGTGGTGGTCGCT
ACGGCCATCGGTGCAGCGAT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MDTGVSSPRVLVVDDDSDVLASLERGLRLSGFEVSTAIDGAEALRNATETRPDAIVLDINMPVLDGVSVVTALRAMDNDV
PVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGATATSSSETIAVGPLEVDIPGRRARVNGVDVDL
TKREFDLLAVLAEHKTTVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEANSGPRLLHTVRGVGFVLRMQ

Sequences:

>Translated_233_residues
MDTGVSSPRVLVVDDDSDVLASLERGLRLSGFEVSTAIDGAEALRNATETRPDAIVLDINMPVLDGVSVVTALRAMDNDV
PVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGATATSSSETIAVGPLEVDIPGRRARVNGVDVDL
TKREFDLLAVLAEHKTTVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEANSGPRLLHTVRGVGFVLRMQ
>Mature_233_residues
MDTGVSSPRVLVVDDDSDVLASLERGLRLSGFEVSTAIDGAEALRNATETRPDAIVLDINMPVLDGVSVVTALRAMDNDV
PVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGATATSSSETIAVGPLEVDIPGRRARVNGVDVDL
TKREFDLLAVLAEHKTTVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEANSGPRLLHTVRGVGFVLRMQ

Specific function: Member of the two-component regulatory system prrB/prrA. Involved specifically in early intracellular multiplication of Mycobacterium [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=39.6396396396396, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=37.8378378378378, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=35.9090909090909, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=37.0044052863436, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=38.6363636363636, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=35.4260089686099, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=39.4736842105263, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=37.3333333333333, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=32.8828828828829, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=34.6666666666667, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=30.3030303030303, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=32.8947368421053, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=37.3831775700935, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=38.7387387387387, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1790437, Length=140, Percent_Identity=32.8571428571429, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788713, Length=113, Percent_Identity=31.858407079646, Blast_Score=61, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=118, Percent_Identity=30.5084745762712, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25110; Mature: 25110

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTGVSSPRVLVVDDDSDVLASLERGLRLSGFEVSTAIDGAEALRNATETRPDAIVLDIN
CCCCCCCCEEEEEECCHHHHHHHHCCCEECCEEEHHHCCHHHHHHHHHCCCCCEEEEEEC
MPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVK
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ALLRRRGATATSSSETIAVGPLEVDIPGRRARVNGVDVDLTKREFDLLAVLAEHKTTVLS
HHHHHCCCCCCCCCCEEEECCEEECCCCCEEEECCCCEEECHHHHHHHHHHHHHHHHHHH
RAQLLELVWGYDFAADTNVVDVFIGYLRRKLEANSGPRLLHTVRGVGFVLRMQ
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEC
>Mature Secondary Structure
MDTGVSSPRVLVVDDDSDVLASLERGLRLSGFEVSTAIDGAEALRNATETRPDAIVLDIN
CCCCCCCCEEEEEECCHHHHHHHHCCCEECCEEEHHHCCHHHHHHHHHCCCCCEEEEEEC
MPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVK
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ALLRRRGATATSSSETIAVGPLEVDIPGRRARVNGVDVDLTKREFDLLAVLAEHKTTVLS
HHHHHCCCCCCCCCCEEEECCEEECCCCCEEEECCCCEEECHHHHHHHHHHHHHHHHHHH
RAQLLELVWGYDFAADTNVVDVFIGYLRRKLEANSGPRLLHTVRGVGFVLRMQ
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]