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The map label for this gene is mntH

Identifier: 221230610

GI number: 221230610

Start: 2494427

End: 2495707

Strand: Direct

Name: mntH

Synonym: MLBr_02098

Alternate gene names: 221230610

Gene position: 2494427-2495707 (Clockwise)

Preceding gene: 221230606

Following gene: 221230616

Centisome position: 76.33

GC content: 58.47

Gene sequence:

>1281_bases
TTGTTCGTTAACCTCACTTGCCTATCGGAGGGTAATGGATCGAGGGGTAAAGCGTTGGCAGAGAGCACCCAGGCCGAGCT
TAAAACGAGCTGGTATTTGCTCGGACCAGCTTTCGTCGCCGCGATCGCCTACGTCGATCCCGGAAATGTGGCAGCCAACG
TCAGCTCCGGCGCACAATTCGGCTATCTGCAACTGTGGGTGGTCGTCGTGGCCAATGTGCTGGCCGGCCTGGTGCAGTAC
CTGTCAGCGAAGCTTGGGCTAGTGACCGGACAGTCACTTCCCCAGGCAATCAGCAAGCAAATGAGTCATCCGTTCCGACT
GGGCTTTTGGTTGCAGGCCGAACTGGTAGCGATGGCAACCGATGTTGCTGAAATCGTAGGCGGGGCCATCGCCTTCCACA
TCTTGTTTAGAGTATCATTGCTGCTCGGCGGGGTGATCACTGGGACGGTGTCGTTGCTGCTACTGATGGTGAAGGACCGT
CGAGGCCAACTCTTGTTCGAGCGCGTCATCACTGGACTGCTGTTTGTCATTGTCGTCGGCTTCACGTCCAGTTTCTTCGT
CGCGACGCCCTCACCCGAAGACATGGTAAACGGCCTACTGCCGCGCTTCCAGGGAACCGAAAGCGTACTGCTGGCCGCCG
CTATCATAGGCGCCACCGTGATGCCGCACGCGGTGTACCTGCATTCCGGTCTTGCCCTGGACCGGCACGGACACCCCCAC
GCGGGCCGTAGCCGGCGTCGACTACTCCGCGTCACCCGCTTGGACGTCATCCTGGCGATGACGATCGCCGGAATCGTGAA
TACGGCGATGCTACTAGTGGCCGCGATCAACCTGCAGCATCATCAGGTAACCGCTTACATCGAGGGCACTTACACCGCCA
TACAGGACACCTTGGGAGCGACGATCGCGATGCTGTTTGCGATCGGGTTACTCGCCTCCAGTTTGGCATCCGCATCGGTG
GGCGCCTATGCCGGTGCCTTGATCATGCAAGGATTGCTACAGCGGTCCATTCCCATGCTGATACGGCGCTTGATCACATT
GTGCCCCGCGATCGCGATCCTGGCGCTCGGTTTCGACCCCACTCGCGCATTGGTGCTATCCCAGATAGTACTGTCCTTCG
GTATACCGTTCGCGGTGCTTCCACTGGTCAAACTGACCAACAACCGCGGACTGATGGGTAACGATACCAACCATCCCGCC
ACAACTGTTCTCGGCTGGGCCGTCGCGATATTGGTTAGTCTGCTTAACGTGGTGCTGATCTACCTGACCGTGACCAGTTA
A

Upstream 100 bases:

>100_bases
CCCCCGGGCAACGTGGTGACCAACCTGTCCAGACAGACCCTCGGTAGGTGCCCAGGGCCAATCCCGACTACCGCTAACCC
GGCCCTCACCATAGCAAGAA

Downstream 100 bases:

>100_bases
ATGCCGGCCGGCATACGTATCTCGCATATGGCCGAACCTGTGCGTAAGGAAGATGACACCGAACAGCTCGACAGCAGGTA
GACGCGCTAAACCTTACCGG

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MFVNLTCLSEGNGSRGKALAESTQAELKTSWYLLGPAFVAAIAYVDPGNVAANVSSGAQFGYLQLWVVVVANVLAGLVQY
LSAKLGLVTGQSLPQAISKQMSHPFRLGFWLQAELVAMATDVAEIVGGAIAFHILFRVSLLLGGVITGTVSLLLLMVKDR
RGQLLFERVITGLLFVIVVGFTSSFFVATPSPEDMVNGLLPRFQGTESVLLAAAIIGATVMPHAVYLHSGLALDRHGHPH
AGRSRRRLLRVTRLDVILAMTIAGIVNTAMLLVAAINLQHHQVTAYIEGTYTAIQDTLGATIAMLFAIGLLASSLASASV
GAYAGALIMQGLLQRSIPMLIRRLITLCPAIAILALGFDPTRALVLSQIVLSFGIPFAVLPLVKLTNNRGLMGNDTNHPA
TTVLGWAVAILVSLLNVVLIYLTVTS

Sequences:

>Translated_426_residues
MFVNLTCLSEGNGSRGKALAESTQAELKTSWYLLGPAFVAAIAYVDPGNVAANVSSGAQFGYLQLWVVVVANVLAGLVQY
LSAKLGLVTGQSLPQAISKQMSHPFRLGFWLQAELVAMATDVAEIVGGAIAFHILFRVSLLLGGVITGTVSLLLLMVKDR
RGQLLFERVITGLLFVIVVGFTSSFFVATPSPEDMVNGLLPRFQGTESVLLAAAIIGATVMPHAVYLHSGLALDRHGHPH
AGRSRRRLLRVTRLDVILAMTIAGIVNTAMLLVAAINLQHHQVTAYIEGTYTAIQDTLGATIAMLFAIGLLASSLASASV
GAYAGALIMQGLLQRSIPMLIRRLITLCPAIAILALGFDPTRALVLSQIVLSFGIPFAVLPLVKLTNNRGLMGNDTNHPA
TTVLGWAVAILVSLLNVVLIYLTVTS
>Mature_426_residues
MFVNLTCLSEGNGSRGKALAESTQAELKTSWYLLGPAFVAAIAYVDPGNVAANVSSGAQFGYLQLWVVVVANVLAGLVQY
LSAKLGLVTGQSLPQAISKQMSHPFRLGFWLQAELVAMATDVAEIVGGAIAFHILFRVSLLLGGVITGTVSLLLLMVKDR
RGQLLFERVITGLLFVIVVGFTSSFFVATPSPEDMVNGLLPRFQGTESVLLAAAIIGATVMPHAVYLHSGLALDRHGHPH
AGRSRRRLLRVTRLDVILAMTIAGIVNTAMLLVAAINLQHHQVTAYIEGTYTAIQDTLGATIAMLFAIGLLASSLASASV
GAYAGALIMQGLLQRSIPMLIRRLITLCPAIAILALGFDPTRALVLSQIVLSFGIPFAVLPLVKLTNNRGLMGNDTNHPA
TTVLGWAVAILVSLLNVVLIYLTVTS

Specific function: H(+)-stimulated, highly selective, manganese uptake system

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family

Homologues:

Organism=Homo sapiens, GI109255241, Length=436, Percent_Identity=29.8165137614679, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI295293178, Length=442, Percent_Identity=26.6968325791855, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI295293167, Length=442, Percent_Identity=26.6968325791855, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI295293175, Length=442, Percent_Identity=26.6968325791855, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI295293173, Length=442, Percent_Identity=26.6968325791855, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI10835169, Length=442, Percent_Identity=26.6968325791855, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI295293171, Length=442, Percent_Identity=26.6968325791855, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI295293169, Length=442, Percent_Identity=26.6968325791855, Blast_Score=128, Evalue=8e-30,
Organism=Escherichia coli, GI1788736, Length=404, Percent_Identity=42.0792079207921, Blast_Score=308, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI17569473, Length=398, Percent_Identity=28.391959798995, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71999499, Length=449, Percent_Identity=27.3942093541203, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI193210616, Length=434, Percent_Identity=26.7281105990783, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI71993856, Length=210, Percent_Identity=32.8571428571429, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6323062, Length=389, Percent_Identity=31.8766066838046, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6321841, Length=416, Percent_Identity=30.0480769230769, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324450, Length=416, Percent_Identity=27.4038461538462, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24648607, Length=446, Percent_Identity=27.8026905829596, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI281362176, Length=446, Percent_Identity=27.8026905829596, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24648609, Length=446, Percent_Identity=27.8026905829596, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI45553443, Length=417, Percent_Identity=28.7769784172662, Blast_Score=158, Evalue=8e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MNTH_MYCLE (Q50103)

Other databases:

- EMBL:   U15184
- EMBL:   AL583924
- PIR:   E87171
- RefSeq:   NP_302396.1
- ProteinModelPortal:   Q50103
- EnsemblBacteria:   EBMYCT00000028736
- GeneID:   908932
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML2098
- NMPDR:   fig|272631.1.peg.1268
- Leproma:   ML2098
- GeneTree:   EBGT00050000016524
- HOGENOM:   HBG312498
- OMA:   WIISEIA
- ProtClustDB:   PRK00701
- BioCyc:   MLEP272631:ML2098-MONOMER
- HAMAP:   MF_00221
- InterPro:   IPR023056
- InterPro:   IPR001046
- PANTHER:   PTHR11706
- PRINTS:   PR00447

Pfam domain/function: PF01566 Nramp

EC number: NA

Molecular weight: Translated: 45138; Mature: 45138

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x2329d9fc)-; HASH(0x225b89c8)-; HASH(0x222f1a70)-; HASH(0x22b71d4c)-; HASH(0x21ce0218)-; HASH(0x225d25bc)-; HASH(0x21c422fc)-; HASH(0x224a9320)-; HASH(0x23a7275c)-; HASH(0x2198c7c4)-; HASH(0x2329d954)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVNLTCLSEGNGSRGKALAESTQAELKTSWYLLGPAFVAAIAYVDPGNVAANVSSGAQF
CEEEEEEEECCCCCCCHHHHHHHHHHHHHHEEEECHHHHHHHHEECCCCCEEECCCCCCH
GYLQLWVVVVANVLAGLVQYLSAKLGLVTGQSLPQAISKQMSHPFRLGFWLQAELVAMAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHH
DVAEIVGGAIAFHILFRVSLLLGGVITGTVSLLLLMVKDRRGQLLFERVITGLLFVIVVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
FTSSFFVATPSPEDMVNGLLPRFQGTESVLLAAAIIGATVMPHAVYLHSGLALDRHGHPH
CCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCC
AGRSRRRLLRVTRLDVILAMTIAGIVNTAMLLVAAINLQHHQVTAYIEGTYTAIQDTLGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHH
TIAMLFAIGLLASSLASASVGAYAGALIMQGLLQRSIPMLIRRLITLCPAIAILALGFDP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
TRALVLSQIVLSFGIPFAVLPLVKLTNNRGLMGNDTNHPATTVLGWAVAILVSLLNVVLI
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YLTVTS
HHEECH
>Mature Secondary Structure
MFVNLTCLSEGNGSRGKALAESTQAELKTSWYLLGPAFVAAIAYVDPGNVAANVSSGAQF
CEEEEEEEECCCCCCCHHHHHHHHHHHHHHEEEECHHHHHHHHEECCCCCEEECCCCCCH
GYLQLWVVVVANVLAGLVQYLSAKLGLVTGQSLPQAISKQMSHPFRLGFWLQAELVAMAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHH
DVAEIVGGAIAFHILFRVSLLLGGVITGTVSLLLLMVKDRRGQLLFERVITGLLFVIVVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
FTSSFFVATPSPEDMVNGLLPRFQGTESVLLAAAIIGATVMPHAVYLHSGLALDRHGHPH
CCCCEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCC
AGRSRRRLLRVTRLDVILAMTIAGIVNTAMLLVAAINLQHHQVTAYIEGTYTAIQDTLGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHH
TIAMLFAIGLLASSLASASVGAYAGALIMQGLLQRSIPMLIRRLITLCPAIAILALGFDP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
TRALVLSQIVLSFGIPFAVLPLVKLTNNRGLMGNDTNHPATTVLGWAVAILVSLLNVVLI
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YLTVTS
HHEECH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11234002