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The map label for this gene is mutB [H]

Identifier: 221230435

GI number: 221230435

Start: 2177830

End: 2180106

Strand: Reverse

Name: mutB [H]

Synonym: MLBr_01799

Alternate gene names: 221230435

Gene position: 2180106-2177830 (Counterclockwise)

Preceding gene: 221230436

Following gene: 221230434

Centisome position: 66.71

GC content: 59.6

Gene sequence:

>2277_bases
ATGACTGTGCGTGACGTCGGCGGCCAGCAGGATAGAGAAACTACATTCGTGGTCGGCAGTTTCGCCGATATCCCGCTGCG
CAGCGATCGTGTCGTGTGGCCACCCTCCGAAGCTGCGGTCGAAAAGCATGTTTTCTCAGCCGCTTCAGCACACGGGTACA
CAGTTGATCAACTGCACTGGCATACGCCGGAAGGTATCGACGTCAAACCGGTCTACATCGCTGCCGACCGTGCCGCCGCC
GAGGCCGGCGGCTACCCGTTGCATAGCTTCCCCGGTGAGCCGCCTTACCTGCGCGGACCTTATCCGACGATGTATGTCAA
CCAGCCGTGGACAATCCGTCAATACGCTGGGTTTTCCACCGCCGCAGATTCCAACGCATTTTACCGTCGGAACCTGGCAG
CCGGCCAGAAGGGCCTGTCGGTAGCCTTCGACCTGGCTACTCACCGCGGGTACGACTCCGACCATCCTCGTGTCCAGGGT
GATGTCGGAATGGCTGGTGTGGCAATCGATTCTATCCTCGACATGCGACAATTGTTCGATGGCATAGACCTCTCAGCGGT
TTCGGTATCGATGACGATGAACGGTGCTGTGCTGCCGATCCTGGCGCTGTATGTGGTAGCAGCTGAGGAACAGGGTGTTC
CTCCGGAGAAGCTGGCAGGCACTATTCAAAACGATATCCTCAAAGAGTTCATGGTCCGCAACACCTACATCTACCCACCT
GAGCCATCGATGCGGATCATATCCGATATATTCGCCTACACCAGCGCCAAGATGCCGAAGTTCAACTCCATCTCGATCTC
TGGCTACCATATACAAGAAGCAGGCGCCACAGCGGATTTGGAACTGGCATATACCTTGGCCGATGGTGTCGACTACATCA
AGGCGGGCTTGGACGCTGGGCTGGACATTGACACTTTTGCGCCGCGGTTGTCCTTCTTTTGGGGCATCGGGATGAACTTC
TTCATGGAAGTTGCCAAACTGCGTGCTGGCCGGCTGTTATGGAGTGAACTGGTCGCCAAATTTGGACCCCAAAGCCCAAA
ATCCCTATCACTGCGCACCCATTCGCAAACCTCTGGATGGTCGTTGACCGCCCAGGACCCGTTCAACAACGTAGCCCGCA
CCTGTATCGAGGCGATGGCCGCAACACAGGGCCATACCCAGTCGCTGCACACCAACGCGTTGGACGAGGCGTTGGCGCTG
CCAACGGACTTTTCCGCCCGGATCGCCCGCAATACTCAGCTTGTATTGCAACAGGAGTCGGGCACTACGCGGCCGATTGA
CCCGTGGGGAGGCTCTTACTATGTGGAGTGGCTGACCCATCAACTGGCTGCCCGTGCTCGTACTCATATCGCCGAGGTTG
CCGAGCATGGCGGCATGGCTGCGGCTATCAGCGACGGCATCCCCAAGCTGCGCATCGAGGAGGCTGCTGCGCGCACCCAG
GCCCGCATCGACTCCGGGCGTCAGCCGGTGGTCGGGGTCAACAAGTACCAAGTCGACCAGGATCACGAGATTGAGGTACT
CAAAGTCGAGAACAGTCGGGTGCGTGCTGAACAAGTGGCCAAATTGCAGCAGCTGCGGGCAAACCGGGATCAGTTGGCGG
TCGACGCGGCTCTGGCCGAGCTGTCTGGTGCCGCTGGGGCCCACGGCCGTGCCGGAGATAATTTGTTGGCGCTTGCTATC
AACGCGGCCCGGGTTCAAGCTACTGTCGGCGAGATCTCCGATGCGCTGGAGAGAGTATATGGGCGTCACCAAGCGAAGAT
CCGTACCATCACCGGGGTCTACCGTCGGGAAGTGGGAGAAGCTGGGAAGGCCACCGATATCGCAAACGCTACAGAACTAG
TCAAAAAATTCGCCGAGGCTGATGGTCGTCGACCCAGGATTCTGGTGGCCAAGATGGGCCAGGACGGCCACGACCGCGGG
CAGAAGGTTGTTGCGACGGCATTCGCCGACCTCGGGTTTGACGTCGATGTCGGATCGCTGTTCTCCACGCCCGAAGAGGT
CGCCCGCCAGGCTGCCGACAACGATGTGCATGTGATAGGTGTGTCGTCGCTGGCCGCTGGCCACCTGACGCTGGTGCCGG
CGCTCCGAGACGCGCTTGCTGACGTGGGCCGGCCTGACATCATGATTGTGGTGGGCGGCGTGATCCCGCCTGATGACTTT
GATGAGTTGTATGCTGCCGGGGCTACTGCCATCTTCCCTCCTGGGACGGTGATAGCCTACGCCGCAATTGGCTTGCTGCA
TAAGCTCGCCGGCCGGCTGGGGTACACTCTCACCTAG

Upstream 100 bases:

>100_bases
TCAACAACGCAAAGAGTCGGCCAGATGAATATATAACTGCGAAAATTAATGCGGTCGAAGCTCTTTCAAATCTGCTCACT
CGATTGGGGGCATAGCCACG

Downstream 100 bases:

>100_bases
ATGGCGGGGGACAGCACCGTGGACAGACTAGTCGCTGCTGTCCGTAGTGGTGATCGCGTGGCATTGCCGCGGGCTATAAC
GTTGGTGGAGTCCACTCGCT

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 758; Mature: 757

Protein sequence:

>758_residues
MTVRDVGGQQDRETTFVVGSFADIPLRSDRVVWPPSEAAVEKHVFSAASAHGYTVDQLHWHTPEGIDVKPVYIAADRAAA
EAGGYPLHSFPGEPPYLRGPYPTMYVNQPWTIRQYAGFSTAADSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQG
DVGMAGVAIDSILDMRQLFDGIDLSAVSVSMTMNGAVLPILALYVVAAEEQGVPPEKLAGTIQNDILKEFMVRNTYIYPP
EPSMRIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIKAGLDAGLDIDTFAPRLSFFWGIGMNF
FMEVAKLRAGRLLWSELVAKFGPQSPKSLSLRTHSQTSGWSLTAQDPFNNVARTCIEAMAATQGHTQSLHTNALDEALAL
PTDFSARIARNTQLVLQQESGTTRPIDPWGGSYYVEWLTHQLAARARTHIAEVAEHGGMAAAISDGIPKLRIEEAAARTQ
ARIDSGRQPVVGVNKYQVDQDHEIEVLKVENSRVRAEQVAKLQQLRANRDQLAVDAALAELSGAAGAHGRAGDNLLALAI
NAARVQATVGEISDALERVYGRHQAKIRTITGVYRREVGEAGKATDIANATELVKKFAEADGRRPRILVAKMGQDGHDRG
QKVVATAFADLGFDVDVGSLFSTPEEVARQAADNDVHVIGVSSLAAGHLTLVPALRDALADVGRPDIMIVVGGVIPPDDF
DELYAAGATAIFPPGTVIAYAAIGLLHKLAGRLGYTLT

Sequences:

>Translated_758_residues
MTVRDVGGQQDRETTFVVGSFADIPLRSDRVVWPPSEAAVEKHVFSAASAHGYTVDQLHWHTPEGIDVKPVYIAADRAAA
EAGGYPLHSFPGEPPYLRGPYPTMYVNQPWTIRQYAGFSTAADSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQG
DVGMAGVAIDSILDMRQLFDGIDLSAVSVSMTMNGAVLPILALYVVAAEEQGVPPEKLAGTIQNDILKEFMVRNTYIYPP
EPSMRIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIKAGLDAGLDIDTFAPRLSFFWGIGMNF
FMEVAKLRAGRLLWSELVAKFGPQSPKSLSLRTHSQTSGWSLTAQDPFNNVARTCIEAMAATQGHTQSLHTNALDEALAL
PTDFSARIARNTQLVLQQESGTTRPIDPWGGSYYVEWLTHQLAARARTHIAEVAEHGGMAAAISDGIPKLRIEEAAARTQ
ARIDSGRQPVVGVNKYQVDQDHEIEVLKVENSRVRAEQVAKLQQLRANRDQLAVDAALAELSGAAGAHGRAGDNLLALAI
NAARVQATVGEISDALERVYGRHQAKIRTITGVYRREVGEAGKATDIANATELVKKFAEADGRRPRILVAKMGQDGHDRG
QKVVATAFADLGFDVDVGSLFSTPEEVARQAADNDVHVIGVSSLAAGHLTLVPALRDALADVGRPDIMIVVGGVIPPDDF
DELYAAGATAIFPPGTVIAYAAIGLLHKLAGRLGYTLT
>Mature_757_residues
TVRDVGGQQDRETTFVVGSFADIPLRSDRVVWPPSEAAVEKHVFSAASAHGYTVDQLHWHTPEGIDVKPVYIAADRAAAE
AGGYPLHSFPGEPPYLRGPYPTMYVNQPWTIRQYAGFSTAADSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGD
VGMAGVAIDSILDMRQLFDGIDLSAVSVSMTMNGAVLPILALYVVAAEEQGVPPEKLAGTIQNDILKEFMVRNTYIYPPE
PSMRIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIKAGLDAGLDIDTFAPRLSFFWGIGMNFF
MEVAKLRAGRLLWSELVAKFGPQSPKSLSLRTHSQTSGWSLTAQDPFNNVARTCIEAMAATQGHTQSLHTNALDEALALP
TDFSARIARNTQLVLQQESGTTRPIDPWGGSYYVEWLTHQLAARARTHIAEVAEHGGMAAAISDGIPKLRIEEAAARTQA
RIDSGRQPVVGVNKYQVDQDHEIEVLKVENSRVRAEQVAKLQQLRANRDQLAVDAALAELSGAAGAHGRAGDNLLALAIN
AARVQATVGEISDALERVYGRHQAKIRTITGVYRREVGEAGKATDIANATELVKKFAEADGRRPRILVAKMGQDGHDRGQ
KVVATAFADLGFDVDVGSLFSTPEEVARQAADNDVHVIGVSSLAAGHLTLVPALRDALADVGRPDIMIVVGGVIPPDDFD
ELYAAGATAIFPPGTVIAYAAIGLLHKLAGRLGYTLT

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=697, Percent_Identity=61.9799139167862, Blast_Score=900, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=684, Percent_Identity=62.719298245614, Blast_Score=842, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=704, Percent_Identity=63.0681818181818, Blast_Score=920, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 81642; Mature: 81511

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRDVGGQQDRETTFVVGSFADIPLRSDRVVWPPSEAAVEKHVFSAASAHGYTVDQLHW
CCCCCCCCCCCCCEEEEEECCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCEECCEEE
HTPEGIDVKPVYIAADRAAAEAGGYPLHSFPGEPPYLRGPYPTMYVNQPWTIRQYAGFST
CCCCCCCEEEEEEECCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEHHHCCCCC
AADSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSILDMRQLFD
CCCCCHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHC
GIDLSAVSVSMTMNGAVLPILALYVVAAEEQGVPPEKLAGTIQNDILKEFMVRNTYIYPP
CCCEEEEEEEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECC
EPSMRIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIKAGLDAG
CCHHHHHHHHHHHHHCCCCCCCEEEEECEEECCCCCCCCEEEEEEHHCCHHHHHHHHCCC
LDIDTFAPRLSFFWGIGMNFFMEVAKLRAGRLLWSELVAKFGPQSPKSLSLRTHSQTSGW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
SLTAQDPFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLVLQQES
EEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCEEEEEEECC
GTTRPIDPWGGSYYVEWLTHQLAARARTHIAEVAEHGGMAAAISDGIPKLRIEEAAARTQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHCCCCCEEHHHHHHHHH
ARIDSGRQPVVGVNKYQVDQDHEIEVLKVENSRVRAEQVAKLQQLRANRDQLAVDAALAE
HHHCCCCCCEECCCEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LSGAAGAHGRAGDNLLALAINAARVQATVGEISDALERVYGRHQAKIRTITGVYRREVGE
HCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AGKATDIANATELVKKFAEADGRRPRILVAKMGQDGHDRGQKVVATAFADLGFDVDVGSL
CCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHH
FSTPEEVARQAADNDVHVIGVSSLAAGHLTLVPALRDALADVGRPDIMIVVGGVIPPDDF
HCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCH
DELYAAGATAIFPPGTVIAYAAIGLLHKLAGRLGYTLT
HHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TVRDVGGQQDRETTFVVGSFADIPLRSDRVVWPPSEAAVEKHVFSAASAHGYTVDQLHW
CCCCCCCCCCCCEEEEEECCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCEECCEEE
HTPEGIDVKPVYIAADRAAAEAGGYPLHSFPGEPPYLRGPYPTMYVNQPWTIRQYAGFST
CCCCCCCEEEEEEECCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEHHHCCCCC
AADSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSILDMRQLFD
CCCCCHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHC
GIDLSAVSVSMTMNGAVLPILALYVVAAEEQGVPPEKLAGTIQNDILKEFMVRNTYIYPP
CCCEEEEEEEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECC
EPSMRIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIKAGLDAG
CCHHHHHHHHHHHHHCCCCCCCEEEEECEEECCCCCCCCEEEEEEHHCCHHHHHHHHCCC
LDIDTFAPRLSFFWGIGMNFFMEVAKLRAGRLLWSELVAKFGPQSPKSLSLRTHSQTSGW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
SLTAQDPFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLVLQQES
EEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCEEEEEEECC
GTTRPIDPWGGSYYVEWLTHQLAARARTHIAEVAEHGGMAAAISDGIPKLRIEEAAARTQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHCCCCCEEHHHHHHHHH
ARIDSGRQPVVGVNKYQVDQDHEIEVLKVENSRVRAEQVAKLQQLRANRDQLAVDAALAE
HHHCCCCCCEECCCEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LSGAAGAHGRAGDNLLALAINAARVQATVGEISDALERVYGRHQAKIRTITGVYRREVGE
HCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AGKATDIANATELVKKFAEADGRRPRILVAKMGQDGHDRGQKVVATAFADLGFDVDVGSL
CCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHH
FSTPEEVARQAADNDVHVIGVSSLAAGHLTLVPALRDALADVGRPDIMIVVGGVIPPDDF
HCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCH
DELYAAGATAIFPPGTVIAYAAIGLLHKLAGRLGYTLT
HHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]