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The map label for this gene is mutA [H]

Identifier: 221230436

GI number: 221230436

Start: 2180112

End: 2182022

Strand: Reverse

Name: mutA [H]

Synonym: MLBr_01800

Alternate gene names: 221230436

Gene position: 2182022-2180112 (Counterclockwise)

Preceding gene: 221230437

Following gene: 221230435

Centisome position: 66.77

GC content: 62.95

Gene sequence:

>1911_bases
GTGTTCGTAGATGTACCCGAGTTCGCCGAACTGGAACAGATTCGCGGGCGGTGGCGACGTGCGGTCGCTGGTGTGCTCTC
GAGGAGCATGCGGAGAGACCCTGCCACGTTTGGGGATCAGCCTGAGCGGCTACTGGACACCGCGACCTACGACGGGTTCG
CCATCCGGCCGCTGTATACCGTGTTCGACGAGTTGCCGGAATCGTCGCTGCCAGGAGAGTGGCCTTACCGCCGCGGTGGC
GATGCGTTACGCGATGTTCATTCCGGCTGGAAGGTCACCGAAGTGTTTCCGGTCGACCCGGCAACCGCAGGGGTGGCTGC
CGACGAGGGCACGGCTAGCAACGCTACAATATTGGCTGCGCTAGCAGAGGGAGTCAGCGCGCTGCGAATCCGGGTGGGCC
AGTCCGGGGTAGCGCCTGGGCAGCTGGACAGCCTGCTTCTCGGTGTGTACGTGGACTTGGTCCCGGTGATTCTTGACGCG
GGCGCTGACTACGTCGAAGCCTGTGATGCGGTGTTGGCCCTGCTGGCCAGGCTGGACTCGAGTCGGCGCACAATGCTATC
GATCGATCTGGGTGCCGACCCGCTGACTGCGTCGCTGAGCGGTCGTCCTGCCCCGTCGATCGACCAGGTGGTTGCAGTCG
CAGCACGGGTCGCCGGCGACCGTGGCGTGCGGGCGATCACCGTCGACGGGCCTGCTTTCCACAATTTGGGGGCCAGCGCG
ACATGGGAGCTCGCCGCTGCGATTGCGGCTGCGGTGACCTACCTTCGGGTGCTCACAGAATCCAAGATGCCGGTCAGCGA
GGCGCTACGGCAAATCAGTTTTCGGCTAGCTGCCGACGACGATCAGTTTTTGACCATCGCTAAAATACGCGCCGTGCGTC
AACTGTGGGCGCGTATCGCAGAAGTCGCGGGGGACCCCGAAGGCGGCGCGGCAGTTGTGCACGCGGAAACGTCGCTGCCG
ATGATGACTCAGCGCGACCCGTGGGTGAACATGCTGCGCGGCACGCTGGCCGCGTTTGGTGCAGGCGTTGGTGGTGCCGA
CACCGTGTTGGTGTTCCCGTTCGATGTGGCGATTCCCGGTGGCTTTCTTGGCATGGCGGCTAGCTTCGCGCGTAGGATTG
CCCGTAACACCCAGCTGCTGCTGTTGGAAGAGTCACACGTTGGCCGGGTGTTGGATCCGGCCGGAGGGTCCTGGTTCGTC
GAGAACCTCACCGAACAACTGGCTCAGCAGGCCTGGCAGCATTTTCAGGCTATCGAGACCTACGGTGGATTTGTCGATGC
CGGTGACTACCTTGCCGGCCAGATCCACGAAACAGCCGCACGCCGTACCGACGACATCGCGCATCGCCGTACCGCGATAA
CCGGTGTCAACGAATATCCGAACTTAGCTGAGCCTGCTCTGCTGCACGGCGGTTCGCCTGTTGTGGCGACTGCTGCGGGA
AACCTGCTGCGCTACGCTGCCGGTTTCGAAGCGCTGCGGGATCGTTCGGATGCTTATCTGGCCCGCACCGGTGCACGTCC
GCAGGTGCTGTTGCTGCCGCTGGGCCCGCTGGCTGAGCACAACATTCGGGCGACGTTTGCGACGAATCTGCTGGCTTCGG
GCGGCATAGCGGCGATCAACCTAGGATCAGTGGACGCACCGGGTGTCGTGCAAGCCGTCGCGCAGGCTGGTTTCATGGCC
GGGTCGTCGATGGTGGTGGTTATCTGTGGCACAGACTTGCGCTATCGGGATGAGGCCGCAGATGTGGTGGAGGCGGCGCG
AGGCGCCGGGGTGTCGTGGGTCTACCTGGCGGGACCTGAGAAAGCGCTGGGTGATATCAACAACGCAAAGAGTCGGCCAG
ATGAATATATAACTGCGAAAATTAATGCGGTCGAAGCTCTTTCAAATCTGCTCACTCGATTGGGGGCATAG

Upstream 100 bases:

>100_bases
GCTTTACGATCGCCGCGATCAATTAGCTTTAATTGGTCGAATGGCATCCTCGAAGCCCTGCATCAAGGGCTCGCCAATTG
CTGGGAAATAGGAGCAGTCG

Downstream 100 bases:

>100_bases
CCACGATGACTGTGCGTGACGTCGGCGGCCAGCAGGATAGAGAAACTACATTCGTGGTCGGCAGTTTCGCCGATATCCCG
CTGCGCAGCGATCGTGTCGT

Product: methylmalonyl-CoA mutase, beta subunit

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 636; Mature: 636

Protein sequence:

>636_residues
MFVDVPEFAELEQIRGRWRRAVAGVLSRSMRRDPATFGDQPERLLDTATYDGFAIRPLYTVFDELPESSLPGEWPYRRGG
DALRDVHSGWKVTEVFPVDPATAGVAADEGTASNATILAALAEGVSALRIRVGQSGVAPGQLDSLLLGVYVDLVPVILDA
GADYVEACDAVLALLARLDSSRRTMLSIDLGADPLTASLSGRPAPSIDQVVAVAARVAGDRGVRAITVDGPAFHNLGASA
TWELAAAIAAAVTYLRVLTESKMPVSEALRQISFRLAADDDQFLTIAKIRAVRQLWARIAEVAGDPEGGAAVVHAETSLP
MMTQRDPWVNMLRGTLAAFGAGVGGADTVLVFPFDVAIPGGFLGMAASFARRIARNTQLLLLEESHVGRVLDPAGGSWFV
ENLTEQLAQQAWQHFQAIETYGGFVDAGDYLAGQIHETAARRTDDIAHRRTAITGVNEYPNLAEPALLHGGSPVVATAAG
NLLRYAAGFEALRDRSDAYLARTGARPQVLLLPLGPLAEHNIRATFATNLLASGGIAAINLGSVDAPGVVQAVAQAGFMA
GSSMVVVICGTDLRYRDEAADVVEAARGAGVSWVYLAGPEKALGDINNAKSRPDEYITAKINAVEALSNLLTRLGA

Sequences:

>Translated_636_residues
MFVDVPEFAELEQIRGRWRRAVAGVLSRSMRRDPATFGDQPERLLDTATYDGFAIRPLYTVFDELPESSLPGEWPYRRGG
DALRDVHSGWKVTEVFPVDPATAGVAADEGTASNATILAALAEGVSALRIRVGQSGVAPGQLDSLLLGVYVDLVPVILDA
GADYVEACDAVLALLARLDSSRRTMLSIDLGADPLTASLSGRPAPSIDQVVAVAARVAGDRGVRAITVDGPAFHNLGASA
TWELAAAIAAAVTYLRVLTESKMPVSEALRQISFRLAADDDQFLTIAKIRAVRQLWARIAEVAGDPEGGAAVVHAETSLP
MMTQRDPWVNMLRGTLAAFGAGVGGADTVLVFPFDVAIPGGFLGMAASFARRIARNTQLLLLEESHVGRVLDPAGGSWFV
ENLTEQLAQQAWQHFQAIETYGGFVDAGDYLAGQIHETAARRTDDIAHRRTAITGVNEYPNLAEPALLHGGSPVVATAAG
NLLRYAAGFEALRDRSDAYLARTGARPQVLLLPLGPLAEHNIRATFATNLLASGGIAAINLGSVDAPGVVQAVAQAGFMA
GSSMVVVICGTDLRYRDEAADVVEAARGAGVSWVYLAGPEKALGDINNAKSRPDEYITAKINAVEALSNLLTRLGA
>Mature_636_residues
MFVDVPEFAELEQIRGRWRRAVAGVLSRSMRRDPATFGDQPERLLDTATYDGFAIRPLYTVFDELPESSLPGEWPYRRGG
DALRDVHSGWKVTEVFPVDPATAGVAADEGTASNATILAALAEGVSALRIRVGQSGVAPGQLDSLLLGVYVDLVPVILDA
GADYVEACDAVLALLARLDSSRRTMLSIDLGADPLTASLSGRPAPSIDQVVAVAARVAGDRGVRAITVDGPAFHNLGASA
TWELAAAIAAAVTYLRVLTESKMPVSEALRQISFRLAADDDQFLTIAKIRAVRQLWARIAEVAGDPEGGAAVVHAETSLP
MMTQRDPWVNMLRGTLAAFGAGVGGADTVLVFPFDVAIPGGFLGMAASFARRIARNTQLLLLEESHVGRVLDPAGGSWFV
ENLTEQLAQQAWQHFQAIETYGGFVDAGDYLAGQIHETAARRTDDIAHRRTAITGVNEYPNLAEPALLHGGSPVVATAAG
NLLRYAAGFEALRDRSDAYLARTGARPQVLLLPLGPLAEHNIRATFATNLLASGGIAAINLGSVDAPGVVQAVAQAGFMA
GSSMVVVICGTDLRYRDEAADVVEAARGAGVSWVYLAGPEKALGDINNAKSRPDEYITAKINAVEALSNLLTRLGA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=458, Percent_Identity=27.7292576419214, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1789284, Length=461, Percent_Identity=28.6334056399132, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25144500, Length=457, Percent_Identity=25.601750547046, Blast_Score=125, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 67188; Mature: 67188

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00544 METMALONYL_COA_MUTASE ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVDVPEFAELEQIRGRWRRAVAGVLSRSMRRDPATFGDQPERLLDTATYDGFAIRPLYT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCEEHHHHHH
VFDELPESSLPGEWPYRRGGDALRDVHSGWKVTEVFPVDPATAGVAADEGTASNATILAA
HHHHCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHH
LAEGVSALRIRVGQSGVAPGQLDSLLLGVYVDLVPVILDAGADYVEACDAVLALLARLDS
HHHCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
SRRTMLSIDLGADPLTASLSGRPAPSIDQVVAVAARVAGDRGVRAITVDGPAFHNLGASA
CCCEEEEEECCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHCCCCCH
TWELAAAIAAAVTYLRVLTESKMPVSEALRQISFRLAADDDQFLTIAKIRAVRQLWARIA
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHH
EVAGDPEGGAAVVHAETSLPMMTQRDPWVNMLRGTLAAFGAGVGGADTVLVFPFDVAIPG
HHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCC
GFLGMAASFARRIARNTQLLLLEESHVGRVLDPAGGSWFVENLTEQLAQQAWQHFQAIET
HHHHHHHHHHHHHHCCCEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YGGFVDAGDYLAGQIHETAARRTDDIAHRRTAITGVNEYPNLAEPALLHGGSPVVATAAG
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCEEEHHHH
NLLRYAAGFEALRDRSDAYLARTGARPQVLLLPLGPLAEHNIRATFATNLLASGGIAAIN
HHHHHHHHHHHHHCCCCHHHEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEE
LGSVDAPGVVQAVAQAGFMAGSSMVVVICGTDLRYRDEAADVVEAARGAGVSWVYLAGPE
CCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCH
KALGDINNAKSRPDEYITAKINAVEALSNLLTRLGA
HHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFVDVPEFAELEQIRGRWRRAVAGVLSRSMRRDPATFGDQPERLLDTATYDGFAIRPLYT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCEEHHHHHH
VFDELPESSLPGEWPYRRGGDALRDVHSGWKVTEVFPVDPATAGVAADEGTASNATILAA
HHHHCCCCCCCCCCCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHH
LAEGVSALRIRVGQSGVAPGQLDSLLLGVYVDLVPVILDAGADYVEACDAVLALLARLDS
HHHCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
SRRTMLSIDLGADPLTASLSGRPAPSIDQVVAVAARVAGDRGVRAITVDGPAFHNLGASA
CCCEEEEEECCCCCCEECCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHCCCCCH
TWELAAAIAAAVTYLRVLTESKMPVSEALRQISFRLAADDDQFLTIAKIRAVRQLWARIA
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHH
EVAGDPEGGAAVVHAETSLPMMTQRDPWVNMLRGTLAAFGAGVGGADTVLVFPFDVAIPG
HHCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCC
GFLGMAASFARRIARNTQLLLLEESHVGRVLDPAGGSWFVENLTEQLAQQAWQHFQAIET
HHHHHHHHHHHHHHCCCEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
YGGFVDAGDYLAGQIHETAARRTDDIAHRRTAITGVNEYPNLAEPALLHGGSPVVATAAG
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCEEEHHHH
NLLRYAAGFEALRDRSDAYLARTGARPQVLLLPLGPLAEHNIRATFATNLLASGGIAAIN
HHHHHHHHHHHHHCCCCHHHEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEE
LGSVDAPGVVQAVAQAGFMAGSSMVVVICGTDLRYRDEAADVVEAARGAGVSWVYLAGPE
CCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCH
KALGDINNAKSRPDEYITAKINAVEALSNLLTRLGA
HHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]