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The map label for this gene is accD6 [H]

Identifier: 221230352

GI number: 221230352

Start: 1997371

End: 1998792

Strand: Direct

Name: accD6 [H]

Synonym: MLBr_01657

Alternate gene names: 221230352

Gene position: 1997371-1998792 (Clockwise)

Preceding gene: 221230351

Following gene: 221230361

Centisome position: 61.12

GC content: 62.1

Gene sequence:

>1422_bases
ATGACAATCACGGCCCCAAAGGTGGTGGGCAAGTCCATTGATCCCCGCGATCCACTACTGCGTCTGAGCAATTTCTTCGA
CGATGGCAGAGTCGAACCGCTGCACGAGCGTAACCAGTCCGGCGTATTCGCTGCGACAGGCACCGTGAACGGTTTACGCA
CCATAGCGTTCTGCACCGACGGCACCGTCATGGGCGGCGCCATGGGTATCGAAGGCTGCGCGCATATCGTCAACGCCTAC
GACACCGCTATTGAAGAGCAGAGCCCCATCGTAGGCATCTGGCACTCGGGCGGGGCCCGGTTAGCCGAGGGAGTGCGGGC
GCTGCACGCAGTCGGACAGGTGTTCGAGGCCATGATCCGCGCATCCGGGTACATTCCGCAAATCTCGGTGGTCGTCGGTT
TCGCTGCCGGCGGCGCCGCTTATGGGCCAGCGCTGACCGACGTCGTCATCATGGCGCCAGAAGGTCGGGTGTTCGTCACC
GGGCCCGACGTGGTACGCAGCGTCACCGGCGAAGACGTGGACATGGCTTCGCTCGGCGGCCCAGAGACCCACCACAAGAA
GTCCGGGGTGTGCCACATCGTTGCCAACGATGAACTCGACGCCTATGAGCGCGGCCGCCGGTTAGTCGGATTGTTCTGCC
AGCAAGGTCATTTCGACCGTAGCAAGGCAGAAGCTGGTGACACCAATATCCAAGCGCTGCTGCCCGAATCGTCCCGACGA
GCCTATGACGTACATCCAGTCGTGACAGCGATCCTGGATGAGAACACGCCTTTCGACGAATTCCAGGCGAATTGGGCACC
GTCCATGGTGGTCGGGCTGGGCCGACTGTCCGGCCGCACGGTGGGCGTACTGGCCAACAACCCGTTGCGACTGGGCGGTT
GTTTGAACTCCGAAAGCGCCGAGAAGGCAGCACGTTTCGTACGACTCTGCGACGCGTTCGGGATCCCGCTGGTGGTCATC
GTCGATGTCCCCGGCTATCTGCCGGGGGTTGACCAAGAGTGGGGCGGCGTGGTGCGCCGAGGTGCTAAACTGTTGCATGC
GTTCGGTGAGTGCACCGTTCCGCGCGTAACGCTGGTTACCCGAAAGACCTACGGCGGGGCCTACATTGCGATGAATTCTC
GATCGTTGAATGCAACAAAGGTATTCGCGTGGCCGGACGCCGAAGTGGCGGTGATGGGCGCCAAGGCGGCCGTCGGCATA
CTTCACAAGCGCAAGTTAGCCGCAGCACCGAACGACGAACGGGAAGCTCTACACGACGACTTAGCTGCCGAGCATGAGCG
CATCGCCGGCGGCGTGGACAGTGCCATCGACATCGGTGTGGTTGACGAGAAGATCAACCCGGCACATACCCGCAGTAAAC
TCACCGAGGCACTGGCCCAGTCGCCTGTGCGCCGCGGTCGCCACAAGAACATCCCGCTGTAA

Upstream 100 bases:

>100_bases
TCGGTATGCGGTCAACAACTCGTTCGGATTCGGCGGTCACAACGTAGCGATCGCCTTCGGCTGCTACTAACCCGAACATC
ACTGACACAGGAGACCTGCG

Downstream 100 bases:

>100_bases
ACACCCGGTGATGTGCACAAGAACAATATCACATGTGATATTGTTCTTGTGCACATCAATGTATAATGTCACGATTCGGA
TTTTCGACGAAAGTAATGCG

Product: acetyl/propionyl CoA carboxylase beta subunit

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTITAPKVVGKSIDPRDPLLRLSNFFDDGRVEPLHERNQSGVFAATGTVNGLRTIAFCTDGTVMGGAMGIEGCAHIVNAY
DTAIEEQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVIMAPEGRVFVT
GPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVANDELDAYERGRRLVGLFCQQGHFDRSKAEAGDTNIQALLPESSRR
AYDVHPVVTAILDENTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVI
VDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGI
LHKRKLAAAPNDEREALHDDLAAEHERIAGGVDSAIDIGVVDEKINPAHTRSKLTEALAQSPVRRGRHKNIPL

Sequences:

>Translated_473_residues
MTITAPKVVGKSIDPRDPLLRLSNFFDDGRVEPLHERNQSGVFAATGTVNGLRTIAFCTDGTVMGGAMGIEGCAHIVNAY
DTAIEEQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVIMAPEGRVFVT
GPDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVANDELDAYERGRRLVGLFCQQGHFDRSKAEAGDTNIQALLPESSRR
AYDVHPVVTAILDENTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVI
VDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGI
LHKRKLAAAPNDEREALHDDLAAEHERIAGGVDSAIDIGVVDEKINPAHTRSKLTEALAQSPVRRGRHKNIPL
>Mature_472_residues
TITAPKVVGKSIDPRDPLLRLSNFFDDGRVEPLHERNQSGVFAATGTVNGLRTIAFCTDGTVMGGAMGIEGCAHIVNAYD
TAIEEQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIRASGYIPQISVVVGFAAGGAAYGPALTDVVIMAPEGRVFVTG
PDVVRSVTGEDVDMASLGGPETHHKKSGVCHIVANDELDAYERGRRLVGLFCQQGHFDRSKAEAGDTNIQALLPESSRRA
YDVHPVVTAILDENTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESAEKAARFVRLCDAFGIPLVVIV
DVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVTRKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGIL
HKRKLAAAPNDEREALHDDLAAEHERIAGGVDSAIDIGVVDEKINPAHTRSKLTEALAQSPVRRGRHKNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=444, Percent_Identity=41.2162162162162, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI295821216, Length=426, Percent_Identity=41.7840375586854, Blast_Score=312, Evalue=3e-85,
Organism=Homo sapiens, GI11545863, Length=460, Percent_Identity=29.1304347826087, Blast_Score=182, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI25147362, Length=445, Percent_Identity=40.4494382022472, Blast_Score=321, Evalue=6e-88,
Organism=Caenorhabditis elegans, GI25147359, Length=445, Percent_Identity=40.4494382022472, Blast_Score=320, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI17552936, Length=372, Percent_Identity=31.7204301075269, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71997163, Length=307, Percent_Identity=22.8013029315961, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24586065, Length=412, Percent_Identity=30.5825242718447, Blast_Score=179, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 50279; Mature: 50148

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITAPKVVGKSIDPRDPLLRLSNFFDDGRVEPLHERNQSGVFAATGTVNGLRTIAFCTD
CCCCCCHHHCCCCCCCCHHHHHHHHCCCCCCCCHHHCCCCCEEEEECCCCCEEEEEEEEC
GTVMGGAMGIEGCAHIVNAYDTAIEEQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIR
CCEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ASGYIPQISVVVGFAAGGAAYGPALTDVVIMAPEGRVFVTGPDVVRSVTGEDVDMASLGG
HCCCCCEEEEEEEEECCCCCCCCCCEEEEEECCCCEEEEECHHHHHHCCCCCCCHHHCCC
PETHHKKSGVCHIVANDELDAYERGRRLVGLFCQQGHFDRSKAEAGDTNIQALLPESSRR
CCCCCCCCCEEEEEECCCCCHHHHCCCEEEHHHHCCCCCCCCCCCCCCCEEEECCCCCCC
AYDVHPVVTAILDENTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESA
EEEHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCEEECCCCCCHHH
EKAARFVRLCDAFGIPLVVIVDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVT
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEE
RKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKRKLAAAPNDEREALHDD
EECCCCEEEEEECCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHH
LAAEHERIAGGVDSAIDIGVVDEKINPAHTRSKLTEALAQSPVRRGRHKNIPL
HHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TITAPKVVGKSIDPRDPLLRLSNFFDDGRVEPLHERNQSGVFAATGTVNGLRTIAFCTD
CCCCCHHHCCCCCCCCHHHHHHHHCCCCCCCCHHHCCCCCEEEEECCCCCEEEEEEEEC
GTVMGGAMGIEGCAHIVNAYDTAIEEQSPIVGIWHSGGARLAEGVRALHAVGQVFEAMIR
CCEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ASGYIPQISVVVGFAAGGAAYGPALTDVVIMAPEGRVFVTGPDVVRSVTGEDVDMASLGG
HCCCCCEEEEEEEEECCCCCCCCCCEEEEEECCCCEEEEECHHHHHHCCCCCCCHHHCCC
PETHHKKSGVCHIVANDELDAYERGRRLVGLFCQQGHFDRSKAEAGDTNIQALLPESSRR
CCCCCCCCCEEEEEECCCCCHHHHCCCEEEHHHHCCCCCCCCCCCCCCCEEEECCCCCCC
AYDVHPVVTAILDENTPFDEFQANWAPSMVVGLGRLSGRTVGVLANNPLRLGGCLNSESA
EEEHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCEEECCCCCCHHH
EKAARFVRLCDAFGIPLVVIVDVPGYLPGVDQEWGGVVRRGAKLLHAFGECTVPRVTLVT
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEE
RKTYGGAYIAMNSRSLNATKVFAWPDAEVAVMGAKAAVGILHKRKLAAAPNDEREALHDD
EECCCCEEEEEECCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHH
LAAEHERIAGGVDSAIDIGVVDEKINPAHTRSKLTEALAQSPVRRGRHKNIPL
HHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]