Click here to switch to the map view.

The map label for this gene is kasB [H]

Identifier: 221230351

GI number: 221230351

Start: 1996063

End: 1997340

Strand: Direct

Name: kasB [H]

Synonym: MLBr_01656

Alternate gene names: 221230351

Gene position: 1996063-1997340 (Clockwise)

Preceding gene: 221230350

Following gene: 221230352

Centisome position: 61.08

GC content: 61.42

Gene sequence:

>1278_bases
ATGATCGCTAGACTCATGACCACATCGCCGGAGCTGGTTACAGGGAAAGCCTTTCCCAATGTGGTCGTCACCGGCATTGC
TATGACGACTGCGCTGGCAACAGACGCGGAGACCACGTGGAAGTTGTTGCTCGACAACCAAAGTGGAATTCGTATGCTCG
ACGACCCGTTCATCGAGGAGTTCAACCTACCGGTTCGCATCGGTGGACATTTGCTGGAGGAATTCGACCACCAGCTGACC
CGCGTCGAGCTGCGCAGGATGGGTTACCTACAGAGAATGTCCACCGTGCTAAGCCGGCGACTGTGGGAGAACGCGGGCTC
ACCCGAAGTGGACACCAATCGGTTAATGGTGTCCATCGGCACCGGGTTGGGCTCGGCCGAGGAGCTGGTCTTCAGCTACG
ACGACATGCGTGCGCGCGGAATGAAGGCAGTCTCGCCACTGGCCGTGCAGAAGTACATGCCCAACGGTGCGGCAGCGGCC
GTCGGGCTGGAGCACCACGCCAAGGCTGGGGTGATGACGCCTGTGTCGGCGTGTGCGTCCGGTTCCGAGGCCATCGCCCA
TGCGTGGCAGCAGATCGTGCTCGGCGAAGCCGACTCGGCGATCTGTGGTGGCGTGGAAACAAAGATCGAGGCCGTGCCAA
TCGCCGGGTTCTCCCAGATGCGCATCGTAATGTCCACCAAGAACGACAACCCCGCCGGTGCATGTCGCCCGTTCGATAGG
GACCGCGACGGCTTCGTGTTCGGTGAGGCCGGCGCGCTCATGCTAATCGAGACCGAGGACAGTGCGAAGGCGCGCAGCGC
CAACATCCTAGCCCGGATCATGGGGGCCAGCATCACCTCGGACGGCTTCCACATGGTGGCACCGGACCCCAACGGGGAAC
GTGCCGGGCATGCTATCGCACGTGCAGTGCACCTAGCGGGCCTCAGTCCGAGCGACATCGACCACGTCAACGCCCATGCC
ACCGGCACCCAGGTCGGTGACCTGGCCGAAGCCAAAGCCATCAACAAAGCCCTCTGCAACAATCGACCGGCGGTGTACGC
ACCCAAATCTGCCCTCGGCCATTCAGTGGGCGCAGTCGGCGCGGTGGAATCAATCTTGACTGTGCTGGCGTTGCGGGACC
AGGTAATCCCACCGACACTGAACCTGGTAAACCTCGATCCAGATATTGACTTGGACGTGGTAGCGGGTAAACCACGGCCG
GGTGATTATCGGTATGCGGTCAACAACTCGTTCGGATTCGGCGGTCACAACGTAGCGATCGCCTTCGGCTGCTACTAA

Upstream 100 bases:

>100_bases
ACCTCGCTACGGCGACTACCGTTACGCGATCAATAACTCCTTCGGGTTCGGTGGCCACAACGTGGCGCTCGCTTTTGGGC
GCTACTAAGCACGGGAAGGA

Downstream 100 bases:

>100_bases
CCCGAACATCACTGACACAGGAGACCTGCGATGACAATCACGGCCCCAAAGGTGGTGGGCAAGTCCATTGATCCCCGCGA
TCCACTACTGCGTCTGAGCA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: Beta-ketoacyl-ACP synthase 2; KAS 2 [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MIARLMTTSPELVTGKAFPNVVVTGIAMTTALATDAETTWKLLLDNQSGIRMLDDPFIEEFNLPVRIGGHLLEEFDHQLT
RVELRRMGYLQRMSTVLSRRLWENAGSPEVDTNRLMVSIGTGLGSAEELVFSYDDMRARGMKAVSPLAVQKYMPNGAAAA
VGLEHHAKAGVMTPVSACASGSEAIAHAWQQIVLGEADSAICGGVETKIEAVPIAGFSQMRIVMSTKNDNPAGACRPFDR
DRDGFVFGEAGALMLIETEDSAKARSANILARIMGASITSDGFHMVAPDPNGERAGHAIARAVHLAGLSPSDIDHVNAHA
TGTQVGDLAEAKAINKALCNNRPAVYAPKSALGHSVGAVGAVESILTVLALRDQVIPPTLNLVNLDPDIDLDVVAGKPRP
GDYRYAVNNSFGFGGHNVAIAFGCY

Sequences:

>Translated_425_residues
MIARLMTTSPELVTGKAFPNVVVTGIAMTTALATDAETTWKLLLDNQSGIRMLDDPFIEEFNLPVRIGGHLLEEFDHQLT
RVELRRMGYLQRMSTVLSRRLWENAGSPEVDTNRLMVSIGTGLGSAEELVFSYDDMRARGMKAVSPLAVQKYMPNGAAAA
VGLEHHAKAGVMTPVSACASGSEAIAHAWQQIVLGEADSAICGGVETKIEAVPIAGFSQMRIVMSTKNDNPAGACRPFDR
DRDGFVFGEAGALMLIETEDSAKARSANILARIMGASITSDGFHMVAPDPNGERAGHAIARAVHLAGLSPSDIDHVNAHA
TGTQVGDLAEAKAINKALCNNRPAVYAPKSALGHSVGAVGAVESILTVLALRDQVIPPTLNLVNLDPDIDLDVVAGKPRP
GDYRYAVNNSFGFGGHNVAIAFGCY
>Mature_425_residues
MIARLMTTSPELVTGKAFPNVVVTGIAMTTALATDAETTWKLLLDNQSGIRMLDDPFIEEFNLPVRIGGHLLEEFDHQLT
RVELRRMGYLQRMSTVLSRRLWENAGSPEVDTNRLMVSIGTGLGSAEELVFSYDDMRARGMKAVSPLAVQKYMPNGAAAA
VGLEHHAKAGVMTPVSACASGSEAIAHAWQQIVLGEADSAICGGVETKIEAVPIAGFSQMRIVMSTKNDNPAGACRPFDR
DRDGFVFGEAGALMLIETEDSAKARSANILARIMGASITSDGFHMVAPDPNGERAGHAIARAVHLAGLSPSDIDHVNAHA
TGTQVGDLAEAKAINKALCNNRPAVYAPKSALGHSVGAVGAVESILTVLALRDQVIPPTLNLVNLDPDIDLDVVAGKPRP
GDYRYAVNNSFGFGGHNVAIAFGCY

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=33.8129496402878, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=43.8356164383562, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI41872631, Length=254, Percent_Identity=30.3149606299213, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1787337, Length=409, Percent_Identity=36.1858190709046, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1788663, Length=404, Percent_Identity=32.1782178217822, Blast_Score=172, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71983541, Length=405, Percent_Identity=30.8641975308642, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71983535, Length=258, Percent_Identity=36.8217054263566, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI212642053, Length=386, Percent_Identity=26.1658031088083, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=285, Percent_Identity=25.9649122807018, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=31.7567567567568, Blast_Score=201, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24644341, Length=436, Percent_Identity=32.7981651376147, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI221330659, Length=426, Percent_Identity=26.056338028169, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI19920632, Length=426, Percent_Identity=26.056338028169, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24581345, Length=433, Percent_Identity=24.7113163972286, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 45082; Mature: 45082

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIARLMTTSPELVTGKAFPNVVVTGIAMTTALATDAETTWKLLLDNQSGIRMLDDPFIEE
CCCEEECCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEECCCCHHHH
FNLPVRIGGHLLEEFDHQLTRVELRRMGYLQRMSTVLSRRLWENAGSPEVDTNRLMVSIG
CCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEE
TGLGSAEELVFSYDDMRARGMKAVSPLAVQKYMPNGAAAAVGLEHHAKAGVMTPVSACAS
CCCCCHHHHEEECCHHHHCCCCCCCHHHHHHHCCCCCCEEECHHHHCCCCCCCHHHHHCC
GSEAIAHAWQQIVLGEADSAICGGVETKIEAVPIAGFSQMRIVMSTKNDNPAGACRPFDR
CHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCC
DRDGFVFGEAGALMLIETEDSAKARSANILARIMGASITSDGFHMVAPDPNGERAGHAIA
CCCCEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHH
RAVHLAGLSPSDIDHVNAHATGTQVGDLAEAKAINKALCNNRPAVYAPKSALGHSVGAVG
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEECCHHHHCCCHHHHH
AVESILTVLALRDQVIPPTLNLVNLDPDIDLDVVAGKPRPGDYRYAVNNSFGFGGHNVAI
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEECCCCCCCEEEEECCCCCCCCCEEEE
AFGCY
EEECC
>Mature Secondary Structure
MIARLMTTSPELVTGKAFPNVVVTGIAMTTALATDAETTWKLLLDNQSGIRMLDDPFIEE
CCCEEECCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEECCCCHHHH
FNLPVRIGGHLLEEFDHQLTRVELRRMGYLQRMSTVLSRRLWENAGSPEVDTNRLMVSIG
CCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEE
TGLGSAEELVFSYDDMRARGMKAVSPLAVQKYMPNGAAAAVGLEHHAKAGVMTPVSACAS
CCCCCHHHHEEECCHHHHCCCCCCCHHHHHHHCCCCCCEEECHHHHCCCCCCCHHHHHCC
GSEAIAHAWQQIVLGEADSAICGGVETKIEAVPIAGFSQMRIVMSTKNDNPAGACRPFDR
CHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCC
DRDGFVFGEAGALMLIETEDSAKARSANILARIMGASITSDGFHMVAPDPNGERAGHAIA
CCCCEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHH
RAVHLAGLSPSDIDHVNAHATGTQVGDLAEAKAINKALCNNRPAVYAPKSALGHSVGAVG
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEECCHHHHCCCHHHHH
AVESILTVLALRDQVIPPTLNLVNLDPDIDLDVVAGKPRPGDYRYAVNNSFGFGGHNVAI
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEECCCCCCCEEEEECCCCCCCCCEEEE
AFGCY
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]