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The map label for this gene is dxr

Identifier: 221230308

GI number: 221230308

Start: 1908140

End: 1909360

Strand: Reverse

Name: dxr

Synonym: MLBr_01583

Alternate gene names: 221230308

Gene position: 1909360-1908140 (Counterclockwise)

Preceding gene: 221230310

Following gene: 221230307

Centisome position: 58.42

GC content: 62.65

Gene sequence:

>1221_bases
GTGAACAATCCGATCGAGGGGCACGCTGGCGGCCGCCTCCGCGTGCTGGTGTTGGGAAGTACTGGCTCAATTGGCACCCA
GGCGCTGGAAGTTATCGCCGCCAATCCGGACCGTTTCGAGGTAGTCGGGCTGGCCGCCGGGGGCGCGCAGCTGGACACGC
TGCTGAGGCAGCGCGCCGCGACCGGCGTCACCAATATCGCCATCGCTGACGATCGCGCGGCTCAGCTGGCCGGCGACATC
CCTTACCACGGGACCGATGCGGTCACCCGGCTGGTTGAGGAGACTGAGGCTGACGTTGTCCTCAATGCGCTGGTCGGGGC
ATTGGGTCTGCGACCCACACTGGCTGCACTGCACACGGGCGCGCGATTGGCGTTGGCCAACAAGGAATCGCTGGTAGCTG
GCGGTTCGCTGGTGTTGGCCGCGGCGCAGCCAGGCCAGATCGTGCCCGTAGACTCGGAACACTCCGCGCTGGCGCAATGC
CTGCGCGGTGGTACCCCCGACGAAGTTGCTAAGTTAGTGCTAACCGCCTCCGGCGGGCCGTTTCGTGGCTGGAACGCCGG
CGACTTGGAGCGCGTTACACCCGAGCAGGCGGGCGTCCATCCGACTTGGTCAATGGGGACGATGAACACGCTGAACTCAG
CGTCTCTGGTTAACAAGGGGCTCGAGCTCATCGAAGCCAACCTGTTGTTCGGCATTCCCTACGACCGCATTGAGGTGGTT
GTGCACCCTCAGTCAATTGTTCATTCGATGGTGACATTCATCGACGGCTCGACGATCGCCCAAGCCAGCCCTCCGGACAT
GAAGCTACCTATTTCTTTGGCGTTGGGCTGGCCACAGCGGGTGGGTGGCGCTGCTCGAGCCTGTGCTTTCACTACCGCAT
CTACCTGGGAATTCGAGCCGCTGGACATCGATGTTTTTCCCGCAGTCGAGCTGGCCCGGCACGCTGGACAGATCGGCGGC
TGTATGACCGCCATTTACGATGCTGCTAATGAGGAGGCTGCAGAGGCCTTCCTCCAAGGTCGGATCGGCTTCCCCGCCAT
CGTCGCAACAATCGCGGATGTGTTGCAGCGTGCCGACCAATGGGCTCCCCAATGGGGTGAGGGACCCGCTACTGTGGATG
ATGTACTCGACGCGCAGCGCTGGGCCCGTGAGCGAGCGTTGTGTGCGGTAGCAACAGCGAGTTCTGGAAAGGTCTCTGAC
ATGGTCTTAGAAAGGTCCTAA

Upstream 100 bases:

>100_bases
GGCCTACTGGCTTAGGGTACCGCTTAAAATTTATATGTTTTAGTACCGATCGTGGTCCGCTTTCTAGCCTGTCGAGTCAG
CGGACGGGCACAATCTTGGG

Downstream 100 bases:

>100_bases
AAGGCTCGATGATGTTCGCTCTCGGCATTGTGCTGTTCGCTATCGCCATTCTTATTTCGGTGGCCCTGCACGAATGTGGC
CACTTGTGGGTGGCGTGCGC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MNNPIEGHAGGRLRVLVLGSTGSIGTQALEVIAANPDRFEVVGLAAGGAQLDTLLRQRAATGVTNIAIADDRAAQLAGDI
PYHGTDAVTRLVEETEADVVLNALVGALGLRPTLAALHTGARLALANKESLVAGGSLVLAAAQPGQIVPVDSEHSALAQC
LRGGTPDEVAKLVLTASGGPFRGWNAGDLERVTPEQAGVHPTWSMGTMNTLNSASLVNKGLELIEANLLFGIPYDRIEVV
VHPQSIVHSMVTFIDGSTIAQASPPDMKLPISLALGWPQRVGGAARACAFTTASTWEFEPLDIDVFPAVELARHAGQIGG
CMTAIYDAANEEAAEAFLQGRIGFPAIVATIADVLQRADQWAPQWGEGPATVDDVLDAQRWARERALCAVATASSGKVSD
MVLERS

Sequences:

>Translated_406_residues
MNNPIEGHAGGRLRVLVLGSTGSIGTQALEVIAANPDRFEVVGLAAGGAQLDTLLRQRAATGVTNIAIADDRAAQLAGDI
PYHGTDAVTRLVEETEADVVLNALVGALGLRPTLAALHTGARLALANKESLVAGGSLVLAAAQPGQIVPVDSEHSALAQC
LRGGTPDEVAKLVLTASGGPFRGWNAGDLERVTPEQAGVHPTWSMGTMNTLNSASLVNKGLELIEANLLFGIPYDRIEVV
VHPQSIVHSMVTFIDGSTIAQASPPDMKLPISLALGWPQRVGGAARACAFTTASTWEFEPLDIDVFPAVELARHAGQIGG
CMTAIYDAANEEAAEAFLQGRIGFPAIVATIADVLQRADQWAPQWGEGPATVDDVLDAQRWARERALCAVATASSGKVSD
MVLERS
>Mature_406_residues
MNNPIEGHAGGRLRVLVLGSTGSIGTQALEVIAANPDRFEVVGLAAGGAQLDTLLRQRAATGVTNIAIADDRAAQLAGDI
PYHGTDAVTRLVEETEADVVLNALVGALGLRPTLAALHTGARLALANKESLVAGGSLVLAAAQPGQIVPVDSEHSALAQC
LRGGTPDEVAKLVLTASGGPFRGWNAGDLERVTPEQAGVHPTWSMGTMNTLNSASLVNKGLELIEANLLFGIPYDRIEVV
VHPQSIVHSMVTFIDGSTIAQASPPDMKLPISLALGWPQRVGGAARACAFTTASTWEFEPLDIDVFPAVELARHAGQIGG
CMTAIYDAANEEAAEAFLQGRIGFPAIVATIADVLQRADQWAPQWGEGPATVDDVLDAQRWARERALCAVATASSGKVSD
MVLERS

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=395, Percent_Identity=39.746835443038, Blast_Score=237, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_MYCLB (B8ZRU7)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503724.1
- ProteinModelPortal:   B8ZRU7
- SMR:   B8ZRU7
- EnsemblBacteria:   EBMYCT00000087451
- GeneID:   7325752
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000016490
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42315; Mature: 42315

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: BINDING 128-128 BINDING 153-153 BINDING 177-177 BINDING 200-200 BINDING 222-222

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNPIEGHAGGRLRVLVLGSTGSIGTQALEVIAANPDRFEVVGLAAGGAQLDTLLRQRAA
CCCCCCCCCCCEEEEEEEECCCCCHHHHHHEEECCCCCEEEEEEECCCHHHHHHHHHHHH
TGVTNIAIADDRAAQLAGDIPYHGTDAVTRLVEETEADVVLNALVGALGLRPTLAALHTG
CCCCEEEEECCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
ARLALANKESLVAGGSLVLAAAQPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGP
CEEEEECCCCEEECCCEEEEECCCCCEEECCCCHHHHHHHHCCCCHHHHEEEEEEECCCC
FRGWNAGDLERVTPEQAGVHPTWSMGTMNTLNSASLVNKGLELIEANLLFGIPYDRIEVV
CCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCEEEE
VHPQSIVHSMVTFIDGSTIAQASPPDMKLPISLALGWPQRVGGAARACAFTTASTWEFEP
ECCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCHHHHCCHHHHHEEEECCCCCCCC
LDIDVFPAVELARHAGQIGGCMTAIYDAANEEAAEAFLQGRIGFPAIVATIADVLQRADQ
CCEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
WAPQWGEGPATVDDVLDAQRWARERALCAVATASSGKVSDMVLERS
CCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHEECC
>Mature Secondary Structure
MNNPIEGHAGGRLRVLVLGSTGSIGTQALEVIAANPDRFEVVGLAAGGAQLDTLLRQRAA
CCCCCCCCCCCEEEEEEEECCCCCHHHHHHEEECCCCCEEEEEEECCCHHHHHHHHHHHH
TGVTNIAIADDRAAQLAGDIPYHGTDAVTRLVEETEADVVLNALVGALGLRPTLAALHTG
CCCCEEEEECCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
ARLALANKESLVAGGSLVLAAAQPGQIVPVDSEHSALAQCLRGGTPDEVAKLVLTASGGP
CEEEEECCCCEEECCCEEEEECCCCCEEECCCCHHHHHHHHCCCCHHHHEEEEEEECCCC
FRGWNAGDLERVTPEQAGVHPTWSMGTMNTLNSASLVNKGLELIEANLLFGIPYDRIEVV
CCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCEEEE
VHPQSIVHSMVTFIDGSTIAQASPPDMKLPISLALGWPQRVGGAARACAFTTASTWEFEP
ECCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCHHHHCCHHHHHEEEECCCCCCCC
LDIDVFPAVELARHAGQIGGCMTAIYDAANEEAAEAFLQGRIGFPAIVATIADVLQRADQ
CCEEHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
WAPQWGEGPATVDDVLDAQRWARERALCAVATASSGKVSDMVLERS
CCCCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA